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Cited by 150Attention Deficit Hyperactivity DisorderObsessive-Compulsive Spectrum DisordersSchizophrenia research and treatment

Motor/vocal tics and compulsive behaviors on stimulant drugs: Is there a common vulnerability?

Borcherding, Breck G., Keysor, Cynthia S., Rapoport, Judith L., Elia, Josephine, Amass, Janet·1990·Psychiatry Research
DOI 10.1016/0165-1781(90)90151-t
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Abstract

The occurrence of abnormal movements or perserverative/compulsive behaviors was noted in 34 (76%) of a group of 45 hyperactive boys during a double-blind crossover treatment trial of methylphenidate and dextroamphetamine given in a wide range of doses. These adverse effects were often subtle and transient, and they usually occurred only on one drug. There was only one case where treatment was discontinued due to the severity of the tic the subject developed during his initial treatment phase. Dextroamphetamine tended to produce more compulsive behaviors, which were also more likely to resemble clinical obsessive-compulsive disorder (OCD), than did methylphenidate. Abnormal movements and compulsive behaviors tended to co-occur on methylphenidate only; no general "Tourette-OCD diathesis" was found for this population.

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  • Dopamine agonists acting on the basal ganglia can generate OCD-like behaviors in animals and humans.

    “dopamine agonists acting on the basal ganglia can generate OCD‐like behaviors in both animals (Szechtman et al., 1998), and humans (Borcherding et al., 1990)”

    From Obsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction (2023) · cites this paper as Borcherding et al., 1990

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Authors
Borcherding, B. G., Keysor, C. S., Rapoport, J. L., Elia, J., & Amass, J.
Affiliations
  • National Institute of Mental Health (US)
  • National Institutes of Health (US)
Corresponding author
Rapoport, Judith L.
ORCID
Elia, Josephine
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
1990-07
Volume
33
Issue
1
Pages
83-94
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/0165-1781(90)90151-t
OpenAlex
W1978755811
Cited by
150
References
27
Citations by year
2025: 1 · 2024: 4 · 2023: 5 · 2022: 6 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 1 · 2016: 8 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
4.19
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
motor tics, vocal tics, compulsive behavior, stimulant side effects, methylphenidate, d-amphetamine, hyperactive children, Tourette syndrome, obsessive-compulsive disorder, perseveration
MeSH terms
Attention Deficit Disorder with Hyperactivity, Child, Compulsive Behavior, Dextroamphetamine, Double-Blind Method, Tourette Syndrome, Humans, Male, Methylphenidate, Motor Activity, Neurologic Examination, Obsessive-Compulsive Disorder, Risk Factors, Stereotyped Behavior, Tic Disorders

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