The scope of preserved procedural memory in amnesia
Open accessAbstract
The finding that patients with amnesia retain the ability to learn certain procedural skills has provided compelling evidence of multiple memory systems in the human brain, but the scope, defining features and ecological significance of the preserved mnemonic abilities have not yet been explored. Here, we tested the hypothesis that subjects with amnesia would be able to learn and retain a broad range of procedural skills, by examining their acquisition and retention performance on five novel experimental tasks. The tasks are based on real-world activities and encompass a broad range of perceptual-motor demands: (i) the weaving task involves weaving pieces of fabric from woollen strings, using a manual weaver's loom; (ii) the geometric figures task consists of tracing geometric figures with a stylus as they move horizontally across a touch screen monitor; (iii) the control stick task involves tracking a sequence of visual target locations using a joystick control; (iv) the pouring task consists of pouring 200 ml of water from a watering can into a series of graduated cylinders, from a point 20 cm above the cylinders; and (v) the spatial sequence task involves learning an ordered sequence of pushing five spatially distributed buttons without visual guidance. Ten chronic and stable amnesic subjects (nine with bilateral medial temporal lobe damage due to herpes simplex encephalitis or anoxia, and one with thalamic stroke) and 25 matching normal comparison subjects were tested on…
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- Findingown data
When baseline performance was taken into account, the amnesic and comparison groups had similar learning curves after the second trial on the weaving task (no significant learning x group interaction, F = 0.04, P = 0.84).
“The analysis showed no significant learning  group interaction (F = 0.04, P = 0.84).This analysis demonstrates that when taking into account baseline performance, the amnesic and the comparison groups have similar learning curves after the second trial.”
Quote in the paperSubstantial claim - Findingown data
When baseline performance was taken into account, the amnesic and comparison groups had similar 24 h retention after the second trial on the weaving task (no significant retention x group interaction, F = 0, P = 1).
“This analysis showed no significant retention  group interaction (F = 0, P = 1).This analysis demonstrates that when taking into account baseline performance, the amnesic and the comparison groups have similar retention after the second trial.”
Quote in the paperSubstantial claim - Findingown data
The comparison group did not show any significant reduction or increase in number of errors across trials.
“The comparison group did not show any significant reduction or increase in number of errors across trials.”
Quote in the paperNot a substantial claim - Findingown data
No significant difference was found for the amnesic group between baseline and time 3 in number of errors.
“No significant difference was found for the amnesic group between baseline and time 3.”
Quote in the paperSubstantial claim - Findingown data
The amnesics spent significantly more time performing the weaving task at baseline than comparison subjects (t = 4.83, P < 0.01).
“The amnesics spent significantly more time (t = 4.83, P < 0.01) performing the task at baseline than comparison subjects.”
Quote in the paperSubstantial claim
- Findingown data
The only subject without hippocampal damage had a medial and anterior thalamic lesion.
“The only subject without hippocampal damage had a medial and anterior thalamic lesion.”
Quote in the paperNot a substantial claim - Findingown data
Amnesic subjects demonstrated acquisition and retention of the five procedural skills despite impaired declarative memory for the tasks.
“Despite impaired declarative memory for the tasks, the amnesic subjects demonstrated acquisition and retention of the five skills; their learning slopes over repeated trials were comparable with those of comparison subjects.”
Quote in the paperSubstantial claim - Findingown data
The t tests for paired samples revealed significant 24 h retention for both groups on the weaving task (amnesics t = 6.4, P < 0.01; comparison subjects t = 5.61, P < 0.01).
“The t tests for paired samples revealed a significant retention for both groups (amnesics t = 6.4,P < 0.01; comparison subjects t = 5.61, P < 0.01).”
Quote in the paperSubstantial claim - Findingown data
When baseline performance was taken into account, the amnesic and comparison groups had similar retention after the second trial at time 3 on the weaving task (no significant retention x group interaction, F = 0.39, P = 0.54).
“This analysis showed no significant retention  group interaction (F = 0.39, P = 0.54).This analysis demonstrates that when taking into account baseline performance, the amnesic and the comparison groups have similar retention after the second trial.”
Quote in the paperSubstantial claim - Findingown data
Three of the four HSE patients also showed amygdala damage.
“all four HSE patients had extensive or complete damage to the hippocampal region bilaterally, and three also showed amygdala damage.”
Quote in the paperNot a substantial claim - Findingown data
All four HSE patients had extensive or complete damage to the hippocampal region bilaterally.
“all four HSE patients had extensive or complete damage to the hippocampal region bilaterally, and three also showed amygdala damage.”
Quote in the paperSubstantial claim - Findingown data
The groups did not differ from one another on the distance from target (DFT) at baseline on the geometric figures task (t = 1.3, P = 0.09).
“The groups did not differ from one another on the DFT at baseline (t = 1.3, P = 0.09).”
Quote in the paperSubstantial claim - Findingown data
The learning slopes of amnesic subjects over repeated trials were comparable with those of comparison subjects.
“Despite impaired declarative memory for the tasks, the amnesic subjects demonstrated acquisition and retention of the five skills; their learning slopes over repeated trials were comparable with those of comparison subjects.”
Quote in the paperSubstantial claim - Findingown data
A 2x2 ANOVA showed a significant learning effect (F = 20.14, P < 0.01).
“A 2 Â 2 ANOVA showed significant learning effects (F = 20.14,P < 0.01)”
Quote in the paperSubstantial claim - Findingown data
The 2x2 ANOVA showed a significant learning effect (F = 34.98, P < 0.01).
“The 2 Â 2 ANOVA showed a significant learning effect (F = 34.98,P < 0.01).”
Quote in the paperSubstantial claim - Findingown data
A 2x2 ANOVA showed no significant learning x group interaction (F = 0.38, P = 0.54).
“and no significant learning  group interaction (F = 0.38, P = 0.54).”
Quote in the paperSubstantial claim - Findingown data
When using ANOVA for repeated measures with baseline competency as covariate, the analyses showed no significant learning x aetiology effect for the weaving task.
“When we used the ANOVA for repeated measures with trial 2 of time 1 as the first level of analyses, and baseline competency as the covariate, the analyses showed no significant learning  aetiology effect.”
Quote in the paperSubstantial claim - Findingown data
An ANOVA for repeated measures with baseline competency as covariate showed a significant retention x group interaction (F = 6.71, P = 0.02).
“An ANOVA for repeated measures, with trial 2 of time 1 and trial 1 of time 3 as the levels of analysis, and baseline competency as the covariate, showed significant retention  group interaction (F = 6.71,P = 0.02).”
Quote in the paperSubstantial claim - Findingown data
No significant learning x group interaction was found (F = 0.41, P = 0.53).
“No significant learning  group interaction (F = 0.41, P = 0.53)”
Quote in the paperSubstantial claim - Findingown data
The comparison subjects demonstrated a significant retention of the skill at time 3 (t = 2.33, P = 0.03).
“The comparison subjects demonstrated a significant retention of the skill (t = 2.33, P = 0.03).”
Quote in the paperNot a substantial claim - Findingown data
The 2x2 ANOVA showed a significant retention effect (F = 6.2, P = 0.02).
“The 2 Â 2 ANOVA showed significant retention effects (F = 6.2, P = 0.02)”
Quote in the paperSubstantial claim - Findingown data
The 2x2 ANOVA showed a significant group effect (F = 6.68, P = 0.01).
“and group effects (F = 6.68,P = 0.01)”
Quote in the paperSubstantial claim - Findingown data
An ANOVA for repeated measures with baseline competency as covariate showed no significant learning x group interaction (F = 0.25, P = 0.62).
“An ANOVA for repeated measures, with trial 2 and trial 5 of time 1 as the levels of analysis, and baseline competency as the covariate, showed no significant learning  group interaction (F = 0.25, P = 0.62).”
Quote in the paperSubstantial claim - Findingown data
The amnesic group did not show a significant difference between baseline and the first trial of time 2 (t = -0.3, P = 0.77).
“the amnesic group did not show a significant difference (t = À0.3,P = 0.77) between baseline and the first trial of time 2.”
Quote in the paperSubstantial claim - Findingown data
Three amnesics were not able to recall any explicit information about the tasks.
“Three amnesics were not able to recall any explicit information about the tasks.”
Quote in the paperNot a substantial claim - Findingown data
An ANOVA for repeated measures with baseline competency as covariate showed no significant retention x group interaction (F = 0.21, P = 0.65) for the geometric figures task.
“An ANOVA for repeated measures, with trial 2 of time 1 and trial 1 of time 2 as the levels of analysis, and baseline competency as the covariate, showed no significant retention  group interaction (F = 0.21, P = 0.65).”
Quote in the paperSubstantial claim - Findingown data
The 2x2 ANOVA showed no significant retention x group interaction (F = 0.01, P = 0.93).
“and no significant retention  group interaction (F = 0.01, P = 0.93).”
Quote in the paperSubstantial claim - Findingown data
In the recognition test, the amnesic group (mean = 78.6%, SD = 16.11) performed worse than the comparison group (mean = 97.1%, SD = 2.67) (t = 3.43, P < 0.01).
“In the recognition test, the amnesic group (mean = 78.6%,SD = 16.11) also performed worse than the comparison group (mean = 97.1%,SD = 2.67) (t = 3.43, P < 0.01).”
Quote in the paperSubstantial claim - Findingown data
An ANOVA for repeated measures with baseline competency as covariate showed no significant learning x group interaction (F = 3.45, P = 0.07).
“An ANOVA for repeated measures, with trial 2 and trial 20 of time 1 as the levels of analysis, and baseline competency as the covariate, showed no significant learning  group interaction (F = 3.45, P = 0.07).”
Quote in the paperSubstantial claim - Findingown data
The amnesics spent significantly more time to perform the control stick task at baseline than comparison subjects (t = 2.19, P = 0.04).
“The amnesics spent significantly more time (t = 2.19, P = 0.04) to perform the task at baseline than comparison subjects.”
Quote in the paperNot a substantial claim - Findingown data
No significant group effect was found (F = 3.56, P = 0.07).
“nor a significant group effect (F = 3.56, P = 0.07) were found.”
Quote in the paperSubstantial claim - Findingown data
At time 3, the amnesics did not show a significant difference from baseline (t = 1.28, P = 0.23).
“At time 3, the amnesics did not show a significant difference from baseline (t = 1.28,P = 0.23).”
Quote in the paperSubstantial claim - Findingown data
At time 3, the amnesics' distance from the figures was significantly smaller than at baseline (t = 4.01, P < 0.01).
“At time 3, the amnesics' distance from the figures was significantly smaller than at baseline (t = 4.01, P < 0.01).”
Quote in the paperSubstantial claim - Findingown data
Only one significant retention x group interaction was found after excluding outliers; this was for the geometric figures task at time 3.
“Only one significant retention  group interaction was found; this was for the geometric figures task at time 3.”
Quote in the paperNot a substantial claim - Findingown data
The amnesics poured a significantly smaller amount of water than comparison subjects on the first trial of time 1 (t = -3.56, P < 0.01).
“The amnesics poured a significantly smaller amount of water (t = -3.56,P < 0.01) than comparison subjects on the first trial of time 1.”
Quote in the paperNot a substantial claim - Findingown data
The 2x2 ANOVA did not show a significant retention x group interaction (F = 1.55, P = 0.22).
“nor retention  group interaction (F = 1.55,P = 0.22).”
Quote in the paperSubstantial claim - Findingown data
An ANOVA for repeated measures with baseline competency as covariate showed no significant learning x group interaction (F = 0.08, P = 0.78) for the geometric figures task.
“An ANOVA for repeated measures, with trial 2 and trial 5 of time 1 as the levels of analysis, and baseline competency as the covariate, showed no significant learning  group interaction (F = 0.08, P = 0.78).”
Quote in the paperSubstantial claim - Findingown data
The comparison group showed a significant difference between baseline and the first trial of time 2 (t = -2.38, P = 0.03).
“As opposed to the comparison group (t = À2.38,P = 0.03), the amnesic group did not show a significant difference (t = À0.3,P = 0.77) between baseline and the first trial of time 2.”
Quote in the paperSubstantial claim - Findingown data
An ANOVA for repeated measures with baseline competency as covariate showed no significant retention x group interaction (F = 1.53, P = 0.22).
“An ANOVA for repeated measures, with trial 2 of time 1 and trial 1 of time 2 as the levels of analysis, and baseline competency as the covariate, showed no significant retention  group interaction (F = 1.53,P = 0.22).”
Quote in the paperSubstantial claim - Findingown data
The 2x2 ANOVA demonstrated a significant retention effect (F = 5.69, P = 0.02).
“The 2 Â 2 ANOVA demonstrated a significant retention effect (F = 5.69, P = 0.02)”
Quote in the paperSubstantial claim - Findingown data
The two groups did not significantly differ on their learning curves or retention results for any of the tasks after excluding outliers.
“Specifically, the two groups did not significantly differ on their learning curves or retention results for any of the tasks.”
Quote in the paperNot a substantial claim - Findingown data
We found a significant interaction between aetiology and learning (F = 5.98, P = 0.03) of the weaving task.
“We found a significant interaction between aetiology and learning (F = 5.98, P = 0.03)”
Quote in the paperSubstantial claim - Findingown data
There was no group x false alarm interaction.
“nor any group  false alarm interaction.”
Quote in the paperNot a substantial claim - Findingown data
After adjusting for age and education, the independent variable group was not a good predictor of retention at time 3 of the weaving task (F = 1.58, P = 0.23).
“and not a good predictor at time 3 (F = 1.58,P = 0.23).”
Quote in the paperSubstantial claim - Findingown data
When analysing only the HSE group and the anoxia group, the interaction between aetiology and learning of the weaving task was nearly significant (F = 4.12, P = 0.08).
“When we analysed only the HSE group and the anoxia group, the interaction between aetiology and learning of the weaving task was nearly significant (F = 4.12, P = 0.08)”
Quote in the paperNot a substantial claim - Findingown data
Neither group demonstrated retention of their task at time 2 or time 3.
“Neither group demonstrated retention of their task at time 2 or time 3.”
Quote in the paperSubstantial claim - Findingown data
A 2x2 ANOVA showed a significant group effect (F = 20.69, P < 0.01).
“significant group effects (F = 20.69,P < 0.01)”
Quote in the paperSubstantial claim - Findingown data
The 2x2 ANOVA demonstrated no significant retention x group interaction (F = 0.71, P = 0.41).
“and no significant retention  group interaction (F = 0.71, P = 0.41).”
Quote in the paperSubstantial claim - Findingown data
An ANOVA for repeated measures with baseline competency as covariate showed no significant retention x group interaction (F = 2.87, P = 0.1).
“An ANOVA for repeated measures, with trial 2 of time 1 and trial 1 of time 2 as the levels of analysis, and baseline competency as the covariate, showed no significant retention  group interaction (F = 2.87, P = 0.1).”
Quote in the paperSubstantial claim - Findingown data
The groups did not differ from one another in the time spent to perform the spatial sequence task at baseline (t = 0.94, P = 0.35).
“The groups did not differ from one another in the time spent to perform the task at baseline (t = 0.94, P = 0.35).”
Quote in the paperSubstantial claim - Findingown data
The 2x2 ANOVA demonstrated nearly significant group effects (F = 4.34, P = 0.05).
“nearly significant group effects (F = 4.34, P = 0.05)”
Quote in the paperNot a substantial claim - Findingown data
The 2x2 ANOVA did not show significant retention effects (F = 2.45, P = 0.13).
“The 2 Â 2 ANOVA did not show significant retention effects (F = 2.45, P = 0.13)”
Quote in the paperSubstantial claim - Findingown data
The amnesic group (mean = 15.28%; SD = 19.54) performed worse than the comparison group (mean = 78.5%, SD = 16.35) on the recall questionnaire (t = 9.45, P < 0.01).
“The amnesic group (mean = 15.28%;SD = 19.54)performed worse than the comparison group (mean = 78.5%,SD = 16.35) on the recall questionnaire (t = 9.45, P < 0.01).”
Quote in the paperSubstantial claim - Findingown data
There were significant group effects (F = 22.75, P < 0.01).
“There were significant group effects (F = 22.75, P < 0.01).”
Quote in the paperNot a substantial claim - Findingown data
There were no trial x false alarm effects for either group.
“There were no trial  false alarm effects for either group, nor any group  false alarm interaction.”
Quote in the paperNot a substantial claim - Findingown data
The comparison subjects' DFT did not differ from baseline at time 3 (t = 1.55, P = 0.16).
“The comparison subjects' DFT did not differ from baseline (t = 1.55,P = 0.16).”
Quote in the paperNot a substantial claim - Findingown data
An ANOVA for repeated measures with baseline competency as covariate showed no significant retention x group interaction (F = 0.52, P = 0.48).
“An ANOVA for repeated measures, with trial 2 of time 1 and trial 1 of time 3 as the levels of analysis, and baseline competency as the covariate, showed no significant retention  group interaction (F = 0.52, P = 0.48).”
Quote in the paperSubstantial claim - Findingown data
We found no significant group effect on learning (F = 0.7, P = 0.53) of the weaving task.
“and no significant group effect on learning (F = 0.7, P = 0.53) of the weaving task.”
Quote in the paperSubstantial claim - Findingown data
When analysing only the HSE group and the anoxia group, no significant aetiology effect (F = 0.12, P = 0.74) was found on learning the weaving task.
“and again no significant aetiology effect (F = 0.12, P = 0.74) was found on learning the weaving task.”
Quote in the paperSubstantial claim - Findingown data
An ANOVA for repeated measures with baseline competency as covariate showed no significant learning x group interaction (F = 0.13, P = 0.72) for the control stick task.
“An ANOVA for repeated measures, with trial 2 and trial 5 time 1 as the levels of analysis, and baseline competency as the covariate, showed no significant learning  group interaction (F = 0.13, P = 0.72).”
Quote in the paperSubstantial claim - Findingown data
There was no significant difference between baseline performance and performance on the first trial of time 2 and 3, in either speed or number of errors.
“There was no significant difference between baseline performance and performance on the first trial of time 2 and 3, in either speed or number of errors.”
Quote in the paperSubstantial claim - Findingown data
The HSE subjects had substantially more extensive temporal lesions than the anoxic subjects.
“With respect to this difference in performance, it is interesting to note that the HSE subjects had substantially more extensive temporal lesions than the anoxic subjects.”
Quote in the paperNot a substantial claim - Findingnone given
The retention results of the amnesic group and of the comparison group on the control stick and pouring tasks were less clear.
“The retention results of the amnesic group and of the comparison group on the control stick and pouring tasks were less clear.”
Quote in the paperNot a substantial claim - Findingown data
Most of the comparison group performance was errorless on the weaving task.
“and that most of the comparison group performance was errorless”
Quote in the paperSubstantial claim - Findingnone given
Within the amnesic group, the HSE subgroup tended to show more improvement on the weaving task than the anoxic subgroup.
“Within the amnesic group, the HSE subgroup tended to show more improvement on the weaving task than the anoxic subgroup.”
Quote in the paperNot a substantial claim - Findingown data
When the second trial (instead of the first trial) was used as the first level of analysis and baseline was controlled for, the differences disappeared.
“When we used the second trial (instead of the first trial) as the first level of analysis and controlled for baseline, the differences disappeared.”
Quote in the paperSubstantial claim - Findingown data
The subjects in the amnesic group committed significantly more errors than did the comparison group on the weaving task.
“The finding that the subjects in the amnesic group committed significantly more errors than did the comparison group”
Quote in the paperSubstantial claim - Findingown data
A significant difference in performance between groups was seen only in the weaving task.
“A significant difference in performance between groups was seen only in the weaving task.”
Quote in the paperSubstantial claim - Findingown data
No significant correlation was found between the Grooved Pegboard (raw) data (performed with the dominant hand) and the baseline performances on tasks 2, 3, 4 and 5.
“No significant correlation was found between the Grooved Pegboard (raw) data (performed with the dominant hand) and the baseline performances on tasks 2, 3, 4 and 5.”
Quote in the paperSubstantial claim - Findingreasoning
The results from the delayed retention phase of the experiment were less consistent across tasks than were the findings from the initial learning phase.
“The results from the delayed retention phase of the experiment were less consistent across tasks than were the findings from the initial learning phase.”
Quote in the paperSubstantial claim - Findingown data
Demographic characteristics of the subjects did not predict learning (at time 1) or retention (times 2 and 3) of any of the tasks.
“Demographic characteristics of the subjects did not predict learning (at time 1) or retention (times 2 and 3) of any of the tasks.”
Quote in the paperSubstantial claim - Findingown data
No significant difference was found between groups on the geometric figures, control stick, pouring and spatial sequence tasks at time 2 and 3.
“However, no significant difference was found between groups on the geometric figures, control stick, pouring and spatial sequence tasks at time 2 and 3.”
Quote in the paperSubstantial claim - Premisecitation
Amnesics have shown the ability to press an imbedded sequence of keys (serial reaction time).
“and the skill to press an imbedded sequence of keys-'serial reaction time' (Nissen and Bullemer, 1987).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Nissen and Bullemer, 1987
Not checked in the free run.
- Interpretationown data
Preserved learning of complex perceptual-motor skills in amnesia can be demonstrated across a variety of conditions and perceptual-motor demands.
“These findings indicate that preserved learning of complex perceptual-motor skills in patients with amnesia is a robust phenomenon, and that it can be demonstrated across a variety of conditions and perceptual-motor demands.”
Quote in the paperSubstantial claim - Interpretationown data
Preserved learning of complex perceptual-motor skills in patients with amnesia is a robust phenomenon.
“These findings indicate that preserved learning of complex perceptual-motor skills in patients with amnesia is a robust phenomenon, and that it can be demonstrated across a variety of conditions and perceptual-motor demands.”
Quote in the paperSubstantial claim - Premisecitation
Amnesics have shown the ability to maintain contact between a hand-held stylus and a target metal disk on a revolving turntable (rotor pursuit).
“the skill to maintain contact between a hand-held stylus and a target metal disk, on a revolving turntable-'rotor pursuit' (Brooks and Baddeley, 1976;Tranel et al., 1994);”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites Brooks and Baddeley, 1976
Not checked in the free run.
- cites Tranel et al., 1994
Not checked in the free run.
- Premisecitation
Amnesia in patients with medial temporal lobe, medial diencephalic, or basal forebrain damage is not complete, but leaves preserved the ability to learn and retain some perceptual-motor skills at normal or near normal levels.
“Amnesia in such patients is not complete, however, but rather leaves preserved the ability to learn and retain some perceptual-motor skills at normal or near normal levels.”
Quote in the paperSubstantial claim - Premisecitation
The basal ganglia, cerebellum and prefrontal/premotor regions are involved in perceptual-motor skill learning.
“indicate that the basal ganglia, cerebellum and the prefrontal/premotor regions are involved in perceptual-motor skill learning.”
Quote in the paperSubstantial claim0 of 3 sources checked- cites Seitz et al., 1990
Not checked in the free run.
- cites Grafton et al., 1992
Not checked in the free run.
- cites Doyon et al., 2002
Not checked in the free run.
- Premisecitation
Severe anterograde amnesia for declarative information can result from damage to medial temporal lobe structures, medial diencephalic nuclei, or basal forebrain nuclei.
“Severe anterograde amnesia for declarative information can result from damage to medial temporal lobe structures (Scoville and Milner, 1957), medial diencephalic nuclei (Graff-Radford et al., 1990) or basal forebrain nuclei (Damasio et al., 1985b).”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites Scoville and Milner, 1957
Not checked in the free run.
- cites Graff-Radford et al., 1990
Not checked in the free run.
- cites Damasio et al., 1985b
Not checked in the free run.
- Premisecitation
Amnesics have shown the ability to learn and retain the skill to trace a figure reflected in the mirror (mirror tracing).
“Amnesics have shown the ability to learn and retain the skill to trace a figure reflected in the mirror-'mirror tracing' (Milner, 1962;Damasio et al., 1985a;Nichelli et al., 1988;Gabrieli et al., 1993;Tranel et al., 1994);”
Quote in the paperSubstantial claim0 of 3 sources checked- cites Milner, 1962
Not checked in the free run.
- cites Damasio et al., 1985a
Not checked in the free run.
- cites Nichelli et al., 1988
Not checked in the free run.
- Premisecitation
At least some perceptual-motor skill learning depends on anatomical systems distinct from those involved in declarative memory.
“There is much evidence to suggest that at least some perceptual-motor skill learning depends on anatomical systems distinct from those involved in declarative memory.”
Quote in the paperSubstantial claim0 of 3 sources checked- cites Pascual-Leone et al., 1993
Not checked in the free run.
- cites Frith et al., 1986
Not checked in the free run.
- cites Heindel et al., 1988
Not checked in the free run.
- Study design and conductreasoning
As a result of the reduction of the number of subjects in the comparison group, the groups were no longer matched for age and education.
“As a result of the reduction of the number of subjects in the comparison group, the groups were no longer matched for age and education.”
Quote in the paperNot a substantial claim - Interpretationreasoning
The significant retention x group interaction for the geometric figures task at time 3 appears to be due to the reduced number of data points available after excluding outlying points, with the comparison group reduced to only five subjects at time 3 for this task.
“This difference appears to be due to the reduced number of data points available after excluding the outlying points, in that the comparison group was reduced to only five subjects at time 3 for this task.”
Quote in the paperNot a substantial claim - Study design and conductreasoning
As a result of the reduction of the number of subjects in the comparison group, the groups were no longer matched for education.
“As a result of the reduction of the number of subjects in the comparison group, the groups were no longer matched for education.”
Quote in the paperNot a substantial claim - Study design and conductown data
After excluding outlying data points identified with stem-and-leaf plots, the results did not alter the key findings.
“We reran the statistical analyses after excluding outlying data points identified with stem-and-leaf plots.In general, the results of these analyses did not alter the key findings.”
Quote in the paperNot a substantial claim - Interpretationcitation
The phenomenon of competing interference between tasks may have affected the consolidation of the motor skills, and consequently the retention results.
“The phenomenon of competing interference between tasks may have affected the consolidation of the motor skills, and consequently the retention results.”
Quote in the paperNot a substantial claim - Interpretationown data
These findings demonstrate that preserved perceptual-motor skill learning in amnesia is not a restricted laboratory phenomenon.
“These findings demonstrate that preserved perceptual-motor skill learning in amnesia is not a restricted laboratory phenomenon.”
Quote in the paperSubstantial claim - Study design and conductnone given
At time 3, the groups were no longer matched for age and/or education.
“At time 3, the groups were no longer matched for age and/or education.”
Quote in the paperNot a substantial claim - Interpretationown data
The amnesics' declarative memory for the tasks performed in the previous session was significantly impaired.
“The amnesics' declarative memory for the tasks performed in the previous session was significantly impaired.”
Quote in the paperSubstantial claim - Interpretationown data
The significant differences on the learning and retention curves of the weaving task may be due to the baseline differences between groups.
“The significant differences on the learning and retention curves may be due to the baseline differences between groups.”
Quote in the paperSubstantial claim - Premisecitation
Combined lesions of the hippocampus and surrounding areas (i.e. the parahippocampal region and the amygdala) tend to cause more severe declarative memory deficits than do lesions restricted to the hippocampus proper.
“We know that combined lesions of the hippocampus and surrounding areas (i.e. the parahippocampal region and the amygdala) tend to cause more severe declarative memory deficits than do lesions restricted to the hippocampus proper (for a review see Eichenbaum and Cohen, 2001).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Eichenbaum and Cohen, 2001
Not checked in the free run.
- Interpretationreasoning
The diversity of retention patterns raises the possibility that different non-declarative memory systems may subserve learning and retention of different perceptual-motor skills.
“The diversity of retention patterns also raises the possibility that different non-declarative memory systems may subserve learning and retention of different perceptual-motor skills.”
Quote in the paperSubstantial claim - Premisecitation
There is competition between memory systems.
“This would be consistent with recent findings suggesting that there is competition between memory systems (Packard et al., 1989;Poldrack et al., 2001; for a review see Poldrack and Packard, 2003).”
Quote in the paperSubstantial claim0 of 3 sources checked- cites Packard et al., 1989
Not checked in the free run.
- cites Poldrack et al., 2001
Not checked in the free run.
- cites Poldrack and Packard, 2003
Not checked in the free run.
- Study design and conductown data
Additional statistical analyses with non-matching subgroups (composed of subjects with available data at time 3) demonstrated that the results (at time 1 and time 2) were comparable with those of the initial matched groups.
“Additional statistical analyses with non-matching subgroups (i.e.composed of subjects with available data at time 3) demonstrated that the results (at time 1 and time 2) were comparable with those of the initial matched groups.”
Quote in the paperNot a substantial claim
- May combine two claims. 50
- Classified as probably not a substantial claim. 34
- The quote only partly states this claim. 3
May combine two claims.
Findingown dataAt time 3, both amnesics (t = 3.08, P = 0.01) and comparison subjects (t = 2.82, P = 0.02) showed significant retention of the weaving skill.
“At this follow-up, the amnesics (t = 3.08, P = 0.01) and the comparison subjects (t = 2.82, P = 0.02) showed significant retention of the weaving skill.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone givenThe hippocampus was particularly atrophic in the anoxic subjects.
“The hippocampus was particularly atrophic in these anoxics.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe amnesic group reduced the number of errors from baseline to the last trial of time 1 (t = 3.47, P < 0.01), and from baseline to time 2 (t = 2.27, P = 0.05).
“The amnesic group reduced the number of errors from baseline to the last trial of time 1 (t = 3.47, P < 0.01), and from baseline to time 2 (t = 2.27, P = 0.05).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe amnesic subjects' cognitive abilities were generally well-preserved, with the exception of severe memory impairment.
“These findings show generally well-preserved cognitive abilities of these subjects, with the exception of their severe memory impairment (Tables 1 and 2).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe amnesics committed significantly more errors at baseline (t = 3.3, P < 0.01) and at the last trial of time 1 (t = 2.36, P < 0.05) than the comparison group.
“The amnesics committed significantly more errors at baseline (t = 3.3, P < 0.01) and at the last (t = 2.36, P < 0.05) trial of time 1 than the comparison group.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe 2 x 2 ANOVA demonstrated a significant retention effect (F = 19.3, P < 0.01), significant group effect (F = 36.49, P < 0.01) and significant retention x group interaction (F = 4.94, P = 0.04) for the weaving task at time 3.
“The 2  2 ANOVA demonstrated a significant retention effect (F = 19.3,P < 0.01), significant group effect (F = 36.49,P < 0.01) and significant retention  group interaction (F = 4.94, P = 0.04).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataAt baseline, the frequency of errors ranged from 0 to 7 (mean = 3.4, SD = 2.8) for the amnesic group, and from 0 to 3 (mean = 0.48, SD = 0.82) for the comparison group.
“At baseline, the frequency of errors ranged from 0 to 7 (mean = 3.4,SD = 2.8) for the amnesic group, and from 0 to 3 (mean = 0.48, SD = 0.82) for the comparison group.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataBoth amnesic and comparison groups significantly reduced the amount of time needed to perform the weaving task (amnesics t = 6.58, P < 0.01; comparison subjects t = 6.17, P < 0.01).
“Both groups significantly reduced the amount of time needed to perform the task (amnesics t = 6.58,P < 0.01; comparison subjects t = 6.17,P < 0.01).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataNo significant difference in number of errors was found between groups at time 2 (t = 2.14, P = 0.06) or time 3 (t = 2.05, P = 0.07).
“No significant difference in number of errors was found between groups at time 2 (t = 2.14, P = 0.06) or time 3 (t = 2.05, P = 0.07).”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingown dataThe mean interval between time 1 and time 3 was 85 days (SD = 51.8) for the amnesic group and 57 days (SD = 5.3) for the comparison group.
“the mean interval between time 1 and time 3 for the qmnesic group was 85 days (SD = 51.8) and for the comparison group was 57 days (SD = 5.3)”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe 2 x 2 ANOVA showed significant retention effects (F = 78.07, P < 0.01), significant retention x group interaction (F = 10.77, P < 0.01), and significant group effects (F = 40.27, P < 0.01) for the weaving task.
“The 2  2 ANOVA showed significant retention effects (F = 78.07,P < 0.01), significant retention  group interaction (F = 10.77,P < 0.01), and significant group effects (F = 40.27;P < 0.01).”
Quote in the paperSubstantial claimMay combine two claims. The quote only partly states this claim.
Findingown dataWhen using ANOVA for repeated measures with baseline competency as covariate, the analyses showed no significant learning x aetiology effect for the HSE and anoxia groups.
“When we used the ANOVA for repeated measures with trial 2 of time 1 as the first level of analyses, and baseline competency as the covariate, the analyses showed no significant learning  aetiology effect.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataBoth groups demonstrated learning on the geometric figures task (amnesics t = 3.6, P < 0.01; comparison subjects t = 3.31, P < 0.01).
“Both groups demonstrated learning (amnesics t = 3.6, P < 0.01; comparison subjects t = 3.31, P < 0.01).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataMultiple regression analyses revealed that age and education were not significant predictors of learning, retention at time 2, nor retention at time 3 of the geometric figures task, control stick task and spatial sequence task.
“Multiple regression analyses revealed that age and education were not significant predictors of learning, retention at time 2, nor retention at time 3 of the geometric figures task, control stick task and spatial sequence task.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataAfter adjusting for age and education, the independent variable group was not a good predictor of learning, retention at time 2 nor retention at time 3 of any of the tasks.
“After adjusting for these factors, the independent variable group was not a good predictor of learning, retention at time 2 nor retention at time 3 of any of the tasks.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataBoth groups demonstrated learning on the control stick task (amnesics t = 6.85, P < 0.01; comparison subjects t = 6.19, P < 0.01).
“Both groups demonstrated learning (amnesics t = 6.85,P < 0.01; comparison subjects t = 6.19,P < 0.01).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataAfter adjusting for age and education, the independent variable group was a good predictor of learning (F = 2.98, P = 0.047) and retention at time 2 (F = 3.54, P = 0.03) of the weaving task.
“After adjusting for these demographic factors, the independent variable group was a good predictor of learning (F = 2.98, P = 0.047) and retention at time 2 (F = 3.54, P = 0.03)”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe overall rate of false alarms per trial ranged between zero and eight in both amnesics and comparison groups.
“The overall rate of false alarms per trial ranged between zero and eight in both amnesics and comparison groups.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataA 2 x 2 ANOVA showed significant learning effects (F = 67.42, P < 0.01), significant group effects (F = 6.23, P = 0.02) and no significant learning x group interaction (F = 1.39, P = 0.25) for the control stick task.
“A 2  2 ANOVA showed significant learning effects (F = 67.42,P < 0.01), significant group effects (F = 6.23,P = 0.02) and no significant learning  group interaction (F = 1.39,P = 0.25).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataMultiple regression analyses revealed that age and education were not significant predictors of learning (F = 0.18, P = 0.32), retention at time 2 (F = 0.02, P = 1) nor retention at time 3 (F = 0.99, P = 0.39) of the weaving task.
“Multiple regression analyses revealed that age and education were not significant predictors of learning (F = 0.18, P = 0.32), retention at time 2 (F = 0.02, P = 1) nor retention at time 3 (F = 0.99, P = 0.39) of the weaving task.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataOn tasks 2, 3, 4 and 5, no aetiology x learning interaction nor aetiology effect were found on the 2x2 ANOVA analyses.
“On tasks 2, 3, 4 and 5, no aetiology  learning interaction nor aetiology effect were found on the 2  2 ANOVA analyses.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataBoth groups significantly increased the volume of water successfully poured (amnesics t = -2.79, P = 0.02; comparison subjects t = -4.5, P < 0.01).
“Both groups significantly increased the volume of water successfully poured (amnesics t = À2.79,P = 0.02; comparison subjects t = À4.5, P < 0.01).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataAt time 3, neither the amnesics (t = 0.35, P = 0.74) nor the comparison subjects (t = -1.93, P = 0.08) showed a significant difference from baseline.
“At time 3, neither the amnesics (t = 0.35, P = 0.74) nor the comparison subjects (t = À1.93,P = 0.08) showed a significant difference from baseline.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataThe 2 x 2 ANOVA demonstrated a significant retention effect (F = 10.26, P < 0.01), no group effects (F = 1.92, P = 0.18) and no significant retention x group interaction (F = 0.34, P = 0.57) for the geometric figures task at time 3.
“The 2  2 ANOVA demonstrated a significant retention effect (F = 10.26,P < 0.01), no group effects (F = 1.92,P = 0.18) and no significant retention  group interaction (F = 0.34, P = 0.57).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataA 2 x 2 ANOVA showed significant learning effects (F = 20.13, P < 0.01), significant group effects (F = 4.62, P = 0.04) and no significant learning x group interaction (F = 0.62, P = 0.44) for the geometric figures task.
“A 2  2 ANOVA showed significant learning effects (F = 20.13,P < 0.01), significant group effects (F = 4.62, P = 0.04) and no significant learning  group interaction (F = 0.62, P = 0.44).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataSignificant learning was demonstrated by the comparison subjects (t = 7.02, P < 0.01) as well as the amnesics (t = 2.46, P = 0.04).
“Significant learning was demonstrated by the comparison subjects (t = 7.02, P < 0.01) as well as the amnesics (t = 2.46, P = 0.04).”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataOne amnesic and one comparison subject were not able to perform a successful trial after 20 consecutive trials.
“One amnesic and one comparison subject were not able to perform a successful trial after 20 consecutive trials.”
Quote in the paperNot a substantial claimThe quote only partly states this claim.
Findingown dataThe ANOVA for repeated measures with baseline competency as covariate showed no significant retention x group interaction (F = 0.69, P = 0.42) for the geometric figures task at time 3.
“The ANOVA for repeated measures with trial 2 of time 1 and trial 1 of time 3 as the levels of analysis, and baseline competency as the covariate, showed no significant retention  group interaction (F = 0.69, P = 0.42).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataOn paired-samples t tests, the 24 h retention level nearly reached significance for both the comparison group (t = 2.07, P = 0.05) and the amnesic group (t = 2.1, P = 0.06).
“On t tests for paired samples, the retention level nearly reached significance for both the comparison group (t = 2.07, P = 0.05) and the amnesic group (t = 2.1, P = 0.06).”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataAn ANOVA for repeated measures with baseline competency as covariate showed no significant retention x group interaction at time 2 (F = 0.27, P = 0.6) or time 3 (F = 0.19, P = 0.67).
“An ANOVA for repeated measures, with trial 2 of time 1 as the first level of analyses, and baseline competency as the covariate, showed no significant retention  group interaction at time 2 (F = 0.27, P = 0.6) or time 3 (F = 0.19, P = 0.67).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe 2 x 2 ANOVA showed significant retention effects (F = 13.17, P < 0.01), no significant group effects (F = 3.61, P = 0.07) and no significant retention x group interaction (F = 1.01, P = 0.32) for the geometric figures task.
“The 2  2 ANOVA showed significant retention effects (F = 13.17,P < 0.01).This test did not show significant group effects (F = 3.61, P = 0.07) nor significant retention  group interaction (F = 1.01,P = 0.32).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThere were no significant differences between groups, or within groups over time, in the number of points available for sampling.
“There were no significant differences between groups, or within groups over time in the number of points available for sampling.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe 24 h retention level of DFT reached significance for the amnesic group (t = 3.05, P = 0.01) and the comparison group (t = 2.38, P = 0.03).
“On t tests for paired samples, the retention level of the DFT reached significance for the amnesic group (t = 3.05, P = 0.01) and the comparison group (t = 2.38, P = 0.03).”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataAmnesic subjects demonstrated more improvement across trials (at time 1) and better delayed retention (at times 2 and 3) than the non-amnesic subjects on the weaving task.
“Amnesic subjects demonstrated more improvement across trials (at time 1) and better delayed retention (at times 2 and 3) than the non-amnesic subjects.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataAlthough the amnesic subjects demonstrated learning on all tasks, the delayed retention of the weaving skill and the ability to trace moving geometric figures contrasted with limited retention of the remaining skills.
“Although the amnesic subjects demonstrated learning on all tasks, the delayed retention of the weaving skill and the ability to trace moving geometric figures contrasted with limited retention of the remaining skills.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim. May combine two claims.
Findingnone givenThe weaving task was completely novel to the subjects; no subject had prior experience operating a weaving loom, but most had some prior experience with apparatus such as a joystick, a watering can and a key pad.
“First, this task was completely novel to the subjects.No subject had prior experience operating a weaving loom, but most had some prior experience with apparatus such as a joystick, a watering can and a key pad.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingnone givenThe weaving task comprised the most complex routine of the five tasks, incorporating continuous ongoing feedback from the experimenter.
“Secondly, the weaving task comprised the most complex routine of the five tasks, incorporating continuous ongoing feedback from the experimenter.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone givenThe weaving task required the coordinated use of both hands.
“Thirdly, it required the coordinated use of both hands.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataAt 24 h and 2 months retention periods, both amnesic and comparison groups showed remarkable retention of the weaving and geometric figures tasks, while on the spatial sequence task neither group showed any retention of the skill.
“At 24 h and 2 months retention periods, both amnesic and comparison groups showed remarkable retention of the weaving and geometric figures tasks, while on the spatial sequence task neither group showed any retention of the skill.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe performances on the weaving task were significantly correlated with the Grooved Pegboard with both the dominant (Pearson's correlation = 0.655, P = 0.04) and the non-dominant hands (Pearson's correlation = 0.67, P = 0.03).
“The performances on the weaving task were significantly correlated with the Grooved Pegboard with both the dominant (Pearson's correlation = 0.655, P = 0.04) and the non-dominant hands (Pearson's correlation = 0.67, P = 0.03).”
Quote in the paperSubstantial claimMay combine two claims.
Findingnone givenWhile lesions in the anoxic subjects were limited to the hippocampus, all four HSE subjects had damage to the hippocampus, and three of the four had damage to the temporal poles, the amygdala, and the fourth and fifth temporal gyri (including entorhinal, parahippocampal and perirhinal cortices).
“While lesions in the anoxic subjects were limited to the hippocampus, all four HSE subjects had damage to the hippocampus, and three of the four had damage to the temporal poles, the amygdala, and the fourth and fifth temporal gyri (including entorhinal, parahippocampal and perirhinal cortices).”
Quote in the paperSubstantial claimMay combine two claims.
FindingreasoningThese two tasks presented the worst and the best retention results, respectively.
“These two tasks presented the worst and the best retention results, respectively.”
Quote in the paperNot a substantial claimMay combine two claims.
InterpretationreasoningSince some procedural memory systems are anatomically distinct from the declarative memory system, amnesic patients should be able to acquire skills with major implications for daily functioning.
“Since some procedural memory systems are anatomically distinct from the declarative memory system, amnesic patients should be able to acquire skills with major implications for daily functioning.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThere was no significant difference between groups on the number of days interval between time 1 and time 3.
“There was no significant difference between groups on the number of days interval between time 1 and time 3.”
- Also stated in: § Number of points available · plain
“There was no significant difference between groups on the number of days interval between time 1 and time 3.”
Quote in the paperNot a substantial claim- Also stated in: § Number of points available · plain
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataInter-rater Pearson rs for tracing the amygdala and hippocampus were 0.917 for the left amygdala, 0.952 for the right amygdala, 0.93 for the left hippocampus, and 0.946 for the right hippocampus.
“inter-rater Pearson rs were 0.917 for the left amygdala, 0.952 for the right amygdala, 0.93 for the left hippocampus and 0.946 for the right hippocampus.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataAt time 3, complete data were only available for nine amnesics and 13 comparison subjects.
“At time 3, complete data were only available for nine amnesics and 13 comparison subjects.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductown dataThe comparison group was matched to the amnesic group in terms of age and years of education.
“The comparison group was matched to the amnesic group in terms of age (mean = 51.4years, SD = 15.4) and years of education (mean = 16 years, SD = 3.2).”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningThe comparability of the tasks employed in this study with real-world activities highlights the potential application of this memory dissociation in the rehabilitation of patients with amnesia.
“The comparability of the tasks employed in this study with real-world activities highlights the potential application of this memory dissociation in the rehabilitation of patients with amnesia.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductnone givenAll amnesic patients were studied at least 5 months after their neurological event, at which time their neurological status and neuropsychological profiles were stable.
“All were studied at least 5 months after their neurological event, at which time their neurological status and neuropsychological profiles were stable.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Study design and conductnone givenThe primary inclusion criterion was the presence of amnesia, operationally defined as severe impairment on standardized measures of both verbal and visual memory (at least 1 Z-score below the mean on the 30 min delayed recall of both the Rey Auditory Verbal Learning Test and the Complex Figure Test).
“The primary inclusion criterion was the presence of amnesia, which was operationally defined as severe impairment on standardized measures of both verbal and visual memory (at least 1 Z-score below the mean on the 30 min delayed recall of both the Rey Auditory Verbal Learning Test and the Complex Figure Test).”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Interpretationnone givenThe fact that the groups were not perfectly matched for age and education raised concerns regarding the interpretation of the results at time 3.
“The fact that the groups were not perfectly matched for age and education raised concerns regarding the interpretation of the results at time 3.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataThe number of years of education and number of days interval between time 1 and time 3 did not differ significantly.
“The number of years of education and number of days interval between time 1 and time 3 did not differ significantly.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe comparison group had significantly more years of education (mean = 18 years; SD = 3.3; t = -2.41, P = 0.02) than the amnesic group.
“The comparison group had significantly more years of education (mean = 18 years; SD = 3.3; t = À2.41,P = 0.02) than the amnesic group.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe comparison group was significantly more educated than the amnesic group (t = -2.47, P = 0.02).
“The comparison group was significantly more educated than the amnesic group (t = À2.47,P = 0.02).”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductown dataAt time 3, complete data were only available for 10 amnesics and 14 comparison subjects.
“At time 3, complete data were only available for 10 amnesics and 14 comparison subjects.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataAt time 3, the two groups were not significantly different in terms of age, years of education and days of interval between time 1 and time 3.
“These two groups were not significantly different in terms of age, years of education and days of interval between time 1 and time 3.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductreasoningAs a result of the reduction of the number of subjects, the groups were no longer matched for age.
“As a result of the reduction of the number of subjects, the groups were no longer matched for age.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThe comparison group was significantly younger (mean = 40.83 years; SD = 8.64; t = 2.67, P = 0.01) than the amnesic group.
“The comparison group was significantly younger (mean = 40.83years; SD = 8.64; t = 2.67, P = 0.01) than the amnesic group.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataThere was a tendency for the comparison group to be younger (mean = 42.4 years; SD = 9.1) than the amnesic group (t = 2.02, P = 0.05).
“There was a tendency for the comparison group to be younger (mean = 42.4 years; SD = 9.1) than the amnesic group (t = 2.02, P = 0.05).”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductown dataThe two groups were not significantly different in terms of age nor on the number of days interval between time 1 and time 3.
“The two groups were not significantly different in terms of age nor on the number of days interval between time 1 and time 3.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductown dataAt time 3, complete data were only available for nine amnesics and 12 comparison subjects.
“At time 3, complete data were only available for nine amnesics and 12 comparison subjects.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). The quote only partly states this claim.
Study design and conductown dataAt time 3, complete data were only available for nine amnesics and 10 comparison subjects on the geometric figures task.
“At time 3, complete data were only available for nine amnesics and 10 comparison subjects.”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductown dataWhen analyses for time 1 and time 2 were rerun with only those subjects who completed the protocol at time 3, the results were largely consistent with those previously presented: the groups' learning curves at time 1 continued to not differ for all tasks, and no significant retention x group interaction was found except for the pouring task.
“We reran the analyses for time 1 and time 2 with only those subjects who completed the protocol at time 3.The results were largely consistent with those previously presented, i.e. the groups' learning curves at time 1 continued to not differ for all tasks, and no significant retention  group interaction was found except for the pouring task (Table 5).”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductown dataAt time 3, complete data were available for 10 amnesics and 16 comparison subjects.
“At time 3, complete data were only available for 10 amnesics and 16 comparison subjects.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing), S4 (based).
Interpretationnone givenOur findings have significant implications for neurorehabilitation.
“Finally, our findings have significant implications for neurorehabilitation.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).
Study design and conductreasoningWe cannot eliminate any possibility of bias in these situations, given that amnesia of this level of severity is quite obvious.
“We cannot eliminate any possibility of bias in these situations, given that amnesia of this level of severity is quite obvious.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
InterpretationreasoningThe tendency for the HSE subgroup to perform better than the anoxic subjects on the weaving task raises the possibility that extensive bilateral lesions of the medial temporal region may actually 'facilitate' certain types of procedural learning by freeing them from declarative interference.
“Therefore, the tendency for the HSE subgroup to perform better than the anoxic subjects on the weaving task raises the possibility that extensive bilateral lesions of the medial temporal region may actually 'facilitate' certain types of procedural learning by freeing them from declarative interference.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing). May combine two claims.
InterpretationcitationMore practice and more spaced practice at time 1 might have resulted in better learning and retention of the skills.
“More practice and more spaced practice at time 1 might have resulted in better learning and retention of the skills.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataOur results substantially extend the known scope of preserved procedural memory capacity in amnesia, and make clear that this preserved ability encompasses the acquisition of skills relevant to real-world activities.
“Our results substantially extend the known scope of preserved procedural memory capacity in amnesia, and make clear that this preserved ability encompasses the acquisition of skills relevant to real-world activities.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataThe ability of amnesic subjects to learn and retain a diverse set of new procedural skills with clear translation to real-world activities indicates that this is a robust phenomenon that probably is relevant to many aspects of daily living.
“Rather, the ability of amnesic subjects to learn and retain a diverse set of new procedural skills with clear translation to real-world activities indicates that this is a robust phenomenon that probably is relevant to many aspects of daily living.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenIn the weaving task, an unblinded examiner provided ongoing verbal correction of errors, raising the possibility of experimenter bias.
“In the weaving task, an unblinded examiner provided ongoing verbal correction of errors, raising the possibility of experimenter bias.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationConsolidation of a motor skill can be disrupted if a second motor task is learned immediately after the first, and the critical time window beyond which little or no interference is found from a competing task is approximately 4-5 h.
“It has been shown that consolidation of a motor skill can be disrupted if a second motor task is learned immediately after the first, and the critical time window beyond which little or no interference is found from a competing task is $4-5 h (Brashers- Krug et al., 1996;Shadmehr and Brashers-Krug, 1997).”
Quote in the paperSubstantial claim0 of 2 sources checked- cites Brashers-Krug et al., 1996
Not checked in the free run.
- cites Shadmehr and Brashers-Krug, 1997
Not checked in the free run.
Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).
InterpretationreasoningProcedural memory tasks relevant to real-world activities may facilitate the integration of amnesic subjects into the workplace, provided that a sheltered environment to compensate for impaired declarative recall can be established.
“At the same time, procedural memory tasks relevant to real-world activities may facilitate the integration of amnesic subjects into the workplace, provided that a sheltered environment to compensate for impaired declarative recall can be established.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataThe between-group differences in demographic factors, when they did occur, were always in the direction of being biased against our hypotheses, i.e. the comparison group was younger and more educated than the amnesic group.
“The between-group differences in demographic factors, when they did occur, were always in the direction of being biased against our hypotheses, i.e. the comparison group was younger and more educated than the amnesic group.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S2 (checkable).
Interpretationown dataOur results help refine our understanding of the dissociation between declarative and procedural memory systems in the human brain.
“Our results also help refine our understanding of the dissociation between declarative and procedural memory systems in the human brain.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe amount of practice and the practice schedule may influence learning and retention of perceptual-motor skills.
“The amount of practice and the practice schedule may influence learning and retention of perceptual-motor skills (Schmidt and Lee, 1999).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Schmidt and Lee, 1999
Not checked in the free run.
May combine two claims.
Interpretationown dataThe finding that the amnesic group committed significantly more errors and that most of the comparison group performance was errorless argues against any bias in favour of the amnesic subjects.
“argues against any bias in favour of the amnesic subjects.”
Quote in the paperSubstantial claim
The paper relies on this without support.
The scope and range of perceptual-motor skills that are preserved in amnesia remain largely unknown.
“Thus, the scope and range of perceptual-motor skills that are preserved in amnesia remain largely unknown.”
The paper relies on this without support.
The notion that procedural memory systems are anatomically distinct from declarative memory has had little impact on neurorehabilitation.
“To date, however, this notion has had little impact on neurorehabilitation.”
The paper relies on this without support.
The mirror tracing, rotor pursuit and serial reaction time tasks have a limited range of perceptual-motor requirements and no clear linkage to real-world activities.
“The mirror tracing, rotor pursuit and serial reaction time tasks all allow careful experimental control, but have a limited range of perceptual-motor requirements and no clear linkage to real-world activities.”
The paper relies on this without support.
To complete the tasks successfully, subjects need not recall, recognize or reflect on prior experiences.
“To complete the tasks successfully, subjects need not recall, recognize or reflect on prior experiences.”
The paper relies on this without support.
Memory impairments are among the most common consequences of injury to the brain.
“Memory impairments are among the most common consequences of injury to the brain, and return to work is one of the most important rehabilitation goals of patients with brain injury.”
The paper relies on this without support.
Return to work is one of the most important rehabilitation goals of patients with brain injury.
“Memory impairments are among the most common consequences of injury to the brain, and return to work is one of the most important rehabilitation goals of patients with brain injury.”
The paper relies on this without support.
Treatment options for memory impairments remain limited.
“Unfortunately, treatment options for memory impairments remain limited.”
The paper relies on this without support.
The approach of using non-declarative methods in clinical rehabilitation settings with amnesic patients remains largely unexplored.
“Although there have been a few attempts to use non-declarative methods in clinical rehabilitation settings with amnesicpatients (e.g.Glisky et al., 1986;Zanetti et al., 1997;Goldstein et al., 1998;Suhr et al., 1999), this approach remains largely unexplored.”
The paper relies on this without support.
The understanding of procedural learning in the normal population and in other brain-damaged populations is still very incomplete.
“The understanding of procedural learning in the normal population and in other brain-damaged populations is still very incomplete.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Abstract claims retention of all five skills despite no spatial-sequence retention
MajorThe abstract says the amnesic subjects retained all five skills, but the spatial-sequence results say neither group retained that skill at either follow-up.
“Despite impaired declarative memory for the tasks, the amnesic subjects demonstrated acquisition and retention of the five skills; their learning slopes over repeated trials were comparable with those of comparison subjects.”
“Neither group demonstrated retention of their task at time 2 or time 3.There was no significant difference between baseline performance and performance on the first trial of time 2 and 3, in either speed or number of errors.”
Recognition questionnaire describes six performed tasks, not five
MinorThe methods describe five experimental tasks, but the recognition-test description says six different tasks in its questionnaire had been performed at time 1.
“Each of the 40 sentences described a different task: six of them pertained to the tasks performed at time 1, and 34 were foils.”
“Five new procedural memory tasks were developed to measure the capacity to acquire and retain a range of perceptual-motor skills.”
Two values reported for the geometric-figures retention statistic
MinorThe results give F = 10.26 for the time-3 geometric-figures retention effect, while Table 5 gives 10.16 for that effect.
“The 2  2 ANOVA demonstrated a significant retention effect (F = 10.26,P < 0.01), no group effects (F = 1.92,P = 0.18) and no significant retention  group interaction (F = 0.34, P = 0.57).”
“Baseline vs. 1st trial of Time 3 | Retention | Comparison Retention by group | subjects 1 effects 2 effects 2 | 2.82 * 19.3 ** 4.94 * | 1.55 10.16 ** 0.34 |”
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- Authors
- Cavaco, S.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Cavaco, S.
- ORCID
- Cavaco, S.
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-06-16
- Volume
- 127
- Issue
- 8
- Pages
- 1853-1867
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W1997007945
- Cited by
- 95
- References
- 72
- Citations by year
- 2025: 7 · 2024: 7 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 24 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 5 · 2012: 6
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Funders
- National Institute of Neurological Disorders and Stroke (P01 NS19632, P01NS019632, NS-19632)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Keywords
- procedural memory, amnesia, multiple memory systems, perceptual-motor learning, skill acquisition, skill retention, herpes simplex encephalitis, thalamic infarction, memory dissociation, pouring task
- MeSH terms
- Adult, Age Factors, Aged, Amnesia, Chronic Disease, Educational Status, Female, Humans, Learning, Magnetic Resonance Imaging, Male, Middle Aged, Motor Skills, Neuropsychological Tests, Retention, Psychology
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