Risk factors for death among cancer patients with fungemia
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In order to identify prognostic factors for death among cancer patients with fungemia, an 18-month survey of fungemia in patients with cancer was undertaken in three hospitals in Rio de Janeiro. For the assessment of risk factors for death, the following variables were analyzed: age; gender; underlying cancer; last treatment for the underlying disease; previous surgery; use of antibiotics, antifungal agents, steroids, or total parenteral nutrition; use of a central venous catheter; chemotherapy; radiotherapy; presence and duration of neutropenia; etiologic agent of the fungemia; treatment of the fungemia; clinical manifestations; and performance status (Karnofsky score) on the day of the positive blood culture. In multivariate analysis, the variables associated with an increased risk for death were older age, persistent neutropenia, and low performance status. Identifying risk factors for death may help to define a group-risk patients for whom new therapeutic options should be tried.
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A few studies have questioned these recommendations, failing to find a significant mortality benefit with prompt removal of the line and advising that removal and placement of a new device does not come without risk and cost.
“A few studies have questioned these recommendations, failing to find a significant mortality benefit with prompt removal of the line and advising that removal and placement of a new device does not come without risk and cost.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [179]
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Schmidt‐Hieber, M., Teschner, D., Desole, M., Link, H., Maschmeyer, G., & Schalk, E. (2022) · Springer Reference Medizin · doi:10.1007/978-3-662-46764-0_155-1
Pasqualotto, A. C. (2004) · Americanae (AECID Library)
- Authors
- Nucci, M., Silveira, M. I., Spector, N., Silveira, F., Velasco, E., Akiti, T., Barreiros, G., Derossi, A., Colombo, A. L., & Pulcheri, W.
- Affiliations
- Universidade Federal do Rio de Janeiro (BR)
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-07
- Volume
- 27
- Issue
- 1
- Pages
- 107-111
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2131920567
- Cited by
- 69
- References
- 22
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- fungemia, cancer patients, mortality risk factors, prognostic factors, neutropenia, performance status, Karnofsky performance status, age, central venous catheters, antifungal therapy, chemotherapy, radiotherapy, blood culture
- MeSH terms
- Adult, Aged, Female, Humans, Male, Middle Aged, Neoplasms, Prognosis, Risk Factors, Multivariate Analysis, Survival Analysis, Fungemia, Statistics, Nonparametric
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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