Cited by 6423D Printing in Biomedical ResearchHydrogels: synthesis, properties, applicationsCellular Mechanics and Interactions

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Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels

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Bertassoni, Luiz E, Cardoso, Juliana C, Manoharan, Vijayan, Cristino, Ana L, Bhise, Nupura S, Araujo, Wesleyan A, Zorlutuna, Pinar, Vrana, Nihal E, Ghaemmaghami, Amir M, Dokmeci, Mehmet R, Khademhosseini, Ali·2014·Biofabrication

DOI 10.1088/1758-5082/6/2/024105PMC PMC4040163

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Abstract

Fabrication of three dimensional (3D) organoids with controlled microarchitectures has been shown to enhance tissue functionality. Bioprinting can be used to precisely position cells and cell-laden materials to generate controlled tissue architecture. Therefore, it represents an exciting alternative for organ fabrication. Despite the rapid progress in the field, the development of printing processes that can be used to fabricate macroscale tissue constructs from ECM-derived hydrogels has remained a challenge. Here we report a strategy for bioprinting of photolabile cell-laden methacrylated gelatin (GelMA) hydrogels. We bioprinted cell-laden GelMA at concentrations ranging from 7 to 15% with varying cell densities and found a direct correlation between printability and the hydrogel mechanical properties. Furthermore, encapsulated HepG2 cells preserved cell viability for at least eight days following the bioprinting process. In summary, this work presents a strategy for direct-write bioprinting of a cell-laden photolabile ECM-derived hydrogel, which may find widespread application for tissue engineering, organ printing and the development of 3D drug discovery platforms.

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Authors: Bertassoni, L. E., Cardoso, J. C., Manoharan, V., Cristino, A. L., Bhise, N. S., Araujo, W. A., Zorlutuna, P., Vrana, N. E., Ghaemmaghami, A. M., Dokmeci, M. R., & Khademhosseini, A.
Affiliations: Brigham and Women's Hospital (US)
University of Nottingham (GB)
Corresponding author: Dokmeci, Mehmet R
Khademhosseini, Ali
ORCID: Bertassoni, Luiz E
Cardoso, Juliana C
Manoharan, Vijayan
Vrana, Nihal E
Ghaemmaghami, Amir M
Dokmeci, Mehmet R
Khademhosseini, Ali
Venue: Biofabrication
Publisher: IOP Publishing
Published: 2014-04-03
Volume: 6
Issue: 2
Pages: 024105
ISSN: 1758-5082 (ISSN-L)
1758-5090
DOI: 10.1088/1758-5082/6/2/024105
PMC: PMC4040163
OpenAlex: W2100081159
Cited by: 642
References: 37
Citations by year: 2026: 17 · 2025: 36 · 2024: 34 · 2023: 44 · 2022: 55 · 2021: 69 · 2020: 72 · 2019: 80 · 2018: 74 · 2017: 68 · 2016: 56 · 2015: 32 · 2014: 4
FWCI: 27.67
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: iopscience.iop.org/info/page/text-and-data-mining (tdm)
iopscience.iop.org/page/copyright (vor)
Locations: Biofabrication (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
Repository@Nottingham (University of Nottingham) (submittedVersion)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico
National Institutes of Health (EB02597)
Defense Threat Reduction Agency
Biotechnology and Biological Sciences Research Council (BB/I02643X/1)
Australian Research Council (DP120104837)
National Heart, Lung, and Blood Institute (HL-099073, R01HL099073)
National Institute of General Medical Sciences (R01GM095906, GM095906)
National Institute of Allergy and Infectious Diseases (R01AI081534, AI081534)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR057837, R01AR057837)
National Institute of Biomedical Imaging and Bioengineering (EB02597)
National Institute of Dental and Craniofacial Research (DE021468, R01DE021468)
Topics: Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords: gelatin methacryloyl, cell-laden hydrogels, 3D organoids, printability, hydrogel mechanical properties, HepG2 cells, cell viability, tissue engineering, organ printing
MeSH terms: Animals, Biocompatible Materials, Cell Survival, Gelatin, Humans, Methacrylates, Hydrogels, Tissue Engineering, NIH 3T3 Cells, Mice, Tissue Scaffolds, Elastic Modulus, Hep G2 Cells, Bioprinting

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