Human milk and related oligosaccharides as prebiotics
Abstract
Human milk oligosaccharides (HMO) are believed to have a range of biological activities beyond providing nutrition to the infant. Principal among these is that they may act as prebiotics. Prebiotics are dietary ingredients, usually oligosaccharides that provide a health benefit to the host mediated by the modulation of the human gut microbiota. While it is clear that such oligosaccharides may have potential applications in infants and adults alike, this potential is limited by the difficulties in manufacturing HMO. Consequently functional alternatives such as galacto-oligosaccharides (GOS) are under investigation. GOS are produced enzymatically from lactose for commercial use in food applications--including addition to infant formulae--as similar to breast milk oligosaccharides, they encourage a gut bacteria population that promotes health and reduces the incidence of intestinal infections. New methods for separation and concentration of complex, breast milk-like oligosaccharides from bovine milk industrial streams that contain only low amounts of these valuable oligosaccharides are providing the opportunity to investigate other viable sources of specific oligosaccharides for use as prebiotics in supplements or food products.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GOS are well-established prebiotics present in human milk.
“Galacto-oligosaccharides are well-established prebiotics known to be present in human milk (Barile and Rastall, 2013;Vandenplas, 2007).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Barile and Rastall, 2013
Cites
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works
Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics
Macfarlane, G. T., Steed, H., & Macfarlane, S. (2007) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2007.03520.x · Cited by 771 · see citing works
Human milk glycans protect infants against enteric pathogens.
Newburg, D., Ruiz-Palacios, G., & Morrow, A. (2005) · Annual review of nutrition · doi:10.1146/annurev.nutr.25.050304.092553 · Cited by 697 · see citing works
A comparative in vitro evaluation of the fermentation properties of prebiotic oligosaccharides
Rycroft, C. E., Jones, M. R., Gibson, G. R., & Rastall, R. A. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01446.x · Cited by 653 · see citing works
Self-citationConsumption of human milk oligosaccharides by gut-related microbes
Marcobal, A., Barboza, M., Froehlich, J. W., Block, D. E., German, J. B., Lebrilla, C. B., & Mills, D. A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9044205 · Cited by 568 · see citing works
SILK, D. B. A., DAVIS, A., VULEVIC, J., TZORTZIS, G., & GIBSON, G. R. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03911.x · Cited by 551 · see citing works
Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides
Sela, D. A., & Mills, D. A. (2010) · Trends in Microbiology · doi:10.1016/j.tim.2010.03.008 · Cited by 468 · see citing works
Bezirtzoglou, E., Tsiotsias, A., & Welling, G. W. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.03.009 · Cited by 453 · see citing works
Vulevic, J., Drakoularakou, A., Yaqoob, P., Tzortzis, G., & Gibson, G. R. (2008) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26242 · Cited by 451 · see citing works
Physiology of Consumption of Human Milk Oligosaccharides by Infant Gut-associated Bifidobacteria
Asakuma, S., Hatakeyama, E., Urashima, T., Yoshida, E., Katayama, T., Yamamoto, K., Kumagai, H., Ashida, H., Hirose, J., & Kitaoka, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.248138 · Cited by 442 · see citing works
Morrow, A. L., Ruiz-Palacios, G. M., Jiang, X., & Newburg, D. S. (2005) · Journal of Nutrition · doi:10.1093/jn/135.5.1304 · Cited by 393 · see citing works
Fallani, M., Amarri, S., Uusijärvi, A., Adam, R., Khanna, S., Aguilera, J., Gil, Á., Vieites, J. M., Norin, E. L., Young, D., et al. (2011) · Microbiology · doi:10.1099/mic.0.042143-0 · Cited by 393 · see citing works
Development of an Annotated Library of Neutral Human Milk Oligosaccharides
Wu, S., Tao, N., German, J. B., Grimm, R., & Lebrilla, C. B. (2010) · Journal of Proteome Research · doi:10.1021/pr100362f · Cited by 312 · see citing works
Oligosaccharides and glycoconjugates in bovine milk and colostrum
Gopal, P. K., & Gill, H. S. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500002270 · Cited by 306 · see citing works
Oligosaccharides of milk and colostrum in non-human mammals
Urashima, T., Saito, T., Nakamura, T., & Messer, M. (2001) · Glycoconjugate Journal · doi:10.1023/a:1014881913541 · Cited by 280 · see citing works
Functional Oligosaccharides: Application and Manufacture
Rastall, R. A. (2010) · Annual Review of Food Science and Technology · doi:10.1146/annurev.food.080708.100746 · Cited by 277 · see citing works
Self-citationChichlowski, M., De Lartigue, G., German, J. B., Raybould, H. E., & Mills, D. A. (2012) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31824fb899 · Cited by 276 · see citing works
Depeint, F., Tzortzis, G., Vulevic, J., I'Anson, K., & Gibson, G. R. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.3.785 · Cited by 268 · see citing works
Annotation and Structural Analysis of Sialylated Human Milk Oligosaccharides
Wu, S., Grimm, R., German, J. B., & Lebrilla, C. B. (2010) · Journal of Proteome Research · doi:10.1021/pr101006u · Cited by 268 · see citing works
Sela, D. A., Garrido, D. A., Lerno, L., Wu, S., Tan, K., Eom, H., Joachimiak, A., Lebrilla, C. B., & Mills, D. A. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.06762-11 · Cited by 255 · see citing works
Tao, N., DePeters, E. J., Freeman, S., German, J. B., Grimm, R., & Lebrilla, C. B. (2008) · Journal of Dairy Science · doi:10.3168/jds.2008-1305 · Cited by 234 · see citing works
LoCascio, R. G., Desai, P., Sela, D. A., Weimer, B., & Mills, D. A. (2010) · Applied and Environmental Microbiology · doi:10.1128/aem.00675-10 · Cited by 229 · see citing works
Tzortzis, G., Goulas, A. K., Gee, J. M., & Gibson, G. R. (2005) · Journal of Nutrition · doi:10.1093/jn/135.7.1726 · Cited by 222 · see citing works
An infant-associated bacterial commensal utilizes breast milk sialyloligosaccharides
Sela, D. A., Li, Y., Lerno, L., Wu, S., Marcobal, A. M., German, J. B., Chen, X., Lebrilla, C. B., & Mills, D. A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.193359 · Cited by 192 · see citing works
Tao, N., DePeters, E. J., German, J. B., Grimm, R., & Lebrilla, C. B. (2009) · Journal of Dairy Science · doi:10.3168/jds.2008-1642 · Cited by 190 · see citing works
Rabiu, B. A., Jay, A. J., Gibson, G. R., & Rastall, R. A. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.6.2526-2530.2001 · Cited by 184 · see citing works
Self-citationBovine Milk as a Source of Functional Oligosaccharides for Improving Human Health
Zivkovic, A. M., & Barile, D. (2011) · Advances in Nutrition · doi:10.3945/an.111.000455 · Cited by 180 · see citing works
Self-citationDrakoularakou, A., Tzortzis, G., Rastall, R. A., & Gibson, G. R. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2009.120 · Cited by 174 · see citing works
Self-citationWalton, G., van den Heuvel, E. G. H. M., Kosters, M. H. W., Rastall, R. A., Tuohy, K. M., & Gibson, G. R. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511004697 · Cited by 173 · see citing works
Self-citationPermeate from cheese whey ultrafiltration is a source of milk oligosaccharides
Barile, D., Tao, N., Lebrilla, C. B., Coïsson, J. D., Arlorio, M., & German, J. B. (2009) · International Dairy Journal · doi:10.1016/j.idairyj.2009.03.008 · Cited by 156 · see citing works
Self-citationGänzle, M. G. (2011) · International Dairy Journal · doi:10.1016/j.idairyj.2011.06.010 · Cited by 150 · see citing works
Mariño, K. V., Lane, J. A., Abrahams, J. L., Struwe, W. B., Harvey, D. J., Marotta, M., Hickey, R. M., & Rudd, P. M. (2011) · Glycobiology · doi:10.1093/glycob/cwr067 · Cited by 143 · see citing works
LoCascio, R. G., Niñonuevo, M. R., Kronewitter, S. R., Freeman, S. L., German, J. B., Lebrilla, C. B., & Mills, D. A. (2008) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2008.00072.x · Cited by 140 · see citing works
Evolutionary Glycomics: Characterization of Milk Oligosaccharides in Primates
Tao, N., Wu, S., Kim, J., An, H. J., Hinde, K., Power, M. L., Gagneux, P., German, J. B., & Lebrilla, C. B. (2011) · Journal of Proteome Research · doi:10.1021/pr1009367 · Cited by 132 · see citing works
Structural Determination and Daily Variations of Porcine Milk Oligosaccharides
Tao, N., Ochonicky, K. L., German, J. B., Donovan, S. M., & Lebrilla, C. B. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf100398u · Cited by 115 · see citing works
Barile, D., Marotta, M., Chu, C., Mehra, R., Grimm, R., Lebrilla, C. B., & German, J. B. (2010) · Journal of Dairy Science · doi:10.3168/jds.2010-3156 · Cited by 106 · see citing works
Self-citationA Specific Prebiotic Mixture Added to Starting Infant Formula Has Long-Lasting Bifidogenic Effects
Salvini, F. M., Riva, E., Salvatici, E., Boehm, G., Jelinek, J., Banderali, G., & Giovannini, M. (2011) · Journal of Nutrition · doi:10.3945/jn.110.136747 · Cited by 96 · see citing works
McBain, A. J., & Macfarlane, G. T. (2001) · Journal of Medical Microbiology · doi:10.1099/0022-1317-50-9-833 · Cited by 91 · see citing works
Natural Variability in Bovine Milk Oligosaccharides from Danish Jersey and Holstein-Friesian Breeds
Sundekilde, U. K., Barile, D., Meyrand, M., Poulsen, N. A., Larsen, L. B., Lebrilla, C. B., German, J. B., & Bertram, H. C. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300015j · Cited by 78 · see citing works
Self-citationTranscriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing
Wickramasinghe, S., Hua, S. S., Rincón, G., Islas‐Trejo, A., German, J. B., Lebrilla, C. B., & Medrano, J. F. F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018895 · Cited by 78 · see citing works
Yang, H., Yu, Y., Song, F., & Liu, S. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0085-0 · Cited by 27 · see citing works
Examining bioactive components of milk. Complex oligosaccharides (Part 1)
Barile, D., Guinard, J., Meyrand, M., & German, J. B. (2011) · Agro food industry hi-tech · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
1 of the 44 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
The infant microbiome development: Mom matters
Mueller, N. T., Bakacs, E., Combellick, J., Grigoryan, Z., & Dominguez-Bello, M. G. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.12.002 · Cited by 943 · see citing works
Industrial applications of enzyme biocatalysis: Current status and future aspects
Choi, J.-M., Han, S., & Kim, H. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.02.014 · Cited by 843 · see citing works
Feeding the microbiota–gut–brain axis: Diet, microbiome, and neuropsychiatry
Sandhu, K. V., Sherwin, E., Schellekens, H., Stanton, C., Dinan, T. G., & Cryan, J. F. (2017) · Translational Research · doi:10.1016/j.trsl.2016.10.002 · Cited by 491 · see citing works
Fernández, J., Redondo-Blanco, S., Gutiérrez‐del‐Río, I., Miguélez, E. M., Villar, C. J., & Lombó, F. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2016.06.032 · Cited by 373 · see citing works
An overview of fermentation in the food industry - looking back from a new perspective
Siddiqui, S. A., Erol, Z., Rugji, J., Taşçı, F., Kahraman, H. A., Toppi, V., Musa, L., Giacinto, G. D., Bahmid, N. A., Mehdizadeh, M., et al. (2023) · Bioresources and Bioprocessing · doi:10.1186/s40643-023-00702-y · Cited by 351 · see citing works
Immunological Effects of Human Milk Oligosaccharides
Triantis, V., Bode, L., & van Neerven, R. J. J. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00190 · Cited by 309 · see citing works
Bifidobacteria exhibit social behavior through carbohydrate resource sharing in the gut
Milani, C., Lugli, G. A., Duranti, S., Turroni, F., Mancabelli, L., Ferrario, C., Mangifesta, M., Hevia, A., Viappiani, A., Scholz, M., et al. (2015) · Scientific Reports · doi:10.1038/srep15782 · Cited by 284 · see citing works
Innovation in precision fermentation for food ingredients
Augustin, M. A., Hartley, C. J., Maloney, G. R., & Tyndall, S. M. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2166014 · Cited by 262 · see citing works
Laforest‐Lapointe, I., & Arrieta, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00788 · Cited by 185 · see citing works
Absolute Quantitation of Human Milk Oligosaccharides Reveals Phenotypic Variations during Lactation
Xu, G., Davis, J. C. C., Goonatilleke, E., Smilowitz, J. T., German, J. B., & Lebrilla, C. B. (2016) · Journal of Nutrition · doi:10.3945/jn.116.238279 · Cited by 163 · see citing works
The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease
Wesemann, D. R., & Nagler‐Anderson, C. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.002 · Cited by 160 · see citing works
Intestinal Microbiota as a Contributor to Chronic Inflammation and Its Potential Modifications
Potrykus, M., Czaja-Stolc, S., Stankiewicz, M., Kaska, Ł., & Małgorzewicz, S. (2021) · Nutrients · doi:10.3390/nu13113839 · Cited by 146 · see citing works
Raiten, D. J., Raghavan, R., Porter, A., Obbagy, J., & Spahn, J. M. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.072140 · Cited by 136 · see citing works
Wu, X., Jackson, R. T., Khan, S. A., Ahuja, J. K. C., & Pehrsson, P. R. (2018) · Current Developments in Nutrition · doi:10.1093/cdn/nzy025 · Cited by 131 · see citing works
Beneficial effects of human milk oligosaccharides on gut microbiota
Musilová, Š., Rada, V., Vlková, E., & Bunešová, V. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0080 · Cited by 127 · see citing works
Kim, K., Song, M., Liu, Y., & Ji, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.885253 · Cited by 127 · see citing works
Commercial probiotic products in public health: current status and potential limitations
Liang, D., Wu, F. L., Zhou, D., Tan, B., & Chen, T. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2169858 · Cited by 124 · see citing works
Xu, G., Amicucci, M. J., Cheng, Z., Galermo, A. G., & Lebrilla, C. B. (2017) · The Analyst · doi:10.1039/c7an01530e · Cited by 117 · see citing works
de Almeida, C. C., Pereira, B. F. D. M., Leandro, K. C., da Costa, M. P., Spisso, B. F., & Conte‐Júnior, C. A. (2021) · International Journal of Food Science · doi:10.1155/2021/8850080 · Cited by 113 · see citing works
Healthy hosts rule within: ecological forces shaping the gut microbiota
Byndloss, M. X., Pernitzsch, S. R., & Bäumler, A. J. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0010-y · Cited by 109 · see citing works
Yin, H., Bultema, J. B., Dijkhuizen, L., & van Leeuwen, S. S. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.01.030 · Cited by 107 · see citing works
Nieto‐Domínguez, M., de Eugenio, L. I., York-Durán, M. J., Rodríguez-Colinas, B., Plou, F. J., Chenoll, E., Pardo, E., Codoñer, F. M., & Martı́nez, M. J. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.03.149 · Cited by 104 · see citing works
Borewicz, K., Diez, M. S., Hechler, C., Beijers, R., de Weerth, C., Arts, I. C. W., Penders, J., Thijs, C. T., Nauta, A., Lindner, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-38268-x · Cited by 106 · see citing works
Boudry, G., Hamilton, M. K., Chichlowski, M., Wickramasinghe, S., Barile, D., Kalanetra, K. M., Mills, D. A., & Raybould, H. E. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-11890 · Cited by 98 · see citing works
Self-citationPérez-Escalante, E., Alatorre‐Santamaría, S., Ovando, A. C., Salazar, V., Bautista, M., Cruz-Guerrero, A. E., Flores-Aguilar, J. F., & González-Olivares, L. G. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1813683 · Cited by 98 · see citing works
Novel insights into prebiotic properties on human health: A review
Neri-Numa, I. A., & Pastore, G. M. (2020) · Food Research International · doi:10.1016/j.foodres.2019.108973 · Cited by 91 · see citing works
Donkey and human milk: Insights into their compositional similarities
Altomonte, I., Salari, F., Licitra, R., & Martini, M. (2018) · International Dairy Journal · doi:10.1016/j.idairyj.2018.09.005 · Cited by 89 · see citing works
Krumbeck, J. A., Maldonado-Gómez, M. X., Ramer‐Tait, A. E., & Hutkins, R. W. (2016) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000249 · Cited by 88 · see citing works
The microbiota composition of the offspring of patients with gestational diabetes mellitus (GDM)
Ponzo, V., Ferrocino, I., Zarovska, A., Amenta, M. B., Leone, F., Monzeglio, C., Rosato, R., Pellegrini, M., Gambino, R., Cassader, M., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226545 · Cited by 86 · see citing works
Liquid Chromatography–Tandem Mass Spectrometry Approach for Determining Glycosidic Linkages
Galermo, A. G., Nandita, E., Barboza, M., Amicucci, M. J., Vo, T.-T. T., & Lebrilla, C. B. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.8b04124 · Cited by 84 · see citing works
Newburg, D. S., & Morelli, L. (2014) · Pediatric Research · doi:10.1038/pr.2014.178 · Cited by 81 · see citing works
Milk Proteins, Peptides, and Oligosaccharides: Effects against the 21st Century Disorders
Hsieh, C., Hernández‐Ledesma, B., Fernández‐Tomé, S., Weinborn, V., Barile, D., & Bell, J. M. L. N. D. M. (2015) · BioMed Research International · doi:10.1155/2015/146840 · Cited by 79 · see citing works
Self-citationJohnstone, N., Milesi, C., Burn, O., van den Bogert, B., Nauta, A., Hart, K. H., Sowden, P. T., Burnet, P. W. J., & Kadosh, K. C. (2021) · Scientific Reports · doi:10.1038/s41598-021-87865-w · Cited by 84 · see citing works
Siméoni, U., Berger, B. W., Junick, J., Blaut, M., Pecquet, S., Rezzonico, E., Grathwohl, D., Sprenger, N., Brüssow, H., The Study Team, et al. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.13144 · Cited by 76 · see citing works
Lactose and lactose-derived oligosaccharides: More than prebiotics?
Chen, X. Y., & Gänzle, M. G. (2016) · International Dairy Journal · doi:10.1016/j.idairyj.2016.10.001 · Cited by 76 · see citing works
Microbiota and Neurodevelopmental Trajectories: Role of Maternal and Early-Life Nutrition
Codagnone, M. G., Stanton, C., O’Mahony, S. M., Dinan, T. G., & Cryan, J. F. (2019) · Annals of Nutrition and Metabolism · doi:10.1159/000499144 · Cited by 73 · see citing works
Tian, T., Freeman, S. L., Corey, M., German, J. B., & Barile, D. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04716 · Cited by 71 · see citing works
Self-citationYarrowia lipolytica as an emerging biotechnological chassis for functional sugars biosynthesis
Bilal, M., Xu, S., Iqbal, H. M. N., & Cheng, H. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1739000 · Cited by 69 · see citing works
Marques, T. M., Cryan, J. F., Shanahan, F., Fitzgerald, G. F., Ross, R. P., Dinan, T. G., & Stanton, C. (2013) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2013.10.016 · Cited by 67 · see citing works
Yang, J., Zhang, T., Tian, C., Zhu, Y., Zeng, Y., Men, Y., Chen, P., Sun, Y., & Ma, Y. (2019) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.06.005 · Cited by 64 · see citing works
Douëllou, T., Montel, M. C., & Thévenot-Sergentet, D. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-11611 · Cited by 63 · see citing works
Recent advances in prebiotics: Classification, mechanisms, and health applications
Ali, S., Hamayun, M., Siraj, M., Khan, S. A., Kim, H., & Lee, B. (2025) · Future Foods · doi:10.1016/j.fufo.2025.100680 · Cited by 70 · see citing works
Relative Importance and Additive Effects of Maternal and Infant Risk Factors on Childhood Asthma
Wu, P., Feldman, A. S., Rosas‐Salazar, C., James, K. M., Escobar, G. J., Gebretsadik, T. S., Li, S. X., Carroll, K. N., Walsh, E. M., Mitchel, E. F., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151705 · Cited by 62 · see citing works
[Prebiotics: concept, properties and beneficial effects].
Corzo, N., Alonsó, J. L., Azpiroz, F., Torras, M. D. L. Á. C., Cirici, M., Leis, R., Lombó, F., Mateos‐Aparicio, I., Plou, F. J., Ruas‐Madiedo, P., et al. (2015) · PubMed · doi:10.3305/nh.2015.31.sup1.8715 · Cited by 67 · see citing works
Human milk oligosaccharide-sharing by a consortium of infant derived Bifidobacterium species
Walsh, C., Lane, J. A., van Sinderen, D., & Hickey, R. M. (2022) · Scientific Reports · doi:10.1038/s41598-022-07904-y · Cited by 56 · see citing works
Analysis, structural characterization, and bioactivity of oligosaccharides derived from lactose
Moreno, F. J., Montilla, A., Villamiel, M., Corzo, N., & Olano, A. (2013) · Electrophoresis · doi:10.1002/elps.201300567 · Cited by 55 · see citing works
Gut Microbiome and Infant Health: Brain-Gut-Microbiota Axis and Host Genetic Factors.
Cong, X. S., Xu, W., Romisher, R., Poveda, S., Forte, S., Starkweather, A. R., & Henderson, W. A. (2016) · PubMed Central · Cited by 55 · see citing works
Exploring the microbiome in health and disease
Scotti, E., Boué, S., Sasso, G. L., Zanetti, F., Belcastro, V., Poussin, C., Sierro, N., Battey, J. N. D., Gimalac, A., Ivanov, N. V., et al. (2017) · Toxicology Research and Application · doi:10.1177/2397847317741884 · Cited by 55 · see citing works
Alsharairi, N. A. (2023) · Life · doi:10.3390/life13020561 · Cited by 51 · see citing works
Protein‐oligosaccharide conjugates as novel prebiotics
Seifert, A., Freilich, S., Kashi, Y., & Livney, Y. D. (2019) · Polymers for Advanced Technologies · doi:10.1002/pat.4658 · Cited by 50 · see citing works
Capillary electrophoresis of sialylated oligosaccharides in milk from different species
Monti, L., Cattaneo, T. M. P., Orlandi, M., & Curadi, M. C. (2015) · Journal of Chromatography A · doi:10.1016/j.chroma.2015.07.076 · Cited by 50 · see citing works
Chikina, A. S., & Vignjevic, D. M. (2021) · Cells and Development · doi:10.1016/j.cdev.2021.203712 · Cited by 48 · see citing works
Engineering of the Bacillus circulans β-Galactosidase Product Specificity
Yin, H., Pijning, T., Meng, X., Dijkhuizen, L., & van Leeuwen, S. S. (2017) · Biochemistry · doi:10.1021/acs.biochem.7b00032 · Cited by 47 · see citing works
Recent Advances in the Production, Analysis, and Application of Galacto-Oligosaccharides
Iqbal, M. W., Riaz, T., Mahmood, S., Liaqat, H., Mushtaq, A., Khan, S., Amin, S., & Qi, X. (2022) · Food Reviews International · doi:10.1080/87559129.2022.2097255 · Cited by 45 · see citing works
Advancement of omics techniques for chemical profile analysis and authentication of milk
Qin, C., Liu, L., Wang, Y., Leng, T., Zhu, M., Gan, B., Xie, J., Yu, Q., & Chen, Y. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.06.001 · Cited by 44 · see citing works
Lohner, S., de Gaudry, D. K., Antes, G., Decsi, T., & Meerpohl, J. J. (2014) · Nutrition Reviews · doi:10.1111/nure.12117 · Cited by 43 · see citing works
Khanal, N., Masellis, C., Kamrath, M. Z., Clemmer, D. E., & Rizzo, T. R. (2018) · The Analyst · doi:10.1039/c8an00230d · Cited by 43 · see citing works
Bondue, P., Crèvecoeur, S., Brose, F., Daube, G., Seghaye, M.-C., Griffiths, M. W., LaPointe, G., & Delcenserie, V. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01460 · Cited by 41 · see citing works
α-l-Fucosidases and their applications for the production of fucosylated human milk oligosaccharides
Wan, L., Zhu, Y., Zhang, W., & Mu, W. (2020) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-020-10635-7 · Cited by 41 · see citing works
Fernández, J., Redondo-Blanco, S., Miguélez, E. M., Villar, C. J., Clemente, A., & Lombó, F. (2015) · AIMS Microbiology · doi:10.3934/microbiol.2015.1.48 · Cited by 41 · see citing works
In vitro digestion and fermentation of sialyllactoses by infant gut microflora
Moon, J. S., Joo, W., Ling, L., Choi, H. S., & Han, N. S. (2016) · Journal of Functional Foods · doi:10.1016/j.jff.2015.12.002 · Cited by 39 · see citing works
Oligosaccharides and Complex Carbohydrates: A New Paradigm for Cranberry Bioactivity
Coleman, C. M., & Ferreira, D. (2020) · Molecules · doi:10.3390/molecules25040881 · Cited by 40 · see citing works
Yañez-Ñeco, C. V., Cervantes, F. V., Amaya-Delgado, L., Ballesteros, A. O., Plou, F. J., & Arrizón, J. (2020) · Electronic Journal of Biotechnology · doi:10.1016/j.ejbt.2020.10.004 · Cited by 38 · see citing works
Figueroa‐Lozano, S., Ren, C., Yin, H., Pham, H. T. T., van Leeuwen, S. S., Dijkhuizen, L., & de Vos, P. (2020) · Food & Function · doi:10.1039/d0fo00064g · Cited by 38 · see citing works
Quantification of prebiotics in commercial infant formulas
Sabater, C., Pródanov, M., Olano, A., Corzo, N., & Montilla, A. (2015) · Food Chemistry · doi:10.1016/j.foodchem.2015.07.127 · Cited by 36 · see citing works
An, J. H., Zhang, L., Li, L., Liu, D., Cheng, H., Wang, H., Nawaz, M. Z., Cheng, H., & Deng, Z. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b06138 · Cited by 36 · see citing works
Poulsen, N. A., Robinson, R. C., Barile, D., Larsen, L. B., & Buitenhuis, B. (2019) · BMC Genomics · doi:10.1186/s12864-019-5786-y · Cited by 36 · see citing works
Self-citationLee, H., Cuthbertson, D. J., Otter, D. E., & Barile, D. (2016) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b02039 · Cited by 35 · see citing works
Self-citationLam, K., Keung, H.-Y., Ko, K.-C., Kwan, H. S., & Cheung, P. C. K. (2017) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2017.07.009 · Cited by 35 · see citing works
Whisner, C. M., & Weaver, C. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-66653-2_10 · Cited by 35 · see citing works
Microbiome, growth retardation and metabolism: are they related?
Hoffman, D. J., Ponce, M. C., Taddei, C. R., & Doak, C. M. (2016) · Annals of Human Biology · doi:10.1080/03014460.2016.1267261 · Cited by 35 · see citing works
Kumar, R., Næss, G., & Sørensen, M. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13523 · Cited by 34 · see citing works
Regulation of oral antigen delivery early in life: Implications for oral tolerance and food allergy
Yokanovich, L. T., Newberry, R. D., & Knoop, K. A. (2021) · Clinical & Experimental Allergy · doi:10.1111/cea.13823 · Cited by 36 · see citing works
Healthy chocolate enriched with probiotics: a review
Hossain, M. N., Ranadheera, C. S., Fang, Z., & Ajlouni, S. (2020) · Food Science and Technology · doi:10.1590/fst.11420 · Cited by 33 · see citing works
What is new about diet in hepatic encephalopathy
Merli, M., Iebba, V., & Giusto, M. (2015) · Metabolic Brain Disease · doi:10.1007/s11011-015-9734-5 · Cited by 33 · see citing works
Development of personalized functional foods needs metabolic profiling
Claus, S. P. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000107 · Cited by 32 · see citing works
Genome of Bifidobacteria and Carbohydrate Metabolism
Bondue, P., & Delcenserie, V. (2015) · Korean Journal for Food Science of Animal Resources · doi:10.5851/kosfa.2015.35.1.1 · Cited by 32 · see citing works
Østergaard, M. V., Shen, R. L., Støy, A. C. F., Skovgaard, K., Krych, Ł., Leth, S. S., Nielsen, D. S., Hartmann, B., Bering, S. B., Schmidt, M. H., et al. (2015) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607114566463 · Cited by 32 · see citing works
Monobody-mediated alteration of enzyme specificity
Tanaka, S., Takahashi, T., Koide, A., Ishihara, S., Koikeda, S., & Koide, S. (2015) · Nature Chemical Biology · doi:10.1038/nchembio.1896 · Cited by 31 · see citing works
Sischo, W. M., Short, D. M., Geissler, M., Bunyatratchata, A., & Barile, D. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-12388 · Cited by 31 · see citing works
Self-citationFecal microbiota relationships with childhood obesity: A scoping comprehensive review
de Cuevillas, B., Milagro, F. I., Tur, J. A., Gil‐Campos, M., Miguel‐Etayo, P. D., Martínez, J. A., & Navas‐Carretero, S. (2021) · Obesity Reviews · doi:10.1111/obr.13394 · Cited by 29 · see citing works
Stiverson, J. A., Williams, T., Chen, J., Adams, S., Hustead, D. S., Price, P., Guerrieri, J. P., Deacon, J. M., & Yu, Z. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.02200-14 · Cited by 30 · see citing works
Xie, Y., Wu, X., Fu, C., Duan, H., Shi, J., Blamey, J. M., & Sun, J. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c07604 · Cited by 29 · see citing works
Basso, M., Johnstone, N., Knytl, P., Nauta, A., Groeneveld, A., & Cohen Kadosh, K. (2022) · Nutrients · doi:10.3390/nu14030614 · Cited by 28 · see citing works
Human milk oligosaccharide lacto-N-tetraose: Physiological functions and synthesis methods
Hu, M., Miao, M., Li, K., Luan, Q., Sun, G., & Zhang, T. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.121067 · Cited by 28 · see citing works
Steinert, R. E., Rehman, A., Sadabad, M. S., Milanese, A., Wittwer, J., Burton, J. P., & Spooren, A. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2477816 · Cited by 30 · see citing works
Marsaux, B., den Abbeele, P. V., Ghyselinck, J., Prioult, G., Marzorati, M., & Bogićević, B. (2020) · Nutrients · doi:10.3390/nu12082268 · Cited by 28 · see citing works
Synergy between oligosaccharides and probiotics: From metabolic properties to beneficial effects
Han, D., Żulewska, J., Xiong, K., & Yang, Z. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2139218 · Cited by 27 · see citing works
Breastfeeding increases microbial community resilience
Carvalho‐Ramos, I. I., Duarte, R. T. D., Brandt, K. G., Martinez, M. B., & Taddei, C. R. (2017) · Jornal de Pediatria · doi:10.1016/j.jped.2017.05.013 · Cited by 27 · see citing works
Gluco and galacto-oligosaccharides in food
Rastall, R. A. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328365b5fd · Cited by 27 · see citing works
Self-citationCheng, L., Xu, Q., Yang, K., He, J., Chen, D., Du, Y., & Yin, H. (2016) · Electrophoresis · doi:10.1002/elps.201500471 · Cited by 26 · see citing works
Dietary management of hepatic encephalopathy revisited
Amodio, P., Canesso, F., & Montagnese, S. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000084 · Cited by 25 · see citing works
Marín‐Manzano, M. C., Hernández‐Hernández, O., Díez‐Municio, M., Delgado‐Andrade, C., Moreno, F. J., & Clemente, A. (2020) · Foods · doi:10.3390/foods9070921 · Cited by 25 · see citing works
Gart, E., Salic, K., Morrison, M. C., Giera, M. A., Attema, J., de Ruiter, C., Caspers, M. P. M., Schuren, F. H. J., Bobeldijk‐Pastorova, I., Heer, M., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.904740 · Cited by 25 · see citing works
Piglet weight gain during the first two weeks of lactation influences the immune system development
Lessard, M., Blais, M., Beaudoin, F., Deschêne, K., Verso, L. L., Bissonnette, N., Lauzon, K., & Guay, F. (2018) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2018.11.005 · Cited by 24 · see citing works
The Microbiota of Non-cow Milk and Products
Alexandraki, V., Κάζου, Μ., Angelopoulou, A., Arena, M. P., Capozzi, V., Russo, P., Fiocco, D., Spano, G., Papadimitriou, K., & Tsakalidou, E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803361-6.00006-5 · Cited by 23 · see citing works
Potential Applications of Non‐Bovine Mammalian Milk in Infant Nutrition
Crowley, S. V., Kelly, A. L., Lucey, J. A., & O’Mahony, J. A. (2017) · doi:10.1002/9781119110316.ch13 · Cited by 22 · see citing works
Chen, W., Zou, L., Shao, Y., Tu, Z., & Liu, J. (2025) · Food Chemistry · doi:10.1016/j.foodchem.2025.144299 · Cited by 21 · see citing works
Usvalampi, A., Maaheimo, H., Tossavainen, O., & Frey, A. D. (2017) · Glycoconjugate Journal · doi:10.1007/s10719-017-9794-3 · Cited by 21 · see citing works
- Authors
- Barile, D., & Rastall, R. A.
- Affiliations
- University of California, Davis (US)
- University of Reading (GB)
- Corresponding author
- Rastall, Robert A
- Venue
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 24
- Issue
- 2
- Pages
- 214-219
- ISSN
- 0958-1669 (ISSN-L)
- OpenAlex
- W2153160404
- Cited by
- 193
- References
- 44
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 12 · 2023: 11 · 2022: 18 · 2021: 14 · 2020: 17 · 2019: 15 · 2018: 16 · 2017: 19 · 2016: 21 · 2015: 17 · 2014: 11 · 2013: 5
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Keywords
- human milk oligosaccharides, prebiotics, galactooligosaccharides, gut microbiota, infant formula, intestinal infection, functional food ingredients
- MeSH terms
- Animals, Bifidobacterium, Fermentation, Galactose, Humans, Lactose, Milk, Milk, Human, Oligosaccharides, Dietary Supplements, Infant Formula, Gastrointestinal Tract, Metagenome, Prebiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review