CoChat
Sign Up
Cited by 266Memory and Neural MechanismsMemory Processes and InfluencesCognitive Functions and Memory

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

The effects of bilateral hippocampal damage on fMRI regional activations and interactions during memory retrieval

Maguire, E. A.·2001·Brain
DOI 10.1093/brain/124.6.1156
Open this paper in CoChat — free account

Abstract

Using functional magnetic resonance imaging (fMRI) we examined successful retrieval of real-world memories in a patient (Jon) with selective bilateral hippocampal pathology resulting from perinatal hypoxia compared with healthy control subjects. Jon activated the same brain regions during memory retrieval as control subjects, both medial and lateral on the left. In contrast to controls, Jon also activated many homologous regions on the right. In spite of having 50% volume loss bilaterally in his hippocampi, retrieval in Jon was associated with increased activation of the hippocampi. Furthermore, hippocampal activity, as with the controls, was differential, being most responsive to retrieval of autobiographical events compared with other memory types (autobiographical facts, public events, general knowledge). Jon made a distinction between events that the control subjects did not make, namely that some of the autobiographical and public events he clearly remembered, while others he found that he knew about but did not truly remember. His hippocampi and medial frontal cortex were significantly more active during retrieval of events for which he had clear and conscious recollection compared with those he knew as much about, including the context, but could not remember experiencing. Although Jon activates the same network of brain regions as the controls (albeit bilaterally), and with the same pattern of response in the hippocampus, the communication between regions differs from controls with regard to hippocampal-cortical connectivity. In controls there was increased effective connectivity between parahippocampal cortex and hippocampus, specifically during the retrieval of autobiographical events. In contrast, this increase was not apparent in Jon; rather, retrieval of autobiographical events elicited greater interaction between the hippocampus and retrosplenial cortex, and also increased interaction between retrosplenial and medial frontal cortex. This study underlines the value of scanning patients using fMRI while they undertake tasks they can perform, in this case allowing us to confirm the functionality of remaining tissue in the damaged hippocampi, and to appreciate the neural basis of a distinction (remember/know) that control subjects do not make. Besides refining our knowledge of the hippocampal role in autobiographical event memory, this study indicates that recruitment of bilateral regions during memory retrieval, and altered patterns of effective connectivity between brain regions may be important indicators of disordered memory.

Overview

Integrity signals

Registry

Crossref · 10.1093/brain/124.6.1156

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 266

Related

See all

Metadata

Authors
Maguire, E. A.
Affiliations
UCL Queen Square Institute of Neurology (GB)
Corresponding author
Maguire, E. A.
ORCID
Maguire, E. A.
Venue
Brain
Publisher
Oxford University Press (OUP)
Published
2001-06-01
Volume
124
Issue
6
Pages
1156-1170
ISSN
  • 0006-8950 (ISSN-L)
  • 1460-2156
DOI
10.1093/brain/124.6.1156
OpenAlex
W2170934763
Cited by
266
References
60
Citations by year
2025: 1 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 17 · 2014: 12 · 2013: 8 · 2012: 17
FWCI
9.04
Type
journal article
Language
en
Open access
closed
Locations
  • Brain (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
memory retrieval, autobiographical memory, perinatal hypoxia, effective connectivity, parahippocampal cortex, retrosplenial cortex, medial frontal cortex, memory disorders
MeSH terms
Adult, Asphyxia Neonatorum, Brain Mapping, Hypoxia, Brain, Cerebral Cortex, Female, Hippocampus, Humans, Infant, Newborn, Functional Laterality, Magnetic Resonance Imaging, Male, Memory, Memory Disorders, Nerve Net, Neurons, Neuropsychological Tests, Psychomotor Performance

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review