Cited by 193Infant Nutrition and HealthMicrobial Metabolites in Food BiotechnologyProtein Hydrolysis and Bioactive Peptides

Human milk and related oligosaccharides as prebiotics

Barile, Daniela, Rastall, Robert A·2013·Current Opinion in Biotechnology

Abstract

Human milk oligosaccharides (HMO) are believed to have a range of biological activities beyond providing nutrition to the infant. Principal among these is that they may act as prebiotics. Prebiotics are dietary ingredients, usually oligosaccharides that provide a health benefit to the host mediated by the modulation of the human gut microbiota. While it is clear that such oligosaccharides may have potential applications in infants and adults alike, this potential is limited by the difficulties in manufacturing HMO. Consequently functional alternatives such as galacto-oligosaccharides (GOS) are under investigation. GOS are produced enzymatically from lactose for commercial use in food applications--including addition to infant formulae--as similar to breast milk oligosaccharides, they encourage a gut bacteria population that promotes health and reduces the incidence of intestinal infections. New methods for separation and concentration of complex, breast milk-like oligosaccharides from bovine milk industrial streams that contain only low amounts of these valuable oligosaccharides are providing the opportunity to investigate other viable sources of specific oligosaccharides for use as prebiotics in supplements or food products.

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Crossref · 10.1016/j.copbio.2013.01.008

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  • GOS are well-established prebiotics present in human milk.

    “Galacto-oligosaccharides are well-established prebiotics known to be present in human milk (Barile and Rastall, 2013;Vandenplas, 2007).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Barile and Rastall, 2013

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Authors
Barile, D., & Rastall, R. A.
Affiliations
  • University of California, Davis (US)
  • University of Reading (GB)
Corresponding author
Rastall, Robert A
Venue
Current Opinion in Biotechnology
Publisher
Elsevier BV
Published
2013-04
Volume
24
Issue
2
Pages
214-219
ISSN
0958-1669 (ISSN-L)
OpenAlex
W2153160404
Cited by
193
References
44
Citations by year
2026: 4 · 2025: 13 · 2024: 12 · 2023: 11 · 2022: 18 · 2021: 14 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 19 · 2016: 21 · 2015: 17 · 2014: 11 · 2013: 5
FWCI
2.04
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
Keywords
human milk oligosaccharides, prebiotics, galactooligosaccharides, gut microbiota, infant formula, intestinal infection, functional food ingredients
MeSH terms
Animals, Bifidobacterium, Fermentation, Galactose, Humans, Lactose, Milk, Milk, Human, Oligosaccharides, Dietary Supplements, Infant Formula, Gastrointestinal Tract, Metagenome, Prebiotics

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