The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Caloric Restriction in Humans: Impact on Physiological, Psychological, and Behavioral Outcomes
Open accessAbstract
The current societal environment is marked by overabundant accessibility of food coupled with a strong trend of reduced physical activity, both leading to the development of a constellation of disorders, including central obesity, insulin resistance, dyslipidemia, and hypertension (metabolic syndrome). Prolonged calorie restriction (CR) has been shown to extend both the median and maximal lifespan in a variety of lower species such as yeast, worms, fish, rats, and mice. Mechanisms of this CR-mediated lifespan extension are not fully elucidated, but possibly involve significant alterations in energy metabolism, oxidative damage, insulin sensitivity, inflammation, and functional changes in both the neuroendocrine and sympathetic nervous systems. Here we review some of the major physiological, psychological, and behavioral changes after 6 months of CR in overweight otherwise healthy volunteers. Special emphasis is given to the first completed clinical studies that have investigated the effects of controlled, high-quality energy-restricted diets on both biomarkers of longevity and on the development of chronic diseases related to age in humans. With the incremental expansion of research endeavors in the area of energy or caloric restriction, data on the effects of CR in animal models and human subjects are becoming more accessible.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The MOS 36-ltem Short-Form Health Survey (SF-36): I. Conceptual Framework and Item Selection
Ware, J. E., & Sherbourne, C. D. (1992) · Medical Care · doi:10.1097/00005650-199206000-00002 · Cited by 30,033
Beck, A. T., Steer, R. A., & Brown, G. (2011) · PsycTESTS Dataset · doi:10.1037/t00742-000 · Cited by 7,535
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Rosamond, W., Flegal, K., Friday, G., Furie, K., Go, A., Greenlund, K., Haase, N., Ho, M., Howard, V., Kissela, B., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.179918 · Cited by 3,277
Short-term retention of individual verbal items.
Peterson, L., & Peterson, M. J. (1959) · Journal of Experimental Psychology · doi:10.1037/h0049234 · Cited by 2,939
A Potential Decline in Life Expectancy in the United States in the 21st Century
Olshansky, S. J., Passaro, D. J., Hershow, R. C., Layden, J., Carnes, B. A., Brody, J., Hayflick, L., Butler, R. N., Allison, D. B., & Ludwig, D. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmsr043743 · Cited by 2,612
The Biology of Human Starvation: Volume I
KEYS, A., BROŽEK, J., HENSCHEL, A., MICKELSEN, O., & TAYLOR, H. L. (1950) · doi:10.5749/j.ctv9b2tqv · Cited by 2,039
Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., et al. (2005) · Cardiology in Review · doi:10.1097/01.crd.0000380842.14048.7e · Cited by 1,600
Dieting and binging: A causal analysis.
Polivy, J., & Herman, C. P. (1985) · American Psychologist · doi:10.1037/0003-066x.40.2.193 · Cited by 1,539 · cited 1×
“Additionally, CR or the intent to restrict intake has been associated with the onset of eating disorders, including anorexia (105) and bulimia nervosa (65), and binge eating disorder (106).”
Robertson, R. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400019200 · Cited by 1,078
DeSouza, C. A., Shapiro, L. F., Clevenger, C. M., Dinenno, F. A., Monahan, K. D., Tanaka, H., & Seals, D. R. (2000) · Circulation · doi:10.1161/01.cir.102.12.1351 · Cited by 896 · cited 1×
“At least a portion of these age-related changes appear to be secondary to increases in adiposity and = or reductions in physical activity (19, 56) and, therefore, may be amenable to improvements through prolonged caloric restriction.”
Calorie Restriction Increases Muscle Mitochondrial Biogenesis in Healthy Humans
Civitarese, A. E., Carling, S., Heilbronn, L. K., Hulver, M. H., Ukropcova, B., Deutsch, W. A., Smith, S. R., & Ravussin, E. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040076 · Cited by 790
Interindividual variation in posture allocation: possible role in human obesity
Levine, J. A., Lanningham-Foster, L. M., McCrady, S. K., Krizan, A. C., Olson, L. R., Kane, P. H., Jensen, M. D., & Clark, M. M. (2005) · Science · doi:10.1126/science.1106561 · Cited by 705
Calorie restriction and aging: review of the literature and implications for studies in humans
Heilbronn, L. K., & Ravussin, E. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.361 · Cited by 701
Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men
Orentreich, N., Brind, J. L., Vogelman, J. H., Andres, R., & Baldwin, H. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.4.1400863 · Cited by 417
Redman, L. M., Heilbronn, L. K., Martin, C. K., de Jonge, L., Williamson, D. A., Delany, J. P., Ravussin, E., & for the Pennington CALERIE team (2009) · PLoS ONE · doi:10.1371/journal.pone.0004377 · Cited by 355
Das, S. K., Gilhooly, C. H., Golden, J. K., Pittas, A. G., Fuss, P. J., Cheatham, R. A., Tyler, S., Tsay, M., McCrory, M. A., Lichtenstein, A. H., et al. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1023 · Cited by 314
Effect of Calorie Restriction with or without Exercise on Body Composition and Fat Distribution
Redman, L. M., Heilbronn, L. K., Martin, C. K., Alfonso, A., Smith, S. R., Ravussin, E., & for the Pennington CALERIE Team (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2184 · Cited by 293
Self-citationEffect of calorie restriction on resting metabolic rate and spontaneous physical activity.
Martin, C. K., Heilbronn, L. K., de Jonge, L., DeLany, J. P., Volaufova, J., Anton, S. D., Redman, L. M., Smith, S. R., & Ravussin, E. (2007) · Obesity · doi:10.1038/oby.2007.354 · Cited by 237
Self-citationCaloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals
Lefevre, M., Redman, L. M., Heilbronn, L. K., Smith, J. V., Martin, C. K., Rood, J. C., Greenway, F. L., Williamson, D. A., Smith, S. R., & Ravussin, E. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.036 · Cited by 217 · cited 1×
“Six months’ CR significantly reduced triacylglycerol and factor VIIc by 18% and 11%, respectively (44).”
Self-citationEnergy Expenditure of Rhesus Monkeys Subjected to 11 Years of Dietary Restriction
Blanc, S., Schoeller, D., Kemnitz, J., Weindruch, R., Colman, R., Newton, W., Wink, K., Baum, S., & Ramsey, J. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020405 · Cited by 128
Impact of Intra-Abdominal Fat and Age on Insulin Sensitivity and β-Cell Function
Utzschneider, K. M., Carr, D. B., Hull, R. L., Kodama, K., Shofer, J. B., Retzlaff, B. M., Knopp, R. H., & Kahn, S. E. (2004) · Diabetes · doi:10.2337/diabetes.53.11.2867 · Cited by 109
Nieman, D. C., Brock, D. W., Butterworth, D., Utter, A. C., & Nieman, C. C. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719233 · Cited by 96
Cited by
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145
Energy intake and exercise as determinants of brain health and vulnerability to injury and disease
Mattson, M. P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.012 · Cited by 434
Moon, S., Kang, J., Kim, S. H., Chung, H. S., Kim, Y. J., Yu, J. M., Cho, S. T., Oh, C.-M., & Kim, T. (2020) · Nutrients · doi:10.3390/nu12051267 · Cited by 231
Cho, Y., Hong, N., Kim, K.-W., Cho, S., Lee, M., Lee, Y.-H., Lee, Y.-H., Kang, E., Cha, B.-S., & Lee, B.-W. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101645 · Cited by 202
Cardiometabolic Benefits of Intermittent Fasting
Varady, K. A., Cienfuegos, S., Ezpeleta, M., & Gabel, K. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-052020-041327 · Cited by 186
Metadata
- Authors
- Redman, L. M., & Ravussin, E.
- Venue
- Antioxidants & Redox Signaling
- Publisher
- SAGE Publications
- Published
- 2011-01-15
- Volume
- 14
- Issue
- 2
- Pages
- 275-287
- ISSN
- 1523-0864 (ISSN-L)
- 1557-7716
- OpenAlex
- W2001738812
- Cited by
- 326
- References
- 23
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
