Emergence of Tics in Children with ADHD: Impact of Once-Daily OROS® Methylphenidate Therapy
Abstract
OBJECTIVES: While stimulants are the recognized first-line choice of pharmacotherapy for ADHD, reports that they may induce or exacerbate tics have tended to limit their use in ADHD children who have a history of tics or a family history of Tourette's syndrome. This study analyzes the incidence of tics reported across five studies of children with ADHD who received methylphenidate (MPH)-based therapy as part of the clinical development program for once-daily OROS MPH (CONCERTA McNeil Consumer & Specialty Pharmaceuticals, Fort Washington, PA). METHODS: Data were analyzed from three placebo-controlled, active-controlled studies (studies 1-3) lasting 1-4 weeks, and two open-label studies lasting 2 years (study 4) and 9 months (study 5), respectively. During the course of the studies, parents were asked at the end of each week of treatment (studies 1 and 2), biweekly (study 3), or monthly (for the first year of study 4, then at 3-month intervals thereafter) whether their child had experienced tics. Tics could also be reported as adverse events in the two open-label studies. RESULTS: Pooled data from the three placebo-controlled studies showed that the incidence of tics was not significantly different across all three treatment groups (OROS MPH, 4.0%; MPH tid, 2.3%; placebo, 3.7%, p = 0.5249). During the first year of the 2-year open-label study, the monthly incidence of tics remained constant, at approximately 5%. Analysis of tic episodes per patient in this study found no correlation between an OROS MPH dose and the frequency of tic episodes. The risk of tic episodes was higher in patients with a history of tics than in those with no history of tics (33% versus 7%, p < 0.0001). However, only 2 children with a history of tics (4%) withdrew from therapy because of their tics. CONCLUSIONS: These data suggest that MPH-based therapy does not significantly induce or exacerbate tics in children with ADHD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This exacerbation, if it occurs, is fully reversible after stimulant withdrawal or dose reduction.
“This exacerbation, if it occurs, is fully reversible after stimulant withdrawal or dose reduction [104, 110].”
From European guidelines on managing adverse effects of medication for ADHD (2011) · cites this paper as [104]
Cites
(1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.12.1073 · Cited by 3,372 · see citing works
Committee on Quality Improvement, S. O. A.-D. D. (2000) · Pediatrics · doi:10.1542/peds.105.5.1158 · Cited by 1,076 · see citing works
Wilens, T. E., Faraone, S. V., Biederman, J., & Gunawardene, S. (2003) · Pediatrics · doi:10.1542/peds.111.1.179 · Cited by 872 · see citing works
Self-citationStimulants : neurochemical, behavioral, and clinical perspectives
Creese, I. (1983) · Raven Press eBooks · Cited by 698 · see citing works
Treatment of ADHD in children with tics: A randomized controlled trial
The Tourette’s Syndrome Study Group (2002) · Neurology · doi:10.1212/wnl.58.4.527 · Cited by 504 · see citing works
Wolraich, M. L., Greenhill, L. L., Pelham, W., Swanson, J., Wilens, T., Palumbo, D., Atkins, M., McBurnett, K., Bukstein, O., August, G., et al. (2001) · Pediatrics · doi:10.1542/peds.108.4.883 · Cited by 502 · see citing works
Self-citationBarkley, R. A., McMurray, M. B., EDELBROCK, C. S., & Robbins, K. (1990) · PubMed · Cited by 433 · see citing works
Pelham, W. E., Gnagy, E. M., Burrows-Maclean, L., Williams, A., Fabiano, G. A., Morrisey, S. M., Chronis, A. M., Forehand, G. L., Nguyen, C. A., Hoffman, M. T., et al. (2001) · Pediatrics · doi:10.1542/peds.107.6.e105 · Cited by 378 · see citing works
Barkley, R. A., McMurray, M. B., EDELBROCK, C. S., & Robbins, K. (1990) · PEDIATRICS · doi:10.1542/peds.86.2.184 · Cited by 372 · see citing works
The behavioral spectrum of tic disorders
Kurlan, R., Como, P. G., Miller, B. M., Palumbo, D. R., Deeley, C., Andresen, E. M., Eapen, S., & McDermott, M. (2002) · Neurology · doi:10.1212/wnl.59.3.414 · Cited by 283 · see citing works
Self-citationSwanson, J., Gupta, S., Lam, A., Shoulson, I., Lerner, M., Modi, N., Lindemulder, E., & Wigal, S. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.2.204 · Cited by 248 · see citing works
Castellanos, F. X., Giedd, J. N., Elia, J., Marsh, W., Ritchie, G. F., Hamburger, S. D., & Rapoport, J. L. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199705000-00008 · Cited by 239 · see citing works
Gadow, K. D., Sverd, J., Sprafkin, J. N., Nolan, E. E., & Grossman, S. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.330 · Cited by 234 · see citing works
Comings, D. E., & Comings, B. G. (1987) · Europe PMC (PubMed Central) · Cited by 233 · see citing works
Comings, D. E., & Comings, B. G. (1984) · Journal of the American Academy of Child Psychiatry · doi:10.1097/00004583-198403000-00004 · Cited by 195 · see citing works
An epidemiologic study of Tourette's syndrome in a single school district.
Comings, D. E., Himes, J., & Comings, B. G. (1990) · PubMed · Cited by 180 · see citing works
The prevalence of Tourette syndrome in a mainstream school population
BSc, A. M., Banerjee, S., Eapen, V., FRCPsych Harry Zeitlin, F. R. C. P., & Robertson, F. M. M. (1998) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.1998.tb15379.x · Cited by 171 · see citing works
Gadow, K. D. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950180030005 · Cited by 168 · see citing works
Motor/vocal tics and compulsive behaviors on stimulant drugs: Is there a common vulnerability?
Borcherding, B. G., Keysor, C. S., Rapoport, J. L., Elia, J., & Amass, J. (1990) · Psychiatry Research · doi:10.1016/0165-1781(90)90151-t · Cited by 150 · see citing works
Tics following methylphenidate administration. A report of 20 cases
Mb, D. (1976) · JAMA · doi:10.1001/jama.235.13.1349 · Cited by 137 · see citing works
Law, S., & Schachar, R. J. (1999) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199908000-00009 · Cited by 130 · see citing works
Tics and psychiatric comorbidity in children and adolescents
Gadow, K. D., Nolan, E. E., Sprafkin, J. N., & Schwartz, J. E. (2002) · Developmental Medicine & Child Neurology · doi:10.1017/s001216220100216x · Cited by 107 · see citing works
Erenberg, G. (2005) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2005.12.003 · Cited by 98 · see citing works
Gadow, K. D., Nolan, E. E., Sprafkin, J. N., & Sverd, J. (1995) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-199506000-00004 · Cited by 94 · see citing works
Psychopharmacological Intervention I
Singh, N. N., Epstein, M. H., Luebke, J. F., & Singh, Y. N. (1990) · The Journal of Special Education · doi:10.1177/002246699002400303 · Cited by 89 · see citing works
Tourette's syndrome in a special education population
Kurlan, R., Whitmore, D., Irvine, C., McDermott, M. P., & Como, P. G. (1994) · Neurology · doi:10.1212/wnl.44.4.699 · Cited by 87 · see citing works
Tics and Dyskinesias Associated With Stimulant Treatment in Attention-Deficit Hyperactivity Disorder
Lipkin, P. H. (1994) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1994.02170080089017 · Cited by 83 · see citing works
Tic disorders: some key issues for DSM-V
Walkup, J. T., Ferrão, Y. A., Leckman, J. F., Stein, D. J., & Singer, H. S. (2010) · Depression and Anxiety · doi:10.1002/da.20711 · Cited by 63 · see citing works
Nolan, E. E., Gadow, K. D., & Sprafkin, J. N. (1999) · PEDIATRICS · doi:10.1542/peds.103.4.730 · Cited by 47 · see citing works
Varley, C. K., Vincent, J., Varley, P., & Calderon, R. (2001) · Comprehensive Psychiatry · doi:10.1053/comp.2001.23145 · Cited by 46 · see citing works
Methylphenidate HCl: therapy for attention deficit hyperactivity disorder
Capp, P. K., Pearl, P. L., & Conlon, C. J. (2005) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.5.3.325 · Cited by 41 · see citing works
Tourette's Syndrome and Attention Deficit Disorder With Hyperactivity
Comings, D. E. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800230103017 · Cited by 39 · see citing works
Tourette's syndrome and attention deficit disorder
Comings, D. E. (1988) · Medical Entomology and Zoology · Cited by 32 · see citing works
Gupta, K. (2016) · TEXILA INTERNATIONAL JOURNAL OF CLINICAL RESEARCH · doi:10.21522/tijcr.2014.03.01.art007 · Cited by 29 · see citing works
Sprafkin, J. N., & Gadow, K. D. (1993) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.1993.3.231 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
the ESSTS Guidelines Group, Roessner, V., Plessen, K. J., Rothenberger, A., Ludolph, A. G., Rizzo, R., Skov, L., Strand, G., Stern, J. S., Termine, C., et al. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-011-0163-7 · Cited by 461 · see citing works
Banaschewski, T., Coghill, D., Santosh, P., Zuddas, A., Asherson, P., Buitelaar, J., Danckaerts, M., Döpfner, M., Faraone, S. V., Rothenberger, A., et al. (2006) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-006-0549-0 · Cited by 375 · see citing works
Self-citationEuropean guidelines on managing adverse effects of medication for ADHD
(for the European Guidelines Group), Graham, J., Banaschewski, T., Buitelaar, J., Coghill, D., Danckaerts, M., Dittmann, R. W., Döpfner, M., Hamilton, R., Hollis, C., et al. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0140-6 · Cited by 374 · see citing works
Roessner, V., Eichele, H., Stern, J. S., Skov, L., Rizzo, R., Debes, N. M., Nagy, P., Cavanna, A. E., Termine, C., Ganos, C., et al. (2021) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-021-01899-z · Cited by 211 · see citing works
Graham, J., & Coghill, D. (2008) · CNS Drugs · doi:10.2165/00023210-200822030-00003 · Cited by 185 · see citing works
European clinical guidelines for Tourette Syndrome and other tic disorders
Roessner, V., Rothenberger, A., Rickards, H. E., & Hoekstra, P. J. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-011-0165-5 · Cited by 171 · see citing works
Erenberg, G. (2005) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2005.12.003 · Cited by 98 · see citing works
Buitelaar, J. K., & Medori, R. (2009) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0056-1 · Cited by 80 · see citing works
Immediate-Release Methylphenidate for ADHD in Children With Comorbid Chronic Multiple Tic Disorder
Gadow, K. D., Sverd, J., Nolan, E. E., Sprafkin, J. N., & Schneider, J. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e31805c0860 · Cited by 75 · see citing works
First-onset tics in patients with attention-deficit–hyperactivity disorder: impact of stimulants
Roessner, V., Robatzek, M., Knapp, G., Banaschewski, T., & Rothenberger, A. (2006) · Developmental Medicine & Child Neurology · doi:10.1017/s0012162206001290 · Cited by 70 · see citing works
Treatment-refractory Tourette Syndrome
Kious, B. M., Shahed, J. J., & Shprecher, D. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.02.003 · Cited by 66 · see citing works
Tourette disorder and other tic disorders
Deeb, W., Malaty, I. A., & Mathews, C. A. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64012-3.00008-3 · Cited by 65 · see citing works
Psychopharmacological Interventions
Biederman, J., & Spencer, T. J. (2008) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2007.12.001 · Cited by 62 · see citing works
Self-citationTic disorders: some key issues for DSM-V
Walkup, J. T., Ferrão, Y. A., Leckman, J. F., Stein, D. J., & Singer, H. S. (2010) · Depression and Anxiety · doi:10.1002/da.20711 · Cited by 63 · see citing works
Long-Term Outcomes with Medications for Attention-Deficit Hyperactivity Disorder
Huang, Y., & Tsai, M.-H. (2011) · CNS Drugs · doi:10.2165/11589380-000000000-00000 · Cited by 54 · see citing works
Groenman, A. P., Schweren, L. J. S., Dietrich, A., & Hoekstra, P. J. (2017) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2017.1301928 · Cited by 46 · see citing works
Methylphenidate HCl: therapy for attention deficit hyperactivity disorder
Capp, P. K., Pearl, P. L., & Conlon, C. J. (2005) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.5.3.325 · Cited by 41 · see citing works
Katzman, M. A., & Sternat, T. (2014) · CNS Drugs · doi:10.1007/s40263-014-0175-1 · Cited by 40 · see citing works
Neuropsychological Effects of Stimulant Medication on Children’s Learning and Behavior
Brown, R. T., & Borden, K. A. (1989) · Critical issues in neuropsychology · doi:10.1007/978-1-4899-6807-4_24 · Cited by 39 · see citing works
An Overview of the Treatment of Tourette's Disorder and Tics
Párraga, H. C., Harris, K., Párraga, K. L., Balen, G. M., & Cruz, C. (2010) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2010.0027 · Cited by 37 · see citing works
Prasad, S., & Steer, C. (2008) · Pediatric Drugs · doi:10.2165/00148581-200810010-00005 · Cited by 35 · see citing works
Osmotic, controlled-release methylphenidate for the treatment of ADHD
Coghill, D., & Seth, S. (2006) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.7.15.2119 · Cited by 33 · see citing works
Banaschewski, T., Coghill, D., Santosh, P., Zuddas, A., Asherson, P. J., Buitelaar, J. K., Danckaerts, M., Döpfner, M., Faraone, S. V., Rothenberger, A., et al. (2008) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917.36.2.81 · Cited by 29 · see citing works
Self-citationBenner, S. J., & Heaton, P. C. (2007) · Current Drug Safety · doi:10.2174/157488607779315444 · Cited by 29 · see citing works
Döpfner, M., Görtz‐Dorten, A., Breuer, D., & Rothenberger, A. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-011-0202-4 · Cited by 26 · see citing works
Long-Term Safety of Stimulant Medications Used to Treat Children with ADHD
Lerner, M., & Wigal, T. L. (2008) · Pediatric Annals · doi:10.3928/00904481-20080101-11 · Cited by 25 · see citing works
Methylphenidate HCL for the treatment of ADHD in children and adolescents
Childress, A. C. (2016) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2016.1182986 · Cited by 23 · see citing works
Safety of stimulant treatment in attention deficit hyperactivity disorder: part II
Merkel, R. L. (2010) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2010.503238 · Cited by 21 · see citing works
Unlocking the potential of patients with ADHD: A model for clinical practice.
Monastra, V. J. (2008) · American Psychological Association eBooks · doi:10.1037/11665-000 · Cited by 21 · see citing works
Drug Class Review on Pharmacologic Treatments for ADHD
McDonagh, M. S., Peterson, K., & Thakurta, S. (2005) · Cited by 21 · see citing works
Long-Term Safety of Stimulant Medications Used to Treat Children with ADHD
Lerner, M., & Wigal, T. L. (2008) · Journal of Psychosocial Nursing and Mental Health Services · doi:10.3928/02793695-20080801-06 · Cited by 20 · see citing works
Primer consenso latinoamericano de trastorno por déficit de atención e hiperactividad
Barragán-Pérez, E., de la Peña, F. R., León, S. O., Ruíz-Garcìa, M., Hernández-Aguilar, J., Palacios‐Cruz, L., & Suárez-Reynaga, A. (2007) · Boletín Médico del Hospital Infantil de México · Cited by 18 · see citing works
Psychopharmacology in the schools
Abrams, L. M., Flood, J., & Phelps, L. (2006) · Psychology in the Schools · doi:10.1002/pits.20163 · Cited by 16 · see citing works
APA Working Group on Psychoactive Medications for Children and Adolescents (2006) · PsycEXTRA Dataset · doi:10.1037/e539722009-001 · Cited by 14 · see citing works
Social skills training for children with attention deficit hyperactivity disorder (ADHD)
Storebø, O. J., Skoog, M., Damm, D., Thomsen, P. H., Simonsen, E. H., & Gluud, C. N. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008223 · Cited by 13 · see citing works
Pediatric psychopharmacology update: psychostimulants and tics - past, present and future.
Pidsosny, I. C., & Virani, A. S. (2006) · PubMed Central · Cited by 11 · see citing works
Attention deficit/hyperactivity disorder: pharmacotherapy.
Elia, J. (2005) · PubMed Central · Cited by 9 · see citing works
Roessner, V., & Rothenberger, A. (2016) · Springer eBooks · doi:10.1007/978-3-662-48624-5_26 · Cited by 8 · see citing works
Drug Class Review: Pharmacologic Treatments for Attention Deficit Hyperactivity Disorder
McDonagh, M. S., & Peterson, K. (2011) · Cited by 7 · see citing works
First-onset tics in patients with attention-deficit-hyperactivity disorder: impact of stimulants
Roessner, V., Robatzek, M., Knapp, G., Banaschewski, T., & Rothenberger, A. (2007) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2006.tb01326.x · Cited by 7 · see citing works
Long-term Safety of Stimulant Medications Used to Treat Children with ADHD
Lerner, M., & Wigal, T. L. (2008) · Psychiatric Annals · doi:10.3928/00485713-20080101-10 · Cited by 6 · see citing works
Graham, J. S., Seth, S., & Coghill, D. (2007) · Medicine · doi:10.1016/j.mpmed.2007.01.002 · Cited by 5 · see citing works
Neuropsychological Effects of Stimulant Medication on Children’s Learning and Behavior
Brown, R. T., & Daly, B. P. (2008) · Springer eBooks · doi:10.1007/978-0-387-78867-8_22 · Cited by 4 · see citing works
Kooij, J. J. S. (2012) · Springer eBooks · doi:10.1007/978-1-4471-4138-9_2 · Cited by 3 · see citing works
Roessner, V., & Rothenberger, A. (2014) · Springer eBooks · doi:10.1007/978-3-7091-1501-5_27 · Cited by 3 · see citing works
Bloch, M. H., Gorman, D. A., & Abi‐Jaoude, E. (2012) · Evidence-Based Child Health A Cochrane Review Journal · doi:10.1002/ebch.1862 · Cited by 2 · see citing works
Pharmacotherapy of Attention-Deficit/Hyperactivity Disorder across the Life Span
Prince, J. B., Spencer, T. J., Wilens, T. E., & Biederman, J. (2008) · Elsevier eBooks · doi:10.1016/b978-0-323-04743-2.50051-2 · Cited by 2 · see citing works
Self-citationTardive dyskinesia in an 8-year old child
Chandradasa, M., Kotalawala, S. W., Siriwardena, G. R., Rathnayake, L. C., Seneviratne, S. N., & Perera, H. (2014) · Sri Lanka Journal of Psychiatry · doi:10.4038/sljpsyc.v5i2.7819 · Cited by 1 · see citing works
Managing attentional disorders
Palumbo, D. R., & Diehl, J. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545894.013 · Cited by 1 · see citing works
Self-citationTourette- und Tic-Störungen in Kindheit und Jugend
Döpfner, M., & Roessner, V. (2021) · Springer Reference Medizin · doi:10.1007/978-3-662-49289-5_122-1 · Cited by 1 · see citing works
Kahrizi, M. S., Mardasi, K. G., Merdasi, P. G., & Assareh, M. (2022) · Neuropsychiatrie de l Enfance et de l Adolescence · doi:10.1016/j.neurenf.2022.02.001 · Cited by 1 · see citing works
Kooij, J. J. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-82812-7_2 · Cited by 1 · see citing works
Hunter, S. J. (2001) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545894.015 · Cited by 1 · see citing works
Roessner, V., Mehler‐Wex, C., & Warnke, A. (2009) · Springer eBooks · doi:10.1007/978-3-211-79275-9_28
Sukhodolsky, D. G., Scahill, L. D., & Leckman, J. F. (2010) · Elsevier eBooks · doi:10.1016/b978-84-458-2021-6.00016-6
Verhaltens- und emotionale Störungen mit Beginn in der Kindheit und Jugend
Warnke, A., Wewetzer, C., Trott, G. E., Wirth, S., & Hemminger, U. (2008) · Springer eBooks · doi:10.1007/978-3-540-33129-2_73
Constantes vitales en niños expuestos a metilfenidato
Aparicio, J. C. R., Mireles, Y. S., Camino, E. R., Acosta, M. L. Y., Martínez, E. C., & Quintero, J. C. R. (2008)
Stimulant medication in children and adolescents
Stevens, J. R., & Wilens, T. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139035491.021
Graham, J. M., Seth, S., & Coghill, D. (2007)
Case 67. Managing Attention Deficit Hyperactivity Disorder
Heaton, P. C., & Swensgard, K. (2009) · The American Pharmacists Association eBooks · doi:10.21019/9781582121055.ch67
TRATAMIENTO FARMACOLÓGICO DEL TDAH Y LAS COMORBILIDADES
Prince, J. B., & Wilens, T. E. (2010) · Elsevier eBooks · doi:10.1016/b978-84-458-2021-6.00019-1
Current awareness in human psychopharmacology
(2005) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.633
Verhaltens- und emotionale Störungen mit Beginn in der Kindheit und Jugend
Warnke, A., Hemminger, U., Klampfl, K., Melfsen, S., Renner, T. J., Romanos, M., & Wewetzer, C. (2011) · Springer eBooks · doi:10.1007/978-3-642-03637-8_72
Verhaltens- und emotionale Störungen mit Beginn in der Kindheit und Jugend
Romanos, M., Banaschewski, T., Egberts, K. M., von Gontard, A., Renner, T., Roessner, V., Melfsen, S., Walitza, S., Wewetzer, C., & Warnke, A. (2017) · Springer eBooks · doi:10.1007/978-3-662-49295-6_84
Verhaltens- und emotionale Störungen mit Beginn in der Kindheit und Jugend
Romanos, M., Banaschewski, T., Egberts, K. M., von Gontard, A., Renner, T., Roessner, V., Melfsen, S., Walitza, S., Wewetzer, C., & Warnke, A. (2016) · Springer eBooks · doi:10.1007/978-3-642-45028-0_84-1
Roessner, V., & Rothenberger, A. (2023) · Springer eBooks · doi:10.1007/978-3-662-65267-1_26
Tourette- und Tic-Störungen in Kindheit und Jugend
Döpfner, M., & Roessner, V. (2024) · Springer Reference Medizin · doi:10.1007/978-3-662-66744-6_122
Long-term Safety of Stimulant Medications: Used to Treat Children with ADHD
Lerner, M., & Wigal, T. L. (2008) · Pediatric Annals · doi:10.3928/0090-4481-20080101-05
- Authors
- Palumbo, D., Spencer, T., Lynch, J., Co-Chien, H., & Faraone, S. V.
- Affiliations
- University of Rochester Medicine (US)
- Harvard University (US)
- McNeil Consumer & Specialty Pharmaceuticals, Fort Washington, Pennsylvania.
- Alza Corporation, Mountain View, California. This study was funded by McNeil Consumer & Specialty Pharmaceuticals, Fort Washington, Pennsylvania.
- Venue
- Journal of Child and Adolescent Psychopharmacology
- Publisher
- SAGE Publications
- Published
- 2004-06
- Volume
- 14
- Issue
- 2
- Pages
- 185-194
- ISSN
- 1044-5463 (ISSN-L)
- 1557-8992
- OpenAlex
- W2031896587
- Semantic Scholar
- 7e898b0891102d68f2b2f02c867c6b6f5f309f1a
- Cited by
- 67
- References
- 35
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2019: 1 · 2017: 2 · 2016: 4 · 2014: 4 · 2012: 2
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child and Adolescent Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Keywords
- attention deficit hyperactivity disorder, tics, methylphenidate, OROS methylphenidate, Concerta, stimulant pharmacotherapy, Tourette syndrome, children, adverse events, dose-response relationship
- MeSH terms
- Adolescent, Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Child, Delayed-Action Preparations, Double-Blind Method, Female, Humans, Longitudinal Studies, Male, Methylphenidate, Verbal Behavior, Cross-Over Studies, Tics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
