Cited by 485Probiotics and Fermented FoodsMicrobial Metabolites in Food BiotechnologyInfant Nutrition and Health

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Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019

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Gill, Harsharnjit S, Rutherfurd, Kay J, Cross, Martin L, Gopal, Pramod K·2001·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/74.6.833

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Abstract

Background The aging process can lead to a decline in cellular immunity. Therefore, the elderly could benefit from safe and effective interventions that restore cellular immune functions.Objective We determined whether dietary supplementation with the known immunostimulating probiotic Bifidobacterium lactis HN019 could enhance aspects of cellular immunity in elderly subjects.Design Thirty healthy elderly volunteers (age range: 63-84 y; median: 69 y) participated in a 3-stage dietary supplementation trial lasting 9 wk. During stage 1 (run-in), subjects consumed low-fat milk (200 mL twice daily for 3 wk) as a base-diet control. During stage 2 (intervention), they consumed milk supplemented with B. lactis HN019 in a typical dose (5 x 10(10) organisms/d) or a low dose (5 x 10(9) organisms/d) for 3 wk. During stage 3 (washout), they consumed low-fat milk for 3 wk. Changes in the relative proportions of leukocyte subsets and ex vivo leukocyte phagocytic and tumor-cell-killing activity were determined longitudinally by assaying peripheral blood samples.Results Increases in the proportions of total, helper (CD4(+)), and activated (CD25(+)) T lymphocytes and natural killer cells were measured in the subjects' blood after consumption of B. lactis HN019. The ex vivo phagocytic capacity of mononuclear and polymorphonuclear phagocytes and the tumoricidal activity of natural killer cells were also elevated after B. lactis HN019 consumption. The greatest changes in immunity were found in subjects who had poor pretreatment immune responses. In general, the 2 doses of B. lactis HN019 had similar effectiveness.Conclusion B. lactis HN019 could be an effective probiotic dietary supplement for enhancing some aspects of cellular immunity in the elderly.

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BackgroundInfluential
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Probiotic Research in Australia, New Zealand and the Asia-Pacific Region
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“Those mechanisms include but are not limited to: upregulation of cytokine expression (22, 23) and stimulating toll-like receptors (24–28).”
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The Comparison of Food and Supplement as Probiotic Delivery Vehicles
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“Since Nestle launched the first commercial product with a probiotic health claim in 1994, there have been many claims in both the scientific and the commercial literature that bifidobacteria assist in the establishment of a desirable microflora in the human intestine and that they produce health benefits; for examples…”
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Nutritional and Physical Activity Interventions to Improve Immunity
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Authors: Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K.
Affiliations: Massey University (NZ)
ORCID: Gopal, Pramod K
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2001-12
Volume: 74
Issue: 6
Pages: 833-839
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/74.6.833
OpenAlex: W1905558879
Cited by: 485
References: 40
Citations by year: 2026: 3 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 25 · 2021: 35 · 2020: 24 · 2019: 21 · 2018: 19 · 2017: 29 · 2016: 20 · 2015: 15 · 2014: 19 · 2013: 23 · 2012: 23
FWCI: 21.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7758 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: probiotics, dietary supplementation, cell-mediated immunity, older adults, aging, T cells, natural killer cells, phagocytic activity, milk supplementation, immunosenescence
MeSH terms: Aged, Aged, 80 and over, Aging, Animals, Bifidobacterium, Female, Humans, Immunity, Cellular, Killer Cells, Natural, Leukocytes, Male, Middle Aged, Milk, Phagocytosis, Colony Count, Microbial, Dietary Supplements, Probiotics

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Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019

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