Cited by 394Redox biology and oxidative stressMitochondrial Function and PathologyCancer and biochemical research

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Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H 2 O 2 Signaling

Rigoulet, Michel, Yoboue, Edgar D., Devin, Anne·2011·Antioxidants & Redox Signaling

DOI 10.1089/ars.2010.3363

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Abstract

Mitochondria are the main source of reactive oxygen species in the cell. These reactive oxygen species have long been known as being involved in oxidative stress. This is a review of the mechanisms involved in reactive oxygen species generation by the respiratory chain and some of the dehydrogenases and the control by thermodynamic and kinetic constraints. Mitochondrial ROS produced at the level of the bc1 complex as well at the level of complex I are discussed. It was recognized more than a decade ago that they can also function as signaling molecules. This signaling role will be developed both in terms of mechanism and in terms of mitochondrial ROS signaling. The notion that hydrogen peroxide acts not only as a damaging oxidant but also as a signaling molecule was proposed more than a decade ago. Hydrogen peroxide signaling can be either direct (oxidation of its target) or indirect (involving peroxiredoxins, for example). The consequences of ROS signaling on crucial biologic processes such as cell proliferation and differentiation are discussed. Antioxid. Redox Signal. 14, 459—468.

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Wang, X. (2012)
Additional file 3 of Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284065
Additional file 2 of Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284062
Additional file 5 of Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284071
Additional file 4 of Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284068
Additional file 6 of Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284074
Additional file 1 of Protective effects of exosomes derived from lyophilized porcine liver against acetaminophen damage on HepG2 cells
Tassinari, R., Cavallini, C., Olivi, E., Taglioli, V., Zannini, C., Ferroni, O., & Ventura, C. (2021) · Figshare · doi:10.6084/m9.figshare.17284059
Myricetin mitigates trifloxystrobin neurotoxicity by modulating the integrated stress response pathway and antioxidant defense in sH-SY5Y cells
Chaabani, H., Ayed‐Boussema, I., Hamdi, H., Rjiba, K., Arnoult, D., & Abid, S. B. (2026) · Drug and Chemical Toxicology · doi:10.1080/01480545.2026.2620407
Contrôle du métabolisme oxydatif des cellules leucémiques par le microenvironnement médullaire
Vignon, C. (2011) · theses.fr (ABES) · doi:10.70675/46c47371z1ee4z4069zb265z15a0300cc74f
Fonctions oncogéniques de STAT5 : rôle dans la régulation du métabolisme oxydatif
Bourgeais, J. (2015) · theses.fr (ABES) · doi:10.70675/642a7bdcz3eb5z47fcza4fez4dd048c937e2
Comment deux lignées cellulaires stromales mésenchymateuses humaines récapitulent in vitro le microenvironnement hématopoïétique ? : Intérêt en ingénierie
Ishac, N. (2015) · theses.fr (ABES) · doi:10.70675/fcbe20caz6b0fz4133zb162z9197bf1da23f
Multiple Functions of Cables1 in Hematopoiesis
He, L. (2018) · theses.fr (ABES) · doi:10.70675/15f425d0zd56fz476bz8344z0f5ca38773ca
Étude de la régulation de la biogénèse mitochondriale chez la levure Saccharomyces cerevisiae
Bouchez, C. L. (2020) · theses.fr (ABES) · doi:10.70675/55097e67z982dz4f15z8b14zb35f36cc3a49
Perioperative Management Considerations for Patients with Suspected MT-ND4 m.11232T>C-Associated Mitochondrial Vulnerability: A Physiology-Guided Narrative Review and Conceptual Framework
Persaud-Sharma, D., & Spiess, B. D. (2026) · Anesthesia Research · doi:10.3390/anesthres3030024
The impact of medium chain triglyceride ketogenic diet on liver mitochondria and cytochrome P450 2E1
Ryan, A. S., Roberts, R. M., Stayer, K. M., Tomasevich, A. A., Misare, K. R., Hollis, F., McQuail, J. A., & Hartman, J. H. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110978
Mitochondrial mechanisms of oxygen toxicity
Alva, R., Wiebe, J. E., Taber, N., Gates, K., & Stuart, J. A. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45078-5.00043-9
Ejercicio y envejecimiento: cambios transcripcionales y epigenéticos en un modelo murino de envejecimiento acelerado
López, Á., & Jesús, M. (2015) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)

Authors: Rigoulet, M., Yoboue, E. D., & Devin, A.
Affiliations: Centre National de la Recherche Scientifique (FR)
ORCID: Yoboue, Edgar D.
Devin, Anne
Venue: Antioxidants & Redox Signaling
Publisher: SAGE Publications
Published: 2011-02
Volume: 14
Issue: 3
Pages: 459-468
ISSN: 1523-0864 (ISSN-L)
1557-7716
DOI: 10.1089/ars.2010.3363
OpenAlex: W1985730402
Semantic Scholar: 72f038ebb891d7e56acea1d3220662223a95864f
Cited by: 394
References: 112
Citations by year: 2026: 6 · 2025: 8 · 2024: 13 · 2023: 24 · 2022: 25 · 2021: 41 · 2020: 23 · 2019: 24 · 2018: 26 · 2017: 25 · 2016: 19 · 2015: 31 · 2014: 25 · 2013: 37 · 2012: 44
FWCI: 2.91
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Antioxidants and Redox Signaling (publishedVersion)
PubMed (publishedVersion)
Funders: Agence Nationale de la Recherche
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: mitochondrial reactive oxygen species, hydrogen peroxide signaling, oxidative stress, electron transport chain, bc1 complex, complex I, dehydrogenase, peroxiredoxin, cell proliferation, cell differentiation
MeSH terms: Animals, Electron Transport, Hydrogen Peroxide, Mitochondria, Models, Molecular, Oxygen, Protein Conformation, Signal Transduction, Oxidants, Reactive Oxygen Species, Oxidative Stress, Cell Proliferation

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Mitochondrial ROS Generation and Its Regulation: Mechanisms Involved in H 2 O 2 Signaling

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