Cited by 112Neuroscience and Neural EngineeringAnalog and Mixed-Signal Circuit DesignCCD and CMOS Imaging Sensors

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Electric crosstalk impairs spatial resolution of multi-electrode arrays in retinal implants

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Wilke, R G H, Moghadam, G Khalili, Lovell, N H, Suaning, G J, Dokos, S·2011·Journal of Neural Engineering

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Abstract

Active multi-electrode arrays are used in vision prostheses, including optic nerve cuffs and cortical and retinal implants for stimulation of neural tissue. For retinal implants, arrays with up to 1500 electrodes are used in clinical trials. The ability to convey information with high spatial resolution is critical for these applications. To assess the extent to which spatial resolution is impaired by electric crosstalk, finite-element simulation of electric field distribution in a simplified passive tissue model of the retina is performed. The effects of electrode size, electrode spacing, distance to target cells, and electrode return configuration (monopolar, tripolar, hexagonal) on spatial resolution is investigated in the form of a mathematical model of electric field distribution. Results show that spatial resolution is impaired with increased distance from the electrode array to the target cells. This effect can be partly compensated by non-monopolar electrode configurations and larger electrode diameters, albeit at the expense of lower pixel densities due to larger covering areas by each stimulation electrode. In applications where multi-electrode arrays can be brought into close proximity to target cells, as presumably with epiretinal implants, smaller electrodes in monopolar configuration can provide the highest spatial resolution. However, if the implantation site is further from the target cells, as is the case in suprachoroidal approaches, hexagonally guarded electrode return configurations can convey higher spatial resolution.

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Authors: Wilke, R. G. H., Moghadam, G. K., Lovell, N. H., Suaning, G. J., & Dokos, S.
Affiliations: UNSW Sydney (AU)
Corresponding author: Lovell, N H
ORCID: Lovell, N H
Suaning, G J
Dokos, S
Venue: Journal of Neural Engineering
Publisher: IOP Publishing
Published: 2011-06-15
Volume: 8
Issue: 4
Pages: 046016
ISSN: 1741-2552 (ISSN-L)
1741-2560
DOI: 10.1088/1741-2560/8/4/046016
OpenAlex: W2084193319
Cited by: 110
References: 34
Citations by year: 2026: 3 · 2025: 9 · 2024: 8 · 2023: 5 · 2022: 15 · 2021: 8 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 10 · 2016: 9 · 2015: 3 · 2014: 6 · 2013: 6 · 2012: 8
FWCI: 2.92
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neural Engineering (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
University of New South Wales
Eberhard Karls Universität Tübingen
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Physical Sciences › Engineering › Electrical and Electronic Engineering › Analog and Mixed-Signal Circuit Design
Physical Sciences › Engineering › Electrical and Electronic Engineering › CCD and CMOS Imaging Sensors
Keywords: retinal prosthesis, microelectrode arrays, spatial resolution, electric field distribution, electrode configuration, monopolar electrodes, electrode diameter, electrode spacing, epiretinal implants, finite element analysis
MeSH terms: Algorithms, Electrodes, Implanted, Electromagnetic Fields, Electronics, Prosthesis Design, Retina, Models, Statistical, Prostheses and Implants, Finite Element Analysis

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Electric crosstalk impairs spatial resolution of multi-electrode arrays in retinal implants

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