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ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells
Abstract
Stem cells have now been described in a variety of tissues, even in those where the cells' turn over rate is slow, such as the brain and the resting mammary gland. There is also accumulating evidence that tumors are derived from and are maintained by a rare population of dysregulated stem cells. However, discrepancies in the markers used and reported have slowed down the functional characterization of these somatic stem cells. To circumvent this challenging issue, universal stem cell markers with properties common to all stem cell types must be discovered and exploited. In line with this idea, the measurement of aldehyde dehydrogenase isoform 1 (ALDH1) activity shows promising potential as a universal marker for the identification and isolation of stem cells from multiple sources. Herein, we review the available data reporting utilization of ALDH1 activity as a means to identify and isolate stem cells and cancer stem cells, with a special focus on the mammary gland and breast cancer.
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Citations
Cites
Prospective identification of tumorigenic breast cancer cells
Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,370
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,439
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1
Till, J. E., & McCulloch, E. A. (2011) · Radiation Research · doi:10.1667/rrxx28.1 · Cited by 4,036
Ginestier, C., Hur, M. H., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., Jacquemier, J., Viens, P., Kleer, C. G., Liu, S., et al. (2007) · Cell Stem Cell · doi:10.1016/j.stem.2007.08.014 · Cited by 4,012
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
Till, J. E., & McCulloch, E. A. (1961) · Radiation Research · doi:10.2307/3570892 · Cited by 3,708
Identification of Pancreatic Cancer Stem Cells
Li, C., Heidt, D. G., Dalerba, P., Burant, C. F., Zhang, L., Adsay, V., Wicha, M., Clarke, M. F., & Simeone, D. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2030 · Cited by 3,339
Proliferation, cell cycle and apoptosis in cancer
Evan, G. I., & Vousden, K. H. (2001) · Nature · doi:10.1038/35077213 · Cited by 2,724
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
Dontu, G., Abdallah, W. M., Foley, J. M., Jackson, K. W., Clarke, M. F., Kawamura, M. J., & Wicha, M. S. (2003) · Genes & Development · doi:10.1101/gad.1061803 · Cited by 2,406
Generation of a functional mammary gland from a single stem cell
Shackleton, M., Vaillant, F., Simpson, K. J., Stingl, J., Smyth, G. K., Asselin-Labat, M.-L., Wu, L., Lindeman, G. J., & Visvader, J. E. (2006) · Nature · doi:10.1038/nature04372 · Cited by 2,005
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871
Primary Bioassay of Human Tumor Stem Cells
Hamburger, A. W., & Salmon, S. E. (1977) · Science · doi:10.1126/science.560061 · Cited by 1,643
Purification and unique properties of mammary epithelial stem cells
Stingl, J., Eirew, P., Ricketson, I., Shackleton, M., Vaillant, F., Choi, D., Li, H. I., & Eaves, C. J. (2006) · Nature · doi:10.1038/nature04496 · Cited by 1,559
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452
The Hedgehog and Wnt signalling pathways in cancer
Taipale, J., & Beachy, P. A. (2001) · Nature · doi:10.1038/35077219 · Cited by 1,393
Cancer stem cells: an old idea–a paradigm shift
Wicha, M. S., Liu, S., & Dontu, G. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3153 · Cited by 1,378
Reynolds, B. A., & Weiss, S. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0090 · Cited by 1,360
Tissue repair and stem cell renewal in carcinogenesis
Beachy, P. A., Karhadkar, S. S., & Berman, D. M. (2004) · Nature · doi:10.1038/nature03100 · Cited by 1,208
Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b
Kroon, E., Krosl, J., Thorsteinsdottir, U., Baban, S., Buchberg, A. M., & Sauvageau, G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.13.3714 · Cited by 640
Stem cell origin of cancer and differentiation therapy
Sell, S. (2004) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2004.04.007 · Cited by 638
Stem cells in normal breast development and breast cancer
Dontu, G., Al‐Hajj, M., Abdallah, W. M., Clarke, M. F., & Wicha, M. S. (2003) · Cell Proliferation · doi:10.1046/j.1365-2184.36.s.1.6.x · Cited by 578
Therapeutic implications of cancer stem cells
Al-Hajj, M., Becker, M. W., Wicha, M., Weissman, I., & Clarke, M. F. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.11.007 · Cited by 566
An entire functional mammary gland may comprise the progeny from a single cell
Kordon, E. C., & Smith, G. H. (1998) · Development · doi:10.1242/dev.125.10.1921 · Cited by 558
Storms, R. W., Trujillo, A. P., Springer, J. B., Shah, L., Colvin, O. M., Ludeman, S. M., & Smith, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9118 · Cited by 551
The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells
Ma, I., & Allan, A. L. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-010-9208-4 · Cited by 539
Stem cells in normal breast development and breast cancer
Wicha, M., Dontu, G., Al-Hajj, M., & Clarke, M. (2003) · Breast Cancer Research · doi:10.1186/bcr709 · Cited by 537
Is there a neural stem cell in the mammalian forebrain?
Weiss, S., Reynolds, B. A., Vescovi, A. L., Morshead, C., Craig, C. G., & der Kooy, D. V. (1996) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10035-7 · Cited by 528
Clonal origin of chronic myelocytic leukemia in man.
Fialkow, P. J., Gartler, S. M., & Yoshida, A. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.4.1468 · Cited by 525
Sca-1pos Cells in the Mouse Mammary Gland Represent an Enriched Progenitor Cell Population
Welm, B. E., Tepera, S. B., Venezia, T., Graubert, T. A., Rosen, J. M., & Goodell, M. A. (2002) · Developmental Biology · doi:10.1006/dbio.2002.0625 · Cited by 520
Chute, J. P., Muramoto, G. G., Whitesides, J., Colvin, M., Safi, R., Chao, N. J., & McDonnell, D. P. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603806103 · Cited by 467
Mammary stem cells, self-renewal pathways, and carcinogenesis
Liu, S., Dontu, G., & Wicha, M. S. (2005) · Breast Cancer Research · doi:10.1186/bcr1021 · Cited by 446
A Quantitative Assay for the Number of Murine Lymphoma Cells capable of Proliferation in vivo
BRUCE, W. R., & VAN DER GAAG, H. (1963) · Nature · doi:10.1038/199079a0 · Cited by 398
Gudjonsson, T., Villadsen, R., Nielsen, H. L., Rønnov-Jessen, L., Bissell, M. J., & Petersen, O. W. (2002) · Genes & Development · doi:10.1101/gad.952602 · Cited by 390
Hess, D. A., Meyerrose, T. E., Wirthlin, L., Craft, T. P., Herrbrich, P. E., Creer, M. H., & Nolta, J. A. (2004) · Blood · doi:10.1182/blood-2004-02-0448 · Cited by 351
Thorsteinsdottir, U., Mamo, A., Kroon, E., Jerome, L., Bijl, J., Lawrence, H. J., Humphries, K., & Sauvageau, G. (2002) · Blood · doi:10.1182/blood.v99.1.121 · Cited by 347
Cohnheim, J. (1867) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf02968135 · Cited by 335
Assessment of aldehyde dehydrogenase in viable cells
Jones, R., Barber, J., Vala, M., Collector, M., Kaufmann, S., Ludeman, S., Colvin, O., & Hilton, J. (1995) · Blood · doi:10.1182/blood.v85.10.2742.bloodjournal85102742 · Cited by 333
Thorsteinsdottir, U., Sauvageau, G., Hough, M. R., Dragowska, W., Lansdorp, P. M., Lawrence, H. J., Largman, C., & Humphries, R. K. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.1.495 · Cited by 325
A putative human breast stem cell population is enriched for steroid receptor-positive cells
Clarke, R. B., Spence, K., Anderson, E., Howell, A., Okano, H., & Potten, C. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.07.044 · Cited by 321
Dissociation of estrogen receptor expression and in vivo stem cell activity in the mammary gland
Sleeman, K. E., Kendrick, H., Robertson, D., Isacke, C. M., Ashworth, A., & Smalley, M. J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200604065 · Cited by 321
Pearce, D. J., Taussig, D., Simpson, C., Allen, K., Rohatiner, A. Z., Lister, T. A., & Bonnet, D. (2005) · STEM CELLS · doi:10.1634/stemcells.2004-0292 · Cited by 309
Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells
Kastan, M., Schlaffer, E., Russo, J., Colvin, O., Civin, C., & Hilton, J. (1990) · Blood · doi:10.1182/blood.v75.10.1947.1947 · Cited by 307
SP analysis may be used to identify cancer stem cell populations
Hadnagy, A., Gaboury, L., Beaulieu, R., & Balicki, D. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.08.030 · Cited by 306
Self-citationSteroid Hormone Receptor Status of Mouse Mammary Stem Cells
Asselin-Labat, M.-L., Shackleton, M., Stingl, J., Vaillant, F., Forrest, N. C., Eaves, C. J., Visvader, J. E., & Lindeman, G. J. (2006) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djj267 · Cited by 293
Functional and molecular characterisation of mammary side population cells
Alvi, A. J., Clayton, H., Joshi, C., Enver, T., Ashworth, A., Vivanco, M. A. M., Dale, T. C., & Smalley, M. J. (2002) · Breast Cancer Research · doi:10.1186/bcr547 · Cited by 289
Corti, S., Locatelli, F., Papadimitriou, D., Donadoni, C., Salani, S., Del Bo, R., Strazzer, S., Bresolin, N., & Comi, G. P. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0217 · Cited by 280
Human aldehyde dehydrogenases: Potential pathological, pharmacological, and toxicological impact
Sládek, N. E. (2003) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.10057 · Cited by 266
Armstrong, L., Stojkovic, M., Dimmick, I., Ahmad, S., Stojkovic, P., Hole, N., & Lako, M. (2004) · STEM CELLS · doi:10.1634/stemcells.2004-0170 · Cited by 250
Sládek, N. E., Kollander, R., Sreerama, L., & Kiang, D. T. (2002) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-001-0412-4 · Cited by 212
Multiple niches for Notch in cancer: context is everything
Weng, A. P., & Aster, J. C. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.11.004 · Cited by 210
Purton, L. E., Dworkin, S., Olsen, G. H., Walkley, C. R., Fabb, S. A., Collins, S. J., & Chambon, P. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052105 · Cited by 198
Characterization of mouse lymphohematopoietic stem cells lacking spleen colony-forming activity
Jones, R., Collector, M., Barber, J., Vala, M., Fackler, M., May, W., Griffin, C., Hawkins, A., Zehnbauer, B., Hilton, J., et al. (1996) · Blood · doi:10.1182/blood.v88.2.487.bloodjournal882487 · Cited by 185
Membrane properties of rat embryonic multipotent neural stem cells
Cai, J., Cheng, A., Luo, Y., Lu, C., Mattson, M. P., Rao, M. S., & Furukawa, K. (2004) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02184.x · Cited by 176
Growth and differentiation of progenitor/stem cells derived from the human mammary gland
Clayton, H., Titley, I., & Vivanco, M. D. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.03.029 · Cited by 175
Cancer stem cell characteristics in retinoblastoma.
Seigel, G. M., Campbell, L. M., Narayan, M., & Gonzalez-Fernandez, F. (2005) · PubMed · Cited by 171
Cai, J., Weiss, M. L., & Rao, M. S. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.03.013 · Cited by 167
The Retinoic Acid Synthesis Gene ALDH1a2 Is a Candidate Tumor Suppressor in Prostate Cancer
Kim, H., Lapointe, J., Kaygusuz, G., Ong, D. E., Li, C., van de Rijn, M., Brooks, J. D., & Pollack, J. R. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4562 · Cited by 143
Nagano, M., Yamashita, T., Hamada, H., Ohneda, K., Kimura, K., Nakagawa, T., Shibuya, M., Yoshikawa, H., & Ohneda, O. (2007) · Blood · doi:10.1182/blood-2006-10-047092 · Cited by 135
Stem cells and cancer: an intimate relationship
Burkert, J., Wright, N., & Alison, M. R. (2006) · The Journal of Pathology · doi:10.1002/path.2016 · Cited by 134
Finding cancer stem cells: are aldehyde dehydrogenases fit for purpose?
Alison, M. R., Guppy, N., Lim, S. M. L., & Nicholson, L. J. (2010) · The Journal of Pathology · doi:10.1002/path.2772 · Cited by 131
Purton, L. E., Bernstein, I. D., & Collins, S. J. (2000) · Blood · doi:10.1182/blood.v95.2.470 · Cited by 131
Erratum to: Functional and molecular characterisation of mammary side population cells
Alvi, A. J., Clayton, H., Joshi, C., Enver, T., Ashworth, A., Vivanco, M. D., Dale, T. C., & Smalley, M. J. (2002) · Breast Cancer Research · doi:10.1186/bcr563 · Cited by 127
Cancer stem cells: a model in the making
Marotta, L. L. C., & Polyák, K. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2008.12.003 · Cited by 119
Characterization of cytosolic aldehyde dehydrogenase from cyclophosphamide resistant L1210 cells.
Russo, J. E., & Hilton, A. (1988) · PubMed · Cited by 118
Purton, L. E., Bernstein, I. D., & Collins, S. J. (1999) · Blood · doi:10.1182/blood.v94.2.483 · Cited by 115
Enzymology of ethanol and acetaldehyde metabolism in mammals.
Riveros‐Rosas, H., Julián‐Sánchez, A., & Pinã, E. (1997) · PubMed · Cited by 109
Growth characteristics of a mouse plasma cell tumor.
Bergsagel, D. E., & Valeriote, F. A. (1968) · PubMed · Cited by 108
The Mammary Gland “Side Population”: A Putative Stem/Progenitor Cell Marker?
Smalley, M. J., & Clarke, R. B. (2005) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-005-2539-0 · Cited by 107
Estes, B. T., Wu, A. W., Storms, R. W., & Guilak, F. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20808 · Cited by 105
Ferrell, C. M., Dorsam, S. T., Ohta, H., Humphries, R. K., Derynck, M. K., Haqq, C., Largman, C., & Lawrence, H. J. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0198 · Cited by 84
Isolation and characterization of human mammary stem cells
Clarke, R. B. (2005) · Cell Proliferation · doi:10.1111/j.1365-2184.2005.00357.x · Cited by 71
Labrecque, J., Bhat, P. V., & Lacroix, A. (1993) · Biochemistry and Cell Biology · doi:10.1139/o93-013 · Cited by 63
Transcriptional Profiling of Mammary Gland Side Population Cells
Behbod, F., Xian, W., Shaw, C. A., Hilsenbeck, S. G., Tsimelzon, A. I., & Rosen, J. M. (2005) · Stem Cells · doi:10.1634/stemcells.2005-0375 · Cited by 57
Yoon, M., Madden, M. C., & Barton, H. A. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfj045 · Cited by 46
Purton, L. E. (2007) · PPAR Research · doi:10.1155/2007/87934 · Cited by 36
Cancer stem cells and telomerase as potential biomarkers in veterinary oncology
Pang, L. Y., & Argyle, D. J. (2010) · The Veterinary Journal · doi:10.1016/j.tvjl.2010.04.008 · Cited by 35
Neoplastic stem cells: Current concepts and clinical perspectives
Schulenburg, A., Brämswig, K. H., Herrmann, H., Karlic, H., Mirkina, I. I., Hubmann, R., Laffer, S., Marian, B., Shehata, M. M., Krepler, C., et al. (2010) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2010.01.001 · Cited by 33
Breast Cancer Biology: The Multifaceted Roles of Mesenchymal Stem Cells
Patel, S. A., Heinrich, A. C., Reddy, B. Y., Srinivas, B. K., Heidaran, N., & Rameshwar, P. (2008) · Journal of Oncology · doi:10.1155/2008/425895 · Cited by 21
Maintenance of Cell Type Diversification in the Human Breast
Fridriksdottir, A. J., Villadsen, R., Guðjónsson, Þ., & PETERSEN, O. W. (2005) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-005-2541-6 · Cited by 18
Recent advances in the development of novel anti‐cancer drugs targeting cancer stem/progenitor cells
Mimeault, M., & Batra, S. K. (2008) · Drug Development Research · doi:10.1002/ddr.20273 · Cited by 17
Cytomics and cellular informatics – coping with asymmetry and heterogeneity in biological systems
Smith, P. J., Khan, I., & Errington, R. J. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2008.11.012 · Cited by 14
Cancer stem cells in urologic cancers
Gedye, C. A., Davidson, A., Elmes, M. R., Cebon, J. S., Bolton, D. M., & Davis, I. D. (2009) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2009.06.010 · Cited by 8
A Quest for Initiating Cells of Head and Neck Cancer and Their Treatment
Chen, C., Köberle, B., Kaufmann, A. M., & Albers, A. E. (2010) · Cancers · doi:10.3390/cancers2031528 · Cited by 7
Cancer Stem Cell Side Populations
Balicki, D., & Beaulieu, R. (2008) · Wiley eBooks · doi:10.1002/9780470391594.ch4 · Cited by 3
Self-citation
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Ren, J., Ding, L., Zhang, D., Shi, G., Xu, Q., Shen, S., Wang, Y., Wang, T., & Hou, Y. (2018) · Theranostics · doi:10.7150/thno.25541 · Cited by 698
van den Hoogen, C., van der Horst, G., Cheung, H., Buijs, J. T., Lippitt, J. M., Guzmán-Ramírez, N., Hamdy, F. C., Eaton, C. L., Thalmann, G. N., Cecchini, M. G., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3806 · Cited by 398
Cellular and molecular pathways of renal repair after acute kidney injury
Kumar, S. (2018) · Kidney International · doi:10.1016/j.kint.2017.07.030 · Cited by 271
Isolation and Characterization of Progenitor-Like Cells from Human Renal Proximal Tubules
Lindgren, D., Boström, A.-K., Nilsson, K., Hansson, J., Sjölund, J., Möller, C., Jirström, K., Nilsson, E., Landberg, G., Axelson, H., et al. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2010.10.026 · Cited by 264
Sun, R., Liu, Y., Li, S.-Y., Shen, S., Du, X.-J., Xu, C.-F., Cao, Z.-T., Bao, Y., Zhu, Y.-H., Li, Y.-P., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.10.018 · Cited by 172
Metadata
- Authors
- Douville, J., Beaulieu, R., & Balicki, D.
- Venue
- Stem Cells and Development
- Publisher
- SAGE Publications
- Published
- 2009-01
- Volume
- 18
- Issue
- 1
- Pages
- 17-26
- ISSN
- 1525-8165 (ISSN-L)
- 1547-3287
- 1557-8534
- OpenAlex
- W2036876826
- Cited by
- 356
- References
- 84
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
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