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Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019
Open accessAbstract
Background The aging process can lead to a decline in cellular immunity. Therefore, the elderly could benefit from safe and effective interventions that restore cellular immune functions.Objective We determined whether dietary supplementation with the known immunostimulating probiotic Bifidobacterium lactis HN019 could enhance aspects of cellular immunity in elderly subjects.Design Thirty healthy elderly volunteers (age range: 63-84 y; median: 69 y) participated in a 3-stage dietary supplementation trial lasting 9 wk. During stage 1 (run-in), subjects consumed low-fat milk (200 mL twice daily for 3 wk) as a base-diet control. During stage 2 (intervention), they consumed milk supplemented with B. lactis HN019 in a typical dose (5 x 10(10) organisms/d) or a low dose (5 x 10(9) organisms/d) for 3 wk. During stage 3 (washout), they consumed low-fat milk for 3 wk. Changes in the relative proportions of leukocyte subsets and ex vivo leukocyte phagocytic and tumor-cell-killing activity were determined longitudinally by assaying peripheral blood samples.Results Increases in the proportions of total, helper (CD4(+)), and activated (CD25(+)) T lymphocytes and natural killer cells were measured in the subjects' blood after consumption of B. lactis HN019. The ex vivo phagocytic capacity of mononuclear and polymorphonuclear phagocytes and the tumoricidal activity of natural killer cells were also elevated after B. lactis HN019 consumption. The greatest changes in immunity were found in subjects who had poor pretreatment immune responses. In general, the 2 doses of B. lactis HN019 had similar effectiveness.Conclusion B. lactis HN019 could be an effective probiotic dietary supplement for enhancing some aspects of cellular immunity in the elderly.
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“Therefore, the administration of specific strains of Lactobacilli and Bifidobacteria as probiotics as well as fructooligosaccharides, galactooligosaccharides, and other prebiotics, or the combination of both might constitute a benefit for immunocompromised people (118–122).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [119]
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“Several studies in humans have shown an increase of NK cells in response to the consumption of probiotics [109, 110], and the same has been in animal models.”
How Science Will Help Shape Future Clinical Applications of Probiotics
Reid, G. (2008) · Clinical Infectious Diseases · doi:10.1086/523340 · Cited by 17
Probiotic microorganisms- identification, metabolic and physiological impact on poultry
Khan, S. H. (2013) · World s Poultry Science Journal · doi:10.1017/s0043933913000603 · Cited by 17
“The principal end products of fermentation by Bifidobacteria are acetate and lactate which are produced in a 3:2 molar ratio (Gill et al., 2001).”
BackgroundProperties of Evidence-Based Probiotics for Human Health
McFarland, L. V., & Elmer, G. W. (2005) · CRC Press eBooks · doi:10.1201/9781420027570.ch5 · Cited by 17
Skillington, O., Mills, S., Gupta, A., Mayer, E. A., Gill, C. I. R., Rio, D. D., O’Riordan, K. J., Cryan, J. F., Ross, R. P., & Stanton, C. (2021) · Nutrition and Healthy Aging · doi:10.3233/nha-210129 · Cited by 18
“[235] Gill HS, Rutherfurd KJ, Cross ML, Gopal PK.”
BackgroundThe Intestinal Microbiota and Probiotics
Forssten, S. D., Lahtinen, S. J., & Ouwehand, A. C. (2011) · Springer eBooks · doi:10.1007/978-94-007-0386-5_2 · Cited by 16
“By interacting with the host cells in the gut, probiotic bacteria may modulate the host immune responses for example by enhancing host innate immune functions (Gill et al. 2001) or by modulating the inflammatory status of the host (Foligne et al. 2007).”
BackgroundPrevention and Control of Diseases by Use of Pro- and Prebiotics (Synbiotics)
Shafi, A., Farooq, U., Akram, K., Hayat, Z., & Murtaza, M. A. (2014) · Food Reviews International · doi:10.1080/87559129.2014.929142 · Cited by 16
“(45) Lactobacillus administration results in strengthening of immune system, modification of the immune responses of mucosa, enhancement in the responses of antibody secreting cells,(46,47) creation of balance in the immunity by reducing the severity of pathogens,(48) increment of phagocytes,(49) and also a check on t…”
BackgroundHugo, A. A., Rolny, I. S., Romanin, D., & Pérez, P. F. (2017) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-017-2219-4 · Cited by 16
“Also in humans, (Schiffrin et al. 1997; Gill et al. 2001) an effect on the phagocytic activity has been demonstrated by oral consumption of lactobacilli.”
BackgroundYang, H., Xiong, J., He, L., Li, C., Qiao, S., & Zeng, X. (2023) · LWT · doi:10.1016/j.lwt.2023.115696 · Cited by 15
Biological control of human digestive microbiota using antimicrobial cultures and bacteriocins
Fliss, I., Hammami, R., & Lay, C. (2011) · Elsevier eBooks · doi:10.1533/9780857090522.2.240 · Cited by 15
Anaerobes as Sources of Bioactive Compounds and Health Promoting Tools
Mamo, G. (2016) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2016_6 · Cited by 15
Nutrition as a Tool to Reverse Immunosenescence?
Larbi, A., Cexus, O., & Bosco, N. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805417-8.00026-3 · Cited by 14
Aging Gut Microbiome in Healthy and Unhealthy Aging
Yangyanqiu, W., Qu, Z., Chu, J., & Han, S. (2024) · Aging and Disease · doi:10.14336/ad.2024.0331 · Cited by 17
Mansour, A., Goodarzi, H., Ziba, O., Sakineh, F., & Jorfi, M. (2011) · African Journal of Microbiology Research · doi:10.5897/ajmr11.481 · Cited by 14
“, 2006), and stimulation of the immune system (Gill et al., 2001; Adel-Patient et al., 2005) then when the vaginal lactobacilli are diminished or absent, other microorganisms may grow excessively, causing disorders including bacterial vaginosis (BV), yeast vaginitis and sexually transmitted diseases (STD) (Burton et a…”
BackgroundShene, C., Mardones, M., Zamora, P., & Bravo, S. (2005) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-004-1792-2 · Cited by 14
“They synthesize vitamins (Young and Lin 2000), stimulate the immune response of the host (Gill et al. 2001), contribute to cholesterol assimilation (Rasic et al.”
BackgroundMartínez‐Abad, B., Garrote, J. A., Bernardo, D., Montalvillo, E., Escudero‐Hernández, C., Vázquez, E., Rueda, R., & Arranz, E. M. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.01.033 · Cited by 14
Modulation of Immune Functions by Foods
Kaminogawa, S. (2004) · Evidence-based Complementary and Alternative Medicine · doi:10.1093/bioinformatics/neh042 · Cited by 14
Immunological Effects of Probiotics and their Significance to Human Health
Gill, H. S., Grover, S., Batish, V. K., & Gill, P. (2009) · Prebiotics and Probiotics Science and Technology · doi:10.1007/978-0-387-79058-9_23 · Cited by 13
Self-citationFormulation and Design of Probiotic Supplements for Rheumatoid Arthritis Patients
Vaghef-Mehrabani, E., Rad, A. H., Alipour, B., Vaghef‐Mehrabany, L., & Saghafi‐Asl, M. (2018) · Pharmaceutical Sciences · doi:10.15171/ps.2018.08 · Cited by 13
Lactic acid bacteria and bacteriocins as biopreservatives
Onyeaka, H. N., & Nwabor, O. F. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85700-0.00012-5 · Cited by 18
Oh, S.-Y., & Seo, H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15668 · Cited by 13
“lactis Bi-07 ⋅ Human ⋅ Enhancement of natural killer (NK) cell, monocyte, and granulocyte activities [50,51] ⋅ B.”
Ojha, L., Kumar, S., Kewalramani, N. J., Sarkar, S., Singh, A., & Tyagi, A. K. (2020) · The Indian Journal of Animal Sciences · doi:10.56093/ijans.v90i1.98217 · Cited by 13
“The two causative pathogens such as Salmonella spp. (Gill et al. 2001) and Escherichia coli (Shu and Gill 2002) are the most frequent etiologic agents in neonatal calf scours during the first week of life (Barrington et al. 2002).”
BackgroundSmoak, P., Harman, N., Flores, V. A., Kisiolek, J. N., Pullen, N., LISANO, J., Hayward, R., & Stewart, L. K. (2021) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000002690 · Cited by 12
“lactis increased classical monocyte percentage when compared with milk without the probiotics (45).”
BackgroundGastrointestinal Microflora and Interactions with Gut Mucosa
Wells, A., Saulnier, D. M. A., & Gibson, G. R. (2008) · CRC Press eBooks · doi:10.1201/9780849381829.ch2 · Cited by 11
Antidiarrheal Effect of Food Fermented by Various Strains of Lactobacillus
Shafi, A., Farooq, U., Akram, K., Jaskani, M., Siddique, F., & Tanveer, A. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12056 · Cited by 12
Development of allergic responses related to microorganisms exposure in early life
Donkor, O. N., Shah, N. P., Apostolopoulos, V., & Vasiljevic, T. (2010) · International Dairy Journal · doi:10.1016/j.idairyj.2009.12.017 · Cited by 12
Live bacterial cells as orally delivered therapeutics
Prakash, S., & Bhathena, J. (2005) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.5.10.1281 · Cited by 12
“Significant improvements in natural killer (NK) cell activity, and increases in the percentage of NK cells in the peripheral blood of human volunteers fed yogurt, milk or sausages containing live bacterial cells have also been reported [2,18,88,89].”
BackgroundThe Microbiome–Neurodegeneration Interface: Mechanisms, Evidence, and Future Directions
Böckels, L., Alexa, D., Antal, D. C., Gațcan, C., Alecu, C., Kacani, K., Cretu, R. A., Piseru, E.-A., Bîlcu, R. V., & Cuciureanu, D. I. (2026) · Cells · doi:10.3390/cells15020135 · Cited by 13
Multi-omics analysis reveals the host–microbe interactions in aged rhesus macaques
Xu, J., Lan, Y., Wang, X., Shang, K., Liu, X., Wang, J., Li, J., Yue, B., Shao, M., & Fan, Z. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.993879 · Cited by 11
“Bifidobacterium is normally considered a probiotic, producing a variety of organic acids, including lactic acid, and showing beneficial effects, such as reducing the number of harmful bacteria in the gut (Gill et al., 2001; Manome et al., 2019).”
Background
Metadata
- Authors
- Gill, H. S., Rutherfurd, K. J., Cross, M. L., & Gopal, P. K.
- Affiliations
- Massey University (NZ)
- ORCID
- Gopal, Pramod K
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2001-12
- Volume
- 74
- Issue
- 6
- Pages
- 833-839
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W1905558879
- Cited by
- 485
- References
- 40
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 11 · 2023: 17 · 2022: 25 · 2021: 35 · 2020: 24 · 2019: 21 · 2018: 19 · 2017: 29 · 2016: 20 · 2015: 15 · 2014: 19 · 2013: 23 · 2012: 23
- FWCI
- 21.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, dietary supplementation, cell-mediated immunity, older adults, aging, T cells, natural killer cells, phagocytic activity, milk supplementation, immunosenescence
- MeSH terms
- Aged, Aged, 80 and over, Aging, Animals, Bifidobacterium, Female, Humans, Immunity, Cellular, Killer Cells, Natural, Leukocytes, Male, Middle Aged, Milk, Phagocytosis, Colony Count, Microbial, Dietary Supplements, Probiotics
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