Effect of Lifestyle Intervention on Cardiometabolic Risk Factors in Overweight and Obese Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
Abstract
The effects of lifestyle interventions (LSIs) on cardiometabolic risk factors in women with polycystic ovary syndrome (PCOS) are controversial. We conducted a systematic review and meta-analysis to assess the effectiveness of LSI on cardiometabolic risk in women with PCOS. We reviewed five databases for randomized controlled trials (RCTs) published between 2012 and December 2016, evaluating the effect of LSI among adult, reproductive age group, overweight, and obese women with PCOS. Outcome measures included weight change, homeostatic model assessment-insulin resistance index (HOMA-IR), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL). A total of 564 studies were screened; 35 full text studies assessed for eligibility, 20 excluded with reasons, 15 included in the systematic review, and 9 studies from 8 RCTs included in a meta-analysis. LSI resulted in significant reduction in weight in sensitivity analyses [study 5 dietary arm as intervention: standardized mean difference (SMD) = −0.81 (95% confidence interval {CI} = −1.24 to −0.39); study 5 combination arm as intervention: SMD = −0.85 (95% CI = −1.26 to −0.45)], HOMA-IR overall [study 5 dietary arm: SMD = −1.46 (95% CI = −2.72 to −0.20); study 5 combination arm SMD = −1.50 (95% CI = −2.76 to −0.23)], and LDL overall [SMD = −1.06 (95% CI = −2.00 to −0.12)]. LSI was more beneficial than Metformin in decreasing LDL [SMD = −2.60 (95% CI = −5.15 to −0.05)] but similar to comparator group in terms of TC, TG, and HDL ( P > 0.05). Short-term LSI can effectively improve weight, insulin resistance, and lipid profile and could be recommended as first-line therapy in overweight and obese PCOS women to reduce cardiometabolic risk.
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The literature tends to only include overweight or obese individuals as study participants.
“the literature tends to only include overweight or obese individuals as study participants [18,39,43,47].”
From Moving beyond Weight: A Narrative Review of the Dietary and Lifestyle Management for Reducing Cardiometabolic Risk in Polycystic Ovary Syndrome (PCOS) (2023) · cites this paper as [47]
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- Authors
- Khatlani, K., Njike, V., & Costales, V. C.
- Affiliations
- Yale University (US)
- Corresponding author
- Khatlani, Khaula
- Venue
- Metabolic Syndrome and Related Disorders
- Publisher
- SAGE Publications
- Published
- 2019-12
- Volume
- 17
- Issue
- 10
- Pages
- 473-485
- ISSN
- 1540-4196 (ISSN-L)
- 1557-8518
- OpenAlex
- W2972318476
- Cited by
- 20
- References
- 42
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 4 · 2020: 1 · 2019: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolic Syndrome and Related Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- polycystic ovary syndrome, lifestyle intervention, cardiometabolic risk, obesity, overweight women, insulin resistance, HOMA-IR, lipid profile, LDL cholesterol, weight loss, dietary intervention, metformin comparison
- MeSH terms
- Cardiovascular Diseases, Female, Humans, Life Style, Metabolic Diseases, Obesity, Polycystic Ovary Syndrome, Risk Factors, Randomized Controlled Trials as Topic, Treatment Outcome, Risk Reduction Behavior, Overweight, Weight Reduction Programs
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