The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.
Electric crosstalk impairs spatial resolution of multi-electrode arrays in retinal implants
Open accessAbstract
Active multi-electrode arrays are used in vision prostheses, including optic nerve cuffs and cortical and retinal implants for stimulation of neural tissue. For retinal implants, arrays with up to 1500 electrodes are used in clinical trials. The ability to convey information with high spatial resolution is critical for these applications. To assess the extent to which spatial resolution is impaired by electric crosstalk, finite-element simulation of electric field distribution in a simplified passive tissue model of the retina is performed. The effects of electrode size, electrode spacing, distance to target cells, and electrode return configuration (monopolar, tripolar, hexagonal) on spatial resolution is investigated in the form of a mathematical model of electric field distribution. Results show that spatial resolution is impaired with increased distance from the electrode array to the target cells. This effect can be partly compensated by non-monopolar electrode configurations and larger electrode diameters, albeit at the expense of lower pixel densities due to larger covering areas by each stimulation electrode. In applications where multi-electrode arrays can be brought into close proximity to target cells, as presumably with epiretinal implants, smaller electrodes in monopolar configuration can provide the highest spatial resolution. However, if the implantation site is further from the target cells, as is the case in suprachoroidal approaches, hexagonally guarded electrode return configurations can convey higher spatial resolution.
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“In contrast, current prosthesis users report seeing highly distorted phosphenes, which vary in shape across subjects as well as electrodes and often fail to assemble into more complex percepts (Wilke et al., 2011; Beyeler et al., 2019; Beauchamp et al., 2020; Erickson-Davis and Korzybska, 2021; Fernández et al., 2021).”
From Towards a Smart Bionic Eye : AI-powered artificial vision for the treatment of incurable blindness (2022) · cites this paper as Wilke et al., 2011
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Gabriel, S., Lau, R.-W.-M., & Gabriel, C. (1996) · Physics in Medicine and Biology · doi:10.1088/0031-9155/41/11/002 · Cited by 4,487
Electrical stimulation of excitable tissue: design of efficacious and safe protocols
Merrill, D. R., Bikson, M., & Jefferys, J. G. R. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.10.020 · Cited by 2,078
Subretinal electronic chips allow blind patients to read letters and combine them to words
Zrenner, E., Bartz-Schmidt, K. U., Benav, H., Besch, D., Bruckmann, A., Gabel, V.-P., Gekeler, F., Greppmaier, U., Harscher, A., Kibbel, S., et al. (2011) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2010.1747 · Cited by 819
Self-citationWill Retinal Implants Restore Vision?
Zrenner, E. (2002) · Science · doi:10.1126/science.1067996 · Cited by 736
Retinal remodeling during retinal degeneration
Jones, B. W., & Marc, R. E. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.03.006 · Cited by 430
Electrical Stimulation of Mammalian Retinal Ganglion Cells With Multielectrode Arrays
Sekirnjak, C., Hottowy, P., Sher, A., Dąbrowski, W., Litke, A. M., & Chichilnisky, E. J. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01168.2005 · Cited by 342
Design of a high-resolution optoelectronic retinal prosthesis
Palanker, D., Vankov, A., Huie, P., & Baccus, S. A. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/1/012 · Cited by 330
Non-linear projection of the retinal image in a wide-angle schematic eye.
Drasdo, N., & Fowler, C. W. (1974) · British Journal of Ophthalmology · doi:10.1136/bjo.58.8.709 · Cited by 312
Axonal Sodium-Channel Bands Shape the Response to Electric Stimulation in Retinal Ganglion Cells
Fried, S. I., Lasker, A., Desai, N. J., Eddington, D. K., & Rizzo, J. F. (2009) · Journal of Neurophysiology · doi:10.1152/jn.91081.2008 · Cited by 206
Current focusing and steering: Modeling, physiology, and psychophysics
Bonham, B. H., & Litvak, L. M. (2008) · Hearing Research · doi:10.1016/j.heares.2008.03.006 · Cited by 198
Research works printed but not linked: 7
- Benav H Wilke R Stett A Zrenner E, 2009, ARVO Meeting Abstracts, 50, 4593
- Dommel N, 2005, Conf. Proc. IEEE Eng. Med. Biol. Soc., 7, 7612
- Lovell N H, 2005, Conf. Proc. IEEE Eng. Med. Biol. Soc., 5, 5242
- Schmid E W, 2008, U S Patent Specification 7840273
- Wilke R, 2011, Invest. Ophthalmol. Vis. Sci.
- Wilke R Greppmaier U Harscher A Benav H Zrenner E, 2010, ARVO Meeting Abstracts, 51, 2026
- Wilke R G, 2011, ARVO Meeting Abstracts, 52, 458
Cited by
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A Materials Roadmap to Functional Neural Interface Design
Wellman, S. M., Eles, J. R., Ludwig, K. A., Seymour, J. P., Michelson, N. J., McFadden, W. E., Vazquez, A. L., & Kozai, T. D. Y. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201701269 · Cited by 389
Retinal stimulation strategies to restore vision: fundamentals and systems
Yue, L., Weiland, J. D., Roska, B., & Humayun, M. S. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2016.05.002 · Cited by 272
A model of ganglion axon pathways accounts for percepts elicited by retinal implants
Beyeler, M., Nanduri, D., Weiland, J. D., Rokem, A., Boynton, G. M., & Fine, I. (2019) · Scientific Reports · doi:10.1038/s41598-019-45416-4 · Cited by 143
Wilke, R., Gabel, V.-P., Sachs, H., Bartz Schmidt, K.-U., Gekeler, F., Besch, D., Szurman, P., Stett, A., Wilhelm, B., Peters, T., et al. (2011) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-6946 · Cited by 155
Self-citationGold nanostructures: synthesis, properties, and neurological applications
Zare, I., Yaraki, M. T., Speranza, G., Najafabadi, A. H., Shourangiz-Haghighi, A., Nik, A. B., Manshian, B. B., Saraiva, C., Soenen, S. J., Kogan, M. J., et al. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01111a · Cited by 133
Metadata
- Authors
- Wilke, R. G. H., Moghadam, G. K., Lovell, N. H., Suaning, G. J., & Dokos, S.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Lovell, N H
- Venue
- Journal of Neural Engineering
- Publisher
- IOP Publishing
- Published
- 2011-06-15
- Volume
- 8
- Issue
- 4
- Pages
- 046016
- ISSN
- 1741-2552 (ISSN-L)
- 1741-2560
- OpenAlex
- W2084193319
- Cited by
- 110
- References
- 34
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 5 · 2022: 15 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 10 · 2016: 9 · 2015: 3 · 2014: 6 · 2013: 6 · 2012: 8
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neural Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- University of New South Wales
- Eberhard Karls Universität Tübingen
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › CCD and CMOS Imaging Sensors
- Keywords
- retinal prosthesis, microelectrode arrays, spatial resolution, electric field distribution, electrode configuration, monopolar electrodes, electrode diameter, electrode spacing, epiretinal implants, finite element analysis
- MeSH terms
- Algorithms, Electrodes, Implanted, Electromagnetic Fields, Electronics, Prosthesis Design, Retina, Models, Statistical, Prostheses and Implants, Finite Element Analysis
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