Quasi-monopolar stimulation: a novel electrode design configuration for performance optimization of a retinal neuroprosthesis
Open accessAbstract
In retinal neuroprostheses, spatial interaction between electric fields from various electrodes - electric crosstalk - may occur in multielectrode arrays during simultaneous stimulation of the retina. Depending on the electrode design and placement, this crosstalk can either enhance or degrade the functional characteristics of a visual prosthesis. To optimize the device performance, a balance must be satisfied between the constructive interference of crosstalk on dynamic range and power consumption and its negative effect on artificial visual acuity. In the present computational modeling study, we have examined the trade-off in these positive and negative effects using a range of currently available electrode array configurations, compared to a recently proposed stimulation strategy - the quasi monopolar (QMP) configuration - in which the return current is shared between local bipolar guards and a distant monopolar electrode. We evaluate the performance of the QMP configuration with respect to the implantation site and electrode geometry parameters. Our simulation results demonstrate that the beneficial effects of QMP are only significant at electrode-to-cell distances greater than the electrode dimensions. Possessing a relatively lower activation threshold, QMP was found to be superior to the bipolar configuration in terms of providing a relatively higher visual acuity. However, the threshold for QMP was more sensitive to the topological location of the electrode in the array, which may need to be considered when programming the manner in which electrode are simultaneously activated. This drawback can be offset with a wider dynamic range and lower power consumption of QMP. Furthermore, the ratio of monopolar return current to total return can be used to adjust the functional performance of QMP for a given implantation site and electrode parameters. We conclude that the QMP configuration can be used to improve visual information-to-stimulation mapping in a visual prosthesis, while maintaining low power consumption.
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In monopolar stimulation, injected current spreads to the common distant ground, preventing confinement of electrical stimulation around the electrode and activating a large portion of neural tissue.
“When the current is injected into the stimulating electrode, the electric field spreads to the common and distant ground, not allowing the confinement of the electrical stimulation around the electrode and resulting in the activation of a large portion of the neural tissue [13].”
From Three-dimensional multilayer concentric bipolar electrodes restrict spatial activation in optic nerve stimulation (2022) · cites this paper as [13]
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- Authors
- Khalili Moghadam, G., Wilke, R., Suaning, G. J., Lovell, N. H., & Dokos, S.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Dokos, Socrates
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-08-26
- Volume
- 8
- Issue
- 8
- Pages
- e73130
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3753255
- OpenAlex
- W2131565716
- Cited by
- 18
- References
- 41
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Australian Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Keywords
- retinal prosthesis, microelectrode arrays, electrode design, monopolar electrodes, return current, visual acuity, activation threshold, dynamic range, power consumption
- MeSH terms
- Electrodes, Implanted, Equipment Design, Humans, Retina, Visual Acuity, Prostheses and Implants
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