Cited by 394Redox biology and oxidative stressMitochondrial Function and PathologyCancer and biochemical research

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Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H 2 O 2 Signaling

Rigoulet, Michel, Yoboue, Edgar D., Devin, Anne·2011·Antioxidants & Redox Signaling

DOI 10.1089/ars.2010.3363

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Abstract

Mitochondria are the main source of reactive oxygen species in the cell. These reactive oxygen species have long been known as being involved in oxidative stress. This is a review of the mechanisms involved in reactive oxygen species generation by the respiratory chain and some of the dehydrogenases and the control by thermodynamic and kinetic constraints. Mitochondrial ROS produced at the level of the bc1 complex as well at the level of complex I are discussed. It was recognized more than a decade ago that they can also function as signaling molecules. This signaling role will be developed both in terms of mechanism and in terms of mitochondrial ROS signaling. The notion that hydrogen peroxide acts not only as a damaging oxidant but also as a signaling molecule was proposed more than a decade ago. Hydrogen peroxide signaling can be either direct (oxidation of its target) or indirect (involving peroxiredoxins, for example). The consequences of ROS signaling on crucial biologic processes such as cell proliferation and differentiation are discussed. Antioxid. Redox Signal. 14, 459—468.

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Rigoulet M, , Mourier A, , Galinier A, , Casteilla L, , Devin A. Electron competition process in respiratory chain: regulatory mechanisms and physiological functions. Biochim Biophys Acta, 1797; 671–677. 2010.

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Authors: Rigoulet, M., Yoboue, E. D., & Devin, A.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Yoboue, Edgar D.
Devin, Anne
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2011-02
Volume: 14
Issue: 3
Pages: 459-468
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2010.3363
OpenAlex: W1985730402
Semantic Scholar: 72f038ebb891d7e56acea1d3220662223a95864f
Cited by: 394
References: 112
Citations by year: 2026: 6 · 2025: 8 · 2024: 13 · 2023: 24 · 2022: 25 · 2021: 41 · 2020: 23 · 2019: 24 · 2018: 26 · 2017: 25 · 2016: 19 · 2015: 31 · 2014: 25 · 2013: 37 · 2012: 44
FWCI: 2.91
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
Funders: Agence Nationale de la Recherche
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: mitochondrial reactive oxygen species, hydrogen peroxide signaling, oxidative stress, electron transport chain, bc1 complex, complex I, dehydrogenase, peroxiredoxin, cell proliferation, cell differentiation
MeSH terms: Animals, Electron Transport, Hydrogen Peroxide, Mitochondria, Models, Molecular, Oxygen, Protein Conformation, Signal Transduction, Oxidants, Reactive Oxygen Species, Oxidative Stress, Cell Proliferation

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Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H 2 O 2 Signaling

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