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Cited by 332

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues

Open access
Hielscher, Andreas H, Alcouffe, Raymond E, Barbour, Randall L·1998·Physics in Medicine and Biology

Abstract

We analyse the limits of the diffusion approximation to the time-independent equation of radiative transfer for homogeneous and heterogeneous biological media. Analytical calculations and finite-difference simulations based on diffusion theory are compared with discrete-ordinate, finite-difference transport calculations. The influence of the ratio of absorption and transport scattering coefficient (mu(a)/mu'(s)) on the accuracy of the diffusion approximation are quantified and different definitions for the diffusion coefficient, D, are discussed. We also address effects caused by void-like heterogeneities in which absorption and scattering are very small compared with the surrounding medium. Based on results for simple homogeneous and heterogeneous systems, we analyse diffusion and transport calculation of light propagation in the human brain. For these simulations we convert density maps obtained from magnetic resonance imaging (MRI) to optical-parameter maps (mu(a) and mu'(s)) of the brain. We show that diffusion theory fails to describe accurately light propagation in highly absorbing regions, such as haematoma, and void-like spaces, such as the ventricles and the subarachnoid space.

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Metadata

Authors
Hielscher, A. H., Alcouffe, R. E., & Barbour, R. L.
Venue
Physics in Medicine and Biology
Published
1998-05-01
Volume
43
Issue
5
Pages
1285-1302
ISSN
  • 0031-9155 (ISSN-L)
  • 1361-6560
OpenAlex
W2065977316
Cited by
332
References
29
FWCI
10.91
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues. https://app.cochat.ai/papers/10.1088/0031-9155/43/5/017
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Hielscher, A. H., Alcouffe, R. E., & Barbour, R. L. (1998). Comparison of finite-difference transport and diffusion calculations for photon migration in homogeneous and heterogeneous tissues. Physics in Medicine and Biology. https://doi.org/10.1088/0031-9155/43/5/017

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