Genetic Variations in MicroRNA Processing Genes Are Associated with Susceptibility in Depression
Abstract
MicroRNAs (miRNAs) are new prominent gene expression regulators that have critical roles in neural development by regulating synaptic functions, and miRNA biogenesis may play an important role in psychiatric disorders. Despite emerging evidences demonstrating that single-nucleotide polymorphisms in the miRNA processing genes were associated with cancer and cardiovascular disorders, evidences about association between variants of the genes and depression are lacking. This study aims to find the association between miRNA processing gene variants and depression. We genotyped three polymorphisms from three miRNA processing genes in a case-control study including 314 patients and 252 matched healthy controls. The high-resolution melting method was used to genotype the three loci. Frequencies of genotypes and alleles showed significant difference between patients with depression and healthy controls in DGCR8 rs3757 and AGO1 rs636832. An allele frequency was significantly higher in rs3757 and lower in rs636832, respectively. Variant allele of DGCR8 rs3757 was associated with increased risk of suicidal tendency and improvement response to antidepressant treatment, whereas the variant of AGO1 rs636832 showed decreased risk of suicidal tendency, suicidal behavior, and recurrence. Besides allele frequency showed significant difference when compared patients with remission to controls, no significant differences were found in GEMIN4 rs7813 between patients and healthy controls. DGCR8 rs3757 and AGO1 rs636832 were found to have significant association with depression, and GEMIN4 rs7813 did not affect susceptibility to depression. These observations suggested that miRNA processing polymorphisms may affect depression risk and treatment.
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A handful of studies have identified depression risk variants in precursor miRNA encoding genes, miRNA target genes, or genes involved in miRNA processing.
“A handful of studies have also identified depression risk variants in precursor miRNA encoding genes, 44 , 45 variants located in or near miRNA target genes 46 , 47 or variants located in genes involved in miRNA processing.”
From Epigenetics and depression (2019) · cites this paper as [48]
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Structured Clinical Interview for DSM-IV Axis I Disorders
Spitzer, R. L., First, M. B., & Gibbon, M. (1997) · Medical Entomology and Zoology · Cited by 3,582 · see citing works
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
Chen, J., Mandel, E. M., Thomson, J. M., Wu, Q., Callis, T. E., Hammond, S. M., Conlon, F. L., & Wang, D.-Z. (2005) · Nature Genetics · doi:10.1038/ng1725 · Cited by 2,763 · see citing works
Wilamowska (2010) · doi:10.1001/archpsyc.1988.01800320058007 · Cited by 2,115 · see citing works
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
Chendrimada, T. P., Gregory, R. I., Kumaraswamy, E., Norman, J. A., Cooch, N. S., Nishikura, K., & Shiekhattar, R. (2005) · Nature · doi:10.1038/nature03868 · Cited by 2,103 · see citing works
A pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102 · see citing works
A brain-specific microRNA regulates dendritic spine development
Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., & Greenberg, M. E. (2006) · Nature · doi:10.1038/nature04367 · Cited by 1,786 · see citing works
MicroRNA-133 controls cardiac hypertrophy
Carè, A., Catalucci, D., Felicetti, F., Bonci, D., Addario, A., Gallo, P., Bang, M., Segnalini, P., Gu, Y., Dalton, N. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1582 · Cited by 1,775 · see citing works
Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex
Han, J., Lee, Y., Yeom, K., Nam, J., Heo, I., Rhee, J., Sohn, S. Y., Cho, Y., Zhang, B.-T., & Kim, V. N. (2006) · Cell · doi:10.1016/j.cell.2006.03.043 · Cited by 1,552 · see citing works
miR-181a Is an Intrinsic Modulator of T Cell Sensitivity and Selection
Li, Q.-J., Chau, J., Ebert, P. J. R., Sylvester, G., Min, H., Liu, G., Braich, R. S., Manoharan, M., Soutschek, J., Skare, P., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.008 · Cited by 1,157 · see citing works
The genetics of depression: A review
Levinson, D. F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.024 · Cited by 855 · see citing works
GSK3 signalling in neural development
Hur, E., & Zhou, F. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2870 · Cited by 828 · see citing works
TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
Li, Y., Luikart, B. W., Birnbaum, S., Chen, J., Kwon, C.-H., Kernie, S. G., Bassel-Duby, R., & Parada, L. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.023 · Cited by 634 · see citing works
Gliogenesis and Glial Pathology in Depression
Rajkowska, G., & Miguel-Hidalgo, J. J. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780619326 · Cited by 612 · see citing works
Altered microRNA regulation in Huntington's disease models
Lee, S., Chu, K., Im, W., Yoon, H., Im, J.-Y., Park, J.-E., Park, K.-H., Jung, K., Lee, S. K., Kim, M., et al. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.10.012 · Cited by 289 · see citing works
Reduced hippocampal volume correlates with executive dysfunctioning in major depression
Frodl, T., Schaub, A., Banac, S., Charypar, M., Jäger, M., Kümmler, P., Ronald Bottlender, A., Zetzsche, T., Born, C., Leinsinger, G. L., et al. (2006) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0636 · Cited by 280 · see citing works
Evaluation of Genetic Variants in MicroRNA-Related Genes and Risk of Bladder Cancer
Yang, H., Dinney, C. P., Ye, Y., Zhu, Y., Grossman, H. B., & Wu, X. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5991 · Cited by 266 · see citing works
Genetics of psychosis; insights from views across the genome
O’Donovan, M. C., Craddock, N. J., & Owen, M. J. (2009) · Human Genetics · doi:10.1007/s00439-009-0703-0 · Cited by 213 · see citing works
Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins
Shpargel, K. B., & Matera, A. G. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508947102 · Cited by 205 · see citing works
Fénelon, K., Mukai, J., Xu, B., Hsu, P.-K., Drew, L. J., Karayiorgou, M., Fischbach, G. D., MacDermott, A. B., & Gogos, J. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101219108 · Cited by 202 · see citing works
Biogenesis and Regulation of Cardiovascular MicroRNAs
Bauersachs, J. K., & Thum, T. (2011) · Circulation Research · doi:10.1161/circresaha.110.228676 · Cited by 168 · see citing works
CREB, neurogenesis and depression
Gass, P., & Riva, M. A. (2007) · BioEssays · doi:10.1002/bies.20658 · Cited by 150 · see citing works
Liang, D., Meyer, L. A., Chang, D. W., Lin, J. M., Pu, X., Ye, Y., Gu, J. H., Wu, X., & Lu, K. H. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0130 · Cited by 132 · see citing works
Lin, J., Horikawa, Y., Tamboli, P., Clague, J., Wood, C. G., & Wu, X. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq168 · Cited by 123 · see citing works
Evidence demonstrating role of microRNAs in the etiopathology of major depression
Dwivedi, Y. (2011) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2011.04.002 · Cited by 107 · see citing works
Schofield, C. M., Hsu, R., Barker, A. J., Gertz, C. C., Blelloch, R. H., & Ullian, E. M. (2011) · Neural Development · doi:10.1186/1749-8104-6-11 · Cited by 86 · see citing works
Major regulators of microRNAs biogenesis Dicer and Drosha are down-regulated in endometrial cancer
Torres, A., Torres, K., Paszkowski, T., Jodłowska‐Jędrych, B., Radomański, T., Książek, A., & Maciejewski, R. (2011) · Tumor Biology · doi:10.1007/s13277-011-0179-0 · Cited by 61 · see citing works
Association of a common AGO1 variant with lung cancer risk: A two‐stage case–control study
Kim, J., Choi, Y. Y., Jin, G., Kang, H., Choi, J., Jeon, H., Lee, W.-K., Kim, D. S., Kim, C. H., Kim, Y. J., et al. (2010) · Molecular Carcinogenesis · doi:10.1002/mc.20672 · Cited by 60 · see citing works
Sung, H., Lee, K.-M., Choi, J., Han, S., Lee, J.-Y., Li, L., Park, S. K., Yoo, K., Noh, D., Ahn, S.-H., et al. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1656-2 · Cited by 53 · see citing works
VGF, a New Player in Antidepressant Action?
Malberg, J. E., & Monteggia, L. M. (2008) · Science Signaling · doi:10.1126/stke.118pe19 · Cited by 30 · see citing works
IL-28B Genetic Variant Is Associated with the Risk of Schizophrenia in the Chinese Han Population
Chen, C., Tan, B., Zhou, Y., Zhou, J., He, Y., Li, S., Ying, B., & Li, Q. (2012) · DNA and Cell Biology · doi:10.1089/dna.2011.1471 · Cited by 11 · see citing works
Self-citationZhou, Y., Wang, J., Wang, K., Li, S., Song, X., Ye, Y., Wang, L., & Ying, B. (2010) · DNA and Cell Biology · doi:10.1089/dna.2010.1075 · Cited by 11 · see citing works
Self-citationNeurotrophin Receptor Activation and Expression in Human Postmortem Brain: Effect of Suicide
Dwivedi, Y., Rizavi, H., Zhang, H., Mondal, A., Roberts, R. C., Conley, R. R., & Pandey, G. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.08.035 · Cited by 3 · see citing works
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Brites, D., & Fernandes, A. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00476 · Cited by 599 · see citing works
Penner-Goeke, S., & Binder, E. B. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/ebinder · Cited by 254 · see citing works
Cao, D., Li, L., & Chan, W. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060842 · Cited by 203 · see citing works
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Geaghan, M. P., & Cairns, M. J. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.009 · Cited by 193 · see citing works
Emerging role of microRNAs in major depressive disorder: diagnosis and therapeutic implications
Dwivedi, Y. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.1/ydwivedi · Cited by 169 · see citing works
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Dalton, V. S., Kolshus, E., & McLoughlin, D. M. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.028 · Cited by 134 · see citing works
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Gururajan, A., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.02.011 · Cited by 134 · see citing works
Maffioletti, E., Tardito, D., Gennarelli, M., & Bocchio‐Chiavetto, L. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00075 · Cited by 121 · see citing works
Ma, K., Guo, L., Xu, A., Cui, S., & Wang, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159093 · Cited by 84 · see citing works
MicroRNAs in depression and suicide: Recent insights and future perspectives
Dwivedi, Y. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.07.075 · Cited by 77 · see citing works
Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease
Kocerha, J., Dwivedi, Y., & Brennand, K. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.30 · Cited by 76 · see citing works
Alural, B., Genç, Ş., & Haggarty, S. J. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.03.010 · Cited by 74 · see citing works
Is there Progress? An Overview of Selecting Biomarker Candidates for Major Depressive Disorder
Young, J. J., Silber, T., Bruno, D., Galatzer‐Levy, I. R., Pomara, N., & Marmar, C. R. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00072 · Cited by 70 · see citing works
Pathogenetic and therapeutic applications of microRNAs in major depressive disorder
Dwivedi, Y. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.02.003 · Cited by 70 · see citing works
microRNAs and the regulation of neuronal plasticity under stress conditions
Schouten, M., Aschrafi, A., Bielefeld, P., Doxakis, E., & Fitzsimons, C. P. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.065 · Cited by 65 · see citing works
Zheng, D., Sabbagh, J. J., Blair, L. J., Darling, A. L., Wen, X., & Dickey, C. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.727941 · Cited by 61 · see citing works
Protein Translation and Psychiatric Disorders
Laguesse, S., & Dorit Ron, A. (2019) · The Neuroscientist · doi:10.1177/1073858419853236 · Cited by 59 · see citing works
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Obrietan, K. H., & Hansen, K. F. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s34811 · Cited by 53 · see citing works
An overview of the neurobiology of suicidal behaviors as one meta-system
Sokolowski, M., Wasserman, J., & Wasserman, D. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.101 · Cited by 50 · see citing works
Gao, G., Zhang, S., Wang, L., Lin, J., Qi, H., Zhu, J., Du, L., & Chu, M. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c06292 · Cited by 47 · see citing works
Self-citationSUMOylation at K707of DGCR8 controls direct function of primary microRNA
Zhu, C., Chen, C., Huang, J. J., Zhang, H., Zhao, X., Deng, R., Dou, J., Jin, H. Z., Chen, R., Xu, M., et al. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv741 · Cited by 45 · see citing works
Heterogeneity and Individuality: microRNAs in Mental Disorders
Hommers, L. G., Domschke, K., & Deckert, J. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-014-1338-4 · Cited by 45 · see citing works
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Kolshus, E., Dalton, V. S., Ryan, K. M., & McLoughlin, D. M. (2013) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12191 · Cited by 44 · see citing works
Zu, Y., Ban, J., Xia, Z., Wang, J., Cai, Y., Wei, P., & Sun, W. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.12.001 · Cited by 39 · see citing works
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Lopizzo, N., Zonca, V., Cattane, N., Pariante, C. M., & Cattaneo, A. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02048-2 · Cited by 37 · see citing works
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Tardito, D., Mallei, A., & Popoli, M. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.749237 · Cited by 37 · see citing works
Mulligan, M. K., DuBose, C., Yue, J., Miles, M. F., Lu, L., & Hamre, K. M. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00126 · Cited by 33 · see citing works
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Zhu, J., Chen, Z., Tian, J., Meng, Z., Ju, M., Wu, G.-C., & Tian, Z. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.2981 · Cited by 30 · see citing works
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Bame, M., McInnis, M. G., & O’Shea, K. S. (2020) · Stem Cells and Development · doi:10.1089/scd.2020.0046 · Cited by 24 · see citing works
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Gedik, H., Erdal, M. E., Yılmaz, Ş. G., Şengül, C., Şengül, C. B., & Herken, H. (2014) · DNA and Cell Biology · doi:10.1089/dna.2014.2549 · Cited by 15 · see citing works
The potential of microRNAs as putative biomarkers in major depressive disorder and suicidal behavior
Serafini, G., Trabucco, A., Corsini, G. P., Escelsior, A., Amerio, A., Aguglia, A., Nasrallah, H. A., & Amore, M. (2021) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2021.100035 · Cited by 14 · see citing works
Zhang, X.-L., Huo, Q., Sun, W., Zhang, C., Wu, Z., Xing, B., & Li, Q. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8929 · Cited by 11 · see citing works
Fawzy, M. S., Toraih, E. A., Alelwani, W., Kattan, S. W., Alnajeebi, A. M., & Hassan, R. (2020) · PubMed Central · Cited by 9 · see citing works
Ryu, C. S., Kim, Y. R., Kim, J. O., An, H. J., Cho, S. H., Ahn, E. H., Kim, J. H., Lee, W. S., & Kim, N. K. (2019) · Bioscience Reports · doi:10.1042/bsr20190342 · Cited by 8 · see citing works
Dobrijević, Z., Matijašević, S., Savić-Pavićević, D., & Brajušković, G. (2020) · Pathology, Research and Practice · doi:10.1016/j.prp.2020.152906 · Cited by 5 · see citing works
Song, H., Sun, X., Niu, W., Zhang, Q., Zhang, L.-Y., & Zhong, A. (2022) · The European Journal of Psychiatry · doi:10.1016/j.ejpsy.2022.09.005 · Cited by 5 · see citing works
Self-citationAssociation of Polymorphic Variants in Argonaute Genes with Depression Risk in a Polish Population
Kowalczyk, M., Kowalczyk, E., Galita, G., Majsterek, I., Talarowska, M. E., Popławski, T., Kwiatkowski, P. A., Lichota, A., & Sienkiewicz, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810586 · Cited by 5 · see citing works
Saba, R., & Booth, S. A. (2013) · Future Neurology · doi:10.2217/fnl.13.25 · Cited by 3 · see citing works
Epigenetic biomarkers in neuropsychiatric disorders
Lin, C.-C., & Huang, T. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800226-1.00003-4 · Cited by 3 · see citing works
Mapping of Nervous System Diseases via MicroRNAs
(2016) · CRC Press eBooks · doi:10.1201/b19229 · Cited by 3 · see citing works
Association between Mir-17-92 gene promoter polymorphisms and depression in a Chinese population
Liang, P., Yang, X., Long, R., Li, Y., Wang, Z., Yang, P., & Liang, Y. (2024) · BMC Medical Genomics · doi:10.1186/s12920-024-01894-8 · Cited by 2 · see citing works
Small RNA Dysregulation in Neurocognitive and Neuropsychiatric Disorders
Geaghan, M. P., & Cairns, M. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804402-5.00013-3 · Cited by 2 · see citing works
Emerging role of microRNAs as novel targets of antidepressants
Manoharan, A., & Paul, A. (2021) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2021.102906 · Cited by 2 · see citing works
In vitro estrogen synthesis by ovaries of high and low mammary tumor strains of mice.
Hollander, N., & Hollander, V. P. (1959) · PubMed · Cited by 2 · see citing works
Kowalczyk, M., Kowalczyk, E., Gogolewska, M., Skrzypek, M., Talarowska, M. E., Majsterek, I., Popławski, T., Kwiatkowski, P. A., & Sienkiewicz, M. (2022) · PeerJ · doi:10.7717/peerj.14317 · Cited by 1 · see citing works
Abdel-Ghany, W. A., Emam, M., EL-Nagar, U. A., Helmy, R., Korayem, O. H., & Hassan, N. M. (2021) · Open Access Macedonian Journal of Medical Sciences · doi:10.3889/oamjms.2021.6160 · Cited by 1 · see citing works
Schouten, M. (2015) · UvA-DARE (University of Amsterdam)
The epigenetics of brain aging and psychiatric disorders
Gong, H., & Xu, X. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800226-1.00008-3
Goff, A. C. (2021) · DigitalGeorgetown (Georgetown University Library)
microRNA Function and Dysregulation in Depression and Suicide
Dwivedi, Y. (2014) · Springer eBooks · doi:10.1007/978-3-319-09964-4_17
- Authors
- He, Y., Zhou, Y., Xi, Q., Cui, H., Luo, T., Song, H., Nie, X., Wang, L., & Ying, B.
- Affiliations
- Sichuan University (CN)
- Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, P.R. China.
- Venue
- DNA and Cell Biology
- Publisher
- SAGE Publications
- Published
- 2012-09
- Volume
- 31
- Issue
- 9
- Pages
- 1499-1506
- ISSN
- 1044-5498 (ISSN-L)
- 1557-7430
- OpenAlex
- W1993878767
- Cited by
- 52
- References
- 33
- Citations by year
- 2024: 1 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 9 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 2
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- DNA and Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- depression, microRNA processing, DGCR8, AGO1, GEMIN4, single nucleotide polymorphisms, genetic susceptibility, suicidality, antidepressant response, depression recurrence, microRNA biogenesis
- MeSH terms
- Adult, Depressive Disorder, Female, Humans, Male, Middle Aged, Proteins, RNA Processing, Post-Transcriptional, Case-Control Studies, RNA-Binding Proteins, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, MicroRNAs, Eukaryotic Initiation Factors, SMN Complex Proteins, Argonaute Proteins
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