The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019
Open accessAbstract
Background The aging process can lead to a decline in cellular immunity. Therefore, the elderly could benefit from safe and effective interventions that restore cellular immune functions.Objective We determined whether dietary supplementation with the known immunostimulating probiotic Bifidobacterium lactis HN019 could enhance aspects of cellular immunity in elderly subjects.Design Thirty healthy elderly volunteers (age range: 63-84 y; median: 69 y) participated in a 3-stage dietary supplementation trial lasting 9 wk. During stage 1 (run-in), subjects consumed low-fat milk (200 mL twice daily for 3 wk) as a base-diet control. During stage 2 (intervention), they consumed milk supplemented with B. lactis HN019 in a typical dose (5 x 10(10) organisms/d) or a low dose (5 x 10(9) organisms/d) for 3 wk. During stage 3 (washout), they consumed low-fat milk for 3 wk. Changes in the relative proportions of leukocyte subsets and ex vivo leukocyte phagocytic and tumor-cell-killing activity were determined longitudinally by assaying peripheral blood samples.Results Increases in the proportions of total, helper (CD4(+)), and activated (CD25(+)) T lymphocytes and natural killer cells were measured in the subjects' blood after consumption of B. lactis HN019. The ex vivo phagocytic capacity of mononuclear and polymorphonuclear phagocytes and the tumoricidal activity of natural killer cells were also elevated after B. lactis HN019 consumption. The greatest changes in immunity were found in subjects who had poor pretreatment immune responses. In general, the 2 doses of B. lactis HN019 had similar effectiveness.Conclusion B. lactis HN019 could be an effective probiotic dietary supplement for enhancing some aspects of cellular immunity in the elderly.
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“Therefore, the administration of specific strains of Lactobacilli and Bifidobacteria as probiotics as well as fructooligosaccharides, galactooligosaccharides, and other prebiotics, or the combination of both might constitute a benefit for immunocompromised people (118–122).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [119]
Citations
Cites
1 retracted
Chandra, R. K. (1992) · The Lancet · doi:10.1016/0140-6736(92)93151-c · Cited by 523
RetractedKaila, M., Isolauri, E., Soppi, E. T., Virtanen, E., Laine, S., & Arvilommi, H. S. (1992) · Pediatric Research · doi:10.1203/00006450-199208000-00002 · Cited by 700
Isolauri, E., Juntunen, M., Rautanen, T., Sillanaukee, P., & Koivula, T. (1991) · PubMed · Cited by 684
Letter: Hypoglycaemia in propranolol-treated dialysis patients.
Jensen, H. A., Bjaeldager, P., & Broch‐Møller, B. (1976) · PubMed · Cited by 649
Immunomodulation of Human Blood Cells Following the Ingestion of Lactic Acid Bacteria
Schiffrin, E. J., Rochat, F., Link‐Amster, H., Aeschlimann, J., & Donnet‐Hughes, A. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76659-0 · Cited by 553
The immunology of exceptional individuals: the lesson of centenarians
Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 535
AGEING, IMMUNE RESPONSE, AND MORTALITY
Roberts-Thomson, I., Youngchaiyud, U., Whittingham, S., & Mackay, I. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91755-3 · Cited by 477
SUCCESSFUL TREATMENT OF RELAPSING CLOSTRIDIUM DIFFICILE COLITIS WITH LACTOBACILLUS GG
Gorbach, S., Chang, T., & Goldin, B. R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92646-8 · Cited by 467
Effect of age on human neutrophil function
Wenisch, C., Patruta, S., Daxböck, F., Krause, R., & Hörl, W. H. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.1.40 · Cited by 452
Aso, Y., Akaza, H., Kotake, T., Tsukamoto, T., Imai, K., Naito, S., & and the BLP Study Group (1995) · European Urology · doi:10.1159/000475138 · Cited by 373
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Penner, R., & Madsen, K. L. (2006) · Wiley eBooks · doi:10.1002/9780470753170.ch4
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Lee, F. J., & Katelaris, C. H. (2010) · Aging Health · doi:10.2217/ahe.10.33
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BackgroundForssten, S. D., Lahtinen, S. J., & Ouwehand, A. C. (2009) · Food Science & Technology Bulletin Functional Foods · doi:10.1616/1476-2137.15746
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Müller, V. T., de Brito, M. A., Malina, A., de Azevedo, Â. C. B., Brito, C. J., & Miarka, B. (2020) · Brazilian Journal of Health Review · doi:10.34119/bjhrv3n1-080
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(2002) · Rejuvenation Research · doi:10.1089/109454502317629363
Floch, M. H. (2012) · Springer eBooks · doi:10.1007/978-1-4419-1623-5_11
N/A (2003) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v11.i11.1839
(2011) · Elsevier eBooks · doi:10.1016/b978-0-7295-3804-6.50037-4
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Rowland, I. R. (2022) · Nutrition and Healthy Aging · doi:10.3233/nha-210140
“Bifidobacterium lactis HN019 in elderly subjects [21] 139 found increases in proportion of total, helper and acti140 vated T lymphocytes, and phagocytic cell activity.”
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Nisar, A., Kathade, S. A., Aswani, M. A., Harsulkar, A., Jagtap, S., & Kunchiraman, B. N. (2022) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/2992
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Kingkaew, E. (2021) · Chula Digiverse · doi:10.58837/chula.the.2021.300
Shu, Q., Qu, F., & Gill, H. S. (2001) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200108000-00014 · Cited by 189
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“Among the many nutritional elements which favorably modify the quality of the immune and inflammatory response, let us mention vitamin D[179], fish oils[180] and probiotics[181].”
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Wang, X., Jing, Y., Zheng, C., Huang, C., Yao, H., Wang, Z., Huang, K., Yan, Y., Jiang, S., Sun, J., et al. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106951
Ov, B., Nb, P., Timokhina, T. V., Костоломова, Е. Г., Paromova, Y. I., Ev, I., Polyanskih, E. D., & Markov, A. A. (2025) · Medical Immunology (Russia) · doi:10.15789/1563-0625-pon-2962
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“…Lactobacillus and Bifidobacterium strains has been proved to be effective in restoring the immune function in the elderly, limiting the effects of immunesenescence (Chiang et al., 2000; Arunachalam et al., 2000; Gill et al., 2001a; Gill et al., 2001b; Sheih et al., 2001; Takeda et al., 2007).”
Background
Metadata
- Authors
- Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K.
- Affiliations
- Massey University (NZ)
- ORCID
- Gopal, Pramod K
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 74
- Issue
- 6
- Pages
- 833-839
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1905558879
- Cited by
- 485
- References
- 40
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 25 · 2021: 35 · 2020: 24 · 2019: 21 · 2018: 19 · 2017: 29 · 2016: 20 · 2015: 15 · 2014: 19 · 2013: 23 · 2012: 23
- FWCI
- 21.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, dietary supplementation, cell-mediated immunity, older adults, aging, T cells, natural killer cells, phagocytic activity, milk supplementation, immunosenescence
- MeSH terms
- Aged, Aged, 80 and over, Aging, Animals, Bifidobacterium, Female, Humans, Immunity, Cellular, Killer Cells, Natural, Leukocytes, Male, Middle Aged, Milk, Phagocytosis, Colony Count, Microbial, Dietary Supplements, Probiotics
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