Budding off: bringing functional genomics to Candida albicans

Anderson, Matthew Z.; Bennett, Richard J.

doi:10.1093/bfgp/elv035

Cited by 11Fungal and yeast genetics researchAntifungal resistance and susceptibilityYeasts and Rust Fungi Studies

Budding off: bringing functional genomics to Candida albicans

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Anderson, Matthew Z., Bennett, Richard J.·2016·Briefings in Functional Genomics

DOI 10.1093/bfgp/elv035PMC PMC5065355

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Abstract

Candida species are the most prevalent human fungal pathogens, with Candida albicans being the most clinically relevant species. Candida albicans resides as a commensal of the human gastrointestinal tract but is a frequent cause of opportunistic mucosal and systemic infections. Investigation of C. albicans virulence has traditionally relied on candidate gene approaches, but recent advances in functional genomics have now facilitated global, unbiased studies of gene function. Such studies include comparative genomics (both between and within Candida species), analysis of total RNA expression, and regulation and delineation of protein-DNA interactions. Additionally, large collections of mutant strains have begun to aid systematic screening of clinically relevant phenotypes. Here, we will highlight the development of functional genomics in C. albicans and discuss the use of these approaches to addressing both commensalism and pathogenesis in this species.

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High genomic plasticity is one characteristic of Candida yeasts that enables their fast adaptation to varying environments.
“High genomic plasticity is one of the characteristics of Candida yeasts that enables their fast adaptation to varying environments [62,63,64].”
From Evolutionary Emergence of Drug Resistance in Candida Opportunistic Pathogens (2018) · cites this paper as [62]

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Most frequent scenario for recurrent Candida vaginitis is strain maintenance with "substrain shuffling": demonstration by sequential DNA fingerprinting with probes Ca3, C1, and CARE2
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Making Sense of Transcription Networks
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Adaptations of Candida albicans for Growth in the Mammalian Intestinal Tract
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Alcohol Dehydrogenase Restricts the Ability of the Pathogen Candida albicans To Form a Biofilm on Catheter Surfaces through an Ethanol-Based Mechanism
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Optimization and Validation of Multilocus Sequence Typing for Candida albicans
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Large-Scale Analysis of Yeast Filamentous Growth by Systematic Gene Disruption and Overexpression
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Evolutionary Tinkering with Conserved Components of a Transcriptional Regulatory Network
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Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis
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Structure of the transcriptional network controlling white‐opaque switching in <scp> C </scp> andida albicans
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Assembly of a phased diploid Candida albicansgenome facilitates allele-specific measurements and provides a simple model for repeat and indel structure
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A Core Filamentation Response Network in Candida albicans Is Restricted to Eight Genes
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Roles of Candida albicans Dfg5p and Dcw1p Cell Surface Proteins in Growth and Hypha Formation
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Gene Annotation and Drug Target Discovery in Candida albicans with a Tagged Transposon Mutant Collection
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A Genetic Screen for Increased Loss of Heterozygosity inSaccharomyces cerevisiae
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Genome-wide Mapping of the Coactivator Ada2p Yields Insight into the Functional Roles of SAGA/ADA Complex inCandida albicans
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BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence
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Normal Adaptation of Candida albicans to the Murine Gastrointestinal Tract Requires Efg1p-Dependent Regulation of Metabolic and Host Defense Genes
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The role of phenotypic switching in the basic biology and pathogenesis ofCandida albicans
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Protein Modularity, Cooperative Binding, and Hybrid Regulatory States Underlie Transcriptional Network Diversification
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Chromosome 1 trisomy compromises the virulence of Candida albicans
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Demonstration of Loss of Heterozygosity by Single-Nucleotide Polymorphism Microarray Analysis and Alterations in Strain Morphology in Candida albicans Strains during Infection
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Chemical Genetic Profiling and Characterization of Small-molecule Compounds That Affect the Biosynthesis of Unsaturated Fatty Acids in Candida albicans
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Comparative Transcript Profiling of Candida albicans and Candida dubliniensis Identifies SFL2 , a C. albicans Gene Required for Virulence in a Reconstituted Epithelial Infection Model
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Candida albicans Induces Arginine Biosynthetic Genes in Response to Host-Derived Reactive Oxygen Species
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Extensive and coordinated control of allele-specific expression by both transcription and translation in Candida albicansPreprint
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Variation in assimilating functions occurs in spontaneous Candida albicans mutants having chromosomal alterations.
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The genes encoding the secreted aspartyl proteinases of Candida albicans constitute a family with at least three members
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The Tlo Proteins Are Stoichiometric Components of Candida albicans Mediator Anchored via the Med3 Subunit
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The "universal" leucine codon CTG in the secreted aspartyl proteinase 1 (SAP1) gene of Candida albicans encodes a serine in vivo
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Authors: Anderson, M. Z., & Bennett, R. J.
Affiliations: Brown University (US)
ORCID: Anderson, Matthew Z.
Bennett, Richard J.
Venue: Briefings in Functional Genomics
Publisher: Oxford University Press (OUP)
Published: 2015-09-30
Volume: 15
Issue: 2
Pages: 85-94
ISSN: 2041-2647 (ISSN-L)
2041-2649
2041-2657
DOI: 10.1093/bfgp/elv035
PMC: PMC5065355
OpenAlex: W2253391407
Cited by: 11
References: 165
Citations by year: 2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2019: 3 · 2018: 3 · 2017: 1
FWCI: 0.13
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Briefings in Functional Genomics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Broad Institute
National Institutes of Health (5r01ai081704-12)
National Institute of Allergy and Infectious Diseases (AI081704, AI12363, AI081704-S1, R21AI112363)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords: Candida albicans, functional genomics, fungal virulence, commensalism, opportunistic fungal infection, comparative genomics, transcriptomics, protein-DNA interactions, Candida species
MeSH terms: Candida albicans, Chromatin, Phylogeny, Transcription, Genetic, Genome, Fungal, Genomics

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Budding off: bringing functional genomics to Candida albicans

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