The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Direct-write bioprinting of cell-laden methacrylated gelatin hydrogels
Open accessAbstract
Fabrication of three dimensional (3D) organoids with controlled microarchitectures has been shown to enhance tissue functionality. Bioprinting can be used to precisely position cells and cell-laden materials to generate controlled tissue architecture. Therefore, it represents an exciting alternative for organ fabrication. Despite the rapid progress in the field, the development of printing processes that can be used to fabricate macroscale tissue constructs from ECM-derived hydrogels has remained a challenge. Here we report a strategy for bioprinting of photolabile cell-laden methacrylated gelatin (GelMA) hydrogels. We bioprinted cell-laden GelMA at concentrations ranging from 7 to 15% with varying cell densities and found a direct correlation between printability and the hydrogel mechanical properties. Furthermore, encapsulated HepG2 cells preserved cell viability for at least eight days following the bioprinting process. In summary, this work presents a strategy for direct-write bioprinting of a cell-laden photolabile ECM-derived hydrogel, which may find widespread application for tissue engineering, organ printing and the development of 3D drug discovery platforms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“By adapting this method, we avoided potentially harsh printing conditions including, low temperature for a prolonged printing period [51] and undesirable shear stress along the length of the nozzle [30].”
From A liver-on-a-chip platform with bioprinted hepatic spheroids (2016) · cites this paper as [30]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hydrogels in regenerative medicine
Slaughter, B. V., Khurshid, S. S., Fisher, O. Z., Khademhosseini, A., & Peppas, N. A. (2009) · Advanced Materials · doi:10.1002/adma.200802106 · Cited by 2,703
Self-citationCell-laden microengineered gelatin methacrylate hydrogels
Nichol, J. W., Koshy, S. T., Bae, H., Hwang, C. M., Yamanlar, S., & Khademhosseini, A. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.064 · Cited by 2,377
Self-citationTissue-engineered autologous bladders for patients needing cystoplasty
Atala, A., Bauer, S. B., Söker, S., Yoo, J. J., & Retik, A. B. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68438-9 · Cited by 1,857
Mechanical Properties of Lungs
Mead, J. (1961) · Physiological Reviews · doi:10.1152/physrev.1961.41.2.281 · Cited by 1,643
Microscale technologies for tissue engineering and biology
Khademhosseini, A., Langer, R., Borenstein, J. T., & Vacanti, J. P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507681102 · Cited by 1,553
Self-citationPrinting and Prototyping of Tissues and Scaffolds
Derby, B. (2012) · Science · doi:10.1126/science.1226340 · Cited by 1,126
Inkjet printing of viable mammalian cells
Xu, T., Jin, J., Gregory, C., Hickman, J. J., & Boland, T. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.04.011 · Cited by 1,036
Mannoor, M. S., Jiang, Z., James, T., Kong, Y. L., Malatesta, K. A., Soboyejo, W. O., Verma, N., Gracias, D. H., & McAlpine, M. C. (2013) · Nano Letters · doi:10.1021/nl4007744 · Cited by 901
Laser assisted bioprinting of engineered tissue with high cell density and microscale organization
Guillotin, B., Souquet, A., Catros, S., Duocastella, M., Pippenger, B. E., Bellance, S., Bareille, R., Rémy, M., Bordenave, L., Amédée, J., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.055 · Cited by 869
Functional Human Vascular Network Generated in Photocrosslinkable Gelatin Methacrylate Hydrogels
Chen, Y., Lin, R., Qi, H., Yang, Y., Bae, H., Melero‐Martin, J. M., & Khademhosseini, A. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201101662 · Cited by 802
Self-citation
Research works printed but not linked: 1
- Xu T, 2013, Biofabrication, 5
Cited by
Sorted by citations
Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Yue, K., Trujillo-de Santiago, G., Alvarez, M. M., Tamayol, A., Annabi, N., & Khademhosseini, A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.045 · Cited by 3,146
“[12] Bertassoni LE, Cardoso JC, Manoharan V, Cristi no AL, Bhise NS, Araujo WA, et al.”
BackgroundMethodSelf-citation3D bioprinting for engineering complex tissues
Mandrycky, C., Wang, Z., Kim, K., & Kim, D. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.12.011 · Cited by 1,818
Current advances and future perspectives in extrusion-based bioprinting
Ozbolat, I. T., & Hospodiuk, M. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.10.076 · Cited by 1,642
Markstedt, K., Mantas, A., Tournier, I., Martínez Ávila, H., Hägg, D., & Gatenholm, P. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00188 · Cited by 1,528
Bioinks for 3D bioprinting: an overview
Gungor‐Ozkerim, P. S., İnci, İ., Zhang, Y. S., Khademhosseini, A., & Dokmeci, M. R. (2018) · Biomaterials Science · doi:10.1039/c7bm00765e · Cited by 1,524
Self-citationProgress in 3D bioprinting technology for tissue/organ regenerative engineering
Matai, I., Kaur, G., Seyedsalehi, A., McClinton, A., & Laurencin, C. T. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119536 · Cited by 1,156
The bioink: A comprehensive review on bioprintable materials
Hospodiuk, M., Dey, M., Sosnoski, D. M., & Ozbolat, I. T. (2017) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.12.006 · Cited by 1,168
3D Printing of Scaffolds for Tissue Regeneration Applications
Do, A., Khorsand, B., Geary, S. M., & Salem, A. K. (2015) · Advanced Healthcare Materials · doi:10.1002/adhm.201500168 · Cited by 949
Hydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs
Bertassoni, L. E., Cecconi, M., Manoharan, V., Nikkhah, M., Hjortnaes, J., Cristino, A. L., Barabaschi, G., Demarchi, D., Dokmeci, M. R., Yang, Y., et al. (2014) · Lab Chip · doi:10.1039/c4lc00030g · Cited by 944
Self-citationMicrofluidic Bioprinting of Heterogeneous 3D Tissue Constructs Using Low‐Viscosity Bioink
Colosi, C., Shin, S. R., Manoharan, V., Massa, S., Costantini, M., Barbetta, A., Dokmeci, M. R., Dentini, M., & Khademhosseini, A. (2016) · Advanced Materials · doi:10.1002/adma.201503310 · Cited by 863
Self-citationGelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair
Klotz, B. J., Gawlitta, D., Rosenberg, A. J. W. P., Malda, J., & Melchels, F. P. W. (2016) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.01.002 · Cited by 880
Zhang, Y. S., Aleman, J., Shin, S. R., Kilic, T., Kim, D., Mousavi Shaegh, S. A., Massa, S., Riahi, R., Chae, S., Hu, N., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612906114 · Cited by 833
Self-citationDesigning Biomaterials for 3D Printing
Güvendiren, M., Molde, J., Soares, R. M. D., & Kohn, J. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00121 · Cited by 761
Advanced Bioinks for 3D Printing: A Materials Science Perspective
Chimene, D., Lennox, K. K., Kaunas, R. R., & Gaharwar, A. K. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1638-y · Cited by 708
Research on the printability of hydrogels in 3D bioprinting
He, Y., Yang, F., Zhao, H., Gao, Q., Xia, B., & Fu, J. (2016) · Scientific Reports · doi:10.1038/srep29977 · Cited by 684
Wang, Z., Abdulla, R., Parker, B., Samanipour, R., Ghosh, S., & Kim, K. (2015) · Biofabrication · doi:10.1088/1758-5090/7/4/045009 · Cited by 633
Recent advances in bioprinting techniques: approaches, applications and future prospects
Li, J., Chen, M., Fan, X., & Zhou, H. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-1028-0 · Cited by 633
A liver-on-a-chip platform with bioprinted hepatic spheroids
Bhise, N. S., Manoharan, V., Massa, S., Tamayol, A., Ghaderi, M., Miscuglio, M., Lang, Q., Shrike Zhang, Y., Shin, S. R., Calzone, G., et al. (2016) · Biofabrication · doi:10.1088/1758-5090/8/1/014101 · Cited by 615
Self-citationYin, J., Yan, M., Wang, Y., Fu, J., & Suo, H. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b16059 · Cited by 602
Hydrogel Bioink Reinforcement for Additive Manufacturing: A Focused Review of Emerging Strategies
Chimene, D., Kaunas, R., & Gaharwar, A. K. (2020) · Advanced Materials · doi:10.1002/adma.201902026 · Cited by 600
Opportunities and challenges of translational 3D bioprinting
Murphy, S. V., Coppi, P. D., & Atala, A. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0471-7 · Cited by 584
Unagolla, J. M., & Jayasuriya, A. C. (2019) · Applied Materials Today · doi:10.1016/j.apmt.2019.100479 · Cited by 567
Processing of collagen based biomaterials and the resulting materials properties
Meyer, M. (2019) · BioMedical Engineering OnLine · doi:10.1186/s12938-019-0647-0 · Cited by 539
Laronda, M. M., Rutz, A. L., Xiao, S., Whelan, K. A., Duncan, F. E., Roth, E. W., Woodruff, T. K., & Shah, R. N. (2017) · Nature Communications · doi:10.1038/ncomms15261 · Cited by 531
Ouyang, L., Highley, C. B., Sun, W., & Burdick, J. A. (2016) · Advanced Materials · doi:10.1002/adma.201604983 · Cited by 525
Extrusion Bioprinting of Shear‐Thinning Gelatin Methacryloyl Bioinks
Liu, W. H., Heinrich, M. A., Zhou, Y., Akpek, A., Hu, N., Liu, X., Guan, X., Zhong, Z., Jin, X., Khademhosseini, A., et al. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201601451 · Cited by 523
Self-citation4D Biofabrication Using Shape‐Morphing Hydrogels
Kirillova, A., Maxson, R., Stoychev, G. V., Gomillion, C. T., & Ionov, L. (2017) · Advanced Materials · doi:10.1002/adma.201703443 · Cited by 509
‘Printability' of Candidate Biomaterials for Extrusion Based 3D Printing: State‐of‐the‐Art
Kyle, S., Jessop, Z. M., Al‐Sabah, A., & Whitaker, I. S. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700264 · Cited by 518
Recent Advances in Bioink Design for 3D Bioprinting of Tissues and Organs
Ji, S., & Güvendiren, M. (2017) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2017.00023 · Cited by 494
From Shape to Function: The Next Step in Bioprinting
Levato, R., Jüngst, T., Scheuring, R. G., Blunk, T., Gröll, J., & Malda, J. (2020) · Advanced Materials · doi:10.1002/adma.201906423 · Cited by 493
Current Status of Bioinks for Micro-Extrusion-Based 3D Bioprinting
Panwar, A., & Tan, L. P. (2016) · Molecules · doi:10.3390/molecules21060685 · Cited by 502
Biomaterials for Integration with 3-D Bioprinting
Skardal, A., & Atala, A. (2014) · Annals of Biomedical Engineering · doi:10.1007/s10439-014-1207-1 · Cited by 476
Bioprinting for vascular and vascularized tissue biofabrication
Datta, P., Ayan, B., & Ozbolat, I. T. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.035 · Cited by 431
Skardal, A., Devarasetty, M., Kang, H.-W., Mead, I., Bishop, C., Shupe, T., Lee, S. J., Jackson, J., Yoo, J., Soker, S., et al. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.07.030 · Cited by 428
Bioprinting Technology: A Current State-of-the-Art Review
Dababneh, A. B., & Ozbolat, I. T. (2014) · Journal of Manufacturing Science and Engineering · doi:10.1115/1.4028512 · Cited by 427
Rapid Continuous Multimaterial Extrusion Bioprinting
Liu, W. H., Zhang, Y. S., Heinrich, M. A., Ferrari, F. D., Jang, H. L., Bakht, S. M., Álvarez, M. M., Yang, J., Li, Y., Santiago, G. T., et al. (2016) · Advanced Materials · doi:10.1002/adma.201604630 · Cited by 442
Self-citationFundamentals and Applications of Photo-Cross-Linking in Bioprinting
Lim, K. S., Galarraga, J. H., Cui, X., Lindberg, G. C. J., Burdick, J. A., & Woodfield, T. B. F. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00812 · Cited by 449
Pepelanova, I., Kruppa, K., Scheper, T. H., & Lavrentieva, A. V. (2018) · Bioengineering · doi:10.3390/bioengineering5030055 · Cited by 415
Crosslinking Strategies for 3D Bioprinting of Polymeric Hydrogels
GhavamiNejad, A., Ashammakhi, N. A., Wu, X. Y., & Khademhosseini, A. (2020) · Small · doi:10.1002/smll.202002931 · Cited by 426
Self-citationBioprinted Osteogenic and Vasculogenic Patterns for Engineering 3D Bone Tissue
Byambaa, B., Annabi, N., Yue, K., Santiago, G. T., Álvarez, M. M., Jia, W., Kazemzadeh‐Narbat, M., Shin, S. R., Tamayol, A., & Khademhosseini, A. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700015 · Cited by 403
Self-citationShear-Thinning and Thermo-Reversible Nanoengineered Inks for 3D Bioprinting
Wilson, S. A., Cross, L., Peak, C. W., & Gaharwar, A. K. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b13602 · Cited by 370
Askari, M., Afzali Naniz, M., Kouhi, M., Saberi, A., Zolfagharian, A., & Bodaghi, M. (2021) · Biomaterials Science · doi:10.1039/d0bm00973c · Cited by 369
New Visible-Light Photoinitiating System for Improved Print Fidelity in Gelatin-Based Bioinks
Lim, K. S., Schon, B. S., Mekhileri, N. V., Lindberg, G. C. J., Chia, C. M., Prabakar, S., Hooper, G. J., & Woodfield, T. B. F. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00149 · Cited by 364
A Review of Three-Dimensional Printing in Tissue Engineering
Sears, N., Seshadri, D. R., Dhavalikar, P., & Cosgriff‐Hernandez, E. (2016) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2015.0464 · Cited by 360
Application areas of 3D bioprinting
Ozbolat, I. T., Peng, W., & Özbolat, V. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.04.006 · Cited by 364
3D Bioprinting for Cartilage and Osteochondral Tissue Engineering
Daly, A. C., Freeman, F. E., Gonzalez‐Fernandez, T., Critchley, S. E., Nulty, J. M., & Kelly, D. J. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700298 · Cited by 351
Bioprinting and its applications in tissue engineering and regenerative medicine
Aljohani, W., Ullah, M. W., Zhang, X., & Yang, G. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.08.171 · Cited by 339
Costantini, M., Testa, S., Mozetic, P., Barbetta, A., Fuoco, C., Fornetti, E., Tamiro, F., Bernardini, S., Jaroszewicz, J., Święszkowski, W., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.03.026 · Cited by 334
Boularaoui, S. M., Hussein, G. A., Khan, K. A., Christoforou, N., & Stefanini, C. (2020) · Bioprinting · doi:10.1016/j.bprint.2020.e00093 · Cited by 349
State-of-the-Art Review of 3D Bioprinting for Cardiovascular Tissue Engineering
Duan, B. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1607-5 · Cited by 323
Evolution of Bioinks and Additive Manufacturing Technologies for 3D Bioprinting
Jose, R. R., Rodríguez, M. J., Dixon, T. A., Omenetto, F. G., & Kaplan, D. L. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00088 · Cited by 307
Towards artificial tissue models: past, present, and future of 3D bioprinting
Yıldız, A. A., Assal, R. E., Chen, P., Güven, S., İnci, F., & Demirci, U. (2016) · Biofabrication · doi:10.1088/1758-5090/8/1/014103 · Cited by 319
3D Bioprinting in Skeletal Muscle Tissue Engineering
Ostrovidov, S., Salehi, S., Costantini, M., Suthiwanich, K., Ebrahimi, M., Sadeghian, R. B., Fujie, T., Shi, X., Cannata, S. M., Gargioli, C., et al. (2019) · Small · doi:10.1002/smll.201805530 · Cited by 296
Self-citationBernal, P. N., Bouwmeester, M., Madrid-Wolff, J. A., Falandt, M., Florczak, S., Rodriguez, N. G., Li, Y., Größbacher, G., Samsom, R., van Wolferen, M. E., et al. (2022) · Advanced Materials · doi:10.1002/adma.202110054 · Cited by 297
Print Me An Organ! Why We Are Not There Yet
Ng, W. L., Chua, C. K., & Shen, Y. (2019) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2019.101145 · Cited by 298
Liu, W. H., Zhong, Z., Hu, N., Zhou, Y., Maggio, L., Miri, A. K., Fragasso, A., Jin, X., Khademhosseini, A., & Zhang, Y. S. (2017) · Biofabrication · doi:10.1088/1758-5090/aa9d44 · Cited by 286
Self-citationPrintability–A key issue in extrusion-based bioprinting
Naghieh, S., & Chen, D. (2021) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2021.02.001 · Cited by 297
3D neural tissue models: From spheroids to bioprinting
Zhuang, P., Sun, A. X., An, J., Chua, C. K., & Chew, S. Y. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.002 · Cited by 269
3D Bioprinting of Vessel-like Structures with Multilevel Fluidic Channels
Gao, Q., Liu, Z., Lin, Z., Qiu, J., Liu, Y., Liu, A., Wang, Y., Xiang, M., Chen, B., Fu, J., et al. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00643 · Cited by 275
Multiscale bioprinting of vascularized models
Miri, A. K., Khalilpour, A., Çeçen, B., Maharjan, S., Shin, S. R., & Khademhosseini, A. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.08.006 · Cited by 277
Self-citationPrinting Technologies for Medical Applications
Shafiee, A., & Atala, A. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.01.003 · Cited by 270
Xu, W., Molino, B. Z., Cheng, F., Molino, P. J., Yue, Z., Su, D., Wang, X., Willför, S. M., Xu, C., & Wallace, G. G. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b21268 · Cited by 270
Polymeric Systems for Bioprinting
Bedell, M. L., Navara, A. M., Du, Y., Zhang, S., & Mikos, A. G. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00834 · Cited by 266
Bioinks and bioprinting: A focused review
Mobaraki, M., Ghaffari, M. S., Yazdanpanah, A., Luo, Y., & Mills, D. K. (2020) · Bioprinting · doi:10.1016/j.bprint.2020.e00080 · Cited by 271
A brief review of extrusion‐based tissue scaffold bio‐printing
Ning, L., & Chen, D. (2017) · Biotechnology Journal · doi:10.1002/biot.201600671 · Cited by 267
Biomaterials-based 3D cell printing for next-generation therapeutics and diagnostics
Jang, J., Park, J. Y., Gao, G., & Cho, D. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.030 · Cited by 254
Review of 3D printable hydrogels and constructs
Li, H., Tan, C., & Li, L. (2018) · Materials & Design · doi:10.1016/j.matdes.2018.08.023 · Cited by 253
Nanoengineered Ionic–Covalent Entanglement (NICE) Bioinks for 3D Bioprinting
Chimene, D., Peak, C. W., Gentry, J. L., Carrow, J. K., Cross, L., Mondragón, E., Cardoso, G. B. C., Kaunas, R. R., & Gaharwar, A. K. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b19808 · Cited by 249
Extrusion bioprinting of soft materials: An emerging technique for biological model fabrication
Jiang, T., Munguia-López, J. G., Flores-Torres, S., Kort-Mascort, J., & Kinsella, J. M. (2019) · Applied Physics Reviews · doi:10.1063/1.5059393 · Cited by 251
Three-Dimensional Bioprinting for Regenerative Dentistry and Craniofacial Tissue Engineering
Obregon, F., Vaquette, C., Ivanovski, S., Hutmacher, D. W., & Bertassoni, L. E. (2015) · Journal of Dental Research · doi:10.1177/0022034515588885 · Cited by 249
Self-citation3D bioprinting and itsin vivoapplications
Hong, N., Yang, G. H., Lee, J., & Kim, G. (2017) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33826 · Cited by 250
3D Bioprinting for Vascularized Tissue Fabrication
Richards, D., Jia, J., Yost, M. J., Markwald, R. R., & Mei, Y. (2016) · Annals of Biomedical Engineering · doi:10.1007/s10439-016-1653-z · Cited by 245
Jin, Y., Liu, C., Chai, W., Compaan, A. M., & Huang, Y. H. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b03613 · Cited by 238
UV-Assisted 3D Bioprinting of Nanoreinforced Hybrid Cardiac Patch for Myocardial Tissue Engineering
Izadifar, M., Chapman, D., Babyn, P., Chen, D., & Kelly, M. (2017) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2017.0346 · Cited by 239
3D bioprinting of photocrosslinkable hydrogel constructs
Pereira, R. F., & Bártolo, P. (2015) · Journal of Applied Polymer Science · doi:10.1002/app.42458 · Cited by 236
Monteiro, N., Thrivikraman, G., Athirasala, A., Tahayeri, A., França, C. M., Ferracane, J. L., & Bertassoni, L. E. (2017) · Dental Materials · doi:10.1016/j.dental.2017.11.020 · Cited by 228
Self-citationRodríguez, M. J., Brown, J. E., Giordano, J. E. M., Lin, S. J., Omenetto, F. G., & Kaplan, D. L. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.046 · Cited by 221
Evaluation of bioink printability for bioprinting applications
Zhang, Z., Jin, Y., Yin, J., Xu, C., Xiong, R., Christensen, K., Ringeisen, B. R., Chrisey, D. B., & Huang, Y. H. (2018) · Applied Physics Reviews · doi:10.1063/1.5053979 · Cited by 227
Tissue Engineering Applications of Three-Dimensional Bioprinting
Zhang, X., & Zhang, Y. (2015) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-015-0531-x · Cited by 218
3D printed microchannel networks to direct vascularisation during endochondral bone repair
Daly, A. C., Pitacco, P., Nulty, J. M., Cunniffe, G. M., & Kelly, D. J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.01.057 · Cited by 221
Extrusion and Microfluidic‐Based Bioprinting to Fabricate Biomimetic Tissues and Organs
Davoodi, E., Sarikhani, E., Montazerian, H., Ahadian, S., Costantini, M., Święszkowski, W., Willerth, S. M., Walus, K., Mofidfar, M., Toyserkani, E., et al. (2020) · Advanced Materials Technologies · doi:10.1002/admt.201901044 · Cited by 228
Self-citationEmergence of FRESH 3D printing as a platform for advanced tissue biofabrication
Shiwarski, D. J., Hudson, A. R., Tashman, J. W., & Feinberg, A. W. (2021) · APL Bioengineering · doi:10.1063/5.0032777 · Cited by 233
Application of 3D Printing for Smart Objects with Embedded Electronic Sensors and Systems
Ota, H., Emaminejad, S., Gao, Y., Zhao, A., Wu, E. G., Challa, S., Chen, K., Fahad, H. M., Jha, A. K., Kiriya, D., et al. (2016) · Advanced Materials Technologies · doi:10.1002/admt.201600013 · Cited by 213
Malekpour, A., & Chen, D. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb13020040 · Cited by 238
Three-dimensional bioprinting of gelatin methacryloyl (GelMA)
Ying, G., Jiang, N., Yu, C., & Zhang, Y. S. (2018) · Bio-Design and Manufacturing · doi:10.1007/s42242-018-0028-8 · Cited by 215
Structural analysis of photocrosslinkable methacryloyl-modified protein derivatives
Yue, K., Li, X., Schrobback, K., Sheikhi, A., Annabi, N., Leijten, J., Zhang, W., Zhang, Y. S., Hutmacher, D. W., Klein, T. J., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.04.050 · Cited by 211
Self-citationNatural and Synthetic Bioinks for 3D Bioprinting
Khoeini, R., Nosrati, H., Akbarzadeh, A., Eftekhari, A., Kavetskyy, T. S., Khalilov, R. I., Ahmadian, E., Nasibova, A. N., Datta, P., Roshangar, L., et al. (2021) · Advanced NanoBiomed Research · doi:10.1002/anbr.202000097 · Cited by 210
Microfluidic organ-on-a-chip models of human liver tissue
Moradi, E., Jalili‐Firoozinezhad, S., & Solati‐Hashjin, M. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.08.041 · Cited by 213
Zhai, X., Ruan, C., Ma, Y., Cheng, D., Wu, M., Liu, W., Zhao, X., Pan, H., & Lu, W. W. (2017) · Advanced Science · doi:10.1002/advs.201700550 · Cited by 199
Hyaluronic acid as a bioink for extrusion-based 3D printing
Petta, D., D’Amora, U., Ambrosio, L., Grijpma, D. W., Eglin, D., & D’Este, M. (2020) · Biofabrication · doi:10.1088/1758-5090/ab8752 · Cited by 200
3D Bioprinted cancer models: Revolutionizing personalized cancer therapy
Augustine, R., Kalva, S. N., Ahmad, R., Zahid, A. A., Hasan, S., Nayeem, A., McClements, L., & Hasan, A. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101015 · Cited by 206
O’Connell, C. D., Zhang, B., Onofrillo, C., Duchi, S., Blanchard, R., Quigley, A. F., Bourke, J., Gambhir, S., Kapsa, R. M. I., Bella, C. D., et al. (2018) · Soft Matter · doi:10.1039/c7sm02187a · Cited by 200
Ophthalmic gels: Past, present and future
Al-Kinani, A. A., Zidan, G., Elsaid, N., Seyfoddin, A., Alani, A. W. G., & Alany, R. G. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.12.017 · Cited by 200
Mohanty, S., Larsen, L. B., Trifol, J., Szabó, P., Burri, H., Canali, C., Dufva, M., Emnéus, J., & Wolff, A. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.06.002 · Cited by 202
(Photo-)crosslinkable gelatin derivatives for biofabrication applications
Hoorick, J. V., Tytgat, L., Dobos, A., Ottevaere, H., Erps, J. V., Hugo Thienpont, A., Ovsianikov, A., Dubruel, P., & Vlierberghe, S. V. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.07.035 · Cited by 205
Osteogenic and angiogenic tissue formation in high fidelity nanocomposite Laponite-gelatin bioinks
Cidonio, G., Alcala‐Orozco, C. R., Lim, K. S., Glinka, M., Mutreja, I., Kim, Y., Dawson, J. I., Woodfield, T. B. F., & Oreffo, R. O. C. (2019) · Biofabrication · doi:10.1088/1758-5090/ab19fd · Cited by 192
Recent advances in high-strength and elastic hydrogels for 3D printing in biomedical applications
Xu, C., Dai, G., & Hong, Y. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.032 · Cited by 195
Athirasala, A., Tahayeri, A., Thrivikraman, G., França, C. M., Monteiro, N., Tran, V., Ferracane, J. L., & Bertassoni, L. E. (2017) · Biofabrication · doi:10.1088/1758-5090/aa9b4e · Cited by 190
Self-citationSánchez, E. M., Gómez-Blanco, J. C., Nieto, E. L., Casado, J. G., Macı́as-Garcı́a, A., Díez, M. A. D., Carrasco-Amador, J. P., Torrejón-Martín, D., Sanchez-Margallo, F. M., & Pagador, J. B. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00776 · Cited by 204
Augustine, R. (2018) · Progress in Biomaterials · doi:10.1007/s40204-018-0087-0 · Cited by 188
Metadata
- Authors
- Bertassoni, L. E., Cardoso, J. C., Manoharan, V., Cristino, A. L., Bhise, N. S., Araujo, W. A., Zorlutuna, P., Vrana, N. E., Ghaemmaghami, A. M., Dokmeci, M. R., & Khademhosseini, A.
- Affiliations
- Brigham and Women's Hospital (US)
- University of Nottingham (GB)
- Corresponding author
- Dokmeci, Mehmet R
- Khademhosseini, Ali
- ORCID
- Venue
- Biofabrication
- Publisher
- IOP Publishing
- Published
- 2014-04-03
- Volume
- 6
- Issue
- 2
- Pages
- 024105
- ISSN
- 1758-5082 (ISSN-L)
- 1758-5090
- PMC
- PMC4040163
- OpenAlex
- W2100081159
- Cited by
- 642
- References
- 37
- Citations by year
- 2026: 17 · 2025: 36 · 2024: 34 · 2023: 44 · 2022: 55 · 2021: 69 · 2020: 72 · 2019: 80 · 2018: 74 · 2017: 68 · 2016: 56 · 2015: 32 · 2014: 4
- FWCI
- 27.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biofabrication (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- Repository@Nottingham (University of Nottingham) (submittedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- National Institutes of Health (EB02597)
- Defense Threat Reduction Agency
- Biotechnology and Biological Sciences Research Council (BB/I02643X/1)
- Australian Research Council (DP120104837)
- National Heart, Lung, and Blood Institute (HL-099073, R01HL099073)
- National Institute of General Medical Sciences (R01GM095906, GM095906)
- National Institute of Allergy and Infectious Diseases (R01AI081534, AI081534)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR057837, R01AR057837)
- National Institute of Biomedical Imaging and Bioengineering (EB02597)
- National Institute of Dental and Craniofacial Research (DE021468, R01DE021468)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- gelatin methacryloyl, cell-laden hydrogels, 3D organoids, printability, hydrogel mechanical properties, HepG2 cells, cell viability, tissue engineering, organ printing
- MeSH terms
- Animals, Biocompatible Materials, Cell Survival, Gelatin, Humans, Methacrylates, Hydrogels, Tissue Engineering, NIH 3T3 Cells, Mice, Tissue Scaffolds, Elastic Modulus, Hep G2 Cells, Bioprinting
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
