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Cited by 22Circadian rhythm and melatoninBlood Pressure and Hypertension StudiesGenetic Associations and Epidemiology

Clock genes explain a large proportion of phenotypic variance in systolic blood pressure and this control is not modified by environmental temperature

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Dashti, Hassan S., Aslibekyan, Stella, Scheer, Frank A.J.L., Smith, Caren E., Lamon-Fava, Stefania, Jacques, Paul, Lai, Chao-Qiang, Tucker, Katherine L. +2 more·2016·American Journal of Hypertension
DOI 10.1093/ajh/hpv082PMC PMC5863877
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Abstract

BACKGROUND: Diurnal variation in blood pressure (BP) is regulated, in part, by an endogenous circadian clock; however, few human studies have identified associations between clock genes and BP. Accounting for environmental temperature may be necessary to correct for seasonal bias. METHODS: We examined whether environmental temperature on the day of participants' assessment was associated with BP, using adjusted linear regression models in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) (n = 819) and the Boston Puerto Rican Health Study (BPRHS) (n = 1,248) cohorts. We estimated phenotypic variance in BP by 18 clock genes and examined individual single-nucleotide polymorphism (SNP) associations with BP using an additive genetic model, with further consideration of environmental temperature. RESULTS: In GOLDN, each additional 1 °C increase in environmental temperature was associated with 0.18 mm Hg lower systolic BP [SBP; β ± SE = -0.18 ± 0.05 mm Hg; P = 0.0001] and 0.10mm Hg lower diastolic BP [DBP; -0.10 ± 0.03 mm Hg; P = 0.001]. Similar results were seen in the BPRHS for SBP only. Clock genes explained a statistically significant proportion of the variance in SBP [V G/V P ± SE = 0.071 ± 0.03; P = 0.001] in GOLDN, but not in the BPRHS, and we did not observe associations between individual SNPs and BP. Environmental temperature did not influence the identified genetic associations. CONCLUSIONS: We identified clock genes that explained a statistically significant proportion of the phenotypic variance in SBP, supporting the importance of the circadian pathway underlying cardiac physiology. Although temperature was associated with BP, it did not affect results with genetic markers in either study. Therefore, it does not appear that temperature measures are necessary for interpreting associations between clock genes and BP. CLINICAL TRIAL REGISTRATION: Trials related to this study were registered at clinicaltrials.gov as NCT00083369 (Genetic and Environmental Determinants of Triglycerides) and NCT01231958 (Boston Puerto Rican Health Study).

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  • Temperature was associated with blood pressure but did not modulate the associations with genetic markers in either whites or Hispanics.

    “Moreover, we demonstrated that whereas temperature was associated with blood pressure, it did not modulate the associations with genetic markers in either whites or Hispanics.”

    From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [54]

  • Associations between clock genes and blood pressure support the importance of circadian rhythm in cardiac physiology.

    “In a more recent study, we have shown associations between clock genes and blood pressure, supporting the importance of the circadian rhythm in cardiac physiology (54).”

    From Circadian rhythms, metabolism, and chrononutrition in rodents and humans (2016) · cites this paper as [54]

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Authors
Dashti, H. S., Aslibekyan, S., Scheer, F. A. J. L., Smith, C. E., Lamon-Fava, S., Jacques, P., Lai, C.-Q., Tucker, K. L., Arnett, D. K., & Ordovás, J. M.
Affiliations
  • Tufts University (US)
  • University of Alabama at Birmingham (US)
  • Brigham and Women's Hospital (US)
  • University of Massachusetts Lowell (US)
ORCID
Venue
American Journal of Hypertension
Publisher
Oxford University Press (OUP)
Published
2015-06-04
Volume
29
Issue
1
Pages
132-140
ISSN
  • 0895-7061 (ISSN-L)
  • 1941-7225
DOI
10.1093/ajh/hpv082
PMC
PMC5863877
OpenAlex
W2302272062
Cited by
22
References
58
Citations by year
2024: 2 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 1
FWCI
1.66
Type
journal article
Language
en
Open access
Licence
public-domain
Locations
  • American Journal of Hypertension (publishedVersion, public-domain)
  • PubMed Central (publishedVersion, public-domain)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Agriculture (58-1950-9-001, 53‐K06‐5‐10)
  • National Institutes of Health (58-1950-9-001, DK075030, HL105185)
  • National Institute on Aging (P01AG023394)
  • National Heart, Lung, and Blood Institute (AG023394, 58-1950-9-001, U01HL072524, R01HL094806, K08HL112845, R01HL091357, P50HL105185, P01 AG023394 and P50 HL105185, 53-K06-5-10)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-075030, R01DK075030)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
clock genes, circadian clock, systolic blood pressure, diastolic blood pressure, ambient temperature, diurnal blood pressure variation, phenotypic variance, single nucleotide polymorphisms, genetic association, seasonal bias, hypertension genetics
MeSH terms
Aged, Blood Pressure, Circadian Rhythm, DNA, Environmental Exposure, Female, Genotype, Humans, Hypertension, Male, Middle Aged, Risk Factors, Systole, Temperature, Blood Pressure Monitoring, Ambulatory, Polymorphism, Single Nucleotide, Circadian Rhythm Signaling Peptides and Proteins

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