MicroRNA-21 Targets Sprouty2 and Promotes Cellular Outgrowths

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

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A microRNA expression signature of human solid tumors defines cancer gene targets

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Silencing of microRNAs in vivo with ‘antagomirs’

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Identification of tissue-specific microRNAs from mouse

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MicroRNA-21 Regulates Expression of the PTEN Tumor Suppressor Gene in Human Hepatocellular Cancer

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MicroRNA-21 Is an Antiapoptotic Factor in Human Glioblastoma Cells

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Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

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MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

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MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer

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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

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MicroRNAs in Development and Disease

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miR‐21: a small multi‐faceted RNA

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MicroRNA as Biomarkers and Diagnostics

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MicroRNA sponges: Progress and possibilities

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Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21

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Regulation and function of miRNA-21 in health and disease

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MicroRNAs Add a New Dimension to Cardiovascular Disease

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Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes

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MicroRNA-21 Is Up-Regulated in Allergic Airway Inflammation and Regulates IL-12p35 Expression

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The Art of MicroRNA Research

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Emerging Roles for Natural MicroRNA Sponges

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miR-21 as a key regulator of oncogenic processes

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Non-coding RNAs in cardiovascular diseases: diagnostic and therapeutic perspectives

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Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

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Apoptosis and the target genes of microRNA-21

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Toward MicroRNA–Based Therapeutics for Heart Disease

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MicroRNA Expression in Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus: Associations with Survival

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MicroRNA-21 protects against the H2O2-induced injury on cardiac myocytes via its target gene PDCD4

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MicroRNA-21 in Cardiovascular Disease

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MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand

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The role of microRNAs in colorectal cancer

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microRNA-21 negatively regulates Cdc25A and cell cycle progression in colon cancer cells

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microRNAs: Master Regulators as Potential Therapeutics in Cancer

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Epigenetics of Colorectal Cancer

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High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients

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High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-β1

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Tumor necrosis factor α suppresses the mesenchymal stem cell osteogenesis promoter miR-21 in estrogen deficiency–induced osteoporosis

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miRNA Therapeutics: A New Class of Drugs with Potential Therapeutic Applications in the Heart

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MicroRNAs in neurodegenerative diseases and their therapeutic potential

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MicroRNA-21 Regulates Astrocytic Response Following Spinal Cord Injury

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MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration

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Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis

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Milk is not just food but most likely a genetic transfection system activating mTORC1 signaling for postnatal growth

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Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer–cell lymphoma/leukemia

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MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells

Xiong, B., Cheng, Y., Ma, L., & ZHANG, C. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1707 · Cited by 207

miR-204-5p Inhibits Proliferation and Invasion and Enhances Chemotherapeutic Sensitivity of Colorectal Cancer Cells by Downregulating RAB22A

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Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

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MicroRNAs as mediators and therapeutic targets in chronic kidney disease

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The Association of MicroRNA Expression with Prognosis and Progression in Early-Stage, Non–Small Cell Lung Adenocarcinoma: A Retrospective Analysis of Three Cohorts

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miR-27a regulates the growth, colony formation and migration of pancreatic cancer cells by targeting Sprouty2

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The microRNA network and tumor metastasis

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MicroRNA miR-21 Regulates the Metastatic Behavior of B16 Melanoma Cells

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microRNA: Emerging therapeutic targets in acute ischemic diseases

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Locked Nucleic Acid In situ Hybridization Analysis of miR-21 Expression during Colorectal Cancer Development

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MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression

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miR‐21 modulates the ERK–MAPK signaling pathway by regulating SPRY2 expression during human mesenchymal stem cell differentiation

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Distinct Roles of MicroRNA-1 and -499 in Ventricular Specification and Functional Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes

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MicroRNAs and cardiovascular diseases

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Axotomy-Induced miR-21 Promotes Axon Growth in Adult Dorsal Root Ganglion Neurons

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Epigenetic Associations between lncRNA/circRNA and miRNA in Hepatocellular Carcinoma

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Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury

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microRNAs in heart disease: putative novel therapeutic targets?

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MicroRNA-Based Therapeutics for Cancer

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Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer

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The developing story of Sprouty and cancer

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Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer

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Downregulation of Spry2 by miR-21 triggers malignancy in human gliomas

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MicroRNAs in control of cardiac hypertrophy

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Involvement of microRNA-21 in mediating chemo-resistance to docetaxel in androgen-independent prostate cancer PC3 cells

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miR-21 promotes migration and invasion by the miR-21-PDCD4-AP-1 feedback loop in human hepatocellular carcinoma

Wang, Z. (2012) · Oncology Reports · doi:10.3892/or.2012.1682 · Cited by 154

MicroRNAs (miRNAs) in cancer invasion and metastasis: therapeutic approaches based on metastasis-related miRNAs

Aigner, A. M. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0716-0 · Cited by 147

MicroRNAs and prostate cancer

Coppola, V., Maria, R. D., & Bonci, D. (2009) · Endocrine Related Cancer · doi:10.1677/erc-09-0172 · Cited by 152

Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target

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MicroRNAs and atrial fibrillation: mechanisms and translational potential

Luo, X., Yang, B., & Nattel, S. (2014) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2014.178 · Cited by 142

Regulation of miRNA-21 by reactive oxygen species-activated ERK/NF-κB in arsenite-induced cell transformation

Ling, M., Li, Y., Xu, Y., Pang, Y., Shen, L., Jiang, R., Zhao, Y., Yang, X., Zhang, J., Zhou, J., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.020 · Cited by 137

MicroRNAs are dynamically regulated in hypertrophic hearts, and miR‐199a is essential for the maintenance of cell size in cardiomyocytes

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MicroRNAs in skin and wound healing

Banerjee, J., Chan, Y. C., & Sen, C. K. (2010) · Physiological Genomics · doi:10.1152/physiolgenomics.00157.2010 · Cited by 139

MicroRNA-95 Promotes Cell Proliferation and Targets Sorting Nexin 1 in Human Colorectal Carcinoma

Huang, Z., Huang, S., Wang, Q., Liang, L., Ni, S., Wang, L., Sheng, W., He, X., & Du, X. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3032 · Cited by 134

microRNA122-regulated transgene expression increases specificity of cardiac gene transfer upon intravenous delivery of AAV9 vectors

Geisler, A., Jungmann, A., Kurreck, J., Poller, W. C., Katus, H. A., Vetter, R., Fechner, H., & Müller, O. J. (2010) · Gene Therapy · doi:10.1038/gt.2010.141 · Cited by 135

Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4

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MiR-21: an environmental driver of malignant melanoma?

Melnik, B. C. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-015-0570-5 · Cited by 131

MicroRNAs in colorectal cancer metastasis

de Krijger, I., Mekenkamp, L. J., Punt, C. J. A., & Nagtegaal, I. D. (2011) · The Journal of Pathology · doi:10.1002/path.2922 · Cited by 126

miRNAs: Key Players in Neurodegenerative Disorders and Epilepsy

Karnati, H. K., Panigrahi, M. K., Gutti, R. K., Greig, N. H., & Tamargo, I. A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150395 · Cited by 126

MicroRNA Regulation and Cardiac Calcium Signaling

Harada, M., Luo, X., Murohara, T., Yang, B., Dobrev, D., & Nattel, S. (2014) · Circulation Research · doi:10.1161/circresaha.114.301798 · Cited by 126

miR-21 in Human Cardiomyopathies

Surina, Fontanella, R. A., Scisciola, L., Marfella, R., Paolisso, G., & Barbieri, M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.767064 · Cited by 123

MicroRNAs: Clinical Relevance in Colorectal Cancer

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Micro‐RNA‐21 regulates TGF‐β‐induced myofibroblast differentiation by targeting PDCD4 in tumor‐stroma interaction

Yao, Q., Cao, S., Li, C., Mengesha, A., Kong, B., & Wei, M. (2010) · International Journal of Cancer · doi:10.1002/ijc.25506 · Cited by 121

MicroRNAs in Heart Failure

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miR-27b controls venous specification and tip cell fate

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Micro‐RNAs and breast cancer

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MicroRNAs as novel targets and tools in cancer therapy

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Diagnostic, prognostic and therapeutic implications of microRNAs in urologic tumors

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Intermolecular Interactions of Sprouty Proteins and Their Implications in Development and Disease

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MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas

Chen, D., Cabay, R. J., Jin, Y., Wang, A., Lu, Y., Shah-Khan, M., & Zhou, X. C. (2013) · Journal of Oral and Maxillofacial Research · doi:10.5037/jomr.2013.4102 · Cited by 113

microRNA-21 promotes cardiac fibrosis and development of heart failure with preserved left ventricular ejection fraction by up-regulating Bcl-2.

Dong, S., Ma, W., Hao, B., Hu, F., Yan, L., Yan, X., Wang, Y., Chen, Z., & Wang, Z. (2014) · Europe PMC (PubMed Central) · Cited by 110

MicroRNAs as Regulators of Signal Transduction in Urological Tumors

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microRNA Therapeutics in Cardiovascular Disease Models

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Milk—A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation

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Considering Exosomal miR-21 as a Biomarker for Cancer

Shi, J. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5040042 · Cited by 113

Mechanisms shaping the role of ERK1/2 in cellular sene scence (Review)

Zou, J., Lei, T., Guo, P., Yu, J., Xu, Q., Luo, Y., Ke, R., & Huang, D. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9712 · Cited by 113

BTG2 loss and miR-21 upregulation contribute to prostate cell transformation by inducing luminal markers expression and epithelial–mesenchymal transition

Coppola, V., Musumeci, M., Patrizii, M., Cannistraci, A., Addario, A., Maugeri‐Saccà, M., Biffoni, M., Francescangeli, F., Cordenonsi, M., Piccolo, S., et al. (2012) · Oncogene · doi:10.1038/onc.2012.194 · Cited by 109

MicroRNAs in the cardiovascular system

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microRNAs with prognostic significance in pancreatic ductal adenocarcinoma: A meta-analysis

Frampton, A. E., Krell, J., Jamieson, N. B., Gall, T., Giovannetti, E., Funel, N., Prado, M. M., Krell, D., Habib, N., Castellano, L., et al. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.04.006 · Cited by 106

miRNA cassettes in viral vectors: Problems and solutions

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Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heart

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The role of microRNAs in coronary artery disease: From pathophysiology to diagnosis and treatment

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Regulation of cancer metastasis by cell-free miRNAs

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MiR-21 Expression in the Tumor Stroma of Oral Squamous Cell Carcinoma: An Independent Biomarker of Disease Free Survival

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Abstract 342: Upregulation Of Mir-21 During Cardiac Hypertrophy Induces Down-regulation Of An Inhibitor Of The Ras-MAPK Pathway, Sprouty 2

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Interplay between microRNA-21 and Sprouty2 in non small cell lung cancer-derived cell lines

Vanas, V. (2012) · University of Vienna · doi:10.25365/thesis.22750

Sprouty keeps bowel kinases regular in colon cancer, while miR-21 targets Sprouty

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MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGF R2) in colon cancer cells

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Abstract 3550: Overexpression Of Mir-21 Delays The Onset Of Cardiac Failure

Sayed, D. H., He, M., Hong, C., Rane, S., Gao, S., & Abdellatif, M. (2008) · Circulation