Partial Support for an Interaction Between a Polygenic Risk Score for Major Depressive Disorder and Prenatal Maternal Depressive Symptoms on Infant Right Amygdalar Volumes
Open accessAbstract
Psychiatric disease susceptibility partly originates prenatally and is shaped by an interplay of genetic and environmental risk factors. A recent study has provided preliminary evidence that an offspring polygenic risk score for major depressive disorder (PRS-MDD), based on European ancestry, interacts with prenatal maternal depressive symptoms (GxE) on neonatal right amygdalar (US and Asian cohort) and hippocampal volumes (Asian cohort). However, to date, this GxE interplay has only been addressed by one study and is yet unknown for a European ancestry sample. We investigated in 105 Finnish mother–infant dyads (44 female, 11–54 days old) how offspring PRS-MDD interacts with prenatal maternal depressive symptoms (Edinburgh Postnatal Depression Scale, gestational weeks 14, 24, 34) on infant amygdalar and hippocampal volumes. We found a GxE effect on right amygdalar volumes, significant in the main analysis, but nonsignificant after multiple comparison correction and some of the control analyses, whose direction paralleled the US cohort findings. Additional exploratory analyses suggested a sex-specific GxE effect on right hippocampal volumes. Our study is the first to provide support, though statistically weak, for an interplay of offspring PRS-MDD and prenatal maternal depressive symptoms on infant limbic brain volumes in a cohort matched to the PRS-MDD discovery sample.
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Greater prenatal maternal depressive symptoms are associated with larger right amygdala volume in infants under 2 months old and girls at 4.5 years old.
“Greater prenatal maternal depressive symptoms are associated with larger right amygdala volume in infants under 2 months old and girls at 4.5 years old [39, 86, 87].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [87]
The Discussion (page not available) describes larger right amygdalar volumes in infants when maternal depressive symptoms are higher as conditional on genetic risk; it reports smaller volumes when both genetic risk and depressive symptoms are high. It also calls its sex-specific infant finding tentative and cites other studies for a more positive association in girls. This paper did not study girls at 4.5 years, so it does not support that age-specific part of the claim. (LLM, conf=0.86)
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Braithwaite, E., Hill, J., Pickles, A. R., Glover, V. A. S., O’Donnell, K. J., & Sharp, H. M. (2018) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174418000181 · Cited by 28 · see citing works
Cortical and subcortical T1 white/gray contrast, chronological age, and cognitive performance
Lewis, J. D., Fonov, V., Collins, D. L., Evans, A. C., Tohka, J., & for the Brain Development Cooperative Group, A. T. P. I. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.04.022 · Cited by 26 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Yilmazer-Hanke DM. 2012. Amygdala. In: Mai JK, Paxinos G, edi- tors. The Human Nervous System. 3rd ed. San Diego: Academic Press. pp. 759-834.
Cited by
Sorted by citations
Wu, Y., De Asis-Cruz, J., & Limperopoulos, C. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02449-0 · Cited by 124 · see citing works
“Greater prenatal maternal depressive symptoms are associated with larger right amygdala volume in infants under 2 months old and girls at 4.5 years old [39, 86, 87].”
BackgroundInfluentialGroenewold, N. A., Wedderburn, C. J., Pellowski, J. A., Fouché, J.-P., Michalak, L., Roos, A., Woods, R. P., Narr, K. L., Zar, H. J., Donald, K. A., et al. (2022) · NeuroImage: Clinical · doi:10.1016/j.nicl.2022.103206 · Cited by 22 · see citing works
Hashempour, N., Tuulari, J. J., Merisaari, H., Acosta, H., Lewis, J. D., Pelto, J., Scheinin, N. M., Fonov, V. S., Collins, D. L., Lehtola, S. J., et al. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15989 · Cited by 20 · see citing works
Self-citationAcosta, H., Kantojärvi, K., Tuulari, J. J., Lewis, J. D., Hashempour, N., Scheinin, N. M., Lehtola, S. J., Nolvi, S., Fonov, V. S., Collins, D. L., et al. (2024) · Development and Psychopathology · doi:10.1017/s0954579423000275 · Cited by 11 · see citing works
Self-citation
- Authors
- Acosta, H., Kantojärvi, K., Hashempour, N., Pelto, J., Scheinin, N. M., Lehtola, S. J., Lewis, J. D., Fonov, V. S., Collins, D. L., Evans, A., Parkkola, R., Lähdesmäki, T., Saunavaara, J., Karlsson, L., Merisaari, H., Paunio, T., Karlsson, H., & Tuulari, J. J.
- Affiliations
- University of Turku (FI)
- University of Helsinki (FI)
- Montreal Neurological Institute and Hospital (CA)
- Turku University Hospital (FI)
- Corresponding author
- Acosta, H
- ORCID
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-07-17
- Volume
- 30
- Issue
- 12
- Pages
- 6121-6134
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W3042486513
- Cited by
- 34
- References
- 86
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 10 · 2023: 8 · 2022: 4 · 2021: 5 · 2020: 1
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cerebral Cortex (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- UTUPub (University of Turku) (submittedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- Jane and Aatos Erkko Foundation
- Academy of Finland (264363, 253270, 134950, 1350941, 253346, 308176)
- Hospital District of Southwest Finland State Research (P3006, P3003, P3498, P3654, K3562)
- Signe and Ane Gyllenberg Foundation
- Yrjö Jahnsson Foundation (6847)
- Alfred Kordellin Foundation
- Turku University Foundation
- Emil Aaltonen Foundation
- Maire Taponen Foundation
- Juho Vainio Foundation
- Sigrid Jusélius Foundation
- Orion Research Foundation
- Azrieli Neurodevelopmental Research Program (ANRP-MIRI13–3388)
- Brain Canada Multi-Investigator Research Initiative
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- major depressive disorder, polygenic risk score, gene-environment interaction, hippocampal volume, postpartum depression, sex differences, mother-infant dyads, European ancestry
- MeSH terms
- Amygdala, Child Development, Depression, Major Depressive Disorder, Female, Hippocampus, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging, Male, Maternal Behavior, Multifactorial Inheritance, White People
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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