Cited by 485Probiotics and Fermented FoodsMicrobial Metabolites in Food BiotechnologyInfant Nutrition and Health

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Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019

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Gill, Harsharnjit S, Rutherfurd, Kay J, Cross, Martin L, Gopal, Pramod K·2001·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/74.6.833

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Abstract

Background The aging process can lead to a decline in cellular immunity. Therefore, the elderly could benefit from safe and effective interventions that restore cellular immune functions.Objective We determined whether dietary supplementation with the known immunostimulating probiotic Bifidobacterium lactis HN019 could enhance aspects of cellular immunity in elderly subjects.Design Thirty healthy elderly volunteers (age range: 63-84 y; median: 69 y) participated in a 3-stage dietary supplementation trial lasting 9 wk. During stage 1 (run-in), subjects consumed low-fat milk (200 mL twice daily for 3 wk) as a base-diet control. During stage 2 (intervention), they consumed milk supplemented with B. lactis HN019 in a typical dose (5 x 10(10) organisms/d) or a low dose (5 x 10(9) organisms/d) for 3 wk. During stage 3 (washout), they consumed low-fat milk for 3 wk. Changes in the relative proportions of leukocyte subsets and ex vivo leukocyte phagocytic and tumor-cell-killing activity were determined longitudinally by assaying peripheral blood samples.Results Increases in the proportions of total, helper (CD4(+)), and activated (CD25(+)) T lymphocytes and natural killer cells were measured in the subjects' blood after consumption of B. lactis HN019. The ex vivo phagocytic capacity of mononuclear and polymorphonuclear phagocytes and the tumoricidal activity of natural killer cells were also elevated after B. lactis HN019 consumption. The greatest changes in immunity were found in subjects who had poor pretreatment immune responses. In general, the 2 doses of B. lactis HN019 had similar effectiveness.Conclusion B. lactis HN019 could be an effective probiotic dietary supplement for enhancing some aspects of cellular immunity in the elderly.

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“There is also strong evidence that signaling molecules/ determinants are preserved in immunobiotic strains [38], and certain immunogenic strains enhance immune function, especially in subjects with less than adequate immune response [39].”
Background
Enhancement of growth performance and hematological changes in rainbow trout (Onchorhynchus mykiss) alevins fed with Bifidobacterium bacteria
Sahandi, J., Jafaryan, H., Soltani, M., & Ebrahimi, P. (2017) · Journal of Fisheries · doi:10.17017/j.fish.51 · Cited by 2
Immunity and Nutrition
Trinh, C. (2007) · Nutrition and disease prevention · doi:10.1201/9781420005493.ch6 · Cited by 2
Artificial cells for oral delivery of live bacterial cells for therapy
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Prebiotics and Probiotics in Aging Population
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Antimicrobial Activity of Probiotic Lactobacilli Against Some Pathogenic Bacteria
(2022) · Advances in Sexual & Reproductive Health Research · doi:10.33140/asrhr.01.01.09 · Cited by 2
Synbiotics in Cervical Cancer
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Luo, J., Wu, Y., Ma, L., Zhang, M., Li, F., Cai, Y., Zheng, F. Y., & Yue, H. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115706 · Cited by 2
Potential for Strengthening Immune Function and Sports Performance with Lactobacillus pentosus b240
Lee, M. C. (2024) · Exercise Science · doi:10.15857/ksep.2024.00255 · Cited by 2
“Lactic acid bacteria b240 have been shown to fortify immune function, with the intake of lactobacillus resulting in increases in blood T-helper (Th) cell count and natural killer (NK) cell count, as well as enhancement of NK cell activity in elderly adults [16].”
Background
Modifying the Gut Microbiome Through Diet: Effects on the Immune System of Elderly Subjects
Childs, C. E., & Calder, P. C. (2017) · Springer eBooks · doi:10.1007/978-3-319-64597-1_160-1 · Cited by 2
Nutraceuticals and Immune Restoration in the Elderly
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“Probiotics have been widely studied and characterized as modulators of humoral, cellular, and non-specific immunity [76, 77], as probiotics decrease pro-inflammatory cytokines [78], restore the composition of the gut microbiota community, and maintain gut permeability and endotoxemia [79].”
Prebiotics and Nutrition in the Elderly
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Immunoregulation of Murine Immunocytes toBifidobacteriaStrain Isolated from Feces of Healthy Korean Children: IL-10 Release and Proportional Change of CD4+CD25+Cells
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A Pilot Study to Determine the Effectiveness of Probiotic Use in Elderly Patients with Antibiotic-Associated Diarrhea
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Immunomodifying Effects of Probiotics
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Probiotics and Prebiotics as Nutraceuticals
Pathak, S., Leet, C., Simon, A., & Pathak, Y. (2009) · CRC Press eBooks · doi:10.1201/9781420082227-c14 · Cited by 1
E¡ects of seven potential probiotic strains on speci¢c immune responses in healthy adults: a double-blind, randomized, controlled trial
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Kidney Bean Yoghurt is Effective to Improve Immune System and Sleep Quality Among Elderly in Yogyakarta
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“Probiotics stimulate immunity by suppressing the growth of disease-causing bacteria (Gill et al. 2001).”
Background
Gut Microbiome in COVID-19: New Insights
Sharma, A. K. (2021) · Springer eBooks · doi:10.1007/978-981-16-5105-2_19 · Cited by 1

Authors: Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K.
Affiliations: Massey University (NZ)
ORCID: Gopal, Pramod K
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2001-12
Volume: 74
Issue: 6
Pages: 833-839
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/74.6.833
OpenAlex: W1905558879
Cited by: 485
References: 40
Citations by year: 2026: 3 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 25 · 2021: 35 · 2020: 24 · 2019: 21 · 2018: 19 · 2017: 29 · 2016: 20 · 2015: 15 · 2014: 19 · 2013: 23 · 2012: 23
FWCI: 21.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7758 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: probiotics, dietary supplementation, cell-mediated immunity, older adults, aging, T cells, natural killer cells, phagocytic activity, milk supplementation, immunosenescence
MeSH terms: Aged, Aged, 80 and over, Aging, Animals, Bifidobacterium, Female, Humans, Immunity, Cellular, Killer Cells, Natural, Leukocytes, Male, Middle Aged, Milk, Phagocytosis, Colony Count, Microbial, Dietary Supplements, Probiotics

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Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019

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