Glycemic Control Across the Menstrual Cycle in Women with Type 1 Diabetes Using the MiniMed 780G Advanced Hybrid Closed-Loop System: The 780MENS Prospective Study

Recent cohort data have indicated that menstrual cycle-related metabolic variability may persist despite advanced hybrid closed-loop therapy.

“Conversely, recent cohort data have indicated that menstrual cycle‐related metabolic variability may persist despite AHCL therapy.”

In that cohort study of advanced hybrid closed-loop users, mean glucose levels increased during the late-luteal phase.

“A cohort study of AHCL users reported that although TIR was maintained with an increase in total daily insulin dose (TDD) during the late‐luteal phase, the mean glucose levels increased 10 .”

In a cohort study of advanced hybrid closed-loop users, Time in Range was maintained with an increase in total daily insulin dose during the late-luteal phase.

“A cohort study of AHCL users reported that although TIR was maintained with an increase in total daily insulin dose (TDD) during the late‐luteal phase, the mean glucose levels increased 10 .”

Monroy et al. examined individuals with relatively high baseline glycemic control (TIR in the 80% range).

“Elhenawy et al. 9 investigated an adolescent and young adult cohort (14–21 years), whereas Monroy et al. 10 examined individuals with relatively high baseline glycemic control (TIR in the 80% range).”

Monroy et al. restricted enrollment to users with auto-mode utilization >95%.

“Monroy et al. 10 restricted enrollment to users with auto‐mode utilization >95%, reflecting near‐continuous algorithm support.”

Recorded carbohydrate amount and carbohydrate entry frequency increased during the late-luteal phase.

“From a behavioral perspective, both the recorded carbohydrate amount and carbohydrate entry frequency increased during the late‐luteal phase, consistent with prior observations of increased carbohydrate intake during this phase 10 .”

Monroy et al. reported increased mean glucose levels and TAR during the luteal phase.

“Elhenawy et al. observed that menstrual phase‐related differences in TIR disappeared after AHCL initiation 9 , whereas Monroy et al. reported increased mean glucose levels and TAR during the luteal phase 10 .”

Body weight-adjusted TDD was higher in this cohort than in prior reports.

“Body weight‐adjusted TDD was higher in this cohort than in prior reports 10 .”

Our results are broadly aligned with prior investigations using the MiniMed 780G system.

“Furthermore, our results are broadly aligned with those of prior investigations using the MiniMed 780G system 9 , 10 .”

The observed increase in insulin demand during the luteal phase corresponds to reports of algorithm-driven increases in insulin delivery during AHCL therapy and increased TDD during the luteal phase.

“The observed increase in insulin demand during the luteal phase corresponds to reports demonstrating algorithm‐driven increases in insulin delivery during AHCL therapy 9 and increased TDD during the luteal phase 10 .”