The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Patient-Specific Stem Cell Lines Derived from Human Parthenogenetic Blastocysts
Abstract
Parthenogenetic activation of human oocytes may be one way to produce histocompatible cells for cell-based therapy. We report the successful derivation of six pluripotent human embryonic stem cell (hESC) lines from blastocysts of parthenogenetic origin. The parthenogenetic human embryonic stem cells (phESC) demonstrate typical hESC morphology, express appropriate markers, and possess high levels of alkaline phosphatase and telomerase activity. The phESC lines have a normal 46, XX karyotype, except one cell line, and have been cultured from between 21 to 35 passages. The phESC lines form embryoid bodies in suspension culture and teratomas after injection to immunodeficient animals and give differentiated derivatives of all three embryonic germ layers. DNA profiling of all six phESC lines demonstrates that they are MHC matched with the oocyte donors. The study of imprinted genes demonstrated further evidence of the parthenogenetic origin of the phESC lines. Our research has resulted in a protocol for the production of human parthenogenetic embryos and the derivation of stem cell lines from them, which minimizes the presence of animal-derived components, making the derived phESC lines more suitable for potential clinical use.
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Citations
Cites
Embryonic Stem Cell Lines Derived from Human Blastocysts
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Feeder Layer- and Serum-Free Culture of Human Embryonic Stem Cells1
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A census of mammalian imprinting
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Cited by
Pluripotent stem cells in disease modelling and drug discovery
Avior, Y., Sagi, I., & Benvenisty, N. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.27 · Cited by 592
De Los Angeles, A., Ferrari, F., Xi, R., Fujiwara, Y., Benvenisty, N., Deng, H., Hochedlinger, K., Jaenisch, R., Lee, S., Leitch, H. G., et al. (2015) · Nature · doi:10.1038/nature15515 · Cited by 396
Yu, J., & Thomson, J. A. (2008) · Genes & Development · doi:10.1101/gad.1689808 · Cited by 342
Teratomas from pluripotent stem cells: A clinical hurdle
Fong, C., Gauthaman, K., & Bongso, A. (2010) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22775 · Cited by 222
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Metadata
- Authors
- Revazova, E. S., Turovets, N. A., Kochetkova, O. D., Kindarova, L. B., Kuzmichev, L. N., Janus, J. D., & Pryzhkova, M. V.
- Venue
- Cloning and Stem Cells
- Publisher
- SAGE Publications
- Published
- 2007-09
- Volume
- 9
- Issue
- 3
- Pages
- 432-449
- ISSN
- 1536-2302 (ISSN-L)
- 1557-7457
- OpenAlex
- W4247165437
- Cited by
- 282
- References
- 19
- FWCI
- 12.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Patient-Specific Stem Cell Lines Derived from Human Parthenogenetic Blastocysts. https://app.cochat.ai/papers/10.1089/clo.2007.0033
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- Revazova, E. S., Turovets, N. A., Kochetkova, O. D., Kindarova, L. B., Kuzmichev, L. N., Janus, J. D., & Pryzhkova, M. V. (2007). Patient-Specific Stem Cell Lines Derived from Human Parthenogenetic Blastocysts. Cloning and Stem Cells. https://doi.org/10.1089/clo.2007.0033
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
