Cited by 394Redox biology and oxidative stressMitochondrial Function and PathologyCancer and biochemical research

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Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H 2 O 2 Signaling

Rigoulet, Michel, Yoboue, Edgar D., Devin, Anne·2011·Antioxidants & Redox Signaling

DOI 10.1089/ars.2010.3363

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Abstract

Mitochondria are the main source of reactive oxygen species in the cell. These reactive oxygen species have long been known as being involved in oxidative stress. This is a review of the mechanisms involved in reactive oxygen species generation by the respiratory chain and some of the dehydrogenases and the control by thermodynamic and kinetic constraints. Mitochondrial ROS produced at the level of the bc1 complex as well at the level of complex I are discussed. It was recognized more than a decade ago that they can also function as signaling molecules. This signaling role will be developed both in terms of mechanism and in terms of mitochondrial ROS signaling. The notion that hydrogen peroxide acts not only as a damaging oxidant but also as a signaling molecule was proposed more than a decade ago. Hydrogen peroxide signaling can be either direct (oxidation of its target) or indirect (involving peroxiredoxins, for example). The consequences of ROS signaling on crucial biologic processes such as cell proliferation and differentiation are discussed. Antioxid. Redox Signal. 14, 459—468.

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Rigoulet M, , Mourier A, , Galinier A, , Casteilla L, , Devin A. Electron competition process in respiratory chain: regulatory mechanisms and physiological functions. Biochim Biophys Acta, 1797; 671–677. 2010.

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Relation between cell death progression, reactive oxygen species production and mitochondrial membrane potential in fermenting Saccharomyces cerevisiae cells under heat-shock conditions
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“None declared.”
Background
Induction of iPS Cells and of Cancer Stem Cells: The Stem Cell or Reprogramming Hypothesis of Cancer?
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“…namely, the generation of a number of reactive oxygen species (ROS’s)/reactive nitrogen species (RNS) (Pervaiz et al., 2009) and to utilize them to act as adaptive signal transducers and gene regulators (Upham and Trosko, 2009; Brigelius-Flohe and Flohe, 2011; Rigoulet et al., 2011).”
Background
Low steady-state oxidative stress inhibits adipogenesis by altering mitochondrial dynamics and decreasing cellular respiration
Fernando, R., Wardelmann, K., Deubel, S., Kehm, R., Jung, T., Mariotti, M., Vasilaki, A., Gladyshev, V. N., Kleinridders, A., Grune, T., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101507 · Cited by 35
Food-derived cyanidin-3- O -glucoside alleviates oxidative stress: evidence from the islet cell line and diabetic db/db mice
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Hypoxia-inducible factor 1α mediates the down-regulation of superoxide dismutase 2 in von Hippel–Lindau deficient renal clear cell carcinoma
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Degradation of cochlear Connexin26 accelerate the development of age‐related hearing loss
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“Previous studies have demonstrated that ROS accumulation causes oxidation damaged to major macromolecules, such as lipids, proteins, and DNA, leading to cell damage (Rigoulet et al., 2011).”
Background
Interconnections of Reactive Oxygen Species Homeostasis and Circadian Rhythm in Neurospora crassa
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Brain superoxide anion formation in immature rats during seizures: Protection by selected compounds
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“It is generally believed that the primary source of superoxide production is mitochondrial respiratory chain, both at the complexes I and III, and also non-electron transport chain sources, like certain dehydrogenases (Forkink et al., 2010; Murphy, 2009; Rigoulet et al., 2011).”
Hypoxia inducible factor‐1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells
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HIF-Independent Regulation of Thioredoxin Reductase 1 Contributes to the High Levels of Reactive Oxygen Species Induced by Hypoxia
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Protective effect of diphlorethohydroxycarmalol against oxidative stress-induced DNA damage and apoptosis in retinal pigment epithelial cells
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“At the same time, mitochondrial dysfunction due to excessive ROS production associated with the destruction of MMP causes an abnormality in the electron transport pathway of the mitochondrial respiratory chain [32-34].”
BackgroundInfluential
Hepatocyte and Sertoli Cell Aquaporins, Recent Advances and Research Trends
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Hepatitis C, systemic inflammation and oxidative stress: correlations with metabolic diseases
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Honokiol ameliorates oxidative stress-induced DNA damage and apoptosis of c2c12 myoblasts by ROS generation and mitochondrial pathway
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“Moreover, the accumulation of ROS could reduce mitochondrial membrane potential (MMP), resulting in compromise of the ATP production (Rigoulet et al. 2011; Sosa et al. 2013).”
BackgroundInfluential
Nrf2/HO-1 mediates neuroprotective effects of pramipexole by attenuating oxidative damage and mitochondrial perturbation after traumatic brain injury
Salman, M., Tabassum, H., & Parvez, S. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.045021 · Cited by 31
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Parthanatos participates in glutamate‐mediated HT22 cell injury and hippocampal neuronal death in kainic acid‐induced status epilepticus rats
Wang, X. L., Zhang, W., Ge, P., Yu, M., & Meng, H. (2022) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13934 · Cited by 31
Combination of Intravenous Ascorbic Acid Administration and Hypothermia After Resuscitation Improves Myocardial Function and Survival in a Ventricular Fibrillation Cardiac Arrest Model in the Rat
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Mitochondrial Dysfunctions and Altered Metals Homeostasis: New Weapons to Counteract HCV-Related Oxidative Stress
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Background
Heme modulates intestinal epithelial cell activation: involvement of NADPHox-derived ROS signaling
Barcellos‐de‐Souza, P., Moraes, J. A., de‐Freitas‐Junior, J. C. M., Morgado‐Díaz, J. A., Barja‐Fidalgo, C., & Arruda, M. A. (2012) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00078.2012 · Cited by 31
“The source of ROS is of extreme importance to the delicate regulation of signaling pathways and to promote precise cellular responses (16, 26, 33).”
Background
Effects of mesoporous SiO 2 , Fe 3 O 4 , and TiO 2 nanoparticles on the biological functions of endothelial cells in vitro
Hou, Y., Lai, M., Chen, X., Li, J., Hu, Y., Luo, Z. Y., Ding, X., & Cai, K. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34839 · Cited by 30
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Protective Effect of Fucoidan Extract from Ecklonia cava on Hydrogen Peroxide-Induced Neurotoxicity
Park, S. K., Kang, J. Y., Kim, J. M., Park, S. H., Kwon, B. S., Kim, G., & Heo, H. J. (2018) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1710.10043 · Cited by 30
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Protective effects of edible insect protein extracts from Protaetia brevitarsis against H2O2-induced oxidative stress in mouse C2C12 myoblast cells
Lee, J. H., Kim, T., Kang, M., Kim, B., & Choi, Y. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102396 · Cited by 29
Alterations of mitochondrial electron transport chain and oxidative stress induced by alkaloid-like α-aminonitriles on Aedes aegypti larvae
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Intermittent Hypobaric Hypoxic Preconditioning Provides Neuroprotection by Increasing Antioxidant Activity, Erythropoietin Expression and Preventing Apoptosis and Astrogliosis in the Brain of Adult Rats Exposed to Acute Severe Hypoxia
Coimbra-Costa, D., Garzón, F., Alva, N., Pinto, T. C. C., Aguado, F., Torrella, J. R., Carbonell, T., & Rama, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105272 · Cited by 28
Mitochondrial adaptations evoked with exercise are associated with a reduction in age-induced testicular atrophy in Fischer-344 rats
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“Paradoxically, mitochondria are not only responsible for ATP production and energy for ‘‘life’’ of cells, but they also contain pro-apoptotic factors that upon release can lead to cellular ‘‘death’’ through apoptosis (Rigoulet et al. 2011).”
The difference in myocardial injuries and mitochondrial damages between asphyxial and ventricular fibrillation cardiac arrests
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“In addition to ROS generated by mitochondrial respiration during ischemia-reperfusion injury [24], cytosol electrolysis during ES is considered to be another ROS source because electrolysis of a physiologic buffer produces a milieu containing several free radicals [25].”
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The redox protein p66shc mediates cochlear vascular dysfunction and transient noise-induced hearing loss
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Inhibition of Cardiac Hypertrophy Effects in D‐Galactose‐Induced Senescent Hearts by Alpinate Oxyphyllae Fructus Treatment
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“Mitochondria are generally considered the major source of reactive oxygen species (ROS) production [18, 19]; other potential sources of ROS include NADPH oxidase, xanthine oxidase, and uncoupled nitric oxide synthase (NOS) [20–22].”
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Tomato SlIDA has a critical role in tomato fertilization by modifying reactive oxygen species homeostasis
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“Mitochondria are considered the main source of ROS, and ROS production is generally associated with impairments of the respiratory chain and mitochondrial function (12,13).”
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Neuroprotective effects of Myricetin on Epoxiconazole-induced toxicity in F98 cells
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Activation of the Nrf2/HO-1 signaling pathway contributes to the protective effects of coptisine against oxidative stress-induced DNA damage and apoptosis in HaCaT keratinocytes
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“Subsequently, apoptogenic proteins, including cytochrome c, are released from the mitochondrial intermembrane space into the cytoplasm, and play a central role in an induction signal for apoptosis (Finkel and Holbrook 2000; Rigoulet et al. 2011).”
Background
cAMP-induced Mitochondrial Compartment Biogenesis
Yoboue, E. D., Augier, E., Galinier, A., Blancard, C., Pinson, B., Casteilla, L., Rigoulet, M., & Devin, A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.302786 · Cited by 26
Self-citation
Nutrient values and bioactivities of the extracts from three fern species in China: a comparative assessment
Qi, G., Yang, L., Xiao, C., Shi, J., Mi, Y., & Liu, X. (2015) · Food & Function · doi:10.1039/c5fo00510h · Cited by 25

Authors: Rigoulet, M., Yoboue, E. D., & Devin, A.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Yoboue, Edgar D.
Devin, Anne
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2011-02
Volume: 14
Issue: 3
Pages: 459-468
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2010.3363
OpenAlex: W1985730402
Semantic Scholar: 72f038ebb891d7e56acea1d3220662223a95864f
Cited by: 394
References: 112
Citations by year: 2026: 6 · 2025: 8 · 2024: 13 · 2023: 24 · 2022: 25 · 2021: 41 · 2020: 23 · 2019: 24 · 2018: 26 · 2017: 25 · 2016: 19 · 2015: 31 · 2014: 25 · 2013: 37 · 2012: 44
FWCI: 2.91
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
Funders: Agence Nationale de la Recherche
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: mitochondrial reactive oxygen species, hydrogen peroxide signaling, oxidative stress, electron transport chain, bc1 complex, complex I, dehydrogenase, peroxiredoxin, cell proliferation, cell differentiation
MeSH terms: Animals, Electron Transport, Hydrogen Peroxide, Mitochondria, Models, Molecular, Oxygen, Protein Conformation, Signal Transduction, Oxidants, Reactive Oxygen Species, Oxidative Stress, Cell Proliferation

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Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H 2 O 2 Signaling

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