The retrosplenial cortex and emotion: new insights from functional neuroimaging of the human brain
Abstract
Little is known about the function of the retrosplenial cortex and until recently, there was no evidence that it had any involvement in emotional processes. Surprisingly, recent functional neuroimaging studies show that the retrosplenial cortex is consistently activated by emotionally salient words. A review of the functional neuroimaging literature reveals a previously overlooked pattern of observations: the retrosplenial cortex is the cortical region most consistently activated by emotionally salient stimuli. Evidence that this region is also involved in episodic memory suggests that it might have a role in the interaction between emotion and episodic memory. Recognition that the retrosplenial cortex has a prominent role in the processing of emotionally salient stimuli invites further studies to define its specific functions and its interactions with other emotion-related brain regions.
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The PCC is thought important for the modality-independent retrieval of autobiographical memories and their integration with current emotional states.
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Neuroimaging results identified that sad mood affects the thalamus, a specific brain region of cognition linked to emotional state.
“Neuroimaging results identified that sad mood affects the thalamus, a specific brain region of cognition linked to emotional state [ 69 ].”
From Anxiety and Depression Symptoms among Youth Survivors of Childhood Sexual Abuse: A Network Analysis (2023) · cites this paper as [69]
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- Authors
- Maddock, R. J.
- Affiliations
- University of California, Davis (US)
- Corresponding author
- Maddock, Richard J.
- ORCID
- Maddock, Richard J.
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 1999-07
- Volume
- 22
- Issue
- 7
- Pages
- 310-316
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2020995685
- Cited by
- 733
- References
- 64
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 2 · 2023: 11 · 2022: 15 · 2021: 21 · 2020: 14 · 2019: 23 · 2018: 13 · 2017: 32 · 2016: 24 · 2015: 23 · 2014: 25 · 2013: 43 · 2012: 31
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- retrosplenial cortex, emotions, emotional salience, episodic memory, emotional processing, brain regions
- MeSH terms
- Mental Disorders, Brain Mapping, Cerebral Cortex, Corpus Callosum, Emotions, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Neural Pathways, Tomography, Emission-Computed
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