Cited by 439Diet and metabolism studiesDietary Effects on HealthMuscle metabolism and nutrition

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Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women

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Farnsworth, Emma, Luscombe, Natalie D, Noakes, Manny, Wittert, Gary, Argyiou, Eleni, Clifton, Peter M·2003·The American Journal of Clinical Nutrition

DOI 10.1093/ajcn/78.1.31

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Abstract

Background It is not clear whether varying the protein-to-carbohydrate ratio of weight-loss diets benefits body composition or metabolism.Objective The objective was to compare the effects of 2 weight-loss diets differing in protein-to-carbohydrate ratio on body composition, glucose and lipid metabolism, and markers of bone turnover.Design A parallel design included either a high-protein diet of meat, poultry, and dairy foods (HP diet: 27% of energy as protein, 44% as carbohydrate, and 29% as fat) or a standard-protein diet low in those foods (SP diet: 16% of energy as protein, 57% as carbohydrate, and 27% as fat) during 12 wk of energy restriction (6-6.3 MJ/d) and 4 wk of energy balance ( approximately 8.2 MJ/d). Fifty-seven overweight volunteers with fasting insulin concentrations > 12 mU/L completed the study.Results Weight loss (7.9 +/- 0.5 kg) and total fat loss (6.9 +/- 0.4 kg) did not differ between diet groups. In women, total lean mass was significantly (P = 0.02) better preserved with the HP diet (-0.1 +/- 0.3 kg) than with the SP diet (-1.5 +/- 0.3 kg). Those fed the HP diet had significantly (P < 0.03) less glycemic response at weeks 0 and 16 than did those fed the SP diet. After weight loss, the glycemic response decreased significantly (P < 0.05) more in the HP diet group. The reduction in serum triacylglycerol concentrations was significantly (P < 0.05) greater in the HP diet group (23%) than in the SP diet group (10%). Markers of bone turnover, calcium excretion, and systolic blood pressure were unchanged.Conclusion Replacing carbohydrate with protein from meat, poultry, and dairy foods has beneficial metabolic effects and no adverse effects on markers of bone turnover or calcium excretion.

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Items 101–200 of 439

Shifts in Diet from High Fat to High Carbohydrate Improved Levels of Adipokines and Pro-inflammatory Cytokines in Mice Fed a High-fat Diet
Lee, I. S., Shin, G., & Choue, R. (2010) · Endocrine Journal · doi:10.1507/endocrj.k09e-046 · Cited by 70
Polycystic Ovary Syndrome and Weight Management
Moran, L., Lombard, C. B., Lim, S. S., Noakes, M., & Teede, H. J. (2010) · Women s Health · doi:10.2217/whe.09.89 · Cited by 70
Self-citation
Comparison of the effects of 52 weeks weight loss with either a high-protein or high-carbohydrate diet on body composition and cardiometabolic risk factors in overweight and obese males
Wycherley, T. P., Brinkworth, G. D., Clifton, P. M., & Noakes, M. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.11 · Cited by 71
Self-citation
Normal vs. high‐protein weight loss diets in men: Effects on body composition and indices of metabolic syndrome
Tang, M., Armstrong, C. L. H., Leidy, H. J., & Campbell, W. W. (2013) · Obesity · doi:10.1002/oby.20078 · Cited by 72
“4 g kg 1 day 1 of protein in women) (8).”
BackgroundInfluential
Protein intake and lean body mass preservation during energy intake restriction in overweight older adults
Backx, E. M. P., Tieland, M., Borgonjen-van den Berg, K. J., Claessen, P. R., van Loon, L. J. C., & de Groot, L. C. P. G. M. (2016) · International Journal of Obesity · doi:10.1038/ijo.2015.182 · Cited by 66
Daily mycoprotein consumption for 1 week does not affect insulin sensitivity or glycaemic control but modulates the plasma lipidome in healthy adults: a randomised controlled trial
Coelho, M. D. F. R., Monteyne, A. J., Dirks, M. L., Finnigan, T. J. A., Stephens, F. B., & Wall, B. T. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520002524 · Cited by 70
“Since high-protein diets have been shown to improve glycaemic control (42) , we cannot discount the possibility that the drop in protein intake obscured any potential changes in IS or glycaemic control; though, if so, we would expect these effects across both groups equivalently and our control…”
Effects of Acute and Chronic Protein Intake on Metabolism, Appetite, and Ghrelin During Weight Loss
Leidy, H. J., Mattes, R. D., & Campbell, W. W. (2007) · Obesity · doi:10.1038/oby.2007.143 · Cited by 68
“Introduction Higher protein weight-loss diets have led to beneficial reductions in body weight (1–5), fat mass (1–5), and food intake (6), while preserving lean body mass (5,7) and improving satiety (5) in overweight and/or obese individuals.”
Background
Comparison of High Protein and High Fiber Weight-Loss Diets in Women with Risk Factors for the Metabolic Syndrome: A Randomized Trial
Te Morenga, L. A., Levers, M. T., Williams, S. M., Brown, R. C., & Mann, J. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-40 · Cited by 64
“This is consistent with studies of similar design and duration [13,14,16,18,19,28,29] with which this study is compared.”
BackgroundResultInfluential
Moderate carbohydrate, moderate protein weight loss diet reduces cardiovascular disease risk compared to high carbohydrate, low protein diet in obese adults: A randomized clinical trial
Lasker, D. A. W., Evans, E. M., & Layman, D. K. (2008) · Nutrition & Metabolism · doi:10.1186/1743-7075-5-30 · Cited by 64
“Serum TAG reduction was favored in PRO over CHO (see Figure 2) which was in agreement with previous studies in our lab [11,19] in addition to other clinical studies investigating weight loss protocols with reduction in dietary carbohydrate [5,9,12,13,15,30,31].”
BackgroundResult
Resistance training and dietary protein: effects on glucose tolerance and contents of skeletal muscle insulin signaling proteins in older persons
Iglay, H. B., Thyfault, J. P., Apolzan, J. W., & Campbell, W. W. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.4.1005 · Cited by 63
“We determined that 36 total subjects—18 subjects in each of the 2 diet groups—was sufficient to test the main effect of time (ie, resistance training) and the group-by-time interaction (ie, differential response of protein intake during resistance training) (7, 29).”
Background
Hypocaloric high-protein diet improves fatty liver and hypertriglyceridemia in sucrose-fed obese rats via two pathways
Uebanso, T., Taketani, Y., Fukaya, M., Sato, K., Takei, Y., Sato, T., Sawada, N., Amo, K., Harada, N., Arai, H., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00014.2009 · Cited by 63
Hair protein and amino acid 13 C and 15 N abundances take more than 4 weeks to clearly prove influences of animal protein intake in young women with a habitual daily protein consumption of more than 1 g per kg body weight
Petzke, K. J., & Lemke, S. (2009) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4025 · Cited by 63
The Impact of Dietary Changes and Dietary Supplements on Lipid Profile
Huang, J., Frohlich, J. J., & Ignaszewski, A. P. (2011) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2010.12.077 · Cited by 60
“Several studies have shown that a high-protein diet (25% of total energy from protein) and a high-carbohydrate diet (50% to 60% of total energy from carbohydrate) lowered TC, LDL-C, and TGs by 5% to 10%.(78,79) However, an extremely high-carbohydrate diet ( 60% of total energy) increased TG levels.”
Background
Predictors of Lifestyle Intervention Attrition or Weight Loss Success in Women with Polycystic Ovary Syndrome Who Are Overweight or Obese
Moran, L. J., Noakes, M., Clifton, P., Buckley, J., Brinkworth, G., Thomson, R., & Norman, R. J. (2019) · Nutrients · doi:10.3390/nu11030492 · Cited by 57
Self-citation
Dietary Proteins in Obesity and in Diabetes
Keller, U. B. (2011) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831/a000059 · Cited by 63
Relation of nutrients and hormones in polycystic ovary syndrome
Kasim-Karakas, S. E., Cunningham, W., & Tsodikov, A. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.688 · Cited by 57
Lifestyle strategies for weight control: experience from the Finnish Diabetes Prevention Study
Lindström, J., Peltonen, M., Tuomilehto, J. O., & for the Finnish Diabetes Prevention Study Group (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2004412 · Cited by 58
“It may also spare lean tissue and induce a greater loss of total and intra-abdominal fat (Parker et al. 2002; Farnsworth et al. 2003).”
Background
Effects of protein quality on appetite and energy metabolism in normal weight subjects
Alfenas, R. D. C. G., Bressan, J., & de Paiva, A. C. (2010) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302010000100008 · Cited by 56
Examining differences between overweight women and men in 12-month weight loss study comparing healthy low-carbohydrate vs. low-fat diets
Aronica, L., Rigdon, J., Offringa, L. C., Stefanick, M. L., & Gardner, C. D. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-00708-y · Cited by 59
“While these studies generally reported greater absolute weight loss for women than for men, these differences were often not significant when adjusted for baseline weight [24, 25].”
Enhanced weight loss with protein‐enriched meal replacements in subjects with the metabolic syndrome
Flechtner‐Mors, M., Boehm, B. O., Wittmann, R., Thoma, U., & Ditschuneit, H. H. (2010) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1097 · Cited by 69
Safety and efficacy of high-protein diets for weight loss
Johnstone, A. M. (2012) · Proceedings of The Nutrition Society · doi:10.1017/s0029665112000122 · Cited by 56
Regular intake of high-oleic peanuts improves fat oxidation and body composition in overweight/obese men pursuing a energy-restricted diet
Alves, R. D. M., Moreira, A. P. B., Macedo, V. S., Alfenas, R. D. C. G., Bressan, J., Mattes, R. D., & Costa, N. M. B. (2014) · Obesity · doi:10.1002/oby.20746 · Cited by 54
“because a reduction in body fat accompanied by an increment in FFM can result in minor difference in weight yet hold important health benefits (29-32).”
Background
Calcium intake and its relationship with adiposity and insulin resistance in post‐pubertal adolescents
Santos, L. C., Cintra, I. D. P., Fisberg, M., & Martini, L. A. (2008) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2008.00848.x · Cited by 53
A high-protein low-fat diet is more effective in improving blood pressure and triglycerides in calorie-restricted obese individuals with newly diagnosed type 2 diabetes
Papakonstantinou, E., Triantafillidou, D., Panagiotakos, D. B., Koutsovasilis, A., Saliaris, M., Manolis, A., Melidonis, A., & Zampelas, A. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.29 · Cited by 52
“However, this observation is in line with other clinical trials (Skov et al., 1999; Farnsworth et al., 2003).”
Result
Effect of high-protein or normal-protein diet on weight loss, body composition, hormone, and metabolic profile in southern Brazilian women with polycystic ovary syndrome: A randomized study
Toscani, M. K., Mario, F. M., Radavelli-Bagatini, S., Wiltgen, D., Cristina Matos, M., & Spritzer, P. M. (2011) · Gynecological Endocrinology · doi:10.3109/09513590.2011.564686 · Cited by 52
“Also, previous studies report that HP improves insulin sensitivity [10], increases basal metabolism and postprandial energy expenditure, and decreases postprandial glucose [11].”
Background
High-protein diet during gestation and lactation affects mammary gland mRNA abundance, milk composition and pre-weaning litter growth in mice
Kucia, M., Langhammer, M., Görs, S., Albrecht, E., Hammon, H. M., Nürnberg, G., & Metges, C. C. (2010) · animal · doi:10.1017/s1751731110001734 · Cited by 52
“In obese and diabetic individuals, a higher utilization of fat reserves and improved glucose homeostasis was reported while subjected to diets containing higher protein contents (Farnsworth et al., 2003; Layman et al., 2003).”
Background
Protein Intake, Weight Loss, and Bone Mineral Density in Postmenopausal Women
Campbell, W. W., & Tang, M. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq083 · Cited by 52
The Effects of Increasing Serum Calcitriol on Energy and Fat Metabolism and Gene Expression
Boon, N., Hul, G. B. J., Sicard, A., Kole, E., Van, D. B. E. R., Viguerie, N., Langin, D., & Saris, W. H. M. (2006) · Obesity · doi:10.1038/oby.2006.200 · Cited by 54
Metabolic effects of high-protein diets
Clifton, P. M., & Keogh, J. B. (2007) · Current Atherosclerosis Reports · doi:10.1007/s11883-007-0063-y · Cited by 52
Self-citation
Rapid weight loss with a high-protein low-energy diet allows the recovery of ideal body composition and insulin sensitivity in obese dogs
Blanchard, G., Nguyen, P., Gayet, C., Leriche, I., Siliart, B., & Paragon, B.-M. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.8.2148s · Cited by 67
Body composition changes after weight-loss interventions for overweight and obesity
Santarpia, L., Contaldo, F., & Pasanisi, F. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.08.016 · Cited by 53
Effects of protein intake and gender on body composition changes: a randomized clinical weight loss trial
Evans, E. M., Mojtahedi, M. C., Thorpe, M. P., Valentine, R. J., Kris‐Etherton, P. M., & Layman, D. K. (2012) · Nutrition & Metabolism · doi:10.1186/1743-7075-9-55 · Cited by 57
“, found that LM is preserved in women, but not in men on a higher protein diet [9].”
BackgroundResultInfluential
Protein metabolic roles in treatment of obesity
Devkota, S., & Layman, D. K. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32833a7737 · Cited by 49
A High-Protein Diet Reduces Weight Gain, Decreases Food Intake, Decreases Liver Fat Deposition, and Improves Markers of Muscle Metabolism in Obese Zucker Rats
French, W. W., Dridi, S., Shouse, S. A., Wu, H., Hawley, A. L., Lee, S., Gu, X., & Baum, J. (2017) · Nutrients · doi:10.3390/nu9060587 · Cited by 48
“The decrease in weight gain was an expected result of the higher protein diet as many studies have shown that increasing protein in the diet reduces weight gain compared to diets lower in protein [4,7,41].”
Background
The Effects of Dairy Intake on Insulin Resistance: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Sochol, K. M., Johns, T. S., Buttar, R. S., Randhawa, L. S., Sanchez, E., Gal, M., Lestrade, K., Merzkani, M. A., Abramowitz, M. K., Mossavar‐Rahmani, Y., et al. (2019) · Nutrients · doi:10.3390/nu11092237 · Cited by 51
“Further, two more tudies provided data for mal and female participants separately, and were include in meta-analysis ccordingly [47,50].”
BackgroundInfluential
Lupin and soya reduce glycaemia acutely in type 2 diabetes
Dove, E. R., Mori, T. A., Chew, G. T., Barden, A. E., Woodman, R. J., Puddey, I. B., Sipsas, S., & Hodgson, J. M. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511001334 · Cited by 48
Effects of Low-Fat Diets Differing in Protein and Carbohydrate Content on Cardiometabolic Risk Factors during Weight Loss and Weight Maintenance in Obese Adults with Type 2 Diabetes
Watson, N. A., Dyer, K. A., Buckley, J. D., Brinkworth, G. D., Coates, A. M., Parfitt, G., Howe, P. R. C., Noakes, M., & Murphy, K. J. (2016) · Nutrients · doi:10.3390/nu8050289 · Cited by 48
“Interestingly, the pattern of change observed is similar to studies previously reported in T2DM individuals [4,5] and overweight and obese adults [30] that show lipids decline with caloric restriction but rebound with weight stabilization and energy balance.”
Self-citation
The effect of diets high in protein or carbohydrate on inflammatory markers in overweight subjects
Due, A., Toubro, S., Stender, S., Skov, A. R., & Astrup, A. V. (2005) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00426.x · Cited by 47
Effects of short-term energy deficit on muscle protein breakdown and intramuscular proteolysis in normal-weight young adults
Carbone, J. W., Pasiakos, S. M., Vislocky, L. M., Anderson, J. M., & Rodriguez, N. R. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0433 · Cited by 49
“The 20% ED equates to an approximate 2100 kJ daily deficit, which is comparable to levels utilized in previous studies of muscle-related effects of ED (Campbell et al. 2009; Farnsworth et al. 2003; Gordon et al. 2008; Pasiakos et al. 2008).”
MethodResult
Feasibility and efficacy of an isocaloric high-protein vs. standard diet on insulin requirement, body weight and metabolic parameters in patients with type 2 diabetes on insulin therapy
Luger, M., Holstein, B., Schindler, K., Kruschitz, R., & Ludvik, B. (2013) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0033-1341472 · Cited by 45
The role of high-protein diets in body weight management and health
Morenga, L. T., & Mann, J. I. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002437 · Cited by 51
“carbohydrate diets high-protein diets appear to preserve lean body mass and/or lead to reduced fat mass during weight loss which is of particular relevance with regard to the metabolic syndrome((40,18,25,41,2,42,30,23,43)).”
Energy balance and hypothalamic effects of a high-protein/low-carbohydrate diet
Kinzig, K. P., Hargrave, S. L., Hyun, J., & Moran, T. H. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.019 · Cited by 45
“It has been demonstrated that maintenance on these types of diets results in improved glycemic control in hyperinsulinemic, obese, or diabetic subjects [11,12].”
Background
A Carbohydrate-Restricted Diet during Resistance Training Promotes More Favorable Changes in Body Composition and Markers of Health in Obese Women with and without Insulin Resistance
Kreider, R. B., Rasmussen, C. J., Kerksick, C. M., Wilborn, C., Taylor, L. W., Campbell, B. I., Magrans-Courtney, T., Fogt, D. L., Ferreira, M. P., Li, R., et al. (2011) · The Physician and Sportsmedicine · doi:10.3810/psm.2011.05.1893 · Cited by 44
Effects of 3 diets with various calcium contents on 24-h energy expenditure, fat oxidation, and adipose tissue message RNA expression of lipid metabolism–related proteins
Boon, N., Hul, G. B. J., Viguerie, N., Sicard, A., Langin, D., & Saris, W. H. M. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/82.6.1244 · Cited by 44
“However, we choose to use a relatively high-protein content to ensure that the protein balance was equally positive in all experimental conditions, because a high-protein diet may affect body weight (29).”
Method
Increasing the Protein Content in a Carbohydrate-Free Diet Enhances Fat Loss during 35% but Not 75% Energy Restriction in Rats
Fromentin, G., Tomé, D., Bensaı̈d, A., Makarios-Lahham, L., Even, P. C., & Marsset‐Baglieri, A. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2646 · Cited by 44
“If the absence of carbohydrate in the diets used in this study indeed played an important role in decreasing body fat and AI in rats with ad libitum consumption and 35% energy restriction, it will be necessary in future studies to test the influence of the ratio of protein to energy concomitantly with the fat to carbo…”
Method
The Relation between Calcium Intake and Body Composition in a Dutch Population
Boon, N., Koppes, L. L. J., Saris, W. H. M., & van Mechelen, W. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi161 · Cited by 47
Diets High in Protein or Saturated Fat Do Not Affect Insulin Sensitivity or Plasma Concentrations of Lipids and Lipoproteins in Overweight and Obese Adults
Chiu, S., Williams, P. T., Dawson, T., Bergman, R. N., Stefanovski, D., Watkins, S. M., & Krauss, R. M. (2014) · Journal of Nutrition · doi:10.3945/jn.114.197624 · Cited by 44
Animal, Plant, Collagen and Blended Dietary Proteins: Effects on Musculoskeletal Outcomes
Deane, C. S., Bass, J. J., Crossland, H., Phillips, B. E., & Atherton, P. J. (2020) · Nutrients · doi:10.3390/nu12092670 · Cited by 48
“3 MJ/d) with a high-protein (27% of energy from meat, poultry and dairy protein) or standard weight loss diet (16% protein energy) [93].”
BackgroundInfluential
Comparison of the effects of weight loss from a high-protein versus standard-protein energy-restricted diet on strength and aerobic capacity in overweight and obese men
Wycherley, T. P., Buckley, J. D., Noakes, M., Clifton, P. M., & Brinkworth, G. D. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0338-0 · Cited by 49
Self-citation
Sex-Specific Variation in Metabolic Responses to Diet
Andrews, R. R., Anderson, K. R., & Fry, J. L. (2024) · Nutrients · doi:10.3390/nu16172921 · Cited by 44
“Similarly, a 16-week trial comparing the effects of a high-protein vs. lower-protein diet in men and women showed that men lost 2.5 kg fat-free body mass on the high-protein diet, while women retained fat-free mass [42].”
BackgroundInfluential
Dietary Intake of Protein Is Positively Associated with Percent Body Fat in Middle-Aged and Older Adults
Vinknes, K. J., de Vogel, S., Elshorbagy, A. K., Nurk, E., Drevon, C. A., Gjesdal, C. G., Tell, G. S., Vollset, S. E., & Refsum, H. (2011) · Journal of Nutrition · doi:10.3945/jn.110.133710 · Cited by 41
Marked weight loss on liraglutide 3.0 mg: Real‐life experience of a Swiss cohort with obesity
Santini, S., Vionnet, N., Pasquier, J., Gonzalez‐Rodriguez, E., Fraga, M., Pitteloud, N., & Favre, L. (2023) · Obesity · doi:10.1002/oby.23596 · Cited by 39
“LM is an important metabolically active tissue contributing to increased resting energy expenditure and improved muscular strength and body functional capacity [6, 7].”
Background
Effect of a High-Protein Energy-Restricted Diet Combined with Resistance Training on Metabolic Profile in Older Individuals with Metabolic Impairments
Amamou, T., Normandin, E., Pouliot, J., Dionne, I. J., Brochu, M., & Riesco, E. (2017) · The Journal of nutrition, health and aging · doi:10.1007/s12603-016-0760-8 · Cited by 40
“Furthermore, it was also established that moderately high-protein caloric restriction (between 20 and 30% of energy intake) induce greater reductions in fat mass (17, 18) while the loss of lean body mass is attenuated in middle-aged healthy obese individuals (19, 20).”
Consumption of diets high in prebiotic fiber or protein during growth influences the response to a high fat and sucrose diet in adulthood in rats
Maurer, A. D., Eller, L. K., Hallam, M. C., Taylor, K., & Reimer, R. A. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-77 · Cited by 40
“Weight loss diets high in protein have also been associated with reductions in abdominal fat and low density lipoprotein cholesterol [14], reduction in serum triacylglycerol concentrations [15] and an improvement of cardiovascular risk profile [16].”
Background
High Protein Intake Affects Lean Body Mass but Not Energy Expenditure in Nonobese Neutered Cats
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A Reduced Carbohydrate, Increased Protein Diet Stabilizes Glycemic Control and Minimizes Adipose Tissue Glucose Disposal in Rats
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The postprandial use of dietary amino acids as an energy substrate is delayed after the deamination process in rats adapted for 2 weeks to a high protein diet
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Background

Authors: Farnsworth, E., Luscombe, N. D., Noakes, M., Wittert, G., Argyiou, E., & Clifton, P. M.
Affiliations: Commonwealth Scientific and Industrial Research Organisation (AU)
Corresponding author: Clifton, Peter M
ORCID: Noakes, Manny
Wittert, Gary
Clifton, Peter M
Venue: The American Journal of Clinical Nutrition
Publisher: Elsevier BV
Published: 2003-07
Volume: 78
Issue: 1
Pages: 31-39
ISSN: 0002-9165 (ISSN-L)
DOI: 10.1093/ajcn/78.1.31
OpenAlex: W2167607978
Cited by: 438
References: 52
Citations by year: 2026: 2 · 2025: 6 · 2024: 15 · 2023: 2 · 2022: 8 · 2021: 15 · 2020: 14 · 2019: 14 · 2018: 11 · 2017: 12 · 2016: 25 · 2015: 14 · 2014: 21 · 2013: 24 · 2012: 37
FWCI: 16.10
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7168 d)
Locations: American Journal of Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords: high-protein diet, caloric restriction, weight loss, protein-carbohydrate ratio, body composition, lean mass preservation, glycemic control, insulin resistance, hyperinsulinemia, obesity, overweight, lipid metabolism, triglycerides, bone turnover, calcium excretion, systolic blood pressure
MeSH terms: Blood Glucose, Body Composition, Energy Intake, Diet, Dietary Proteins, Fatty Acids, Nonesterified, Female, Humans, Hyperinsulinism, Insulin Resistance, Lipids, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Obesity, Triglycerides

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Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women

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