Cited by 57Pomegranate: compositions and health benefitsMedicinal Plants and NeuroprotectionAlzheimer's disease research and treatments

Punica granatum Protects Against Oxidative Stress in PC12 Cells and Oxidative Stress-Induced Alzheimer's Symptoms in Mice

Choi, Soo Jung, Lee, Ju-Hyun, Heo, Ho Jin, Cho, Hong Yon, Kim, Hye Kyung, Kim, Chang-Ju, Kim, Myeong Ok, Suh, Soo Hwan +1 more·2011·Journal of Medicinal Food

Abstract

Alzheimer's disease (AD) is a progressive degenerative brain disorder that is characterized by neuronal loss, neurofibrillary tangles, and the abnormal deposition of senile plaque and amyloid β peptide (Aβ). The brains of AD patients are under intense oxidative stress. The overproduction of Aβ leads to Aβ-associated free radical oxidative stress. In this study, the antioxidative and neuronal protective effects of Punica granatum extract were investigated against oxidative stress-induced cytotoxicity in PC12 cells. The ethanol extracts of P. granatum protected PC12 cells from hydrogen peroxide (H₂O₂-induced oxidative stress. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assays revealed a significant increase in cell viability when oxidatively stressed PC12 cells were treated with the P. granatum extract. To examine the effects of P. granatum on Aβ₁₋₄₂-induced learning and memory impairment in mice, in vivo behavioral tests were performed. Treatment with the extract of P. granatum increased step-through latency in mice injected with Aβ₁₋₄₂. The results of this study suggest that the ethanol extract of P. granatum mitigated H₂O₂-induced oxidative stress in PC12 cells. In addition, the extract inhibited neuronal cell death caused by Aβ-induced oxidative stress and Aβ-induced learning and memory deficiency.

Integrity signals

Registry

Crossref · 10.1089/jmf.2010.1452

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Juice and extracts from Punica granatum have shown neuroprotective effects in animal models, potentially by counteracting oxidative damage, minimizing inflammation of the brain and soluble Aβ42 and hippocampal amyloid deposition.

    “Likewise, juice and extracts from Punica granatum have also shown neuroprotective effects in animal models, potentially by counteracting oxidative damage, minimizing inflammation of the brain and soluble Aβ 42 and hippocampal amyloid deposition [182,183].”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Choi, S. J., Lee, J.-H., Heo, H. J., Cho, H. Y., Kim, H. K., Kim, C.-J., Kim, M. O., Suh, S. H., & Shin, D.-H.
Affiliations
  • North Carolina State University (US)
  • Korea University (KR)
  • Gyeongsang National University (KR)
  • Hanseo University (KR)
  • Kyung Hee University (KR)
Corresponding author
Shin, Dong-Hoon
Venue
Journal of Medicinal Food
Published
2011-07
Volume
14
Issue
7-8
Pages
695-701
ISSN
  • 1096-620X (ISSN-L)
  • 1557-7600
OpenAlex
W2000610936
Cited by
57
References
41
Citations by year
2026: 1 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 10 · 2021: 6 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 2
FWCI
3.25
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Medicinal Food (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Research Foundation of Korea
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Punica granatum, pomegranate extract, Alzheimer's disease, oxidative stress, amyloid-beta, hydrogen peroxide, PC12 cells, neuronal cell death, learning and memory impairment, neuroprotection, antioxidant activity
MeSH terms
Alzheimer Disease, Animals, Antioxidants, Cell Survival, Disease Models, Animal, Hydrogen Peroxide, Male, Memory, Mice, Inbred ICR, Neurons, Plant Extracts, Amyloid beta-Peptides, PC12 Cells, Oxidative Stress, Protective Agents, Lythraceae, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review