Effects of two high-fat diets with different fatty acid compositions on glucose and lipid metabolism in healthy young women

Uusitupa, M; Schwab, U; Mäkimattila, S; Karhapää, P; Sarkkinen, E; Maliranta, H; Agren, J; Penttilä, I

doi:10.1093/ajcn/59.6.1310

Cited by 95Fatty Acid Research and HealthDiet, Metabolism, and DiseaseLipid metabolism and biosynthesis

Effects of two high-fat diets with different fatty acid compositions on glucose and lipid metabolism in healthy young women

Uusitupa, M, Schwab, U, Mäkimattila, S, Karhapää, P, Sarkkinen, E, Maliranta, H, Agren, J, Penttilä, I·1994·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/59.6.1310

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Abstract

Effects of two experimental diets with a relatively high fat content--one enriched with saturated fatty acids (SAFA-diet) and the other with a low content of erucic acid rapeseed oil and rich in monounsaturated fatty acids (MUFA-diet)--on glucose and lipid metabolism were examined in healthy young women. The study was carried out with a randomized, crossover study design with each diet lasting 3 wk and a 2-wk washout period between the experimental diets. Glucose area under the curve during the intravenous glucose tolerance test (glucose dose 300 mg/kg, plasma samples before glucose dose and at 10-min intervals for 90 min) was significantly lower and the glucose disappearance rate after a glucose injection tended to be steeper after the MUFA-diet than after the SAFA-diet. After the MUFA-diet serum total cholesterol was 21.6% lower and serum low-density-lipoprotein cholesterol 29.5% lower than after the SAFA-diet, but high-density-lipoprotein cholesterol did not differ between the diets. The results give suggestive evidence that the dietary fatty acid composition affects glucose tolerance of healthy subjects.

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Dietary supplementation with monounsaturated FAs improves insulin sensitivity and adipokine and lipid profiles in HF-fed mice and healthy young subjects.
“Dietary supplementation with monounsaturated FAs improves insulin sensitivity and adipokine and lipid profiles in the HF-fed mice and healthy young subjects (44, 47).”
From Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle (2012) · cites this paper as [44]

Quantitative Effects of Dietary Fat on Serum Cholesterol in Man
Hegsted, D. M., McGandy, R. B., Myers, M. L., & Stare, F. J. (1965) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/17.5.281 · Cited by 1,589 · see citing works
Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man.
Mattson, F. H., & Grundy, S. M. (1985) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34389-3 · Cited by 1,354 · see citing works
Dietary influences on serum lipids and lipoproteins.
Grundy, S. M., & Denke, M. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42625-2 · Cited by 1,044 · see citing works
Influence of Dietary Fat Composition on Development of Insulin Resistance in Rats: Relationship to Muscle Triglyceride and ω-3 Fatty Acids in Muscle Phospholipid
Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967 · see citing works
Effect of a Diet Enriched with Monounsaturated or Polyunsaturated Fatty Acids on Levels of Low-Density and High-Density Lipoprotein Cholesterol in Healthy Women and Men
Mensink, R. P., & Katan, M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908173210705 · Cited by 542 · see citing works
Serum cholesterol response to changes in the diet
Keys, A. B., Anderson, J. T., & Grande, F. (1965) · Metabolism · doi:10.1016/0026-0495(65)90003-x · Cited by 485 · see citing works
Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats
Storlien, L. H., James, D. E., Burleigh, K. M., Chisholm, D. J., & Kraegen, E. W. (1986) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1986.251.5.e576 · Cited by 458 · see citing works
Serum cholesterol response to changes in the diet
Keys, A. B., Anderson, J. T., & Grande, F. (1965) · Metabolism · doi:10.1016/0026-0495(65)90001-6 · Cited by 450 · see citing works
Diet and risk of clinical diabetes in women
Colditz, G. A., Manson, J., Stampfer, M. J., ROSNER, B. A., Willett, W. C., & Speizer, F. E. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.5.1018 · Cited by 428 · see citing works
Comparison of a High-Carbohydrate Diet with a High-Monounsaturated-Fat Diet in Patients with Non-Insulin-Dependent Diabetes Mellitus
Garg, A., Bonanome, A., Grundy, S. M., Zhang, Z.-J., & Unger, R. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198809293191304 · Cited by 394 · see citing works
Effects of diets rich in monounsaturated fatty acids on plasma lipoproteins—the Jerusalem Nutrition Study: high MUFAs vs high PUFAs
Berry, E., Eisenberg, S., Haratz, D., Friedlander, Y., Norman, Y., Kaufmann, N., & Stein, Y. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.4.899 · Cited by 334 · see citing works
Rapid separation of serum lipids for fatty acid analysis by a single aminopropyl column.
Agren, J., Julkunen, A., & Penttilä, I. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41345-8 · Cited by 229 · see citing works
Self-citation
Effect of the Membrane Lipid Environment on the Properties of Insulin Receptors
Ginsberg, B. H., Brown, T. J., Simon, I., & Spector, A. A. (1981) · Diabetes · doi:10.2337/diab.30.9.773 · Cited by 223 · see citing works
A high-monounsaturated-fat/low-carbohydrate diet improves peripheral insulin sensitivity in non-insulin-dependent diabetic patients
Parillo, M., Rivellese, A. A., Ciardullo, A. V., Capaldo, B., Giacco, A., Genovese, S., & Riccardi, G. (1992) · Metabolism · doi:10.1016/0026-0495(92)90111-m · Cited by 211 · see citing works
Decreased Insulin Binding, Glucose Transport, and Glucose Metabolism in Soleus Muscle of Rats Fed a High Fat Diet
Grundleger, M. L., & Thenen, S. W. (1982) · Diabetes · doi:10.2337/diab.31.3.232 · Cited by 157 · see citing works
Comparison of different analytical and precipitation methods for direct estimation of serum high-density lipoprotein cholesterol
Penttilä, I., Voutilainen, E., Laitinen, P. H., & Juutilainen, P. (1981) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365518109092057 · Cited by 157 · see citing works
Self-citation
Deterioration in Carbohydrate Metabolism and Lipoprotein Changes Induced by Modern, High Fat Diet in Pima Indians and Caucasians
Swinburn, B. A., Boyce, V., Bergman, R. N., Howard, B. V., & Bogardus, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-1-156 · Cited by 154 · see citing works
Deleterious metabolic effects of high-carbohydrate, sucrose-containing diets in patients with non-insulin-dependent diabetes mellitus
Coulston, A. M., Hollenbeck, C. B., Swislocki, A., Chen, Y. I., & Reaven, G. M. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90058-1 · Cited by 152 · see citing works
Consumption of olive oil, butter, and vegetable oils and coronary heart disease risk factors. The Research Group ATS-RF2 of the Italian National Research Council
Trevisan, M. (1990) · JAMA · doi:10.1001/jama.263.5.688 · Cited by 152 · see citing works
Nutrient composition of foods
Smolin, L. A., & Grosvenor, M. B. (2005) · Medical Entomology and Zoology · Cited by 143 · see citing works
Effects of diets rich in monounsaturated fatty acids on plasma lipoproteins—the Jerusalem Nutrition Study. II Monounsaturated fatty acids vs carbohydrates
Berry, E., Eisenberg, S., Friedlander, Y., Harats, D., Kaufmann, N., Norman, Y., & Stein, Y. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/56.2.394 · Cited by 129 · see citing works
Substituting polyunsaturated for saturated fat as a single change in a Swedish diet: effects on serum lipoprotein metabolism and glucose tolerance in patients with hyperlipoproteinaemia
Vessby, B., Gustafsson, I., Boberg, J., Karlström, B., Lithell, H., & Werner, I. (1980) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1980.tb00020.x · Cited by 127 · see citing works
Effects of a monounsaturated rapeseed oil and a polyunsaturated sunflower oil diet on lipoprotein levels in humans.
Valsta, L. M., Jauhiainen, M., Aro, A., Katan, M., & Mutanen, M. L. (1992) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.12.1.50 · Cited by 117 · see citing works
Insulin secretion and insulin action related to the serum phospholipid fatty acid pattern in healthy men
Pelikánová, T., Kohout, M., Válek, J., Baše, J., & Kazdová, L. (1989) · Metabolism · doi:10.1016/0026-0495(89)90261-8 · Cited by 103 · see citing works
Linoleic-acid-enriched diet: long-term effects on serum lipoprotein and apolipoprotein concentrations and insulin sensitivity in noninsulin-dependent diabetic patients
Heine, R. J., Mulder, C., Popp‐Snijders, C., van der Meer, J., & van der Veen, E. A. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/49.3.448 · Cited by 97 · see citing works
Fatty acid composition of serum cholesterol esters in different degrees of glucose intolerance: A population-based study
Salomaa, V. V., Ahola, I., Tuomilehto, J., Aro, A., Pietinen, P., KORHONEN, H. J., & Penttilä, I. (1990) · Metabolism · doi:10.1016/0026-0495(90)90185-f · Cited by 89 · see citing works
Self-citation
Reducing total dietary fat without reducing saturated fatty acids does not significantly lower total plasma cholesterol concentrations in normal males
Barr, S. L., Ramakrishnan, R., Johnson, C. K., Holleran, S., Dell, R., & Ginsberg, H. (1992) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/55.3.675 · Cited by 67 · see citing works
Alteration of Insulin-Receptor Kinase Activity by High-Fat Feeding
Watarai, T., Kobayashi, M., Takata, Y., Sasaoka, T., Iwasaki, M., & Shigeta, Y. (1988) · Diabetes · doi:10.2337/diab.37.10.1397 · Cited by 60 · see citing works
Dietary Fats and the Diabetic Patient
Kinsell, L. W., Walker, G., Michaels, G. D., Olson, F., COELHO, M., McBride, Y., Fukayama, G., & Conklin, J. (1959) · New England Journal of Medicine · doi:10.1056/nejm195908272610904 · Cited by 52 · see citing works
Evaluation of Metabolic Effects of Substitution of Complex Carbohydrates for Saturated Fat in Individuals with Obesity and NIDDM
Howard, B. V., Abbott, W. G. H., & Swinburn, B. A. (1991) · Diabetes Care · doi:10.2337/diacare.14.9.786 · Cited by 41 · see citing works
High-fat feeding induces tissue-specific alteration in proportion of activated insulin receptors in rats
Nagy, K., Levy, J., & Grunberger, G. (1990) · European Journal of Endocrinology · doi:10.1530/acta.0.1220361 · Cited by 37 · see citing works
Polyunsaturated fats enhance peripheral glucose utilization in rats.
Lardinois, C. K., & Starich, G. H. (1991) · Journal of the American College of Nutrition · doi:10.1080/07315724.1991.10718161 · Cited by 33 · see citing works

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The Metabolic Syndrome
Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., Van Pelt, R. E., Wang, H., & Eckel, R. H. (2008) · Endocrine Reviews · doi:10.1210/er.2008-0024 · Cited by 2,162 · see citing works
Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake
Hodson, L., Skeaff, C. M., & Fielding, B. A. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2008.03.003 · Cited by 1,315 · see citing works
“A number of these studies have specifically investigated the effect of dietary fat on plasma lipid concentrations as markers of cardiovascular risk [137,163–169].”
Background
The Metabolic Syndrome
Grundy, S. M. (2010) · Springer eBooks · doi:10.1007/978-1-4419-5839-6_1 · Cited by 1,225 · see citing works
Diet and risk of type II diabetes: the role of types of fat and carbohydrate
Hu, F. B., Liu, S., & van Dam, R. M. (2001) · Diabetologia · doi:10.1007/s001250100547 · Cited by 758 · see citing works
Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle
Jheng, H.-F., Tsai, P.-J., Guo, S.-M., Kuo, L.-H., Chang, C.-S., Su, I.-J., Chang, C.-R., & Tsai, Y.-S. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.05603-11 · Cited by 650 · see citing works
“Dietary supplementation with monounsaturated FAs improves insulin sensitivity and adipokine and lipid profiles in the HF-fed mice and healthy young subjects (44, 47).”
Background
Dietary fat, insulin sensitivity and the metabolic syndrome
Riccardi, G., Giacco, R., & Rivellese, A. A. (2004) · Clinical Nutrition · doi:10.1016/j.clnu.2004.02.006 · Cited by 620 · see citing works
Dietary Monounsaturated Fatty Acids Are Protective Against Metabolic Syndrome and Cardiovascular Disease Risk Factors
Gillingham, L. G., Harris‐Janz, S., & Jones, P. J. H. (2011) · Lipids · doi:10.1007/s11745-010-3524-y · Cited by 550 · see citing works
“[91] Healthy subjects (n = 10) Randomized, crossover 3 weeks SFA”
Background
Nut and peanut butter consumption and risk of type 2 diabetes in women
Jiang, R. (2002) · JAMA · doi:10.1001/jama.288.20.2554 · Cited by 489 · see citing works
Dietary fat and incidence of type 2 diabetes in older Iowa women
Meyer, K. A., Kushi, L. H., Jacobs, D. R., & Folsom, A. R. (2001) · Diabetes Care · doi:10.2337/diacare.24.9.1528 · Cited by 382 · see citing works
Diet, nutrition and the prevention of type 2 diabetes
Steyn, N., Mann, J., Bennett, P., Temple, N., Zimmet, P., Tuomilehto, J., Lindström, J., & Louheranta, A. (2004) · Public Health Nutrition · doi:10.1079/phn2003586 · Cited by 367 · see citing works
Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise
Corcoran, M. P., Lamon-Fava, S., & Fielding, R. A. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.662 · Cited by 341 · see citing works
Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men
Vessby, B., Tengblad, S., & Lithell, H. (1994) · Diabetologia · doi:10.1007/bf00400468 · Cited by 323 · see citing works
Evidence of health benefits of canola oil
Lin, L., Allemekinders, H., Dansby, A., Campbell, L., Durance-Tod, S., Berger, A., & Jones, P. J. H. (2013) · Nutrition Reviews · doi:10.1111/nure.12033 · Cited by 285 · see citing works
Novel Insights into the Pathogenesis and Management of the Metabolic Syndrome
Wang, H. H., Lee, D. K., Liu, M., Portincasa, P., & Wang, D. Q. ‐. (2020) · Pediatric Gastroenterology Hepatology & Nutrition · doi:10.5223/pghn.2020.23.3.189 · Cited by 294 · see citing works
“This suggested that it may be the type of fats consumed, rather than the total amount of intake, producing a greater effect on the components of the metabolic syndrome [321,322].”
Relationship of dietary fat to glucose metabolism
Lichtenstein, A. H., & Schwab, U. (2000) · Atherosclerosis · doi:10.1016/s0021-9150(99)00504-3 · Cited by 248 · see citing works
“[93] compared the effect of 9 or 20% saturated fat diets (total dietary fat 40% of energy) on glucose metabolism in normal female subjects.”
BackgroundSelf-citation
High saturated fat and low starch and fibre are associated with hyperinsulinaemia in a non-diabetic population: The San Luis Valley Diabetes Study
Marshall, J. A., Bessesen, D. H., & Hamman, R. F. (1997) · Diabetologia · doi:10.1007/s001250050697 · Cited by 246 · see citing works
“These animal data are at odds with data obtained in normal individuals [66] and those with NIDDM [67] where diets enriched in monounsaturated fats have not been found to worsen glycaemia and have been advocated as an alternative to the usual low-fat diabetic diet [68].”
Result
Cold-pressed rapeseed (Brassica napus) oil: Chemistry and functionality
Chew, S. C. (2020) · Food Research International · doi:10.1016/j.foodres.2020.108997 · Cited by 240 · see citing works
Effects of Diet and Simvastatin on Serum Lipids, Insulin, and Antioxidants in Hypercholesterolemic Men
Jula, A., Marniemi, J., Huupponen, R., Virtanen, A., Rastas, M., & Rönnemaa, T. (2002) · JAMA · doi:10.1001/jama.287.5.598 · Cited by 198 · see citing works
“A diet low in saturated fat and rich in monounsaturated and polyunsaturated fats improves glucose tolerance in healthy women.(26) Fatty acid composition of cell membranes, reflecting fatty acid intakeandmetabolism,may modulate insulin binding and glucose transport.”
Background
Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle‐aged men
Laaksonen, D. E., Lakka, T. A., Lakka, H.-M., Nyyssönen, K., Rissanen, T., NISKANEN, L. K., & Salonen, J. T. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00707.x · Cited by 193 · see citing works
Rapeseed (Brassica napus): Processing, Utilization, and Genetic Improvement
Raboanatahiry, N. H., Li, H., Yu, L., & Li, M. (2021) · Agronomy · doi:10.3390/agronomy11091776 · Cited by 191 · see citing works
“A lower blood glucose level was also reported in diabetic subjects who consumed rapeseed oil [105,108].”
Background
A review of potential metabolic etiologies of the observed association between red meat consumption and development of type 2 diabetes mellitus
Kim, Y., Keogh, J., & Clifton, P. (2015) · Metabolism · doi:10.1016/j.metabol.2015.03.008 · Cited by 181 · see citing works
“[27] Uusitupa M, Schwab U, Makimattila S, Karhapaa P, Sarkkinen E, Maliranta H, et al.”
Background
Effects of walnut consumption on plasma fatty acids and lipoproteins in combined hyperlipidemia
Almario, R. U., Vonghavaravat, V., Wong, R., & Kasim-Karakas, S. E. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/74.1.72 · Cited by 180 · see citing works
The influence of dietary fat on insulin resistance
Lovejoy, J. C. (2002) · Current Diabetes Reports · doi:10.1007/s11892-002-0098-y · Cited by 161 · see citing works
Influence of hydrogenated fat and butter on CVD risk factors: remnant-like particles, glucose and insulin, blood pressure and C-reactive protein
Lichtenstein, A. H. (2003) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.07.005 · Cited by 147 · see citing works
“Saturated fat intake is positively associated with increased LDL cholesterol levels and CVD risk and has been associated with a deterioration of glucose control [11–13].”
Background
Possible protective effect of bread and dairy products on the risk of the metabolic syndrome
Mennen, L. I., Lafay, L., Feskens, E. J. M., Novak, M., Lépinay, P., & Balkau, B. (2000) · Nutrition Research · doi:10.1016/s0271-5317(00)00127-5 · Cited by 145 · see citing works
Harnessing Microbes for Sustainable Development: Food Fermentation as a Tool for Improving the Nutritional Quality of Alternative Protein Sources
Kårlund, A., Gómez-Gallego, C., Korhonen, J., Palo-oja, O.-M., El-Nezami, H. S., & Kolehmainen, M. (2020) · Nutrients · doi:10.3390/nu12041020 · Cited by 123 · see citing works
Effect of inulin supplementation and dietary fat source on performance, blood serum metabolites, liver lipids, abdominal fat deposition, and tissue fatty acid composition in broiler chickens
Velasco, S., Ortiz, L., Alzueta, C., Rebolé, A., Treviño, J., & Rodríguez, M. L. (2010) · Poultry Science · doi:10.3382/ps.2010-00687 · Cited by 120 · see citing works
“This seems to be in line with previous observations from studies conducted in rats and humans (Uusitupa et al., 1994; Storlien et al., 2000) suggesting that the fatty acid profile of dietary fat, particularly PUFA:SFA ratio, may regulate glucose metabolism.”
Result
A Systematic Review of High-Oleic Vegetable Oil Substitutions for Other Fats and Oils on Cardiovascular Disease Risk Factors: Implications for Novel High-Oleic Soybean Oils
Huth, P. J., Fulgoni, V. L. I., & Larson, B. T. (2015) · Advances in Nutrition · doi:10.3945/an.115.008979 · Cited by 116 · see citing works
Prevention of Type 2 Diabetes by Diet and Lifestyle Modification
Bazzano, L., Serdula, M. K., & Liu, S. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719479 · Cited by 114 · see citing works
“A few studies using more standard measures reported a relationship between fat content and insulin sensitivity [20].”
Background
A high-trans fatty acid diet and insulin sensitivity in young healthy women
Louheranta, A. M., Turpeinen, A., Vidgren, H. M., Schwab, U., & Uusitupa, M. I. J. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90221-4 · Cited by 103 · see citing works
Self-citation
Alterations in Carbohydrate and Lipid Metabolism Induced by a Diet Rich in Coconut Oil and Cholesterol in a Rat Model
Zulet, M. Á., Barber, A., Garcin, H., Higueret, P., & Martínez, J. A. (1999) · Journal of the American College of Nutrition · doi:10.1080/07315724.1999.10718825 · Cited by 98 · see citing works
Early lifestyle intervention in patients with non-insulin-dependent diabetes mellitus and impaire glucose tolerance
Uusitupa, M. I. J. (1996) · Annals of Medicine · doi:10.3109/07853899608999106 · Cited by 91 · see citing works
Self-citation
Dietary fatty acids and insulin resistance
Lovejoy, J. C. (1999) · Current Atherosclerosis Reports · doi:10.1007/s11883-999-0035-5 · Cited by 86 · see citing works
Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes
Lefevre, M., Lovejoy, J. C., Smith, S. R., DeLany, J. P., Champagne, C. M., Most, M. M., Denkins, Y. M., de Jonge, L., Rood, J. C., & Bray, G. A. (2005) · Metabolism · doi:10.1016/j.metabol.2005.06.015 · Cited by 85 · see citing works
Replacing dairy fat with rapeseed oil causes rapid improvement of hyperlipidaemia: a randomized controlled study
Iggman, D., Gustafsson, I., Berglund, L., Vessby, B., Marckmann, P., & Risérus, U. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02383.x · Cited by 82 · see citing works
Thematic review series: Patient-Oriented Research. Nutritional determinants of insulin resistance
McAuley, K. A., & Mann, J. I. (2006) · Journal of Lipid Research · doi:10.1194/jlr.r600015-jlr200 · Cited by 74 · see citing works
“, 1994 (55) Healthy (10) fsIVGTT 3 weeks 3 2 20% SAFA, 15% MUFA versus 10% SAFA, 20% MUFA 4”
Quality of dietary fatty acids, insulin sensitivity and type 2 diabetes
Rivellese, A. A., & Lilli, S. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(03)00003-9 · Cited by 68 · see citing works
Host-microbial interactions in the metabolism of different dietary fats
Chadaideh, K. S., & Carmody, R. N. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.011 · Cited by 63 · see citing works
Dietary Modeling Shows that the Substitution of Canola Oil for Fats Commonly Used in the United States Would Increase Compliance with Dietary Recommendations for Fatty Acids
Johnson, G. H., Keast, D. R., & Kris‐Etherton, P. M. (2007) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2007.07.015 · Cited by 64 · see citing works
The potential role of olive oil‐derived MUFA in insulin sensitivity
Tierney, A. C., & Roche, H. M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700143 · Cited by 63 · see citing works
Lauric and Palmitic Acid-Enriched Diets have Minimal Impact on Serum Lipid and Lipoprotein Concentrations and Glucose Metabolism in Healthy Young Women
Schwab, U., NISKANEN, L. K., Maliranta, H. M., Savolainen, M. J., Kesemi, Y. A., & Uusitupa, M. I. J. (1995) · Journal of Nutrition · doi:10.1093/jn/125.3.466 · Cited by 61 · see citing works
Self-citation
PPAR-γ response element activity in intact primary human adipocytes: effects of fatty acids
Sauma, L., Stenkula, K. G., Kjølhede, P., Strålfors, P., Söderström, M., & Nyström, F. H. (2005) · Nutrition · doi:10.1016/j.nut.2005.04.011 · Cited by 59 · see citing works
C-reactive protein and dietary nutrients in urban Asian Indian adolescents and young adults
Arya, S., Isharwal, S., Misra, A., Pandey, R. M., Rastogi, K., Vikram, N. K., Dhingra, V., Chatterjee, A., Sharma, R., & Luthra, K. (2006) · Nutrition · doi:10.1016/j.nut.2006.05.002 · Cited by 58 · see citing works
Trafficking of dietary oleic, linolenic, and stearic acids in fasted or fed lean rats
Bessesen, D. H., Vensor, S. H., & Jackman, M. R. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.278.6.e1124 · Cited by 56 · see citing works
Hyperglycaemia is associated with impaired muscle signalling and aerobic adaptation to exercise
MacDonald, T. L., Pattamaprapanont, P., Pathak, P., Fernandez, N., de Freitas, E. C., Hafida, S., Mitri, J., Britton, S. L., Koch, L. G., & Lessard, S. J. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0240-7 · Cited by 56 · see citing works
Effects of Canola Oil Consumption on Lipid Profile: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Ghobadi, S., Hassanzadeh-Rostami, Z., Mohammadian, F., Zare, M., & Faghih, S. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1475270 · Cited by 54 · see citing works
Role of different dietary saturated fatty acids for cardiometabolic risk
Iggman, D., & Risérus, U. (2011) · Clinical Lipidology · doi:10.2217/clp.11.7 · Cited by 52 · see citing works
A high-stearic acid diet does not impair glucose tolerance and insulin sensitivity in healthy women
Louheranta, A. M., Turpeinen, A., Schwab, U., Vidgren, H. M., Parviainen, M. T., & Uusitupa, M. I. J. (1998) · Metabolism · doi:10.1016/s0026-0495(98)90235-9 · Cited by 51 · see citing works
Self-citation
An intensified lifestyle intervention programme may be superior to insulin treatment in poorly controlled Type 2 diabetic patients on oral hypoglycaemic agents: results of a feasibility study
Aas, A., Bergstad, I., Thorsby, P. M., Johannesen, Ø., Solberg, M., & Birkeland, K. I. (2005) · Diabetic Medicine · doi:10.1111/j.1464-5491.2005.01421.x · Cited by 49 · see citing works
The effects of Canola oil on cardiovascular risk factors: A systematic review and meta-analysis with dose-response analysis of controlled clinical trials.
Amiri, M., Raeisi-Dehkordi, H., Sarrafzadegan, N., Forbes, S. C., & Salehi-Abargouei, A. (2020) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.06.007 · Cited by 47 · see citing works
Saturated and cis/trans Unsaturated Acyl CoA Esters Differentially Regulate Wild-Type and Polymorphic β-Cell ATP-Sensitive K+ Channels
Riedel, M. J., & Light, P. E. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2070 · Cited by 44 · see citing works
“Our data lend support to previous clinical studies that suggest replacement of saturated fat with either monounsaturated or polyunsaturated fat as a means to improving glucose tolerance in healthy (37) and glucose-intolerant (38) subjects and reducing the incidence of newly diagnosed type 2 diabetes (6) and has implic…”
Result
Clinical Outcomes of Dietary Replacement of Saturated Fatty Acids with Unsaturated Fat Sources in Adults with Overweight and Obesity: A Systematic Review and Meta-Analysis of Randomized Control Trials
Hannon, B. A., Thompson, S. V., An, R., & Terán-Garcı́a, M. (2017) · Annals of Nutrition and Metabolism · doi:10.1159/000477216 · Cited by 42 · see citing works
Nutritional fats and the risk of type 2 diabetes and cancer
Stoeckli, R., & Keller, U. B. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.030 · Cited by 40 · see citing works
A study of the interactive effects of oral contraceptive use and dietary fat intake on blood pressure, cardiovascular reactivity and glucose tolerance in normotensive women
Straznicky, N. E., Barrington, V. E., Branley, P., & Louis, W. J. (1998) · Journal of Hypertension · doi:10.1097/00004872-199816030-00013 · Cited by 40 · see citing works
Chronic stress, but not hypercaloric diet, impairs vascular function in rats
das Neves, V. J., Moura, M. J. C. S., Almeida, B., Costa, R., Sanches, A., Ferreira, R., Tamascia, M. L., Romani, E. A. O., Novaes, P. D., & Marcondes, F. K. (2011) · Stress · doi:10.3109/10253890.2011.601369 · Cited by 38 · see citing works
“It has also been reported that the area under the curve during the intravenous glucose tolerance test was significantly lower, or did not change, after healthy women were treated with a diet enriched with monounsaturated fatty acid or SFA, respectively (Uusitupa et al. 1994).”
Background
Divergent incorporation of dietary trans fatty acids in different serum lipid fractions
Vidgren, H. M., Louheranta, A. M., Ågren, J. J., Schwab, U., & Uusitupa, M. I. J. (1998) · Lipids · doi:10.1007/s11745-998-0292-9 · Cited by 37 · see citing works
Self-citation
Oil Nutrition and Utilization
Aukema, H. M., & Campbell, L. (2011) · Elsevier eBooks · doi:10.1016/b978-0-9818936-5-5.50013-9 · Cited by 36 · see citing works
Health benefits and evaluation of healthcare cost savings if oils rich in monounsaturated fatty acids were substituted for conventional dietary oils in the United States
Abdullah, M. M. H., Jew, S., & Jones, P. J. H. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nuw062 · Cited by 36 · see citing works
Regular peanut consumption improves plasma lipid levels in healthy Ghanaians
Lokko, P., Lartey, A. A., Armar‐Klemesu, M., & Mattes, R. D. (2007) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637480701198067 · Cited by 34 · see citing works
“High MUFA diets also improve glucose tolerance of healthy individuals (Uusitupa et al. 1994).”
Background
Fatty Acids in the Causation and Therapy of Metabolic Syndrome
Singh, R. B., Meester, F. D., Mechírová, V., Pella, D., & Otsuka, K. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-330-1_19 · Cited by 28 · see citing works
The Effect of Canola Oil on Body Weight and Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials
Raeisi‐Dehkordi, H., Amiri, M., Humphries, K. H., & Salehi‐Abargouei, A. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy108 · Cited by 28 · see citing works
“SFAs are stored in adipose tissue rather than being oxidized (89, 90); however, PUFAs (91) and MUFAs (91, 92) are oxidized.”
MethodInfluential
Cross‐Sectional Associations of Food Consumption with Plasma Fatty Acid Composition and Estimated Desaturase Activities in Finnish Children
Venäläinen, T. M., Schwab, U., Ågren, J., de Mello, V. D., Lindi, V., Eloranta, A., Kiiskinen, S., Laaksonen, D. E., & Lakka, T. A. (2014) · Lipids · doi:10.1007/s11745-014-3894-7 · Cited by 27 · see citing works
“These findings provide further evidence for the results of other Finnish studies in adults and children [33, 34].”
Self-citation
The Tsim Tsoum Approaches for Prevention of Cardiovascular Disease
Singh, R. B., DeMeester, F., & Wilczynska, A. (2010) · Cardiology Research and Practice · doi:10.4061/2010/824938 · Cited by 26 · see citing works
“A few studies using more standard measures reported a relationship between fat content and insulin sensitivity [54].”
Background
Cold pressed rapeseed (Brassica napus) oil
Chew, S. C. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818188-1.00007-4 · Cited by 23 · see citing works
Nut and peanut butter consumption and risk of type 2 diabetes in women
Jiang, R., Manson, J. E., & Stampfer, M. J. (2003) · ACC Current Journal Review · doi:10.1016/s1062-1458(03)00043-6 · Cited by 23 · see citing works
Comparison of the effect of rapeseed oil or amaranth seed oil supplementation on weight loss, body composition, and changes in the metabolic profile of obese patients following 3-week body mass reduction program: a randomized clinical trial
Moszak, M., Zawada, A. E., Juchacz, A., Grzymislawski, M. B., & Bogdański, P. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01330-7 · Cited by 22 · see citing works
Nutritional value of rapeseed oil and its high oleic/low linolenic variety – A call for differentiation
Barth, C. A. (2009) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.200900019 · Cited by 22 · see citing works
Relationship of the Polyunsaturated to Saturated Fatty Acid Ratio to Cardiovascular Risk Factors and Metabolic Syndrome in Japanese: the INTERLIPID Study
Guo, Z., Miura, K., Turin, T. C., Hozawa, A., Okuda, N., Okamura, T., Saitoh, S., Sakata, K., Nakagawa, H., Okayama, A., et al. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.4135 · Cited by 21 · see citing works
Effects of dietary fat modification on fibrinogen, factor VII, and plasminogen activator inhibitor-1 activity in subjects with impaired glucose tolerance
NISKANEN, L. K., Schwab, U., Sarkkinen, E. S., Krusius, T., Vahtera, E. M., & Uusitupa, M. I. J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90011-1 · Cited by 21 · see citing works
Self-citation
Impact of saturated compared with unsaturated dietary fat on insulin sensitivity, pancreatic β-cell function and glucose tolerance: a systematic review and meta-analysis of randomized, controlled trials
Lytrivi, M., Cauduro, C. G. D. S., Kibanda, J., Kristanto, P., Paesmans, M., & Cnop, M. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.07.018 · Cited by 20 · see citing works
Dietary Polyunsaturated to Saturated Fatty Acid Ratio as an Indicator for LDL Cholesterol Response: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Hart, T. L., Damani, J. J., DiMattia, Z. S., Tate, K. E., Jafari, F., & Petersen, K. S. (2025) · Advances in Nutrition · doi:10.1016/j.advnut.2025.100502 · Cited by 16 · see citing works
Effects of dietarycisandtransunsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats
Bernal, C., Rovira, J., Colandré, M. E., Cussó, R., & Cadefau, J. A. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061756 · Cited by 16 · see citing works
The effect of canola oil compared with sesame and sesame-canola oil on cardio-metabolic biomarkers in patients with type 2 diabetes: Design and research protocol of a randomized, triple-blind, three-way, crossover clinical trial.
Amiri, M., Ghaneian, M. T., Sakhvidi, M. J. Z., Rahmanian, M., Nadjarzadeh, A., Moghtaderi, F., Raeisi‐Dehkordi, H., Zimorovat, A., Jafari, F., Reza, J. Z., et al. (2019) · PubMed Central · doi:10.22122/arya.v15i4.1940 · Cited by 15 · see citing works
Diagnostic utility of glycosylated hemoglobin concentrations in the cat
Hoenig, M. E., & Ferguson, D. C. (1999) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(98)00050-2 · Cited by 15 · see citing works
Dietary management of pancreatic beta-cell homeostasis and control of diabetes
Ramesh, B. N. (1996) · Medical Hypotheses · doi:10.1016/s0306-9877(96)90187-5 · Cited by 11 · see citing works
Metabolic effects of high sucrose and saturated oil feeding on insulin resistance in Sprague-Dawley rats.
Motshakeri, M., Goh, Y. M., & Ebrahimi, M. M. (2015) · PubMed · Cited by 11 · see citing works
High-fat feeding of different fats during pregnancy and lactation in rats: Effects on maternal metabolism, pregnancy outcome, milk and tissue fatty acid profiles
Buison, A. M., Lu, H., Guo, F., & Jen, K.-L. C. (1997) · Nutrition Research · doi:10.1016/s0271-5317(97)00150-4 · Cited by 11 · see citing works
[FREQUENTLY USED VEGETABLE OILS IN SOUTH AMERICA: FEATURES AND PROPERTIES].
Durán‐Agüero, S., Torres, J., & Catalán, J. S. (2015) · PubMed · doi:10.3305/nh.2015.32.1.8874 · Cited by 5 · see citing works
Reduction of risk for lifestyle diseases: group diet and physical activity intervention in the workplace
Cumin, M. B. (2004) · Tuwhera (Auckland University of Technology) · Cited by 3 · see citing works
Diet and the Prevention of Type 2 Diabetes
Temple, N. J., & Steyn, N. P. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-894-8_7 · Cited by 2 · see citing works
Edible oils: an overview with diabetes perspective.
Gupta, A., & Nigam, A. N. (2015) · World Journal of Pharmacy and Pharmaceutical Sciences · Cited by 1 · see citing works
Low-Carbohydrate Diets in the Treatment of the Metabolic Syndrome
Cornier, M., & Draznin, B. (2013) · Springer eBooks · doi:10.1007/978-3-7091-1331-8_7 · Cited by 1 · see citing works
The effects of altering macronutrient composition on diabetes risk
Morenga, T., & Anne, L. (2010) · Otago University Research Archive (University of Otago) · Cited by 1 · see citing works
Nutrition: Its Relevance in Development and Treatment of the Metabolic Syndrome
Morenga, L. T., & Mann, J. I. (2011) · Wiley eBooks · doi:10.1002/9781444347319.ch17 · Cited by 1 · see citing works
Comparison of effects of two different monounsaturated oils on biliary secretion in rats
Vázquez, C. M., López, M., Bravo, L. E., & Ruíz-Gutiérrez, V. (1999) · Nutrition Research · doi:10.1016/s0271-5317(99)00070-6 · Cited by 1 · see citing works
Efeitos dos tratamentos com os ácidos oleico ou linoleico in vitro e in vivo sobre a produção de mediadores inflamatórios por macrófagos.
Magdalon, J. (2011) · doi:10.11606/d.42.2011.tde-23012012-161945
Study on the Effect of Rapeseed Oils (Sarsoon and Canola) and Hydrogenated Fat on Serum Lipid Fractions of Rats
Sultana, R., Bhatti, N., Hashmi, A. S., Alia, A., & Javed, M. T. (1998) · Pakistan Journal of Biological Sciences · doi:10.3923/pjbs.1998.376.379
Estudi del paper de la fructosa-2,6-Bifosfat i l'enzim fosfofructo-2-quinasa/fructosa-2,6-bifosfatasa en múscul
Rovira, J. (2006) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Identifizierung und Charakterisierung eines mit dem Risiko für Typ-2-Diabetes assoziierten Ernährungsmusters in der EPIC-Potsdam-Studie
Heidemann, C. (2006) · DepositOnce · doi:10.14279/depositonce-1451
“Dementsprechend kann ab bestimmten Plasmakonzentrationen von Glukose, die zu einem zufälligen Zeitpunkt, im Nüchternzustand bzw. nach erfolgtem oralen Glukosetoleranztest gemessen wurden, ein manifester Diabetes diagnostiziert werden [16].”
BackgroundInfluential
Dietary Fat Intake and Hemoglobin A1c in Japanese Women Living in Toyama
Takeuchi, H., Hirosawa, Y., Tomoto, M., Yahata, K., & Mearashi, S. (2016) · Nippon Eiyo Shokuryo Gakkaishi · doi:10.4327/jsnfs.69.117
EFFECTS OF SUBSTITUTING PALM OLEIN WITH CARBOHYDRATES ON INSULIN SENSITIVITY: A REVIEW
Teng, K. (2016) · Journal of Oil Palm Research · doi:10.21894/jopr.2016.2803.01
Ernährungsphysiologischer Wert von Rapsöl und der High oleic/low linolenic (HOLLi)-Qualität - Argumente für eine differenzierte Beurteilung
Barth, C. A. (2009)
The impact of substituting clarified butter with canola oil on the components of metabolic syndrome, fatty liver index, and insulin resistance among individuals diagnosed with metabolic syndrome: a quasi-experimental study
Sedgi, F. M., Hosseiniazar, M. M., & Alizadeh, M. (2024) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-024-01453-z
“Addi - tionally, a previous trial demonstrated that replacing larger amounts of butter with canola or rapeseed oil resulted in a 29.5% reduction in LDL levels [ 44 ].”
Influential
A ketogenic diet, regardless of fish oil content, does not affect glucose homeostasis or muscle insulin response in male rats
Budd, J. M., Notaro, N. M., MacLeod, B., Mutch, D. M., & Dyck, D. J. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00236.2024
Effects of canola oil on body weight and composition in adults: an updated systematic review and meta-analysis of 32 randomized controlled trials
Mohtashamian, A., Mahabady, M., Bagheri, F., Barghchi, H., & Aminianfar, A. (2025) · Nutrition Journal · doi:10.1186/s12937-025-01117-5
“Thirty studies including a total of 1772 participants reported BW as an outcome measure [44–61 Combined results from the fixed effects model indicated that BW did not change significantly following CO consumption (MD:—0.017 kg, 95% CI: − 0.195, 0.161, P value: 0.85) (Fig.”
Influential

Makimattila S: Effects of two high-fat diets with different fatty acid composition on glucose and lipid metabolism in healthy young women. Am J Clin Nutr 59
Uusitupa, M., Schwab, U., Sarkkinen, E. S., & Agren, J. (1994)
Self-citation
Association of the fatty acid profile of serum lipids with glucose and insulin metabolism during 2 fat-modified diets in subjects with impaired glucose tolerance
Louheranta, A. M., Sarkkinen, E. S., Vidgren, H. M., Schwab, U., & Uusitupa, M. I. J. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.2.331 · Cited by 26 · see citing works
Self-citation
A high-trans fatty acid diet and insulin sensitivity in young healthy women
Louheranta, A. M., Turpeinen, A., Vidgren, H. M., Schwab, U., & Uusitupa, M. I. J. (1999) · Metabolism · doi:10.1016/s0026-0495(99)90221-4 · Cited by 103 · see citing works
Self-citation
Comparison of the effects on insulin resistance and glucose tolerance of 6-mo high-monounsaturated-fat, low-fat, and control diets
Due, A., Larsen, T. M., Hermansen, K., Stender, S., Holst, J. J., Toubro, S., Martinussen, T., & Astrup, A. V. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.855 · Cited by 123 · see citing works
Effects of a High-Monounsaturated Fat Diet on Glucose and Lipid Metabolisms in Normal and Diabetic Mice
KOTAKE, J., Tanaka, Y., Umehara, N., MIYASHITA, A., Tsuru, T., HIKIDA, S., & MIZOTE, H. (2004) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.50.106 · Cited by 10 · see citing works

Authors: Uusitupa, M., Schwab, U., Mäkimattila, S., Karhapää, P., Sarkkinen, E., Maliranta, H., Agren, J., & Penttilä, I.
Affiliations: University of Eastern Finland (FI)
Corresponding author: Uusitupa, M
ORCID: Uusitupa, M
Schwab, U
Sarkkinen, E
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 1994-06
Volume: 59
Issue: 6
Pages: 1310-1316
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/59.6.1310
OpenAlex: W2189519006
Cited by: 95
References: 32
Citations by year: 2025: 2 · 2024: 2 · 2023: 1 · 2021: 2 · 2020: 7 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 1 · 2013: 2 · 2012: 1
FWCI: 3.13
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: high-fat diet, dietary fatty acid composition, saturated fatty acids, monounsaturated fatty acids, glucose tolerance, glucose metabolism, lipid metabolism, serum cholesterol, LDL cholesterol, HDL cholesterol, young women
MeSH terms: Adult, Dietary Fats, Fatty Acids, Fatty Acids, Monounsaturated, Female, Glucose, Glucose Tolerance Test, Humans, Lipid Metabolism

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Effects of two high-fat diets with different fatty acid compositions on glucose and lipid metabolism in healthy young women

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