The Role of Energy Metabolism Dysfunction and Oxidative Stress in Schizophrenia Revealed by Proteomics

KEGG: Kyoto Encyclopedia of Genes and Genomes

Kanehisa, M. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.1.27 · Cited by 37,077 · see citing works

KEGG: Kyoto Encyclopedia of Genes and Genomes

Ogata, H., Goto, S., Sato, K., Fujibuchi, W., Bono, H., & Kanehisa, M. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.1.29 · Cited by 31,232 · see citing works

GLUTATHIONE TRANSFERASES

Hayes, J. D., Flanagan, J. U., & Jowsey, I. R. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.095857 · Cited by 3,565 · see citing works

Recent advances in the phencyclidine model of schizophrenia

(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.10.1301 · Cited by 2,904 · see citing works

The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway

Howes, O. D., & Kapur, S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp006 · Cited by 2,693 · see citing works

Direct analysis of protein complexes using mass spectrometry

Link, A. J., Eng, J. K., Schieltz, D. M., Carmack, E., Mize, G. J., Morris, D. R., Garvik, B. M., & Yates, J. R. (1999) · Nature Biotechnology · doi:10.1038/10890 · Cited by 2,218 · see citing works

The neuropathology of schizophrenia

Harrison, P. J. (1999) · Brain · doi:10.1093/brain/122.4.593 · Cited by 1,677 · see citing works

Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology

Gygi, S. P., Corthals, G. L., Zhang, Y., Rochon, Y. P., & Aebersold, R. H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.160270797 · Cited by 1,311 · see citing works

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

Prabakaran, S., SWATTON, J. E., Ryan, M. M., Huffaker, S. J., Huang, J.-J., Griffin, J. L., Wayland, M. T., Freeman, T., Dudbridge, F., Lilley, K. S., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001511 · Cited by 973 · see citing works

Progress with gene‐product mapping of the Mollicutes: Mycoplasma genitalium

Wasinger, V. C., Cordwell, S. J., Poljak, A., Yan, J. X., Gooley, A. A., Wilkins, M. R., Duncan, M. W., Harris, R. J., Williams, K. L., & Humphery‐Smith, I. (1995) · Electrophoresis · doi:10.1002/elps.11501601185 · Cited by 962 · see citing works

Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis

Coyle, J. T. (2006) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-006-9062-8 · Cited by 917 · see citing works

Impaired Fasting Glucose Tolerance in First-Episode, Drug-Naive Patients With Schizophrenia

Ryan, M. C. M., Collins, P. B., & Thakore, J. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.2.284 · Cited by 828 · see citing works

Limbic System Abnormalities Identified in Schizophrenia Using Positron Emission Tomography With Fluorodeoxyglucose and Neocortical Alterations With Deficit Syndrome

Tamminga, C. A. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820070016003 · Cited by 546 · see citing works

Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder

Johnston-Wilson, N. L., Sims, C. D., Hofmann, J.-P., Anderson, L., Shore, A. D., Torrey, E. F., Yolken, R. H., & the Stanley Neuropathology Consortium (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000696 · Cited by 531 · see citing works

Structural Abnormalities in the Frontal System in Schizophrenia

Andreasen, N. C. (1986) · Archives of General Psychiatry · doi:10.1001/archpsyc.1986.01800020042006 · Cited by 488 · see citing works

The membrane phospholipid hypothesis as a biochemical basis for the neurodevelopmental concept of schizophrenia

Horrobin, D. F. (1998) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00151-5 · Cited by 456 · see citing works

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

Prabakaran, S., SWATTON, J. E., Ryan, M. M., Huffaker, S. J., Huang, J. T.-J., Griffin, J. L., Wayland, M. T., Freeman, T., Dudbridge, F., Lilley, K. S., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001532 · Cited by 375 · see citing works

Impaired glucose tolerance in first‐episode drug‐naïve patients with schizophrenia

Spelman, L., Walsh, P., Sharifi, N., Collins, P. B., & Thakore, J. H. (2007) · Diabetic Medicine · doi:10.1111/j.1464-5491.2007.02092.x · Cited by 318 · see citing works

Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography

Wolkin, A., Jaeger, J., Brodie, J. D., Wolf, A. P., Fowler, J. S., Rotrosen, J., Gomez-Mont, F., & Cancro, R. (1985) · American Journal of Psychiatry · doi:10.1176/ajp.142.5.564 · Cited by 293 · see citing works

Membrane phospholipid abnormalities in postmortem brains from schizophrenic patients

Yao, J. K., Leonard, S. S., & Reddy, R. D. (2000) · Schizophrenia Research · doi:10.1016/s0920-9964(99)00095-x · Cited by 290 · see citing works

Proteomic analysis of the anterior cingulate cortex in the major psychiatric disorders: Evidence for disease‐associated changes

Beasley, C. L., Pennington, K., Behan, Á. T., Wait, R., Dunn, M. J., & Cotter, D. (2006) · PROTEOMICS · doi:10.1002/pmic.200500069 · Cited by 284 · see citing works

Oxidative Damage and Schizophrenia

Yao, J. K., Reddy, R. D., & van Kammen, D. P. (2001) · CNS Drugs · doi:10.2165/00023210-200115040-00004 · Cited by 280 · see citing works

Metabolic profile of antipsychotic-naive individuals with non-affective psychosis

Fernández-Egea, E., Bernardo, M., Donner, T. W., Conget, I., Parellada, E., Justicia, A., Esmatjes, E., García‐Rizo, C., & Kirkpatrick, B. W. (2009) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.108.052605 · Cited by 242 · see citing works

Metabolic syndrome and mental illness.

Newcomer, J. W. (2007) · PubMed · Cited by 233 · see citing works

Prominent synaptic and metabolic abnormalities revealed by proteomic analysis of the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder

Pennington, K., Beasley, C. L., Dicker, P., Fagan, A., English, J., Pariante, C. M., Wait, R., Dunn, M. J., & Cotter, D. R. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002098 · Cited by 227 · see citing works

Supramolecular Structure of the Mitochondrial Oxidative Phosphorylation System

Boekema, E. J., & Braun, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600031200 · Cited by 224 · see citing works

High Throughput Lipidomic Profiling of Schizophrenia and Bipolar Disorder Brain Tissue Reveals Alterations of Free Fatty Acids, Phosphatidylcholines, and Ceramides

Schwarz, E., Prabakaran, S., Whitfield, P. D., Major, H. J., Leweke, F. M., Koethe, D., McKenna, P. J., & Bahn, S. (2008) · Journal of Proteome Research · doi:10.1021/pr800188y · Cited by 222 · see citing works

Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia

Martins‐de‐Souza, D., Gattaz, W. F., Schmitt, A., Rewerts, C., Maccarrone, G., Dias‐Neto, E., & Turck, C. W. (2009) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-008-0847-2 · Cited by 203 · see citing works

Proteome analysis of the thalamus and cerebrospinal fluid reveals glycolysis dysfunction and potential biomarkers candidates for schizophrenia

Martins‐de‐Souza, D., Maccarrone, G., Wobrock, T., Zerr, I., Gormanns, P., Reckow, S., Falkai, P., Schmitt, A., & Turck, C. W. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2010.04.014 · Cited by 198 · see citing works

Three-Dimensional Analysis With MRI and PET of the Size, Shape, and Function of the Thalamus in the Schizophrenia Spectrum

Hazlett, E. A., Buchsbaum, M. S., Byne, W. M., Wei, T.-C., Spiegel-Cohen, J., Geneve, C., Kinderlehrer, R., Haznedar, M. M., Shihabuddin, L., & Siever, L. J. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1190 · Cited by 197 · see citing works

Mitochondria, synaptic plasticity, and schizophrenia.

Ben-Shachar, D., & Laifenfeld, D. (2004) · International review of neurobiology · doi:10.1016/s0074-7742(04)59011-6 · Cited by 193 · see citing works

Insulin and Insulin-Like Growth Factor-1 Abnormalities in Antipsychotic-Naive Schizophrenia

Venkatasubramanian, G., Chittiprol, S., Neelakantachar, N., Naveen, M. N., Thirthall, J., Gangadhar, B. N., & Shetty, K. T. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07020233 · Cited by 191 · see citing works

SCHIZOPHRENIA AS A PROSTAGLANDIN DEFICIENCY DISEASE

Horrobin, D. F. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92228-0 · Cited by 188 · see citing works

Increased serum phospholipase A2 activity in schizophrenia: a replication study.

Wf, G., Cv, H., Tj, N., Thuren, T. Y., & Pk, K. (1990) · PubMed · Cited by 186 · see citing works

Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia

Martins‐de‐Souza, D., Gattaz, W. F., Schmitt, A., Maccarrone, G., Hunyadi‐Gulyás, É., Eberlin, M. N., Souza, G. H. M. F., Marangoni, S., Novello, J. C., Turck, C. W., et al. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.11.006 · Cited by 177 · see citing works

Multifunctional roles of enolase in Alzheimer’s disease brain: beyond altered glucose metabolism

Butterfield, D. A., & Lange, M. L. B. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06397.x · Cited by 175 · see citing works

A proteome analysis of the anterior cingulate cortex gray matter in schizophrenia

Clark, D., Dedova, I. V., Cordwell, S. J., & Matsumoto, I. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001806 · Cited by 153 · see citing works

Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis

Martins‐de‐Souza, D., Gattaz, W. F., Schmitt, A., Rewerts, C., Marangoni, S., Novello, J. C., Maccarrone, G., Turck, C. W., & Dias‐Neto, E. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0156-y · Cited by 146 · see citing works

New onset diabetes and atypical antipsychotics

Liebzeit, K. A., Markowitz, J. S., & Caley, C. F. (2001) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(00)00127-9 · Cited by 144 · see citing works

Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation

Martins‐de‐Souza, D., Gattaz, W. F., Schmitt, A., Novello, J. C., Marangoni, S., Turck, C. W., & Dias‐Neto, E. (2009) · BMC Psychiatry · doi:10.1186/1471-244x-9-17 · Cited by 144 · see citing works

Results of phase 3 of the CATIE schizophrenia trial

Stroup, T. S., Lieberman, J. A., McEvoy, J. P., Thomas, S., Swartz, M. S., Keefe, R. S. E., Miller, A. L., Rosenheck, R. A., & Hsiao, J. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.10.011 · Cited by 141 · see citing works

Schizophrenia, the metabolic syndrome and diabetes

Holt, R. I. G., Peveler, R., & Byrne, C. D. (2004) · Diabetic Medicine · doi:10.1111/j.1464-5491.2004.01199.x · Cited by 139 · see citing works

Recovery of neuropsychological functions during reduction in use of phencyclidine

Cosgrove, J., & Newell, T. G. (1991) · Journal of Clinical Psychology · doi:10.1002/1097-4679(199101)47:1 · Cited by 138 · see citing works

The Liver-Brain Axis of Alcohol-Mediated Neurodegeneration: Role of Toxic Lipids

de la Monte, S. M., Longato, L., Tong, M., DeNucci, S. M., & Wands, J. R. (2009) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph6072055 · Cited by 137 · see citing works

Metformin as an adjunctive treatment to control body weight and metabolic dysfunction during olanzapine administration: A multicentric, double-blind, placebo-controlled trial

Baptista, T., Rangel, N., Fernández, V., Carrizo, E., Fakih, Y. E., Uzcátegui, E., Galeazzi, T., Gutiérrez, M. A. M., Servigna, M., Dávila, A., et al. (2007) · Schizophrenia Research · doi:10.1016/j.schres.2007.03.029 · Cited by 137 · see citing works

Altered thalamic membrane phospholipids in schizophrenia: a postmortem study

Schmitt, A., Wilczek, K., Blennow, K., Maras, A., Jatzko, A., Petroianu, G. A., Braus, D. F., & Gattaz, W. F. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.03.019 · Cited by 134 · see citing works

Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues

Huang, J. T.-J., Wang, L., Prabakaran, S., Wengenroth, M., Lockstone, H. E., Koethe, D., Gerth, C. W., Gross, S., Schreiber, D., Lilley, K. S., et al. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002108 · Cited by 133 · see citing works

Combined analysis of monocyte and lymphocyte messenger RNA expression with serum protein profiles in patients with scleroderma

Duan, H., Fleming, J. N., Pritchard, D. K., Amon, L. M., Xue, J., Arnett, H. A., Chen, G., Breen, P., Buckner, J. H., Molitor, J. A., et al. (2008) · Arthritis & Rheumatism · doi:10.1002/art.23451 · Cited by 128 · see citing works

Increased levels of circulating insulin-related peptides in first-onset, antipsychotic naïve schizophrenia patients

Guest, P. C., Wang, L., Harris, L. W., Burling, K., Levin, Y., Ernst, A., Wayland, M. T., Umrania, Y., Herberth, M., Koethe, D., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.81 · Cited by 126 · see citing works

Label‐free LC‐MS/MS quantitative proteomics for large‐scale biomarker discovery in complex samples

Levin, Y., Schwarz, E., Wang, L., Leweke, F. M., & Bahn, S. (2007) · Journal of Separation Science · doi:10.1002/jssc.200700189 · Cited by 119 · see citing works

Multiplex proteomic analysis by two‐dimensional differential in‐gel electrophoresis

Knowles, M. R., Cervino, S., Skynner, H. A., Hunt, S. P., Felipe, C. D., Salim, K., Meneses‐Lorente, G., McAllister, G., & Guest, P. C. (2003) · PROTEOMICS · doi:10.1002/pmic.200300437 · Cited by 118 · see citing works

Increased mitochondrial complex I activity in platelets of schizophrenic patients

Ben‐Shachar, D., Zuk, R., Gazawi, H., Reshef, A., Sheinkman, A., & Klein, E. (1999) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145799001649 · Cited by 113 · see citing works

2-D DIGE Analysis of Liver and Red Blood Cells Provides Further Evidence for Oxidative Stress in Schizophrenia

Prabakaran, S., Wengenroth, M., Lockstone, H. E., Lilley, K. S., Leweke, F. M., & Bahn, S. (2006) · Journal of Proteome Research · doi:10.1021/pr060308a · Cited by 109 · see citing works

Implication du stress oxydant dans la physiopathologie de la schizophrénie : revue de la literature

Fendri, C., Mechri, A., Khiari, G., Othman, A., Kerkeni, A., & Gaha, L. (2006) · L Encéphale · doi:10.1016/s0013-7006(06)76151-6 · Cited by 109 · see citing works

Brain mitochondria as a primary target in the development of treatment strategies for Alzheimer disease

Aliev, G. M., Palacios, H. H., Walrafen, B., Lipsitt, A. E., Obrenovich, M. E., & Morales, L. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.03.015 · Cited by 104 · see citing works

Hepatic Insulin Resistance in Antipsychotic Naive Schizophrenic Patients: Stable Isotope Studies of Glucose Metabolism

van Nimwegen, L. J. M., Storosum, J. G., Blümer, R. M. E., Allick, G., Venema, H. W., de Haan, L., Becker, H. E., van Amelsvoort, T., Ackermans, M. T., Fliers, E., et al. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1167 · Cited by 101 · see citing works

HYPERGLYÆMIA IN MENTAL DISORDERS

Kooy, F. H. (1919) · Brain · doi:10.1093/brain/42.3.214 · Cited by 100 · see citing works

Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients

Herberth, M., Koethe, D., Cheng, T. M. K., Krzyszton, N. D., Schoeffmann, S., Guest, P. C., Rahmoune, H., Harris, L. W., Kranaster, L., Leweke, F. M., et al. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.71 · Cited by 98 · see citing works

Glucose abnormalities in the siblings of people with schizophrenia

Fernández-Egea, E., Bernardo, M., Parellada, E., Justicia, A., García‐Rizo, C., Esmatjes, E., Conget, I., & Kirkpatrick, B. W. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.04.017 · Cited by 98 · see citing works

Extended release metformin for metabolic control assistance during prolonged clozapine administration: A 14 week, double-blind, parallel group, placebo-controlled study

Carrizo, E., Fernández, V., Connell, L., Sandia, I., Prieto, D., Mogollón, J., Valbuena, D., Fernández, I., de Baptista, E. A., & Baptista, T. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.05.007 · Cited by 98 · see citing works

Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations

Delaleu, N., Immervoll, H., Cornelius, J., & Jonsson, R. (2008) · Arthritis Research & Therapy · doi:10.1186/ar2375 · Cited by 96 · see citing works

Abnormal pathways in the genu of the corpus callosum in schizophrenia pathogenesis: a proteome study

Sivagnanasundaram, S., Crossett, B., Dedova, I. V., Cordwell, S. J., & Matsumoto, I. (2007) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200700230 · Cited by 90 · see citing works

Proteome analysis of schizophrenia brain tissue

Martins‐de‐Souza, D., Dias‐Neto, E., Schmitt, A., Falkai, P., Gormanns, P., Maccarrone, G., Turck, C. W., & Gattaz, W. F. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970903490626 · Cited by 89 · see citing works

Multianalyte Profiling of Serum Antigens and Autoimmune and Infectious Disease Molecules to Identify Biomarkers Dysregulated in Epithelial Ovarian Cancer

Bertenshaw, G. P., Yip, P. F., Seshaiah, P., Zhao, J., Chen, T., Wiggins, W. S., Mapes, J. P., & Mansfield, B. C. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0464 · Cited by 82 · see citing works

Phospholipid profile in the postmortem hippocampus of patients with schizophrenia and bipolar disorder: No changes in docosahexaenoic acid species

Hamazaki, K., Choi, K. H., & Kim, H. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.11.017 · Cited by 80 · see citing works

Decreased glutathione levels and altered antioxidant defense in an animal model of schizophrenia: Long-term effects of perinatal phencyclidine administration

Radonjić, N. V., Knežević, I. D., Vilimanovich, U., Kravić-Stevović, T., Marina, L. V., Nikolić, T., Todorović, V., Bumbaširević, V., & Petronijević, N. D. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.12.009 · Cited by 75 · see citing works

Homeostatic Imbalance of Purine Catabolism in First-Episode Neuroleptic-Naïve Patients with Schizophrenia

Yao, J. K., Dougherty, G. G., Reddy, R. D., Keshavan, M. S., Montrose, D. M., Matson, W. R., McEvoy, J. P., & Kaddurah-Daouk, R. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009508 · Cited by 74 · see citing works

Reversibility of Hemodynamic Hypofrontality in Schizophrenia

Géraud, G., Arné‐Bes, M., Güell, A., & Bès, A. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.2 · Cited by 72 · see citing works

Proteomic analysis reveals protein changes within layer 2 of the insular cortex in schizophrenia

Pennington, K., Dicker, P., Dunn, M. J., & Cotter, D. (2008) · PROTEOMICS · doi:10.1002/pmic.200800415 · Cited by 72 · see citing works

A Comparative Proteomics Analysis of Rat Mitochondria from the Cerebral Cortex and Hippocampus in Response to Antipsychotic Medications

Ji, B., La, Y., Gao, L., Zhu, H., Tian, N., Zhang, M., Yang, Y., Zhao, X., Tang, R., Ma, G., et al. (2009) · Journal of Proteome Research · doi:10.1021/pr800876z · Cited by 70 · see citing works

Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol

Kristiana, I., Sharpe, L. J., Catts, V. S., Lutze-Mann, L. H., & Brown, A. J. (2009) · The Pharmacogenomics Journal · doi:10.1038/tpj.2009.62 · Cited by 64 · see citing works

Elevated S100B levels in schizophrenia are associated with insulin resistance

Steiner, J. H., Walter, M., Guest, P. C., Myint, A.-M., Schiltz, K., Panteli, B., Brauner, M., Hg, B., Gos, T., Herberth, M., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.87 · Cited by 62 · see citing works

Isoprostenes as indicators of oxidative stress in schizophrenia

Dietrich‐Muszalska, A., & Olas, B. (2008) · The World Journal of Biological Psychiatry · doi:10.1080/15622970701361263 · Cited by 59 · see citing works

Antipsychotic Treatment Alters Protein Expression Associated with Presynaptic Function and Nervous System Development in Rat Frontal Cortex

Ma, D., Chan, M. K., Lockstone, H. E., Pietsch, S., Jones, D. N. C., Cilia, J., Hill, M. D. W., Robbins, M. J., Benzel, I. M., Umrania, Y., et al. (2009) · Journal of Proteome Research · doi:10.1021/pr800983p · Cited by 56 · see citing works

The interplay between mitochondrial complex I, dopamine and Sp1 in schizophrenia

Ben-Shachar, D. (2009) · Journal of neural transmission · doi:10.1007/s00702-009-0319-5 · Cited by 54 · see citing works

Lipid status, anti-oxidant enzyme defence and haemoglobin content in the blood of long-term clozapine-treated schizophrenic patients

Miljević, Č., Nikolic, M. R., Nikolić‐Kokić, A., Jones, D. R., Niketić, V., Lečić‐Toševski, D., & Spasić, M. B. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.11.024 · Cited by 53 · see citing works

Phospholipase A2 and the hypofrontality hypothesis of schizophrenia

Gattaz, W. F., & Brunner, J. (1996) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(96)90154-4 · Cited by 52 · see citing works

Age- and dose-dependent glucose-induced increases in memory and attention in schizophrenia

Fucetola, R. P., Newcomer, J. W., Craft, S., & Melson, A. K. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00063-3 · Cited by 51 · see citing works

Phase I study of eptifibatide in patients with sickle cell anaemia

Lee, S. P., Ataga, K. I., Zayed, M. A., Manganello, J. M., Orringer, E. P., Phillips, D. R., & Parise, L. V. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06787.x · Cited by 50 · see citing works

Hypofrontality in Schizophrenia: A Review of the Evidence *

Williamson, P. (1987) · The Canadian Journal of Psychiatry · doi:10.1177/070674378703200516 · Cited by 46 · see citing works

Biomarker analysis by fluorokine multianalyte profiling distinguishes patients requiring intervention from patients with long-term quiescent coronary artery disease: A potential approach to identify atherosclerotic disease progression

Gurbel, P. A., Kreutz, R. P., Bliden, K. P., DiChiara, J., & Tantry, U. S. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.08.021 · Cited by 41 · see citing works

Decreased levels of apolipoprotein A-I in plasma of schizophrenic patients

La, Y., Wan, C., Zhu, H., Yang, Y., Chen, Y. S., Pan, Y. X., Feng, G., & He, L. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0607-2 · Cited by 40 · see citing works

Identification of Targeted Analyte Clusters for Studies of Schizophrenia

Cheng, T. M. K., Lu, Y.-E., Guest, P. C., Rahmoune, H., Harris, L. W., Wang, L., Ma, D., Stelzhammer, V., Umrania, Y., Wayland, M. T., et al. (2009) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900372-mcp200 · Cited by 27 · see citing works

Abnormal transbilayer distribution of phospholipids in red blood cell membranes in schizophrenia

Nuss, P., Tessier, C., Ferreri, F., Binder, M. D., Peuskens, J., Trugnan, G., Masliah, J., & Wolf, C. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2009.01.009 · Cited by 26 · see citing works

Cerebral Blood Flow Patterns Studied by Rheoencephalography in Schizophrenia

Jacquy, J., Wilmotte, J., Piraux, A., & Noël, G. (2008) · Neuropsychobiology · doi:10.1159/000117536 · Cited by 18 · see citing works

Higher fasting serum insulin levels are associated with a better psychopathology profile in acutely ill non-diabetic inpatients with schizophrenia

Fan, X., Liu, E., Pristach, C. A., GOFF, D. C., & Henderson, D. C. (2006) · Schizophrenia Research · doi:10.1016/j.schres.2006.04.010 · Cited by 18 · see citing works

Membrane Pathology in Schizophrenia: Implication for Arachidonic Acid Signaling

Yao, J. K., & Reddy, R. K. (2002) · The Scientific World JOURNAL · doi:10.1100/tsw.2002.870 · Cited by 12 · see citing works

Differences in Protein Profiles in Schizophrenia Prefrontal Cortex Compared to Other Major Brain Disorders

Harris, L. W., SWATTON, J. E., Wengenroth, M., Wayland, M. T., Lockstone, H. E., Holland, A. J., Faull, R. L. M., Lilley, K. S., & Bahn, S. (2007) · Clinical Schizophrenia & Related Psychoses · doi:10.3371/csrp.1.1.7 · Cited by 9 · see citing works

Proteomics is not only a biomarker discovery tool

Martins‐de‐Souza, D. (2009) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200900096 · Cited by 8 · see citing works

Multi‐Analyte Profiling of Post‐Myocardial Infarction Plasma Samples

Escobar, G. P., & Lindsey, M. L. (2007) · The FASEB Journal · doi:10.1096/fasebj.21.6.a865-a · Cited by 6 · see citing works

[Change in the activity of phosphofructokinase in the tissues of rabbits with different stages of fever].

Dubinina, E. E. (1966) · PubMed · Cited by 2 · see citing works

Dendritic spine pathology in schizophrenia

Glausier, J. R., & Lewis, D. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.044 · Cited by 581 · see citing works

Oxidative stress in schizophrenia: An integrated approach

Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.008 · Cited by 474 · see citing works

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

Allen, J., Romay-Tallón, R., Brymer, K. J., Caruncho, H. J., & Kalynchuk, L. E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00386 · Cited by 350 · see citing works

Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis

Hardingham, G. E., & Do, K. Q. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.19 · Cited by 304 · see citing works

Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity: Supplementary Issue: Brain Plasticity and Repair

Beckhauser, T. F., Francis-Oliveira, J., & De Pasquale, R. (2016) · Journal of Experimental Neuroscience · doi:10.4137/jen.s39887 · Cited by 301 · see citing works

Antioxidants, Redox Signaling, and Pathophysiology in Schizophrenia: An Integrative View

Yao, J. K., & Keshavan, M. S. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3603 · Cited by 285 · see citing works

Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology?

Steullet, P., Cabungcal, J. H., Monin, A., Dwir, D., O'Donnell, P., Cuenod, M., & Do, K. Q. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2014.06.021 · Cited by 262 · see citing works

Potential metabolite markers of schizophrenia

Yang, J., Chen, T., Sun, L., Zhao, Z., Qi, X., Zhou, K., Cao, Y., Wang, X., Qiu, Y., Su, M., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.131 · Cited by 251 · see citing works

Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients

Martins‐de‐Souza, D., Guest, P. C., Harris, L. W., Vanattou‐Saïfoudine, N., Webster, M. J., Rahmoune, H., & Bahn, S. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.13 · Cited by 202 · see citing works

The Energy Metabolism Dysfunction in Psychiatric Disorders Postmortem Brains: Focus on Proteomic Evidence

Zuccoli, G. S., Saia-Cereda, V. M., Nascimento, J. M., & Martins-de-Souza, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00493 · Cited by 157 · see citing works

N-acetylcysteine in a Double-Blind Randomized Placebo-Controlled Trial: Toward Biomarker-Guided Treatment in Early Psychosis

Conus, P., Seidman, L. J., Fournier, M., Xin, L., Cleusix, M., Baumann, P., Ferrari, C., Cousins, A., Alameda, L., Gholam‐Rezaee, M., et al. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx093 · Cited by 163 · see citing works

The Current Status of the Ketogenic Diet in Psychiatry

Bostock, E. C. S., Kirkby, K. C., & Taylor, B. V. M. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00043 · Cited by 127 · see citing works

The proteome of schizophrenia

Nascimento, J. M., & Martins‐de‐Souza, D. (2015) · Schizophrenia · doi:10.1038/npjschz.2014.3 · Cited by 125 · see citing works

Exosomal miRNA-320a Is Released from hAMSCs and Regulates SIRT4 to Prevent Reactive Oxygen Species Generation in POI

Ding, C., Qian, C., Hou, S., Lu, J., Zou, Q., Li, H., & Huang, B. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.05.013 · Cited by 112 · see citing works

Mitochondrial dysfunction in schizophrenia: With a focus on postmortem studies

Roberts, R. C. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.11.009 · Cited by 110 · see citing works

Insights into myelin dysfunction in schizophrenia and bipolar disorder

Valdés‐Tovar, M., Rodríguez‐Ramírez, A. M., Rodríguez-Cárdenas, L., Sotelo-Ramírez, C. E., Camarena, B., Sanabrais‐Jiménez, M. A., Solís‐Chagoyán, H., Argueta, J., & López-Riquelme, G. O. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i2.264 · Cited by 96 · see citing works

Proteomics, metabolomics, and protein interactomics in the characterization of the molecular features of major depressive disorder

Martins‐de‐Souza, D. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.1/dmartins · Cited by 96 · see citing works

Quantitative Proteomic and Genetic Analyses of the Schizophrenia Susceptibility Factor Dysbindin Identify Novel Roles of the Biogenesis of Lysosome-Related Organelles Complex 1

Gokhale, A., Larimore, J., Werner, E., So, L., Moreno-De-Luca, A., Lese-Martin, C., Lupashin, V. V., Smith, Y., & Faundez, V. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5640-11.2012 · Cited by 85 · see citing works

Prenatal Choline Supplementation Diminishes Early-Life Iron Deficiency–Induced Reprogramming of Molecular Networks Associated with Behavioral Abnormalities in the Adult Rat Hippocampus

Tran, P. V., Kennedy, B. C., Pisansky, M. T., Won, K., Gewirtz, J. C., Simmons, R. A., & Georgieff, M. (2016) · Journal of Nutrition · doi:10.3945/jn.115.227561 · Cited by 83 · see citing works

Ultrastructural alterations of oligodendrocytes in prefrontal white matter in schizophrenia: a post-mortem morphometric study

Vikhreva, O. V., Rakhmanova, V. I., Orlovskaya, D. D., & Uranova, N. A. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.04.023 · Cited by 82 · see citing works

Energy metabolism in childhood neurodevelopmental disorders

Oyarzábal, A., Musokhranova, U., Barros, L. F., & García‐Cazorla, À. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103474 · Cited by 76 · see citing works

Oxidative Stress in Schizophrenia: Pathogenetic and Therapeutic Implications

Yao, J. K., & Reddy, R. D. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3646 · Cited by 76 · see citing works

Depression-like behaviors are accompanied by disrupted mitochondrial energy metabolism in chronic corticosterone-induced mice

Xie, X., Shen, Q., Yu, C., Xiao, Q., Zhou, J., Xiong, Z., Li, Z., & Fu, Z. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105607 · Cited by 73 · see citing works

GC-MS based metabolomics identification of possible novel biomarkers for schizophrenia in peripheral blood mononuclear cells

Liu, M., Zheng, P., Liu, Z., Xu, Y., Mu, J., Guo, J., Huang, T., Meng, H., & Xie, P. (2014) · Molecular BioSystems · doi:10.1039/c4mb00157e · Cited by 72 · see citing works

Proteomics of the corpus callosum unravel pivotal players in the dysfunction of cell signaling, structure, and myelination in schizophrenia brains

Saia-Cereda, V. M., Cassoli, J. S., Schmitt, A., Falkai, P., Nascimento, J. M., & Martins‐de‐Souza, D. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-015-0621-1 · Cited by 69 · see citing works

Ketogenic diet reverses behavioral abnormalities in an acute NMDA receptor hypofunction model of schizophrenia

Kraeuter, A.-K., Loxton, H., Lima, B. C., Rudd, D., & Sarnyai, Z. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.10.041 · Cited by 69 · see citing works

Pharmacology of Olive Biophenols

Obied, H. K., Prenzler, P. D., Omar, S. H., Ismael, R., Servili, M., Esposto, S., Taticchi, A., Selvaggini, R., & Urbani, S. (2012) · Advances in molecular toxicology · doi:10.1016/b978-0-444-59389-4.00006-9 · Cited by 68 · see citing works

The Complex Interaction of Mitochondrial Genetics and Mitochondrial Pathways in Psychiatric Disease

Cuperfain, A. B., Zhang, Z. L., Kennedy, J. L., & Gonçalves, V. F. (2018) · Complex Psychiatry · doi:10.1159/000488031 · Cited by 68 · see citing works

Advances in Biomarkers of Major Depressive Disorder

Huang, T., & Lin, C.-C. (2015) · Advances in clinical chemistry · doi:10.1016/bs.acc.2014.11.003 · Cited by 67 · see citing works

Crosstalk between endoplasmic reticulum stress and oxidative stress in schizophrenia: The dawn of new therapeutic approaches

Patel, S., Sharma, D., Kalia, K., & Tiwari, V. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.08.025 · Cited by 64 · see citing works

Metabolomics of Oxidative Stress in Recent Studies of Endogenous and Exogenously Administered Intermediate Metabolites

Liu, J., Litt, L. L., Segal, M. R., Kelly, M. J. S., Pelton, J. G., & Kim, M. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12106469 · Cited by 62 · see citing works

Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes

Steiner, J. H., Martins‐de‐Souza, D., Schiltz, K., Sarnyai, Z., Westphal, S., Isermann, B., Dobrowolny, H., Turck, C. W., Bogerts, B., Bernstein, H., et al. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00384 · Cited by 58 · see citing works

Effects of the Antioxidant Sulforaphane on Hyperlocomotion and Prepulse Inhibition Deficits in Mice after Phencyclidine Administration

Shirai, Y., Fujita, Y., & Hashimoto, K. (2012) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2012.10.2.94 · Cited by 54 · see citing works

Mapping pathologic circuitry in schizophrenia

Glausier, J. R., & Lewis, D. A. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00025-6 · Cited by 52 · see citing works

Regulation of Reactive Oxygen Species-Mediated Damage in the Pathogenesis of Schizophrenia

Madireddy, S., & Madireddy, S. (2020) · Brain Sciences · doi:10.3390/brainsci10100742 · Cited by 55 · see citing works

MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia

Guest, P. C., Iwata, K., Kato, T. A., Steiner, J. H., Schmitt, A., Turck, C. W., & Martins‐de‐Souza, D. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00180 · Cited by 53 · see citing works

Nutritional psychiatry in the treatment of psychotic disorders: Current hypotheses and research challenges

Teasdale, S. B., Mörkl, S., & Mueller‐Stierlin, A. S. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100070 · Cited by 54 · see citing works

Ketogenic diet for schizophrenia

Sarnyai, Z., Kraeuter, A.-K., & Palmer, C. (2019) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000535 · Cited by 52 · see citing works

Psychiatric drugs impact mitochondrial function in brain and other tissues

Chan, S. T., McCarthy, M. J., & Vawter, M. P. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.09.007 · Cited by 51 · see citing works

Mitochondrial Dysfunction, Altered Mitochondrial Oxygen, and Energy Metabolism Associated with the Pathogenesis of Schizophrenia

Fizíková, I., Dragašek, J., & Račay, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097991 · Cited by 45 · see citing works

Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism

Knapman, A., Kaltwasser, S. F., Martins‐de‐Souza, D., Holsboer, F., Landgraf, R., Turck, C. W., Czisch, M., & Touma, C. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07968.x · Cited by 44 · see citing works

Metabolomics in Psychiatric Disorders: What We Learn from Animal Models

Humer, E. C., Probst, T., & Pieh, C. (2020) · Metabolites · doi:10.3390/metabo10020072 · Cited by 44 · see citing works

Brain works principle followed by neural information processing: a review of novel brain theory

Wang, R., Wang, Y., Xu, X., Li, Y., & Pan, X. (2023) · Artificial Intelligence Review · doi:10.1007/s10462-023-10520-5 · Cited by 43 · see citing works

Abnormal Grey Matter Arteriolar Cerebral Blood Volume in Schizophrenia Measured With 3D Inflow-Based Vascular-Space-Occupancy MRI at 7T

Hua, J., Brandt, A. S., Lee, S. W., Blair, N. I. S., Wu, Y., Lui, S., Patel, J., Faria, A. V., Lim, I. A. L., Unschuld, P. G., et al. (2016) · Schizophrenia Bulletin · doi:10.1093/schbul/sbw109 · Cited by 39 · see citing works

Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms

Schmitt, A., Martins‐de‐Souza, D., Akbarian, S., Cassoli, J. S., Ehrenreich, H., Fischer, A., Fonteh, A. N., Gattaz, W. F., Gawlik, M., Gerlach, M., et al. (2016) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2016.1224929 · Cited by 41 · see citing works

Maternal Immune Activation Induces Changes in Myelin and Metabolic Proteins, Some of Which Can Be Prevented with Risperidone in Adolescence

Farrelly, L., Föcking, M., Piontkewitz, Y., Dicker, P., English, J., Wynne, K. J., Cannon, M. D., Cagney, G., & Cotter, D. (2015) · Developmental Neuroscience · doi:10.1159/000368305 · Cited by 38 · see citing works

Effect of MK-801 and Clozapine on the Proteome of Cultured Human Oligodendrocytes

Cassoli, J. S., Iwata, K., Steiner, J. H., Guest, P. C., Turck, C. W., Nascimento, J. M., & Martins‐de‐Souza, D. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00052 · Cited by 36 · see citing works

Development of the MAM model of schizophrenia in mice: Sex similarities and differences of hippocampal and prefrontal cortical function

Chalkiadaki, K., Velli, A., Kyriazidis, E., Stavroulaki, V., Vouvoutsis, V., Chatzaki, Ε., Aivaliotis, M., & Sidiropoulou, K. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.10.026 · Cited by 36 · see citing works

Mitochondrial dysfunction in schizophrenia: an evolutionary perspective

Gonçalves, V. F., Andreazza, A. C., & Kennedy, J. L. (2014) · Human Genetics · doi:10.1007/s00439-014-1491-8 · Cited by 35 · see citing works

Unbiased Lipidomic Profiling Reveals Metabolomic Changes during the Onset and Antipsychotics Treatment of Schizophrenia Disease

Yan, L., Zhou, J., Wang, D., Si, D., Liu, Y., Zhong, L., & Yin, Y. (2018) · Metabolomics · doi:10.1007/s11306-018-1375-3 · Cited by 36 · see citing works

The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia

Martins‐de‐Souza, D., Alsaif, M., Ernst, A., Harris, L. W., Aerts, N., Lenaerts, I., Peeters, P. J., Amess, B., Rahmoune, H., Bahn, S., et al. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-146 · Cited by 35 · see citing works

Behavioral and Molecular Biomarkers in Translational Animal Models for Neuropsychiatric Disorders

Sarnyai, Z., Alsaif, M., Bahn, S., Ernst, A., Guest, P. C., Hradetzky, E., Kluge, W. F., Stelzhammer, V., & Wesseling, H. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-387718-5.00008-0 · Cited by 35 · see citing works

Metabolomic Analysis Reveals Metabolic Disturbance in the Cortex and Hippocampus of Subchronic MK-801 Treated Rats

Sun, L., Li, J., Zhou, K., Zhang, M., Yang, J., Li, Y., Ji, B., Zhang, Z., Zhu, H., Yang, L., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060598 · Cited by 33 · see citing works

The use of Proteomic Biomarkers for Improved Diagnosis and Stratification Of Schizophrenia Patients

Guest, P. C., Chan, M. K., Gottschalk, M. G., & Bahn, S. (2013) · Biomarkers in Medicine · doi:10.2217/bmm.13.83 · Cited by 34 · see citing works

Proteomic approaches to unravel the complexity of schizophrenia

Martins‐de‐Souza, D., Guest, P. C., Rahmoune, H., & Bahn, S. (2012) · Expert Review of Proteomics · doi:10.1586/epr.11.70 · Cited by 31 · see citing works

Comparative Analysis of the Pre- and Post-Medication Effects of Antipsychotic Agents on the Blood-Based Oxidative Stress Biomarkers in Patients with Schizophrenia: A Meta-Analysis

Yang, M., Wang, C., Zhao, G., Kong, D., Liu, L., Yuan, S., Chen, W., Feng, C., & Li, Z. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220706101021 · Cited by 30 · see citing works

Abnormalities in metabolism and hypothalamic-pituitary-adrenal axis function in schizophrenia.

Guest, P., Martins-de-Souza, D., Vanattou-Saifoudine, N., Harris, L., & Bahn, S. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-387718-5.00006-7 · Cited by 29 · see citing works

The glial phosphorylase of glycogen isoform is reduced in the dorsolateral prefrontal cortex in chronic schizophrenia

Pinacho, R., Vila, È., Prades, R., Tarragó, T., Castro, E., Ferrer, I., & Ramos, B. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.04.024 · Cited by 29 · see citing works

Proteomics Tackling Schizophrenia as a Pathway Disorder

Martins‐de‐Souza, D. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs094 · Cited by 29 · see citing works

Proteomics as a Tool for Understanding Schizophrenia

Martins‐de‐Souza, D. (2011) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2011.9.3.95 · Cited by 28 · see citing works

Galantamine-Memantine Combination as an Antioxidant Treatment for Schizophrenia

Koola, M. M., Praharaj, S. K., & Pillai, A. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-00174-5 · Cited by 27 · see citing works

Toward a Global Roadmap for Precision Medicine in Psychiatry: Challenges and Opportunities

Dalvie, S., Koen, N., McGregor, N. W., O’Connell, K. S., Warnich, L., Ramesar, R., Nievergelt, C. M., & Stein, D. J. (2016) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2016.0110 · Cited by 27 · see citing works

Search for peripheral biomarkers in patients affected by acutely psychotic bipolar disorder: a proteomic approach

Giusti, L., Mantua, V., Valle, Y. D., Ciregia, F., Ventroni, T., Orsolini, G., Donadio, E., Giannaccini, G., Mauri, M., Cassano, G. B., et al. (2014) · Molecular BioSystems · doi:10.1039/c4mb00068d · Cited by 26 · see citing works

Proteomic profiling in schizophrenia: enabling stratification for more effective treatment

Guest, P. C., Martins‐de‐Souza, D., Schwarz, E., Rahmoune, H., Alsaif, M., Tomasik, J., Turck, C. W., & Bahn, S. (2013) · Genome Medicine · doi:10.1186/gm429 · Cited by 26 · see citing works

Neuroprotection in Schizophrenia and Its Therapeutic Implications

Kim, Y., & Na, K. (2017) · Psychiatry Investigation · doi:10.4306/pi.2017.14.4.383 · Cited by 22 · see citing works

Targeting d-Amino Acid Oxidase (DAAO) for the Treatment of Schizophrenia: Rationale and Current Status of Research

Kuo, C.-Y., Lin, C., & Lane, H. (2022) · CNS Drugs · doi:10.1007/s40263-022-00959-5 · Cited by 22 · see citing works

Gene expression in superior temporal cortex of schizophrenia patients

Sellmann, C., Pildaín, L. V., Schmitt, A., Leonardi‐Essmann, F., Durrenberger, P. F., Spanagel, R., Arzberger, T., Kretzschmar, H. A., Zink, M., Gruber, O., et al. (2013) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0473-5 · Cited by 22 · see citing works

Promoter polymorphisms in two overlapping 6p25 genes implicate mitochondrial proteins in cognitive deficit in schizophrenia

Jablensky, A. V., Angelicheva, D., Donohoe, G. J., Cruickshank, M. N., Azmanov, D. N., Morris, D. W., McRae, A. F., Weickert, C. S., Carter, K. W., Chandler, D., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.129 · Cited by 22 · see citing works

Leukocyte Proteomic Profiling in First-Episode Schizophrenia Patients: Does Oxidative Stress Play Central Roles in the Pathophysiology Network of Schizophrenia?

Jiang, J., Peng, C., Sun, L., Li, J., Qing, Y., Hu, X., Yang, X., Li, Y., Xu, C., Zhang, J., et al. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7805 · Cited by 21 · see citing works

Omega-3 fatty acid deficiency disrupts endocytosis, neuritogenesis, and mitochondrial protein pathways in the mouse hippocampus

English, J. A., Harauma, A., Föcking, M., Wynne, K. J., Scaife, C., Cagney, G., Moriguchi, T., & Cotter, D. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00208 · Cited by 20 · see citing works

Meta-analysis of brain samples of individuals with schizophrenia detects down-regulation of multiple ATP synthase encoding genes in both females and males

Shroitman, N. K., Yitzhaky, A., Ben‐Shachar, D., Gurwitz, D., & Hertzberg, L. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.01.005 · Cited by 19 · see citing works

Recent Reports on Redox Stress-Induced Mitochondrial DNA Variations, Neuroglial Interactions, and NMDA Receptor System in Pathophysiology of Schizophrenia

Beeraka, N. M., Ávila-Rodriguez, M., & Aliev, G. M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-021-02703-4 · Cited by 18 · see citing works

What Have Mass Spectrometry-Based Proteomics and Metabolomics (Not) Taught Us about Psychiatric Disorders?

Turck, C. W., & Filiou, M. D. (2015) · Complex Psychiatry · doi:10.1159/000381902 · Cited by 18 · see citing works

Employing proteomics to unravel the molecular effects of antipsychotics and their role in schizophrenia

Cassoli, J. S., Guest, P. C., Santana, A. G., & Martins‐de‐Souza, D. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500109 · Cited by 18 · see citing works

Proteome profiling of peripheral mononuclear cells from human blood

Maccarrone, G., Rewerts, C., Lebar, M., Turck, C. W., & Martins‐de‐Souza, D. (2012) · PROTEOMICS · doi:10.1002/pmic.201200377 · Cited by 17 · see citing works

Oral acetate supplementation attenuates N-methyl D-aspartate receptor hypofunction-induced behavioral phenotypes accompanied by restoration of acetyl-histone homeostasis

Singh, S., Choudhury, A., Gusain, P., Parvez, S., Palit, G., Shukla, S., & Ganguly, S. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4213-1 · Cited by 17 · see citing works

Deciphering the Human Brain Proteome: Characterization of the Anterior Temporal Lobe and Corpus Callosum As Part of the Chromosome 15-centric Human Proteome Project

Martins‐de‐Souza, D., Carvalho, P. C., Schmitt, A., Junqueira, M., Nogueira, F. C. S., Turck, C. W., & Domont, G. B. (2013) · Journal of Proteome Research · doi:10.1021/pr4009157 · Cited by 16 · see citing works

Mitochondrial, cell cycle control and neuritogenesis alterations in an iPSC-based neurodevelopmental model for schizophrenia

Zuccoli, G. S., Nascimento, J. M., Codo, A. C., Moraes-Vieira, P. M., Rehen, S. K., & Martins‐de‐Souza, D. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01605-x · Cited by 15 · see citing works

Review: Genes Involved in Mitochondrial Physiology Within 22q11.2 Deleted Region and Their Relevance to Schizophrenia

Kolář, D., Krajčovič, B., Kletečková, L., Kunčická, D., Valeš, K., & Brožka, H. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad066 · Cited by 16 · see citing works

Proteomics in neurodegenerative diseases: Methods for obtaining a closer look at the neuronal proteome

Plum, S., Steinbach, S., Abel, L., Marcus, K., Helling, S., & May, C. (2014) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400030 · Cited by 15 · see citing works

Alterations in Prefrontal Cortical Circuitry and Cognitive Dysfunction in Schizophrenia

Lewis, D. A., & Glausier, J. R. (2016) · Nebraska Symposium on Motivation/The Nebraska symposium on motivation · doi:10.1007/978-3-319-30596-7_3 · Cited by 15 · see citing works

Rapid and simple analysis of disease-associated biomarkers of Taiwanese patients with schizophrenia using matrix-assisted laser desorption ionization mass spectrometry

Huang, T., Lo, L., Shiea, J., & Su, H. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.08.011 · Cited by 13 · see citing works

The need for phosphoproteomic approaches in psychiatric research

Martins‐de‐Souza, D., Guest, P. C., Vanattou‐Saïfoudine, N., Wesseling, H., Rahmoune, H., & Bahn, S. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.04.007 · Cited by 13 · see citing works

Ultrastructural pathology of oligodendrocytes in the white matter in continuous paranoid schizophrenia: a role for microglia

Uranova, N. A., Vikhreva, O. V., Рахманова, В. И., & Orlovskaya, D. D. (2017) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro20171179176-81 · Cited by 13 · see citing works

Loss of neurexin-1 in Drosophila melanogaster results in altered energy metabolism and increased seizure susceptibility

Levy, K. A., Weisz, E. D., & Jongens, T. A. (2022) · Human Molecular Genetics · doi:10.1093/hmg/ddac115 · Cited by 12 · see citing works

Acute Phencyclidine Treatment Induces Extensive and Distinct Protein Phosphorylation in Rat Frontal Cortex

Palmowski, P., Rogowska-Wrzesińska, A., Williamson, J. C., Beck, H. C., Mikkelsen, J. D., Hansen, H. H., & Jensen, O. N. (2014) · Journal of Proteome Research · doi:10.1021/pr4010794 · Cited by 12 · see citing works

Rapid detection of alteration of serum IgG in patients with schizophrenia after risperidone treatment by matrix‐assisted laser desorption ionization/time‐of‐flight mass spectrometry

Lo, L., Shiea, J., & Huang, T. (2016) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.7753 · Cited by 12 · see citing works

Analysis of Molecular Networks in the Cerebellum in Chronic Schizophrenia: Modulation by Early Postnatal Life Stressors in Murine Models

Vera-Montecinos, A., Rodríguez‐Mias, R. A., MacDowell, K. S., García‐Bueno, B., Bris, Á. G., Caso, J. R., Villén, J., & Ramos, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810076 · Cited by 12 · see citing works

Proteomic Similarities Between Heterozygous Reeler Mice and Schizophrenia

Schmitt, A., Turck, C. W., Pilz, P. K. D., Malchow, B., von Wilmsdorff, M., Falkai, P., & Martins‐de‐Souza, D. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.03.023 · Cited by 11 · see citing works

Insights into myelin dysfunction in schizophrenia and bipolar disorder

Valdés‐Tovar, M., Rodríguez‐Ramírez, A. M., Rodríguez-Cárdenas, L., Sotelo-Ramírez, C. E., Camarena, B., Sanabrais‐Jiménez, M. A., Solís‐Chagoyán, H., Argueta, J., & López-Riquelme, G. O. (2022) · World Journal of Psychiatry · doi:10.5498/wjp.v12.i2.268 · Cited by 11 · see citing works

Clinical utility of serum biomarkers for major psychiatric disorders

van Beveren, N. J. M., & Hoogendijk, W. J. G. (2011) · International review of neurobiology · doi:10.1016/b978-0-12-387718-5.00014-6 · Cited by 9 · see citing works

Effects on Glial Cell Glycolysis in Schizophrenia: An Advanced Aging Phenotype?

Zuccoli, G. S., Guest, P. C., & Martins‐de‐Souza, D. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-25650-0_2 · Cited by 9 · see citing works

Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis

Monteiro, J., Lemos, G. G. M., de‐Souza‐Ferreira, E., Marques, A. M., Neves, G. A., Silveira, M. S., & Galina, A. (2019) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-019-09816-5 · Cited by 8 · see citing works

Nicotine Exposure in a Phencyclidine-Induced Mice Model of Schizophrenia: Sex-Selective Medial Prefrontal Cortex Protein Markers of the Combined Insults in Adolescent Mice

Rodríguez-Vega, A., Dutra-Tavares, A. C., de Souza, T. P., Semeão, K. A., Filgueiras, C. C., Ribeiro‐Carvalho, A., Manhães, A. C., & Abreu‐Villaça, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914634 · Cited by 7 · see citing works

Elevations in the Mitochondrial Matrix Protein Cyclophilin D Correlate With Reduced Parvalbumin Expression in the Prefrontal Cortex of Patients With Schizophrenia

O'Brien, J. T., Jalilvand, S. P., Suji, N. A., Jupelly, R. K., Phensy, A. J., Mwirigi, J. M., Elahi, H., Price, T. J., & Kroener, S. (2024) · Schizophrenia Bulletin · doi:10.1093/schbul/sbae016 · Cited by 7 · see citing works

Postmortem Brains: What Can Proteomics Tell us About the Sources of Schizophrenia?

Reis‐de‐Oliveira, G., Smith, B. J., & Martins‐de‐Souza, D. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-97182-3_1 · Cited by 7 · see citing works

Does Neuroinflammation Underlie the Cognitive Changes Observed With Dietary Interventions?

Robbins, J. P., & Solito, E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.854050 · Cited by 5 · see citing works

Expression Analysis of 4-Hydroxynonenal Modified Proteins in Schizophrenia Brain; Relevance to Involvement in Redox Dysregulation

Manzoor, S., Ayesha, K., Hasan, B., Mushtaq, S., & Ahmed, N. (2021) · Current Proteomics · doi:10.2174/1570164618666210121151004 · Cited by 5 · see citing works

Oxidative Stress in Schizophrenia

Dietrich‐Muszalska, A. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_2 · Cited by 5 · see citing works

Protein Succinylation and Malonylation as Potential Biomarkers in Schizophrenia

Smith, B. J., Brandão‐Teles, C., Zuccoli, G. S., Reis‐de‐Oliveira, G., Fioramonte, M., Saia-Cereda, V. M., & Martins‐de‐Souza, D. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091408 · Cited by 5 · see citing works

Mitochondrial dysfunction in schizophrenia: evidence for compromised brain metabolism and oxidative stress

Prabakaran, S., SWATTON, J. E., Ryan, M. M., Huffaker, S. J., Huang, J.-J., Griffin, J. L., Wayland, M. T., Freeman, T., Dudbridge, F., Lilley, K. S., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001511 · Cited by 973 · see citing works

Mitochondrial Dysfunction, Altered Mitochondrial Oxygen, and Energy Metabolism Associated with the Pathogenesis of Schizophrenia

Fizíková, I., Dragašek, J., & Račay, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097991 · Cited by 45 · see citing works

Human brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia

Koopmans, F., Dijkstra, A. A., Li, W.-P., Klaassen, R. V., Gouwenberg, Y., Yao, S., Bast, L., Verhage, M., Karlsson, R., Dwork, A. J., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-68950-y · Cited by 11 · see citing works

Oxidative Stress in Schizophrenia

Dietrich‐Muszalska, A. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-0440-2_2 · Cited by 5 · see citing works

Mitochondrial Oxidative Phosphorylation System Dysfunction in Schizophrenia.

E, M. C. O.-B. D. M.-P. A. B. M. R. N. G. P. M. L. P. (2025) · Rovira & Virgili repository