CoChat
Sign Up
Cited by 80

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Ultra-Processed Foods Consumption Increases the Risk of Hypertension in Adults: A Systematic Review and Meta-Analysis

Wang, Mei, Du, Xinyi, Huang, Wei, Xu, Yong·2022·American Journal of Hypertension
DOI 10.1093/ajh/hpac069
Open this paper in CoChat — free account

Abstract

Background: Effect of ultra-processed foods (UPFs) consumption on health has attracted widespread attention in recent years. However, the relationship between UPFs consumption and hypertension is unclear. This meta-analysis was conducted to analyze the above association. Methods: We systematically searched PubMed, Embase, and Cochrane Library for all relevant studies published up to 31 January 2022 without language limitation. The random-effects model was selected to pool the effect sizes and 95% confidence intervals (CIs). Results: Nine observational studies involving 111,594 participants were included. Results from this meta-analysis showed that higher UPFs consumption significantly increased the risk of hypertension (odds ratio: 1.23; 95% CI: 1.11, 1.37; P = 0.034). Furthermore, analyses were performed based on gender, study design, exposure assessment, outcome assessment, body mass index, energy intake, and physical activity, which suggested that the results remained statistically significant. Conclusions: Our findings suggested that UPFs might have detrimental effects on the incidence of hypertension in the general population. Although current evidence is limited, it cannot be denied that reducing consumption of UPFs may contribute to decrease the risk of chronic noncommunicable diseases.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1093/ajh/hpac069

Cites

7 of 7 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 7 references

Research works printed but not linked: 52

  1. Swinburn, 2011, The global obesity pandemic: shaped by global drivers and local environments, Lancet, 378, 804, 10.1016/S0140-6736(11)60813-1 · DOI · Paper page
  2. Zobel, 2016, Global changes in food supply and the obesity epidemic, Curr Obes Rep, 5, 449, 10.1007/s13679-016-0233-8 · DOI
  3. Monteiro, 2013, Ultra-processed products are becoming dominant in the global food system, Obes Rev, 14, 21, 10.1111/obr.12107 · DOI · Paper page
  4. Monteiro, 2018, The UN Decade of Nutrition, the NOVA food classification and the trouble with ultra-processing, Public Health Nutr, 21, 5, 10.1017/S1368980017000234 · DOI · Paper page
  5. Moubarac, 2017, Consumption of ultra-processed foods predicts diet quality in Canada, Appetite, 108, 512, 10.1016/j.appet.2016.11.006 · DOI
  6. Martínez Steele, 2016, Ultra-processed foods and added sugars in the US diet: evidence from a nationally representative cross-sectional study, BMJ Open, 6, e009892, 10.1136/bmjopen-2015-009892 · DOI · Paper page
  7. Poti, 2017, Ultra-processed food intake and obesity: what really matters for health-processing or nutrient content?, Curr Obes Rep, 6, 420, 10.1007/s13679-017-0285-4 · DOI · Paper page
  8. Forouzanfar, 2016, Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015, Lancet, 388, 1659, 10.1016/S0140-6736(16)31679-8 · DOI · Paper page
  9. Srour, 2019, Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé), BMJ, 365, l1451, 10.1136/bmj.l1451 · DOI · Paper page
  10. Bonaccio, 2021, Ultra-processed food consumption is associated with increased risk of all-cause and cardiovascular mortality in the Moli-sani Study, Am J Clin Nutr, 113, 446, 10.1093/ajcn/nqaa299 · DOI · Paper page
  11. Blanco-Rojo, 2019, Consumption of ultra-processed foods and mortality: a National Prospective Cohort in Spain, Mayo Clin Proc, 94, 2178, 10.1016/j.mayocp.2019.03.035 · DOI
  12. Rico-Campà, 2019, Association between consumption of ultra-processed foods and all cause mortality: SUN prospective cohort study, BMJ, 365, l1949, 10.1136/bmj.l1949 · DOI
  13. Mendonça, 2016, Ultraprocessed food consumption and risk of overweight and obesity: the University of Navarra Follow-Up (SUN) cohort study, Am J Clin Nutr, 104, 1433, 10.3945/ajcn.116.135004 · DOI · Paper page
  14. Nardocci, 2019, Consumption of ultra-processed foods and obesity in Canada, Can J Public Health, 110, 4, 10.17269/s41997-018-0130-x · DOI
  15. Romaguera, 2021, Consumption of ultra-processed foods and drinks and colorectal, breast, and prostate cancer, Clin Nutr, 40, 1537, 10.1016/j.clnu.2021.02.033 · DOI
  16. Gómez-Donoso, 2020, Ultra-processed food consumption and the incidence of depression in a Mediterranean cohort: the SUN Project, Eur J Nutr, 59, 1093, 10.1007/s00394-019-01970-1 · DOI
  17. Mozaffarian, 2011, Changes in diet and lifestyle and long-term weight gain in women and men, N Engl J Med, 364, 2392, 10.1056/NEJMoa1014296 · DOI · Paper page
  18. Alinia, 2009, The potential association between fruit intake and body weight—a review, Obes Rev, 10, 639, 10.1111/j.1467-789X.2009.00582.x · DOI
  19. Ivancovsky-Wajcman, 2021, Ultra-processed food is associated with features of metabolic syndrome and non-alcoholic fatty liver disease, Liver Int, 41, 2635, 10.1111/liv.14996 · DOI
  20. Lavigne-Robichaud, 2018, Diet quality indices in relation to metabolic syndrome in an Indigenous Cree (Eeyouch) population in northern Québec, Canada, Public Health Nutr, 21, 172, 10.1017/S136898001700115X · DOI
  21. Martínez Steele, 2019, Dietary share of ultra-processed foods and metabolic syndrome in the US adult population, Prev Med, 125, 40, 10.1016/j.ypmed.2019.05.004 · DOI
  22. Mendonça, 2017, Ultra-processed food consumption and the incidence of hypertension in a Mediterranean cohort: the Seguimiento Universidad de Navarra Project, Am J Hypertens, 30, 358, 10.1093/ajh/hpw137 · DOI · Paper page
  23. Monge, 2021, Ultraprocessed beverages and processed meats increase the incidence of hypertension in Mexican women, Br J Nutr, 126, 600, 10.1017/S0007114520004432 · DOI
  24. Nardocci, 2021, Consumption of ultra-processed foods is associated with obesity, diabetes and hypertension in Canadian adults, Can J Public Health, 112, 421, 10.17269/s41997-020-00429-9 · DOI
  25. Nasreddine, 2018, A minimally processed dietary pattern is associated with lower odds of metabolic syndrome among Lebanese adults, Public Health Nutr, 21, 160, 10.1017/S1368980017002130 · DOI
  26. Rezende-Alves, 2021, Food processing and risk of hypertension: Cohort of Universities of Minas Gerais, Brazil (CUME Project), Public Health Nutr, 24, 4071, 10.1017/S1368980020002074 · DOI
  27. Scaranni, 2021, Ultra-processed foods, changes in blood pressure and incidence of hypertension: the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil), Public Health Nutr, 24, 3352, 10.1017/S136898002100094X · DOI
  28. Pagliai, 2021, Consumption of ultra-processed foods and health status: a systematic review and meta-analysis, Br J Nutr, 125, 308, 10.1017/S0007114520002688 · DOI · Paper page
  29. Barbosa, 2022, A systematic review on processed/ultra-processed foods and arterial hypertension in adults and older people, Nutrients, 14, 1215, 10.3390/nu14061215 · DOI
  30. Askari, 2020, Ultra-processed food and the risk of overweight and obesity: a systematic review and meta-analysis of observational studies, Int J Obes (Lond), 44, 2080, 10.1038/s41366-020-00650-z · DOI
  31. Shivappa, 2017, Dietary inflammatory index and colorectal cancer risk-a meta-analysis, Nutrients, 9, 1043, 10.3390/nu9091043 · DOI
  32. Higgins, 2002, Quantifying heterogeneity in a meta-analysis, Stat Med, 21, 1539, 10.1002/sim.1186 · DOI · Paper page
  33. Slimani, 2009, Contribution of highly industrially processed foods to the nutrient intakes and patterns of middle-aged populations in the European Prospective Investigation into Cancer and Nutrition study, Eur J Clin Nutr, 63, S206, 10.1038/ejcn.2009.82 · DOI
  34. Moradi, 2021, Ultra-processed food consumption and adult obesity risk: a systematic review and dose-response meta-analysis, Crit Rev Food Sci Nutr, 1, 10.1080/10408398.2021.2015283 · DOI
  35. Schulte, 2015, Which foods may be addictive? The roles of processing, fat content, and glycemic load, PLoS One, 10, e0117959, 10.1371/journal.pone.0117959 · DOI
  36. Thornley, 2008, The obesity epidemic: is glycemic index the key to unlocking a hidden addiction?, Med Hypotheses, 71, 709, 10.1016/j.mehy.2008.07.006 · DOI
  37. Ebbeling, 2003, A reduced-glycemic load diet in the treatment of adolescent obesity, Arch Pediatr Adolesc Med, 157, 773, 10.1001/archpedi.157.8.773 · DOI
  38. Hall, 2017, A review of the carbohydrate-insulin model of obesity, Eur J Clin Nutr, 71, 323, 10.1038/ejcn.2016.260 · DOI · Paper page
  39. Takeuchi, 2015, Assessment of the concentrations of various advanced glycation end-products in beverages and foods that are commonly consumed in Japan, PLoS One, 10, e0118652, 10.1371/journal.pone.0118652 · DOI
  40. Uribarri, 2007, Single oral challenge by advanced glycation end products acutely impairs endothelial function in diabetic and nondiabetic subjects, Diabetes Care, 30, 2579, 10.2337/dc07-0320 · DOI
  41. Sharma, 2015, Advanced glycation end-products (AGEs): an emerging concern for processed food industries, J Food Sci Technol, 52, 7561, 10.1007/s13197-015-1851-y · DOI
  42. Feig, 2008, Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension: a randomized trial, JAMA, 300, 924, 10.1001/jama.300.8.924 · DOI
  43. Glushakova, 2008, Fructose induces the inflammatory molecule ICAM-1 in endothelial cells, J Am Soc Nephrol, 19, 1712, 10.1681/ASN.2007121304 · DOI
  44. Zhao, 2009, Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats, J Pharmacol Exp Ther, 328, 610, 10.1124/jpet.108.143396 · DOI
  45. Brito, 2008, Parasympathetic dysfunction is associated with insulin resistance in fructose-fed female rats, Braz J Med Biol Res, 41, 804, 10.1590/S0100-879X2008005000030 · DOI
  46. Singh, 2008, Fructose-induced hypertension: essential role of chloride and fructose absorbing transporters PAT1 and Glut5, Kidney Int, 74, 438, 10.1038/ki.2008.184 · DOI
  47. Louzada, 2018, The share of ultra-processed foods determines the overall nutritional quality of diets in Brazil, Public Health Nutr, 21, 94, 10.1017/S1368980017001434 · DOI
  48. Jang, 2011, Modified apolipoprotein (apo) A–I by artificial sweetener causes severe premature cellular senescence and atherosclerosis with impairment of functional and structural properties of apoA–I in lipid-free and lipid-bound state, Mol Cells, 31, 461, 10.1007/s10059-011-1009-3 · DOI
  49. Stallings-Smith, 2018, Exploring the association between polycyclic aromatic hydrocarbons and diabetes among adults in the United States, Environ Res, 166, 588, 10.1016/j.envres.2018.06.041 · DOI
  50. Lee, 2020, Association between urinary polycyclic aromatic hydrocarbons and hypertension in the Korean population: data from the Second Korean National Environmental Health Survey (2012–2014), Sci Rep, 10, 17142, 10.1038/s41598-020-74353-w · DOI
  51. Zhang, 2018, Exposure to acrylamide and the risk of cardiovascular diseases in the National Health and Nutrition Examination Survey 2003–2006, Environ Int, 117, 154, 10.1016/j.envint.2018.04.047 · DOI
  52. Feroe, 2016, Acrolein metabolites, diabetes and insulin resistance, Environ Res, 148, 1, 10.1016/j.envres.2016.03.015 · DOI · Paper page

Cited by

Sorted by citations

See all 80

Metadata

Authors
Wang, M., Du, X., Huang, W., & Xu, Y.
Affiliations
Department of Endocrinology and Metabolism, Affiliated Hospital of Southwest Medical University , Luzhou, Sichuan , China
ORCID
Xu, Yong
Venue
American Journal of Hypertension
Publisher
Oxford University Press (OUP)
Published
2022-06-24
Volume
35
Issue
10
Pages
892-901
ISSN
  • 0895-7061
  • 1941-7225
DOI
10.1093/ajh/hpac069
Cited by
80
References
7
Language
en
Licence
academic.oup.com/pages/standard-publication-reuse-rights (vor)
Funders
  • Sichuan Science and Technology Program (2020YFS0456, 2019YFS0537)
  • Luzhou-Southwest Medical University cooperation project, Luzhou, Sichuan, China (2018LZXNYD—PT01)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review