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Cited by 294Memory and Neural MechanismsSpatial Cognition and NavigationMemory Processes and Influences

Remote spatial memory in an amnesic person with extensive bilateral hippocampal lesions

Rosenbaum, R. Shayna, Priselac, Sandra, Köhler, Stefan, Black, Sandra E., Gao, Fuqiang, Nadel, Lynn, Moscovitch, Morris·2000·Nature Neuroscience
DOI 10.1038/79867
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Abstract

The hippocampus may have a time-limited role in memory, being needed only until information is permanently stored elsewhere, or this region may permanently represent long-term allocentric spatial information or cognitive maps in memory. To test these ideas, we investigated remote spatial memory in K.C., a patient with bilateral hippocampal lesions and amnesia for autobiographical events. In his spatial knowledge, general aspects were preserved, but details were lost, a pattern that resembled his memory loss in other domains. K.C. performed normally on allocentric spatial tests of his neighborhood and the world. He had difficulty, however, in recognizing and identifying non-salient neighborhood landmarks, and in recognizing city locations on world maps. This suggests that the hippocampus is not crucial for maintenance and retrieval of remotely formed spatial representations of major landmarks, routes, distances and directions, but is necessary for specifying location details, regardless of when they were acquired.

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Crossref · 10.1038/79867

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32 of 32 references verified0 citation errors · 0 not checkable

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  • Schematic aspects of remote spatial memories are those features that survive HPC damage and continue to support navigation.

    “Schematic aspects of remote spatial memories are those features that survive HPC damage and continue to support navigation 27,80 .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [80]

  • Schematized spatial memories primarily include geometric properties rather than surface properties.

    “Schematized spatial memories primarily include geometric properties [G], rather than surface properties [G] 27,70,80,83 .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [80]

  • In individuals with bilateral HPC damage, memory for details or surface properties is lost.

    “whereas memory for details or surface properties is lost [80][81][82]123,124 .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [80]

  • In individuals with bilateral HPC damage, the gist or overall layout of a familiar environment learned before the onset of HPC damage is preserved.

    “Neuropsychological evidence in individuals with bilateral HPC damage, such as K.C. described above 80 , indicates that the gist or overall layout of a familiar environment learned before the onset of HPC damage is preserved 3,[80][81][82][122][123][124] , whereas memory for details or surface properties is lost [80][81][82]123,124 .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [80]

  • Several amnesic case studies have displayed impressive retention of spatial memories for environments learned before the onset of extensive hippocampal damage.

    “Several amnesic case studies have displayed impressive retention of spatial memories for environments learned before the onset of extensive hippocampal damage (Teng and Squire 1999; Rosenbaum et al. 2000; Maguire et al. 2006; Herdman et al. 2015).”

    From Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment (2019) · cites this paper as Rosenbaum et al. 2000

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Authors
Rosenbaum, R. S., Priselac, S., Köhler, S., Black, S. E., Gao, F., Nadel, L., & Moscovitch, M.
Affiliations
  • University of Toronto (CA)
  • Montreal Neurological Institute and Hospital (CA)
  • Sunnybrook Health Science Centre (CA)
  • University of Arizona (US)
Corresponding author
  • Rosenbaum, R. Shayna
  • Moscovitch, Morris
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2000-10
Volume
3
Issue
10
Pages
1044-1048
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/79867
OpenAlex
W1516636262
Cited by
293
References
31
Citations by year
2026: 2 · 2025: 9 · 2024: 16 · 2023: 7 · 2022: 6 · 2021: 12 · 2020: 12 · 2019: 8 · 2018: 16 · 2017: 21 · 2016: 9 · 2015: 13 · 2014: 14 · 2013: 7 · 2012: 15
FWCI
4.52
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
hippocampus, amnesia, bilateral hippocampal lesions, allocentric spatial representation, cognitive maps, landmark detection, world map, autobiographical memory, long-term memory storage
MeSH terms
Amnesia, Brain Injuries, Hippocampus, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Neuropsychological Tests, Pattern Recognition, Visual, Psychomotor Performance, Space Perception

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