Genome-wide scans for footprints of natural selection
Open accessAbstract
Detecting recent selected ‘genomic footprints’ applies directly to the discovery of disease genes and in the imputation of the formative events that molded modern population genetic structure. The imprints of historic selection/adaptation episodes left in human and animal genomes allow one to interpret modern and ancestral gene origins and modifications. Current approaches to reveal selected regions applied in genome-wide selection scans (GWSSs) fall into eight principal categories: (I) phylogenetic footprinting, (II) detecting increased rates of functional mutations, (III) evaluating divergence versus polymorphism, (IV) detecting extended segments of linkage disequilibrium, (V) evaluating local reduction in genetic variation, (VI) detecting changes in the shape of the frequency distribution (spectrum) of genetic variation, (VII) assessing differentiating between populations ( F ST ), and (VIII) detecting excess or decrease in admixture contribution from one population. Here, we review and compare these approaches using available human genome-wide datasets to provide independent verification (or not) of regions found by different methods and using different populations. The lessons learned from GWSSs will be applied to identify genome signatures of historic selective pressures on genes and gene regions in other species with emerging genome sequences. This would offer considerable potential for genome annotation in functional, developmental and evolutionary contexts.
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Rsb is a powerful method to detect selection signature when the selected allele has reached fixation.
“in agreement with Rsb being a powerful method to detect selection signature when the selected allele has reached fixation (Tang et al., 2007; Oleksyk et al., 2010; Bahbahani et al., 2018).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Oleksyk et al., 2010
The Extended linkage disequilibrium segments section discusses haplotype-based tests for detecting selection, but does not identify Rsb or assess its power when an allele has reached fixation. Searches for “Rsb,” “fixation,” and fixed sweeps found no passage addressing that specific claim; the section instead describes LD tests as most useful for recent, incomplete sweeps. (LLM, conf=0.75)
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Cites
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216 · see citing works
Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.
Tajima, F. (1989) · Genetics · doi:10.1093/genetics/123.3.585 · Cited by 13,991 · see citing works
THE GENETICAL STRUCTURE OF POPULATIONS
Wright, S. (1949) · Annals of Eugenics · doi:10.1111/j.1469-1809.1949.tb02451.x · Cited by 6,729 · see citing works
A haplotype map of the human genome
The International HapMap Consortium (2005) · Nature · doi:10.1038/nature04226 · Cited by 5,858 · see citing works
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438 · see citing works
Statistical tests of neutrality of mutations.
Fu, Y., & Li, W. (1993) · Genetics · doi:10.1093/genetics/133.3.693 · Cited by 4,051 · see citing works
The hitch-hiking effect of a favourable gene
Smith, J. M., & Haigh, J. (1974) · Genetical Research · doi:10.1017/s0016672300014634 · Cited by 3,415 · see citing works
Adaptive protein evolution at the Adh locus in Drosophila
McDonald, J. H., & Kreitman, M. (1991) · Nature · doi:10.1038/351652a0 · Cited by 3,320 · see citing works
A Map of Recent Positive Selection in the Human Genome
Voight, B. F., Kudaravalli, S., Wen, X., & Pritchard, J. K. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040072 · Cited by 2,912 · see citing works
The hitch-hiking effect of a favourable gene
MAYNARD, J., & Haigh, J. (2007) · Genetics Research · doi:10.1017/s0016672308009579 · Cited by 2,663 · see citing works
Genome sequence, comparative analysis and haplotype structure of the domestic dog
members, B. S. P., Lindblad-Toh, K., Wade, C. M., Mikkelsen, T. S., Karlsson, E. K., Jaffe, D. B., Kamal, M., Clamp, M., Chang, J. L., Kulbokas, E. J., et al. (2005) · Nature · doi:10.1038/nature04338 · Cited by 2,568 · see citing works
Dean, M. C., Carrington, M. N., Winkler, C. A., Huttley, G. A., Smith, M. W., Allikmets, R. L., Goedert, J. J., Buchbinder, S., Vittinghoff, E., Gomperts, E. D., et al. (1996) · Science · doi:10.1126/science.273.5283.1856 · Cited by 2,499 · see citing works
Self-citationInitial sequence of the chimpanzee genome and comparison with the human genome
The Chimpanzee Sequencing and Analysis Consortium (2005) · Nature · doi:10.1038/nature04072 · Cited by 2,459 · see citing works
Genome-wide detection and characterization of positive selection in human populations
The International HapMap Consortium, Sabeti, P. C., Varilly, P., Fry, B., Lohmueller, J., Hostetter, E., Cotsapas, C., Xie, X., Byrne, E. H., McCarroll, S. A., et al. (2007) · Nature · doi:10.1038/nature06250 · Cited by 2,131 · see citing works
Detecting recent positive selection in the human genome from haplotype structure
Sabeti, P. C., Reich, D. E., Higgins, J. M., Levine, H. Z. P., Richter, D. J., Schaffner, S. F., Gabriel, S. B., Platko, J. V., Patterson, N. J., McDonald, G. J., et al. (2002) · Nature · doi:10.1038/nature01140 · Cited by 2,106 · see citing works
Hitchhiking Under Positive Darwinian Selection
Fay, J. C., & Wu, C.-I. (2000) · Genetics · doi:10.1093/genetics/155.3.1405 · Cited by 1,819 · see citing works
A Test of Neutral Molecular Evolution Based on Nucleotide Data
Hudson, R. R., Kreitman, M., & Aguadé, M. (1987) · Genetics · doi:10.1093/genetics/116.1.153 · Cited by 1,788 · see citing works
Evaluating loci for use in the genetic analysis of population structure
(1996) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1996.0237 · Cited by 1,733 · see citing works
Nielsen, R., & Yang, Z. (1998) · Genetics · doi:10.1093/genetics/148.3.929 · Cited by 1,622 · see citing works
Convergent adaptation of human lactase persistence in Africa and Europe
Tishkoff, S. A., Reed, F. A., Ranciaro, A., Voight, B. F., Babbitt, C. C., Silverman, J. S., Powell, K., Mortensen, H. M., Hirbo, J. B., Osman, M., et al. (2007) · Nature Genetics · doi:10.1038/ng1946 · Cited by 1,615 · see citing works
Molecular evolution of FOXP2, a gene involved in speech and language
Enard, W., Przeworski, M., Fisher, S. E., Lai, C. S. L., Wiebe, V., Kitano, T., Monaco, A. P., & Pääbo, S. (2002) · Nature · doi:10.1038/nature01025 · Cited by 1,603 · see citing works
DISTRIBUTION OF GENE FREQUENCY AS A TEST OF THE THEORY OF THE SELECTIVE NEUTRALITY OF POLYMORPHISMS
Lewontin, R. C., & Krakauer, J. (1973) · Genetics · doi:10.1093/genetics/74.1.175 · Cited by 1,181 · see citing works
Positive Natural Selection in the Human Lineage
Sabeti, P. C., Schaffner, S. F., Fry, B., Lohmueller, J., Varilly, P., Shamovsky, O., Palma, A., Mikkelsen, T. S., Altshuler, D., & Lander, E. S. (2006) · Science · doi:10.1126/science.1124309 · Cited by 1,157 · see citing works
Identifying adaptive genetic divergence among populations from genome scans
Beaumont, M., & Balding, D. J. (2004) · Molecular Ecology · doi:10.1111/j.1365-294x.2004.02125.x · Cited by 1,130 · see citing works
How Malaria Has Affected the Human Genome and What Human Genetics Can Teach Us about Malaria
Kwiatkowski, D. P. (2005) · The American Journal of Human Genetics · doi:10.1086/432519 · Cited by 1,106 · see citing works
Genetic signatures of strong recent positive selection at the lactase gene.
Bersaglieri, T., Sabeti, P. C., Patterson, N., VanderPloeg, T., Schaffner, S., Drake, J. A., Rhodes, M., Reich, D., & Hirschhorn, J. (2004) · American Journal of Human Genetics · doi:10.1086/421051 · Cited by 1,098 · see citing works
SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans
Lamason, R. L., Mohideen, M.-A. P. K., Mest, J. R., Wong, A. C., Norton, H. L., Aros, M. C., Jurynec, M. J., Mao, X., Humphreville, V. R., Humbert, J. E., et al. (2005) · Science · doi:10.1126/science.1116238 · Cited by 1,043 · see citing works
Identification of a variant associated with adult-type hypolactasia
Enattah, N. S., Sahi, T., Savilahti, E., Terwilliger, J. D., Peltonen, L., & Järvelä, I. E. (2002) · Nature Genetics · doi:10.1038/ng826 · Cited by 1,029 · see citing works
Genomic scans for selective sweeps using SNP dataPreprint
Nielsen, R., Williamson, S., Kim, Y., Hubisz, M. J., Clark, A. G., & Bustamante, C. D. (2005) · Genome Research · doi:10.1101/gr.4252305 · Cited by 1,024 · see citing works
VISTA : visualizing global DNA sequence alignments of arbitrary length
Mayor, C., Brudno, M., Schwartz, J. R., Poliakov, A., Rubin, E. M., Frazer, K. A., Pachter, L. S., & Dubchak, I. L. (2000) · Bioinformatics · doi:10.1093/bioinformatics/16.11.1046 · Cited by 1,017 · see citing works
Simple methods for testing the molecular evolutionary clock hypothesis.
Tajima, F. (1993) · Genetics · doi:10.1093/genetics/135.2.599 · Cited by 948 · see citing works
Interrogating a high-density SNP map for signatures of natural selection.Preprint
Akey, J., Zhang, G., Zhang, K., Jin, L., & Shriver, M. (2002) · Genome Research · doi:10.1101/gr.631202 · Cited by 932 · see citing works
Robbins, L. S. (1993) · Cell · doi:10.1016/0092-8674(93)90572-8 · Cited by 884 · see citing works
Natural selection on protein-coding genes in the human genome
Bustamante, C. D., Fledel-Alon, A., Williamson, S., Nielsen, R., Hubisz, M. J., Glanowski, S., Tanenbaum, D. M., White, T. J., Sninsky, J. J., Hernandez, R. D., et al. (2005) · Nature · doi:10.1038/nature04240 · Cited by 788 · see citing works
Lander, E., Linton, L., Birren, B. W., & Nusbaum, C. (2001) · Cited by 772 · see citing works
Genetic determinants of hair, eye and skin pigmentation in Europeans
Sulem, P., Gudbjartsson, D. F., Stacey, S. N., Helgason, A., Rafnar, T., Magnusson, K. P., Manolescu, A., Karason, A., Palsson, A., Thorleifsson, G., et al. (2007) · Nature Genetics · doi:10.1038/ng.2007.13 · Cited by 750 · see citing works
Tournamille, C., Colin, Y., Cartron, J. P., & Le Van Kim, C. (1995) · Nature Genetics · doi:10.1038/ng0695-224 · Cited by 741 · see citing works
The limits of selection during maize domestication
Wang, R.-L., Stec, A., Hey, J., Lukens, L., & Doebley, J. (1999) · Nature · doi:10.1038/18435 · Cited by 740 · see citing works
Beutler, E. (1994) · Blood · doi:10.1182/blood.v84.11.3613.bloodjournal84113613 · Cited by 737 · see citing works
Sawyer, S. L., Wu, L. I., Emerman, M., & Malik, H. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409853102 · Cited by 688 · see citing works
Synonymous and nonsynonymous rate variation in nuclear genes of mammals
Yang, Z., & Nielsen, R. (1998) · Journal of Molecular Evolution · doi:10.1007/pl00006320 · Cited by 679 · see citing works
Tishkoff, S. A., Varkonyi, R., Cahinhinan, N., Abbes, S., Argyropoulos, G., Destro-Bisol, G., Drousiotou, A., Dangerfield, B., Lefranc, G., Loiselet, J., et al. (2001) · Science · doi:10.1126/science.1061573 · Cited by 630 · see citing works
CCR5 deficiency increases risk of symptomatic West Nile virus infection
Glass, W. G., McDermott, D., Lim, J. K., Lekhong, S., Yu, S., Frank, W. A., Pape, J., Cheshier, R. C., & Murphy, P. (2006) · Journal of Experimental Medicine · doi:10.1084/jem.20051970 · Cited by 543 · see citing works
Genome 10K: A Proposal to Obtain Whole-Genome Sequence for 10 000 Vertebrate Species
Scientists, G. 1. C. O. (2009) · Journal of Heredity · doi:10.1093/jhered/esp086 · Cited by 539 · see citing works
Dating the Origin of the CCR5-Δ32 AIDS-Resistance Allele by the Coalescence of Haplotypes
Stephens, J. C., Reich, D. E., Goldstein, D. B., Shin, H. D., Smith, M. W., Carrington, M., Winkler, C., Huttley, G. A., Allikmets, R., Schriml, L., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/301867 · Cited by 520 · see citing works
Self-citationOvcharenko, I., Nobrega, M. A., Loots, G. G., & Stubbs, L. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh355 · Cited by 519 · see citing works
The Signature of Positive Selection at Randomly Chosen Loci
Przeworski, M. (2002) · Genetics · doi:10.1093/genetics/160.3.1179 · Cited by 509 · see citing works
Evidence of positive selection acting at the human dopamine receptor D4 gene locus
Ding, Y. C., Chi, H. C., Grady, D., Morishima, A., Kidd, J., Kidd, K., Flodman, P., Spence, M., Schuck, S., Swanson, J., et al. (2001) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.012464099 · Cited by 506 · see citing works
Recent and ongoing selection in the human genome
Nielsen, R., Hellmann, I., Hubisz, M. J., Bustamante, C. D., & Clark, A. G. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2187 · Cited by 501 · see citing works
Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5
Martin, M. P. (1998) · Science · doi:10.1126/science.282.5395.1907 · Cited by 473 · see citing works
Genomic insights into positive selection
Biswas, S., & Akey, J. M. (2006) · Trends in Genetics · doi:10.1016/j.tig.2006.06.005 · Cited by 471 · see citing works
Ongoing Adaptive Evolution of ASPM , a Brain Size Determinant in Homo sapiens
Mekel-Bobrov, N., Gilbert, S. L., Evans, P. D., Vallender, E. J., Anderson, J. R., Hudson, R. R., Tishkoff, S. A., & Lahn, B. T. (2005) · Science · doi:10.1126/science.1116815 · Cited by 463 · see citing works
A High-Density Admixture Map for Disease Gene Discovery in African Americans
Smith, M. W., Patterson, N., Lautenberger, J. A., Truelove, A. L., McDonald, G. J., Waliszewska, A., Kessing, B. D., Malasky, M. J., Scafe, C., Le, E., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/420856 · Cited by 459 · see citing works
Self-citationLong-Range LD Can Confound Genome Scans in Admixed Populations
Price, A. L., Weale, M. E., Patterson, N., Myers, S. R., Need, A. C., Shianna, K. V., Ge, D., Rotter, J. I., Torres, E., Taylor, K. D., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.06.005 · Cited by 443 · see citing works
Drift, admixture, and selection in human evolution: a study with DNA polymorphisms.
Bowcock, A. M., Kidd, J. R., Mountain, J. L., Hebert, J. M., Carotenuto, L., Kídd, K. K., & Cavalli-Sforza, L. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.3.839 · Cited by 414 · see citing works
Chakraborty, R., & Weiss, K. (1988) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.85.23.9119 · Cited by 404 · see citing works
The Genetic Architecture of Selection at the Human Dopamine Receptor D4 (DRD4) Gene Locus
Wang, E., Ding, Y.-C., Flodman, P. L., Kidd, J. R., Kídd, K. K., Grady, D. L., Ryder, O. A., Spence, M. A., Swanson, J. M., & Moyzis, R. K. (2004) · The American Journal of Human Genetics · doi:10.1086/420854 · Cited by 401 · see citing works
Evidence for Variable Selective Pressures at MC1R
Harding, R. M., Healy, E., Ray, A. J., Ellis, N. S., Flanagan, N., Todd, C., Dixon, C., Sajantila, A., Jackson, I. J., Birch-Machin, M. A., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/302863 · Cited by 389 · see citing works
Melanocortin‐1 receptor structure and functional regulation
García-Borrón, J. C., Sánchez‐Laorden, B. L., & Jiménez‐Cervantes, C. (2005) · Pigment Cell Research · doi:10.1111/j.1600-0749.2005.00278.x · Cited by 382 · see citing works
Melanocortin Receptor 1 (MC1R) Mutations and Coat Color in Pigs
Kijas, J. M. H., Wales, R., Törnsten, A., Chardon, P., Moller, M. J., & Andersson, L. (1998) · Genetics · doi:10.1093/genetics/150.3.1177 · Cited by 377 · see citing works
Initial sequence and comparative analysis of the cat genome
Pontius, J. U., Mullikin, J. C., Smith, D. R., Agencourt Sequencing Team, Lindblad-Toh, K., Gnerre, S., Clamp, M., Chang, J., Stephens, R., Neelam, B., et al. (2007) · Genome Research · doi:10.1101/gr.6380007 · Cited by 368 · see citing works
Self-citationGlobal landscape of recent inferred Darwinian selection for Homo sapiens
Wang, E. T., Kodama, G., Baldi, P., & Moyzis, R. K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509691102 · Cited by 367 · see citing works
The genetics of pigmentation: from fancy genes to complex traits
Barsh, G. S. (1996) · Trends in Genetics · doi:10.1016/0168-9525(96)10031-7 · Cited by 358 · see citing works
Detection of the Signature of Natural Selection in Humans: Evidence from the Duffy Blood Group Locus
Hamblin, M. T., & Rienzo, A. D. (2000) · The American Journal of Human Genetics · doi:10.1086/302879 · Cited by 352 · see citing works
Marklund, L., Moller, M. J., Sandberg, K., & Andersson, L. (1996) · Mammalian Genome · doi:10.1007/s003359900264 · Cited by 322 · see citing works
Molecular Genetics and Evolution of Melanism in the Cat Family
Eduardo Eizirik, C., Yuhki, N., Johnson, W. E., Menotti-Raymond, M. A., Hannah, S. S., & O’Brien, S. J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00128-3 · Cited by 320 · see citing works
Self-citationO’Brien, S. J., & Nelson, G. W. (2004) · Nature Genetics · doi:10.1038/ng1369 · Cited by 317 · see citing works
Self-citationCYP3A variation and the evolution of salt-sensitivity variants.
Thompson, E., Kuttab-Boulos, H., Witonsky, D., Yang, L., Roe, B., & Rienzo, A. D. (2004) · American Journal of Human Genetics · doi:10.1086/426406 · Cited by 313 · see citing works
Evidence for Selective Advantage of Pathogenic FGFR2 Mutations in the Male Germ Line
Goriely, A., McVean, G., Rojmyr, M., Ingemarsson, B., & Wilkie, A. O. M. (2003) · Science · doi:10.1126/science.1085710 · Cited by 310 · see citing works
Genomic regions exhibiting positive selection identified from dense genotype data
Carlson, C. S., Thomas, D. J., Eberle, M. A., Swanson, J. E., Livingston, R. J., Rieder, M. J., & Nickerson, D. A. (2005) · Genome Research · doi:10.1101/gr.4326505 · Cited by 298 · see citing works
From Malaria to Chemokine Receptor: The Emerging Physiologic Role of the Duffy Blood Group Antigen
Hadley, T. J., & Peiper, S. C. (1997) · Blood · doi:10.1182/blood.v89.9.3077 · Cited by 295 · see citing works
Libert, F. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.3.399 · Cited by 292 · see citing works
High Polymorphism at the Human Melanocortin 1 Receptor Locus
Rana, B. K., Hewett‐Emmett, D., Li, J., Chang, B. H.-J., Sambuughin, N., Lin, M., Watkins, W. S., Bamshad, M. J., Jorde, L. B., Ramsay, M., et al. (1999) · Genetics · doi:10.1093/genetics/151.4.1547 · Cited by 284 · see citing works
A Genomewide Admixture Map for Latino Populations
Price, A. L., Patterson, N., Yu, F., Cox, D. R., Waliszewska, A., McDonald, G. J., Tandon, A., Schirmer, C., Neubauer, J., Bedoya, G., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/518313 · Cited by 282 · see citing works
Complex Signatures of Natural Selection at the Duffy Blood Group Locus
Hamblin, M. T., Thompson, E. E., & Rienzo, A. D. (2002) · The American Journal of Human Genetics · doi:10.1086/338628 · Cited by 278 · see citing works
Galvani, A. P., & Slatkin, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2435085100 · Cited by 270 · see citing works
Olds, L. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg244 · Cited by 255 · see citing works
Osier, M., Pakstis, A., Soodyall, H., Comas, D., Goldman, D., Odunsi, A., Okonofua, F., Parnas, J., Schulz, L. O., Bertranpetit, J., et al. (2002) · American Journal of Human Genetics · doi:10.1086/341290 · Cited by 254 · see citing works
O’Brien, S. J., & Moore, J. P. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.17710.x · Cited by 254 · see citing works
Self-citationDisentangling the effects of demography and selection in human history.
Stajich, J., & Hahn, M. (2004) · Molecular biology and evolution · doi:10.1093/molbev/msh252 · Cited by 252 · see citing works
The Geographic Spread of the CCR5 Δ32 HIV-Resistance Allele
Novembre, J., Galvani, A. P., & Slatkin, M. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030339 · Cited by 250 · see citing works
Melanocortin 1 Receptor Variants in an Irish Population
Smith, R., Healy, E., Siddiqui, S., Flanagan, N., Steijlen, P. M., Rosdahl, I. K., Jacques, J. P., Rogers, S., Turner, R., Jackson, I. J., et al. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00252.x · Cited by 248 · see citing works
A strong signature of balancing selection in the 5′ cis -regulatory region of CCR5
Bamshad, M. J., Mummidi, S., Gonzalez, E., Ahuja, S. S., Dunn, D. M., Watkins, W. S., Wooding, S., Stone, A. C., Jorde, L. B., Weiss, R. B., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162046399 · Cited by 236 · see citing works
Genetics of HIV-1infection: chemokine receptor CCR5 polymorphism and its consequences
Carrington, M. N. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.10.1939 · Cited by 235 · see citing works
Gonzalez, E., Dhanda, R., Bamshad, M., Mummidi, S., Geevarghese, R., Catano, G., Anderson, S. A., Walter, E. A., Stephan, K. T., Hammer, M. F., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091056898 · Cited by 225 · see citing works
Host Switch Leads to Emergence of Plasmodium vivax Malaria in Humans
Mu, J., Joy, D. A., Duan, J., Huang, Y., Carlton, J. M., Walker, J. C., Barnwell, J. W., Beerli, P., Charleston, M., Pybus, O. G., et al. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi160 · Cited by 220 · see citing works
Mapping by admixture linkage disequilibrium: advances, limitations and guidelines
Smith, M. W., & O’Brien, S. J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1657 · Cited by 215 · see citing works
Self-citationMelanocortin 1 receptor variation in the domestic dog
Newton, J. M., Wilkie, A. L., He, L., Jordan, S. A., Bannasch, D. L., Holmes, N. G., Jackson, I. J., & Barsh, G. S. (2000) · Mammalian Genome · doi:10.1007/s003350010005 · Cited by 215 · see citing works
The Case for Selection at CCR5-Δ32
Sabeti, P. C., Walsh, E. C., Schaffner, S. F., Varilly, P., Fry, B., Hutcheson, H. B., Cullen, M., Mikkelsen, T. S., Roy, J., Patterson, N. J., et al. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030378 · Cited by 205 · see citing works
Self-citationAn upstream polymorphism associated with lactase persistence has increased enhancer activity
Troelsen, J. T., Olsen, J., Møller, J., & Sjöström, H. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.031 · Cited by 194 · see citing works
A Scan for Linkage Disequilibrium Across the Human Genome
Huttley, G. A., Smith, M. W., Carrington, M. N., & O’Brien, S. J. (1999) · Genetics · doi:10.1093/genetics/152.4.1711 · Cited by 193 · see citing works
Self-citationHuman pigmentation variation: evolution, genetic basis, and implications for public health
Parra, E. J. (2007) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20727 · Cited by 191 · see citing works
Lactase haplotype diversity in the Old World.
Hollox, E., Poulter, M., Zvarík, M., Ferák, V., Krause, A., Jenkins, T., Saha, N., Kozlov, A., & Swallow, D. (2001) · American Journal of Human Genetics · doi:10.1086/316924 · Cited by 188 · see citing works
Algorithms for Phylogenetic Footprinting
Blanchette, M., Schwikowski, B., & Tompa, M. (2002) · Journal of Computational Biology · doi:10.1089/10665270252935421 · Cited by 176 · see citing works
Lewinsky, R., Jensen, T. G. K., Møller, J., Stensballe, A., Olsen, J., & Troelsen, J. T. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi418 · Cited by 176 · see citing works
Recent Genetic Selection in the Ancestral Admixture of Puerto Ricans
Tang, H., Choudhry, S., Mei, R., Morgan, M. T., Rodríguez-Cintrón, W., Burchard, E. G., & RISCH, N. J. (2007) · The American Journal of Human Genetics · doi:10.1086/520769 · Cited by 175 · see citing works
Every genome sequence needs a good mapPreprint
Lewin, H. A., Larkin, D. M., Pontius, J. U., & O’Brien, S. J. (2009) · Genome Research · doi:10.1101/gr.094557.109 · Cited by 172 · see citing works
Self-citationGenetic Variation at the MC1R Locus and the Time since Loss of Human Body Hair
Rogers, A. R., Iltis, D., & Wooding, S. (2004) · Current Anthropology · doi:10.1086/381006 · Cited by 169 · see citing works
Mulcare, C., Weale, M., Jones, A. L., Connell, B., Zeitlyn, D., Tarekegn, A., Swallow, D., Bradman, N., & Thomas, M. G. (2004) · American Journal of Human Genetics · doi:10.1086/421050 · Cited by 165 · see citing works
The Human CC Chemokine Receptor 5 (CCR5) Gene
Mummidi, S., Ahuja, S. S., McDaniel, B. L., & Ahuja, S. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.30662 · Cited by 165 · see citing works
Spread of an Inactive Form of Caspase-12 in Humans Is Due to Recent Positive Selection
Xue, Y., Daly, A., Yngvadóttir, B., Liu, M., Coop, G., Kim, Y., Sabeti, P. C., Chen, Y., Stalker, J., Huckle, E. J., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/503116 · Cited by 159 · see citing works
Chaudhuri, A., Polyakova, J., Zbrzezna, V., & Pogo, A. (1995) · Blood · doi:10.1182/blood.v85.3.615.bloodjournal853615 · Cited by 157 · see citing works
Nielsen, R., & Signorovitch, J. (2003) · Theoretical Population Biology · doi:10.1016/s0040-5809(03)00005-4 · Cited by 153 · see citing works
Evans, P. D., Mekel-Bobrov, N., Vallender, E. J., Hudson, R. R., & Lahn, B. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606966103 · Cited by 153 · see citing works
Lewontin-Krakauer test for neutral genes
Nei, M., & Maruyama, T. (1975) · Genetics · doi:10.1093/genetics/80.2.395 · Cited by 152 · see citing works
Comprehensive evaluation of allele frequency differences ofMC1Rvariants across populations
Gerstenblith, M. R., Goldstein, A. M., Fargnoli, M. C., Peris, K., & Landi, M. T. (2007) · Human Mutation · doi:10.1002/humu.20476 · Cited by 148 · see citing works
Novel Alleles of the Chemokine-Receptor Gene CCR5
Carrington, M. N., Kissner, T. L., Gerrard, B., Ivanov, S. V., O’Brien, S. J., & Dean, M. C. (1997) · The American Journal of Human Genetics · doi:10.1086/301645 · Cited by 148 · see citing works
Self-citationGoriely, A., McVean, G. A. T., van Pelt, A. M. M., O'Rourke, A. W., Wall, S. A., de Rooij, D. G., & Wilkie, A. O. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500267102 · Cited by 146 · see citing works
Nakajima, T., Wooding, S., Sakagami, T., Emi, M., Tokunaga, K., Tamiya, G., Ishigami, T., Umemura, S., Munkhbat, B., Jin, F., et al. (2004) · American Journal of Human Genetics · doi:10.1086/420793 · Cited by 140 · see citing works
The nature of diversity and diversification at the ABO locus
Seltsam, A. W., Hallensleben, M., Kollmann, A., & Blasczyk, R. (2003) · Blood · doi:10.1182/blood-2003-03-0955 · Cited by 139 · see citing works
Functional variation of MC1R alleles from red-haired individuals
Healy, E. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.21.2397 · Cited by 138 · see citing works
Poulter, M., Hollox, E. J., Harvey, C. B., Mulcare, C. A., Peuhkuri, K., Kajander, K., Sarner, M., Korpela, R., & Swallow, D. M. (2003) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2003.00048.x · Cited by 133 · see citing works
Positive Selection on a Human-Specific Transcription Factor Binding Site Regulating IL4 Expression
Rockman, M. V., Hahn, M. W., Soranzo, N., Goldstein, D. B., & Wray, G. A. (2003) · Current Biology · doi:10.1016/j.cub.2003.11.025 · Cited by 131 · see citing works
Boll, W., Wagner, P., & Mantei, N. (1991) · Europe PMC (PubMed Central) · Cited by 130 · see citing works
Detection of the CCR5-Δ32 HIV resistance gene in Bronze Age skeletons
Hummel, S., Schmidt, D., Kremeyer, B., Herrmann, B., & Oppermann, M. (2005) · Genes & Immunity · doi:10.1038/sj.gene.6364172 · Cited by 129 · see citing works
Fullerton, S., Bartoszewicz, A., Ybazeta, G., Horikawa, Y., Bell, G., Kidd, K., Cox, N., Hudson, R., & Rienzo, A. D. (2002) · American Journal of Human Genetics · doi:10.1086/339930 · Cited by 126 · see citing works
Nucleotide Variability at G6pd and the Signature of Malarial Selection in Humans
Saunders, M. A., Hammer, M. F., & Nachman, M. W. (2002) · Genetics · doi:10.1093/genetics/162.4.1849 · Cited by 123 · see citing works
The Duffy blood groups, vivax malaria, and malaria selection in human populations: a review.
Livingstone, F. B. (1984) · PubMed · Cited by 120 · see citing works
Population-Based Study of Natural Variation in the Melanocortin-1 Receptor Gene and Melanoma
Kanetsky, P. A., Rebbeck, T. R., Hummer, A., Panossian, S., Armstrong, B. K., Kricker, A., Marrett, L. D., Millikan, R. C., Gruber, S. B., Culver, H. A., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1634 · Cited by 114 · see citing works
Linkage disequilibrium in admixed populations: applications in gene mapping.
Briscoe, D., Stephens, J., & O'Brien, S. J. (1994) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a111397 · Cited by 111 · see citing works
Self-citationPatterns of linkage disequilibrium in the MHC region on human chromosome 6p
Stenzel, A., Lu, T. T., Koch, W. A., Hampe, J., Guenther, S. M., Vega, F. M. D. L., Krawczak, M., & Schreiber, S. (2004) · Human Genetics · doi:10.1007/s00439-003-1075-5 · Cited by 108 · see citing works
Worldwide polymorphism at the MC1R locus and normal pigmentation variation in humans
Makova, K., & Norton, H. (2005) · Peptides · doi:10.1016/j.peptides.2004.12.032 · Cited by 101 · see citing works
Of mice and men: phylogenetic footprinting aids the discovery of regulatory elements.
Zhang, Z., & Gerstein, M. (2003) · Journal of Biology · doi:10.1186/1475-4924-2-11 · Cited by 100 · see citing works
Evidence for positive selection and population structure at the human MAO-A gene
Gilad, Y., Rosenberg, S., Przeworski, M., Lancet, D., & Skorecki, K. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.022614799 · Cited by 97 · see citing works
Ganczakowski, M., Town, M., Bowden, D. K., Vulliamy, T., Kaneko, A., Clegg, J. B., Weatherall, D. J., & Luzzatto, L. (1995) · Europe PMC (PubMed Central) · Cited by 96 · see citing works
Oleksyk, T. K., Zhao, K., Vega, F. M. D. L., Gilbert, D. A., O’Brien, S. J., & Smith, M. W. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001712 · Cited by 95 · see citing works
Self-citationSignificant admixture linkage disequilibrium across 30 cM around the FY locus in African Americans.
Lautenberger, J., Stephens, J., O'Brien, S. J., & Smith, M. W. (2000) · American Journal of Human Genetics · doi:10.1086/302820 · Cited by 90 · see citing works
Self-citationHuman DNA Sequence Variation in a 6.6-kb Region Containing the Melanocortin 1 Receptor Promoter
Makova, K. D., Ramsay, M., Jenkins, T., & Li, W. (2001) · Genetics · doi:10.1093/genetics/158.3.1253 · Cited by 87 · see citing works
Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ
Evans, P. D., Vallender, E. J., & Lahn, B. T. (2006) · Gene · doi:10.1016/j.gene.2006.02.019 · Cited by 84 · see citing works
Positive Selection in the Human Genome: From Genome Scans to Biological Significance
Kelley, J. L., & Swanson, W. J. (2008) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164411 · Cited by 83 · see citing works
Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 region
Choudhry, S., Taub, M. A., Mei, R., Rodríguez‐Santana, J., Rodríguez-Cintrón, W., Shriver, M. D., Ziv, E., RISCH, N. J., & Burchard, E. G. (2008) · Human Genetics · doi:10.1007/s00439-008-0495-7 · Cited by 82 · see citing works
Simulating genealogies of selected alleles in a population of variable size
Slatkin, M. (2001) · Genetics Research · doi:10.1017/s0016672301005183 · Cited by 82 · see citing works
Red hair is the null phenotype of MC1R
Beaumont, K. A., Shekar, S. N., Cook, A. L., Duffy, D. L., & Sturm, R. A. (2008) · Human Mutation · doi:10.1002/humu.20788 · Cited by 81 · see citing works
Positive Selection on MMP3 Regulation Has Shaped Heart Disease Risk
Rockman, M. V., Hahn, M. W., Soranzo, N., Loisel, D. A., Goldstein, D. B., & Wray, G. A. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.051 · Cited by 81 · see citing works
Natural selection and the evolutionary history of major histocompatibility complex loci
Hughes, A. L. (1998) · Frontiers in bioscience · doi:10.2741/a298 · Cited by 78 · see citing works
Ayodo, G., Price, A. L., Keinan, A., Ajwang, A., OTIENO, M. F., Orago, A. S. S., Patterson, N. J., & Reich, D. (2007) · The American Journal of Human Genetics · doi:10.1086/519221 · Cited by 77 · see citing works
JOHN, P. R., MAKOVA, K., LI, W., JENKINS, T., & RAMSAY, M. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb03193.x · Cited by 72 · see citing works
Nachman, M. W., & Crowell, S. L. (2000) · Genetics · doi:10.1093/genetics/155.4.1855 · Cited by 71 · see citing works
Sub-Saharan African coding sequence variation and haplotype diversity at theNAT2gene
Patin, É., Harmant, C., Kidd, K., Kídd, K. K., Froment, A., Mehdi, S. Q., Sica, L., Heyer, É., & Quintana‐Murci, L. (2006) · Human Mutation · doi:10.1002/humu.9438 · Cited by 69 · see citing works
Fernandez, L., Milne, R., Bravo, J., Lopez, J., Avilés-Izquierdo, J. A., Longo-Imedio, M., Benitez, J. J., Lázaro, P., & Ribas, G. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm084 · Cited by 68 · see citing works
Testing the Heterogeneity of F Values
Lewontin, R. C., & Krakauer, J. (1975) · Genetics · doi:10.1093/genetics/80.2.397 · Cited by 59 · see citing works
Molecular analysis of a new splice variant of the human melanocortin‐1 receptor
Tan, C. P., McKee, K. K., Weinberg, D. H., MacNeil, T., Palyha, O. C., Feighner, S. D., Hreniuk, D. L., der Ploeg, L. H. T. V., MacNeil, D. J., & Howard, A. D. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00525-6 · Cited by 55 · see citing works
TRPV6 exhibits unusual patterns of polymorphism and divergence in worldwide populations
Akey, J. M. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl134 · Cited by 53 · see citing works
Ojeda, A., Huang, L.-S., Ren, J., Angiolillo, A., Cho, I. C., Soto, H., Flores, C. L., Makuza, S. M., Folch, J. M., & Miguel Pérez-enciso, A. (2008) · Genetics · doi:10.1534/genetics.107.084269 · Cited by 51 · see citing works
Sequence Variation and Haplotype Structure at the Human HFE Locus
Toomajian, C., & Kreitman, M. (2002) · Genetics · doi:10.1093/genetics/161.4.1609 · Cited by 50 · see citing works
de Meaux, J., Hu, J., Tartler, U., & Goebel, U. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803218105 · Cited by 49 · see citing works
Andr�s, A., Soldevila, M., Navarro, A., Kidd, K., Oliva, B., & Bertranpetit, J. (2004) · Human Genetics · doi:10.1007/s00439-004-1179-6 · Cited by 44 · see citing works
Civetta, A., Rajakumar, S. A., Brouwers, B., & Bacik, J. P. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msj074 · Cited by 43 · see citing works
Genetic Variant of Lactase‐Persistent C/T ‐13910 Is Associated with Bone Fractures in Very Old Age
Enattah, N. S., Sulkava, R. O., Halonen, P. M., KONTULA, K. K., & Järvelä, I. E. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2005.53014.x · Cited by 42 · see citing works
Possible epistatic role of ADH7 in the protection against alcoholism
Osier, M. V., Lu, R. B., PAKSTIS, A. J., Kidd, J. R., Huang, S., & Kídd, K. K. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20136 · Cited by 40 · see citing works
Regional localization of the lactase‐phlorizin hydrolase gene, LCT, to chromosome 2q21
Harvey, C. B., FOX, M. F., Jeggo, P. A., Mantei, N., Povey, S., & Swallow, D. M. (1993) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1993.tb01593.x · Cited by 40 · see citing works
Nucleotide diversity and population differentiation of the Melanocortin 1 Receptor gene, MC1R
Savage, S. A., Gerstenblith, M. R., Goldstein, A. M., Mirabello, L. J., Fargnoli, M. C., Peris, K., & Landi, M. T. (2008) · BMC Genetics · doi:10.1186/1471-2156-9-31 · Cited by 36 · see citing works
Sequence diversity and haplotype structure at the human CYP3A cluster
Thompson, E. E., Kuttab-Boulos, H., Yang, L., Roe, B. A., & Rienzo, A. D. (2005) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500347 · Cited by 36 · see citing works
Human populations show reduced DNA sequence variation at the factor IX locus.
Harris, E. E., & Hey, J. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00223-8 · Cited by 35 · see citing works
Contrasting Histories of G6PD Molecular Evolution and Malarial Resistance in Humans and Chimpanzees
Verrelli, B. C., Tishkoff, S. A., Stone, A. C., & Touchman, J. W. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msl024 · Cited by 34 · see citing works
Local adaptation and population differentiation at the interleukin 13 and interleukin 4 loci
Sakagami, T., Witherspoon, D. J., Nakajima, T., Jinnai, N., Wooding, S., Jorde, L. B., Hasegawa, T., Suzuki, E., Gejyo, F., & Inoue, I. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364109 · Cited by 29 · see citing works
Microsatellite Variation and Evolution of the Human Duffy Blood Group Polymorphism
Seixas, S., Ferrand, N., & Rocha, J. (2002) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a004003 · Cited by 23 · see citing works
Tang, H., Choudhry, S., Mei, R., Morgan, M. T., Rodríguez-Cintrón, W., Burchard, E. G., & RISCH, N. J. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.06.009 · Cited by 9 · see citing works
Chen, X., Shi, H., Liu, X., & Su, B. (2006) · Gene · doi:10.1016/j.gene.2005.11.014 · Cited by 5 · see citing works
Flagged first, then by citations
2 of the 161 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- Maynard Smith J. Haigh J. 1974 The hitchhiking effect of a favorable gene. Genet Res 23, 23– 35 4407212
- Tajima F. 1993 Simple methods for testing molecular clock hypothesis. Genetics 135, 599– 607 8244016 PMC1205659
Cited by
Sorted by citations
Genomics and the future of conservation genetics
Allendorf, F. W., Hohenlohe, P. A., & Luikart, G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2844 · Cited by 1,586 · see citing works
Lotterhos, K. E., & Whitlock, M. C. (2015) · Molecular Ecology · doi:10.1111/mec.13100 · Cited by 568 · see citing works
Genome-Wide Scan for Adaptive Divergence and Association with Population-Specific Covariates
Gautier, M. (2015) · Genetics · doi:10.1534/genetics.115.181453 · Cited by 505 · see citing works
Guiblet, W. M., Zhao, K., O’Brien, S. J., Massey, S. E., Roca, A. L., & Oleksyk, T. K. (2015) · GigaScience · doi:10.1186/2047-217x-4-1 · Cited by 374 · see citing works
Self-citationYang, J. H., Li, W., Lv, F., He, S., Tian, S., Peng, W., Sun, Y., Zhao, Y., Tu, X.-L., Zhang, M., et al. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw129 · Cited by 342 · see citing works
Natural variation in CTB4a enhances rice adaptation to cold habitats
Zhang, Z., Li, J., Pan, Y., Li, J., Zhou, L., Shi, H., Zeng, Y., Guo, H., ShuMing, Y., Zheng, W., et al. (2017) · Nature Communications · doi:10.1038/ncomms14788 · Cited by 323 · see citing works
Using genomics to characterize evolutionary potential for conservation of wild populations
Harrisson, K. A., Pavlova, A., Telonis‐Scott, M., & Sunnucks, P. (2014) · Evolutionary Applications · doi:10.1111/eva.12149 · Cited by 318 · see citing works
The Genome 10K Project: A Way Forward
Koepfli, K.-P., Paten, B., Scientists, T. G. 1. C. O., & O’Brien, S. J. (2015) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-090414-014900 · Cited by 311 · see citing works
Self-citationEarly selection of bZIP73 facilitated adaptation of japonica rice to cold climates
Liu, C., Ou, S., Mao, B., Tang, J., Wang, W., Wang, H., Cao, S., Schläppi, M., Zhao, B., Xiao, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05753-w · Cited by 281 · see citing works
Development of a Comprehensive Genotype-to-Fitness Map of Adaptation-Driving Mutations in Yeast
Venkataram, S., Dunn, B. L., Li, Y., Agarwala, A., Chang, J. K., Ebel, E. R., Geiler‐Samerotte, K., Hérissant, L., Blundell, J. R., Levy, S. F., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.002 · Cited by 271 · see citing works
Kemen, E. M., Gardiner, A., Schultz‐Larsen, T., Kemen, A. C., Balmuth, A. L., Robert‐Seilaniantz, A., Bailey, K., Holub, E. B., Studholme, D. J., MacLean, D., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001094 · Cited by 256 · see citing works
Hohenlohe, P. A., Phillips, P. C., & Cresko, W. A. (2010) · International Journal of Plant Sciences · doi:10.1086/656306 · Cited by 220 · see citing works
Pavlidis, P., Jensen, J. D., Stephan, W., & Stamatakis, A. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss136 · Cited by 221 · see citing works
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Kirk, H., & Freeland, J. R. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12063966 · Cited by 219 · see citing works
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Xu, L., Bickhart, D. M., Cole, J. B., Schroeder, S., Song, J., Tassell, C. P. V., Sonstegard, T. S., & Liu, G. E. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu333 · Cited by 202 · see citing works
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Amambua‐Ngwa, A., Tetteh, K. K. A., Manske, M., Gomez‐Escobar, N., Stewart, L. B., Deerhake, M. E., Cheeseman, I. H., Newbold, C., Holder, A. A., Knuepfer, E., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002992 · Cited by 166 · see citing works
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Yu, J., Miao, J., Zhang, Z., Xiong, H., Zhu, X., Sun, X., Pan, Y., Liang, Y., Zhang, Q., Rehman, R. M. A., et al. (2018) · Plant Biotechnology Journal · doi:10.1111/pbi.12903 · Cited by 160 · see citing works
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Fischer, M. C., Rellstab, C., Tedder, A., Zoller, S., Gugerli, F., Shimizu, K. K., Holderegger, R., & Widmer, A. (2013) · Molecular Ecology · doi:10.1111/mec.12521 · Cited by 148 · see citing works
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Eyheramendy, S., Martínez, F. I., Manevy, F., Vial, C., & Repetto, G. M. (2015) · Nature Communications · doi:10.1038/ncomms7472 · Cited by 144 · see citing works
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Saravanan, K. A., Panigrahi, M., Kumar, H., Bhushan, B., Dutt, T., & Mishra, B. P. (2020) · Livestock Science · doi:10.1016/j.livsci.2020.104257 · Cited by 150 · see citing works
Kai, W., Kikuchi, K., Tohari, S., Chew, A. K., Tay, A., Fujiwara, A., Hosoya, S., Suetake, H., Naruse, K., Brenner, S., et al. (2011) · Genome Biology and Evolution · doi:10.1093/gbe/evr041 · Cited by 146 · see citing works
Staubach, F., Lorenc, A., Messer, P. W., Tang, K., Petrov, D. A., & Tautz, D. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002891 · Cited by 146 · see citing works
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Vitte, C., Fustier, M., Alix, K., & Tenaillon, M. I. (2014) · Briefings in Functional Genomics · doi:10.1093/bfgp/elu002 · Cited by 143 · see citing works
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Kim, S., Cho, Y. S., Kim, H., Chung, O., Kim, H., Jho, S., Seomun, H., Kim, J., Bang, W. Y., Kim, C., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1071-4 · Cited by 140 · see citing works
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Variations in CYP 78 A 13 coding region influence grain size and yield in rice
Xu, F., Fang, J., Ou, S., Gao, S., Zhang, F., Du, L., XIAO, Y., Wang, H., Sun, X., Chu, J., et al. (2014) · Plant Cell & Environment · doi:10.1111/pce.12452 · Cited by 129 · see citing works
Plissonneau, C., Benevenuto, J., Mohd‐Assaad, N., Fouché, S., Hartmann, F. E., & Croll, D. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00119 · Cited by 126 · see citing works
Genome Scans for Detecting Footprints of Local Adaptation Using a Bayesian Factor Model
Duforet-Frebourg, N., Bazin, É., & Blum, M. G. B. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu182 · Cited by 117 · see citing works
McManus, K. F., Oill, A. M. T., Henn, B. M., Bustamante, C. D., Sikora, M., & Cornejo, O. E. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006560 · Cited by 112 · see citing works
Identification of selection signatures in livestock species
Gouveia, J. J. D. S., da Silva, M. V. G. B., Paiva, S. R., & de Oliveira, S. M. P. (2014) · Genetics and Molecular Biology · doi:10.1590/s1415-47572014000300004 · Cited by 115 · see citing works
Recent human adaptation: genomic approaches, interpretation and insights
Scheinfeldt, L., & Tishkoff, S. A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3604 · Cited by 113 · see citing works
Genomic selection signatures in sheep from the Western Pyrenees
Ruiz-Larrañaga, O., Langa, J., Rendo, F., Manzano, C., Iriondo, M., & Estonba, A. (2018) · Genetics Selection Evolution · doi:10.1186/s12711-018-0378-x · Cited by 111 · see citing works
On the concepts and measures of diversity in the genomics era
Kanaka, K. K., Sukhija, N., Goli, R. C., Singh, S., Ganguly, I., Dixit, S. P., Dash, A., & Malik, A. A. (2023) · Current Plant Biology · doi:10.1016/j.cpb.2023.100278 · Cited by 112 · see citing works
From molecules to mating: Rapid evolution and biochemical studies of reproductive proteins
Wilburn, D. B., & Swanson, W. J. (2015) · Journal of Proteomics · doi:10.1016/j.jprot.2015.06.007 · Cited by 110 · see citing works
Bahbahani, H. M., Clifford, H., Wragg, D., Mbole-Kariuki, M. N., Tassell, C. P. V., Sonstegard, T. S., Woolhouse, M. E. J., & Hanotte, O. (2015) · Scientific Reports · doi:10.1038/srep11729 · Cited by 110 · see citing works
Utsunomiya, Y. T., O’Brien, A. M. P., Sonstegard, T. S., Tassell, C. P. V., do Carmo, A. S., Mészáros, G., Sölkner, J., & Garcia, J. F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064280 · Cited by 108 · see citing works
Randhawa, I. A. S., Khatkar, M. S., Thomson, P. C., & Raadsma, H. W. (2014) · BMC Genetics · doi:10.1186/1471-2156-15-34 · Cited by 105 · see citing works
Genomic Divergence during Speciation Driven by Adaptation to Altitude
Chapman, M. A., Hiscock, S. J., & Filatov, D. A. (2013) · Molecular Biology and Evolution · doi:10.1093/molbev/mst168 · Cited by 104 · see citing works
Genomic toolboxes for conservation biologists
Angeloni, F., Wagemaker, C. A. M., Vergeer, P., & Ouborg, J. (2011) · Evolutionary Applications · doi:10.1111/j.1752-4571.2011.00217.x · Cited by 103 · see citing works
Taye, M., Kim, J., Yoon, S. H., Lee, W., Hanotte, O., Dessie, T., Kemp, S. J., Mwai, O. A., Caetano-Anollés, K., Cho, S., et al. (2017) · BMC Genetics · doi:10.1186/s12863-016-0467-1 · Cited by 104 · see citing works
Manel, S., Perrier, C., Pratlong, M., Abi‐Rached, L., Paganini, J., Pontarotti, P., & Aurelle, D. (2015) · Molecular Ecology · doi:10.1111/mec.13468 · Cited by 101 · see citing works
Ahbara, A., Bahbahani, H. M., Almathen, F. S., Al‐Abri, M., Agoub, M. O., Abeba, A., Kebede, A., Musa, H. H., Mastrangelo, S., Pilla, F., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2018.00699 · Cited by 99 · see citing works
A Meta-Assembly of Selection Signatures in Cattle
Randhawa, I. A. S., Khatkar, M. S., Thomson, P. C., & Raadsma, H. W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153013 · Cited by 101 · see citing works
Detecting signatures of positive selection in non-model species using genomic data
Weigand, H., & Leese, F. (2018) · Zoological Journal of the Linnean Society · doi:10.1093/zoolinnean/zly007 · Cited by 99 · see citing works
VolcanoFinder: Genomic scans for adaptive introgression
Setter, D., Mousset, S., Cheng, X., Nielsen, R., DeGiorgio, M., & Hermisson, J. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008867 · Cited by 88 · see citing works
Detecting ancient positive selection in humans using extended lineage sorting
Peyrégne, S., Boyle, M. J., Dannemann, M., & Prüfer, K. (2017) · Genome Research · doi:10.1101/gr.219493.116 · Cited by 93 · see citing works
Lawal, R. A., Al-Atiyat, R. M., Aljumaah, R. S., Silva, P., Mwacharo, J. M., & Hanotte, O. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00264 · Cited by 92 · see citing works
Genomics of Parallel Experimental Evolution in Drosophila
Graves, J. L., Hertweck, K. L., Phillips, M., Han, M., Cabral, L. G., Barter, T. T., Greer, L. F., Burke, M. K., Mueller, L. D., & Rose, M. R. (2016) · Molecular Biology and Evolution · doi:10.1093/molbev/msw282 · Cited by 91 · see citing works
Localization of adaptive variants in human genomes using averaged one-dependence estimation
Sugden, L. A., Atkinson, E. G., Fischer, A. P., Rong, S., Henn, B. M., & Ramachandran, S. (2018) · Nature Communications · doi:10.1038/s41467-018-03100-7 · Cited by 88 · see citing works
Genome-wide detection of natural selection in African Americans pre- and post-admixturePreprint
Jin, W., Xu, S., Wang, H., Yu, Y., Shen, Y., Wu, B.-L., & Li, J. (2011) · Genome Research · doi:10.1101/gr.124784.111 · Cited by 88 · see citing works
Harris, S. E., Munshi‐South, J., Obergfell, C. J., & O'Neill, R. J. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074938 · Cited by 89 · see citing works
Hill, E. W., Gu, J., McGivney, B. A., & MacHugh, D. E. (2010) · Animal Genetics · doi:10.1111/j.1365-2052.2010.02104.x · Cited by 84 · see citing works
Ron, M., Dorrity, M. W., de Lucas, M., Toal, T., Hernandez, R. I., Little, S. A., Maloof, J., Kliebenstein, D. J., & Brady, S. M. (2013) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.217802 · Cited by 84 · see citing works
Harris, S. E., & Munshi‐South, J. (2017) · Molecular Ecology · doi:10.1111/mec.14369 · Cited by 88 · see citing works
A General Mechanistic Model for Admixture Histories of Hybrid Populations
Verdu, P., & Rosenberg, N. A. (2011) · Genetics · doi:10.1534/genetics.111.132787 · Cited by 80 · see citing works
Zou, X., Suppanz, I., Raman, H., Hou, J., Wang, J., Yan, L., Jung, C., & Meng, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045751 · Cited by 82 · see citing works
Selection on a Genetic Polymorphism Counteracts Ecological Speciation in a Stick Insect
Comeault, A. A., Flaxman, S. M., Riesch, R., Curran, E. V., Soria‐Carrasco, V., Gompert, Z., Farkas, T. E., Muschick, M., Parchman, T. L., Schwander, T., et al. (2015) · Current Biology · doi:10.1016/j.cub.2015.05.058 · Cited by 81 · see citing works
Mwacharo, J. M., Kim, E.-S., Elbeltagy, A. R., Aboul-Naga, A. M., Rischkowsky, B., & Rothschild, M. F. (2017) · Scientific Reports · doi:10.1038/s41598-017-17775-3 · Cited by 79 · see citing works
An Evolutionary Perspective on the Impact of Genomic Copy Number Variation on Human Health
Saitou, M., & Gökçümen, Ö. (2019) · Journal of Molecular Evolution · doi:10.1007/s00239-019-09911-6 · Cited by 79 · see citing works
Freitas, P. H. F., Wang, Y., Yan, P., de Oliveira, H. R., Schenkel, F. S., Zhang, Y., Xu, Q., & Brito, L. F. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.604823 · Cited by 77 · see citing works
Fagny, M., Patin, É., Enard, D., Barreiro, L. B., Quintana‐Murci, L., & Laval, G. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu118 · Cited by 74 · see citing works
Russell, J., Dawson, I. K., Flavell, A. J., Steffenson, B. J., Weltzien, E., Booth, A., Ceccarelli, S., Grando, S., & Waugh, R. (2011) · New Phytologist · doi:10.1111/j.1469-8137.2011.03704.x · Cited by 75 · see citing works
Perrier, C., Guyomard, R., Baglinière, J.-L., & Evanno, G. (2011) · Molecular Ecology · doi:10.1111/j.1365-294x.2011.05266.x · Cited by 75 · see citing works
Ramsuran, V., Kulkarni, H. R., He, W., Mlisana, K. P., Wright, E., Werner, L., Castiblanco, J., Dhanda, R., Le, T., Dolan, M. J., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir119 · Cited by 75 · see citing works
Microsatellites as Targets of Natural Selection
Haasl, R. J., & Payseur, B. A. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss247 · Cited by 74 · see citing works
Tigers of the World: Genomics and Conservation
Luo, S., Liu, Y.-C., & Xu, X. J. (2019) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-020518-115106 · Cited by 71 · see citing works
Byars, S., Huang, Q. Q., Gray, L.-A., Bakshi, A., Ripatti, S., Abraham, G., Stearns, S. C., & Inouye, M. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006328 · Cited by 73 · see citing works
Cádiz, M. I., López, M. E., Diaz-Domínguez, D., Cáceres, G., Yoshida, G., Gomez‐Uchida, D., & Yañez, J. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-68064-5 · Cited by 70 · see citing works
The population genetics of chronic kidney disease: insights from the MYH9–APOL1 locus
Rosset, S., Tzur, S., Behar, D. M., Wasser, W. G., & Skorecki, K. L. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.52 · Cited by 67 · see citing works
Genomic signatures of adaptation to wine biological ageing conditions in biofilm‐forming flor yeasts
Coi, A. L., Bigey, F., Mallet, S., Marsit, S., Zara, G., Gladieux, P., Galéote, V., Budroni, M. A., Dequin, S., & Legras, J. (2017) · Molecular Ecology · doi:10.1111/mec.14053 · Cited by 67 · see citing works
Signatures of positive selection in African Butana and Kenana dairy zebu cattle
Bahbahani, H., Salim, B., Almathen, F., Al Enezi, F., Mwacharo, J. M., & Hanotte, O. (2018) · PLOS ONE · doi:10.1371/journal.pone.0190446 · Cited by 67 · see citing works
Genome-wide search for signatures of selection in three major Brazilian locally adapted sheep breeds
Gouveia, J. J. D. S., Paiva, S. R., Mcmanus, C. M., Caetano, A. R., Kijas, J., Facó, O., Azevedo, H. C., de Araújo, A. M., de Souza, C. J. H., Yamagishi, M. E. B., et al. (2017) · Livestock Science · doi:10.1016/j.livsci.2017.01.006 · Cited by 63 · see citing works
Bakhtiarizadeh, M. R., & Alamouti, A. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-70527-8 · Cited by 64 · see citing works
Chen, M., Wang, J., Wang, Y., Wu, Y., Fu, J., & Liu, J. (2018) · BMC Genetics · doi:10.1186/s12863-018-0622-y · Cited by 61 · see citing works
A genome-wide scan for signatures of selection in Azeri and Khuzestani buffalo breeds
Mokhber, M., Moradi-Shahrbabak, M., Sadeghi, M., Moradi-Shahrbabak, H., Stella, A., Nicolzzi, E., Rahmaninia, J., & Williams, J. L. (2018) · BMC Genomics · doi:10.1186/s12864-018-4759-x · Cited by 63 · see citing works
Dissecting evolution and disease using comparative vertebrate genomics
Meadows, J. R. S., & Lindblad‐Toh, K. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.51 · Cited by 59 · see citing works
Wu, Z., Periaswamy, B., Şahin, O., Yaeger, M. J., Plummer, P. J., Zhai, W., Shen, Z., Dai, L., Chen, S. L., & Zhang, Q. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605869113 · Cited by 61 · see citing works
Randhawa, I. A. S., Khatkar, M. S., Thomson, P. C., & Raadsma, H. W. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.017772 · Cited by 59 · see citing works
The characterization of goat genetic diversity: Towards a genomic approach
Ajmone‐Marsan, P., Colli, L., Han, J., Achilli, A., Lancioni, H., Joost, S., Crepaldi, P., Pilla, F., Stella, A., Taberlet, P., et al. (2014) · Small Ruminant Research · doi:10.1016/j.smallrumres.2014.06.010 · Cited by 60 · see citing works
Roulin, A. C., Routtu, J., Hall, M. D., Janicke, T., Colson, I., Haag, C. R., & Ebert, D. (2013) · Molecular Ecology · doi:10.1111/mec.12308 · Cited by 58 · see citing works
Population genetics of chronic kidney disease: The evolving story of APOL1
Wasser, W. G., Tzur, S., Wolday, D., Adu, D., Baumstein, D. I., Rosset, S., & Skorecki, K. L. (2012) · Journal of Nephrology · doi:10.5301/jn.5000179 · Cited by 55 · see citing works
Genomics of adaptive divergence with chromosome‐scale heterogeneity in crossover rate
Berner, D., & Roesti, M. (2017) · Molecular Ecology · doi:10.1111/mec.14373 · Cited by 54 · see citing works
Kosch, T. A., Silva, C. N. S., Brannelly, L. A., Roberts, A. A., Lau, Q., Marantelli, G., Berger, L., & Skerratt, L. F. (2018) · Animal Conservation · doi:10.1111/acv.12459 · Cited by 55 · see citing works
Bahbahani, H. M., Musa, H. H., Wragg, D., Shuiep, E. S., Almathen, F. S., & Hanotte, O. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00893 · Cited by 55 · see citing works
Abied, A., Bagadi, A., Bordbar, F., Pu, Y., Augustino, S. M. A., Xue, X., Xing, F., Gebreselassie, G., Han, J., Mwacharo, J. M., et al. (2020) · Genes · doi:10.3390/genes11050494 · Cited by 53 · see citing works
Convergent evolution in Arabidopsis halleri and Arabidopsis arenosa on calamine metalliferous soils
Preite, V., Sailer, C., Syllwasschy, L., Bray, S., Ahmadi, H., Krämer, U., & Yant, L. J. (2019) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0243 · Cited by 53 · see citing works
Whole Genome Scan and Selection Signatures for Climate Adaption in Yanbian Cattle
Shen, J., Hanif, Q., Cao, Y., Yu, Y., Lei, C., Zhang, G., & Zhao, Y. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00094 · Cited by 53 · see citing works
López, M. E., Benestan, L., Moore, J., Perrier, C., Gilbey, J., Genova, A. D., Maass, A., Diaz-Domínguez, D., Lhorente, J. P., Correa, K., et al. (2018) · Evolutionary Applications · doi:10.1111/eva.12689 · Cited by 53 · see citing works
Illa, S. K., Mukherjee, S., Nath, S., & Mukherjee, A. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.699422 · Cited by 53 · see citing works
Genetic Differentiation and Evolutionary Adaptation inCryptomeria japonica
Tsumura, Y., Uchiyama, K., Moriguchi, Y., Kimura, M., Ueno, S., & Ujino‐Ihara, T. (2014) · G3 Genes Genomes Genetics · doi:10.1534/g3.114.013896 · Cited by 52 · see citing works
Association Mapping in Plant Genomes
Braulio, J., & Cloutier, S. (2012) · InTech eBooks · doi:10.5772/33005 · Cited by 51 · see citing works
Klassmann, A., Vitalis, R., & Gautier, M. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262024 · Cited by 44 · see citing works
Fuller, Z. L., Niño, E. L., Patch, H. M., Bedoya-Reina, O. C., Baumgarten, T., Muli, E., Mumoki, F. N., Ratan, A., McGraw, J., Frazier, M. T., et al. (2015) · BMC Genomics · doi:10.1186/s12864-015-1712-0 · Cited by 49 · see citing works
Oh, K. P., Aldridge, C. L., Forbey, J. S., Dadabay, C., & Oyler‐McCance, S. J. (2019) · Genome Biology and Evolution · doi:10.1093/gbe/evz112 · Cited by 49 · see citing works
Whose trait is it anyways? Coevolution of joint phenotypes and genetic architecture in mutualisms
O'Brien, A., Jack, C. N., Friesen, M., & Frederickson, M. E. (2021) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2020.2483 · Cited by 46 · see citing works
- Authors
- Oleksyk, T. K., Smith, M. W., & O'Brien, S. J.
- Affiliations
- Biology Department, University of Puerto Rico at Mayaguez, Mayaguez 00681, Puerto Rico
- National Cancer Institute (US)
- Laboratory of Genomic Diversity, National Cancer Institute at Frederick, Frederick, MD 21702, USA
- ORCID
- Smith, Michael W.
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2010-01-12
- Volume
- 365
- Issue
- 1537
- Pages
- 185-205
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- PMC
- PMC2842710
- OpenAlex
- W2143606043
- Cited by
- 340
- References
- 161
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 12 · 2023: 18 · 2022: 19 · 2021: 27 · 2020: 17 · 2019: 18 · 2018: 31 · 2017: 28 · 2016: 20 · 2015: 28 · 2014: 27 · 2013: 21 · 2012: 18
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- NSUWorks (Nova Southeastern University) (submittedVersion)
- Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Cancer Institute (N01CO12400)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- natural selection, linkage disequilibrium, genetic variation, genetic differentiation, F(ST), admixture, disease-associated genes, phylogenetic footprinting, functional mutations, genome annotation, human genome, animal genomes
- MeSH terms
- Animals, Base Sequence, Humans, Phylogeny, Selection, Genetic, Genetic Variation, Genome, Human, Evolution, Molecular, Genome-Wide Association Study
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