The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Therapeutic Potential of Multipotent Mesenchymal Stromal Cells and Their Extracellular Vesicles
Abstract
The therapeutic potential of mesenchymal stromal cells (MSCs) is evident by the number of new and ongoing trials targeting an impressive variety of conditions. In bone and cartilage repair, MSCs are expected to replace the damaged tissue, while in other therapies they modulate a therapeutic response by the secretion of bioactive molecules. MSCs possess a phenotypic plasticity and harbor an arsenal of bioactive molecules that can be released upon sensing signals in the local milieu either directly or packaged in extracellular vesicles (EVs). The reported paracrine effects comprise many of the important functions of MSCs, including supporting hematopoietic stem cells in the bone marrow, promoting angiogenesis, and modulating the immune system. The major drawback in MSC therapy is the incomplete understanding of cell fate following systemic administration as well as the mechanisms by which these cells correct disease. In this review we discuss what is known about MSC engraftment, hemocompatibility, and immunomodulation, as well as the potential of bringing the MSC-EV field toward a clinical translation.
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Mesenchymal Stem/Stromal Cells (MSCs): Role as Guardians of Inflammation
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Cited by
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper
Lener, T., Gimona, M., Aigner, L., Börger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,491
Self-citationCosenza, S., Toupet, K., Maumus, M., Luz-Crawford, P., Blanc-Brude, O., Jorgensen, C., & Noël, D. (2018) · Theranostics · doi:10.7150/thno.21072 · Cited by 490
Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine
Fais, S., O’Driscoll, L., Borras, F. E., Buzas, E., Camussi, G., Cappello, F., Carvalho, J., Cordeiro da Silva, A., Del Portillo, H., El Andaloussi, S., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b08015 · Cited by 481
Mesenchymal stromal/stem cell (MSC)-Derived exosomes in clinical trials
Lotfy, A., AboQuella, N. M., & Wang, H. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03287-7 · Cited by 482
Mesenchymal stem cell-derived exosomes for clinical use
Mendt, M., Rezvani, K., & Shpall, E. (2019) · Bone Marrow Transplantation · doi:10.1038/s41409-019-0616-z · Cited by 465
Metadata
- Authors
- Heldring, N., Mäger, I., Wood, M. J. A., Le Blanc, K., & Andaloussi, S. E. L.
- Venue
- Human Gene Therapy
- Publisher
- SAGE Publications
- Published
- 2015-08
- Volume
- 26
- Issue
- 8
- Pages
- 506-517
- ISSN
- 1043-0342 (ISSN-L)
- 1557-7422
- OpenAlex
- W1490526869
- Cited by
- 191
- References
- 12
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
