MRI volume of the amygdala: a reliable method allowing separation from the hippocampal formation
Open accessAbstract
Studies of MRI-derived volume of the amygdala have been mostly performed on coronal sections where its boundaries with the hippocampus and the entorhinal cortex are indistinct. To date, all reports of in vivo amygdala volume have consistently overestimated the size of the structure. We have developed a method for the MRI-based in vivo measurement of the amygdala volume which allows a better separation of the amygdala from the adjoining hippocampal formation. In nine normal volunteers we obtained three-dimensional spoiled gradient recalled acquisition, 1.3-mm thick, T1 weighted sagittal MR images and created electronically linked reformatted images in the coronal and axial planes. On the original sagittal and the reformatted axial planes, where it is more readily apparent, we delineated the boundaries between the amygdala and the hippocampus and the amygdala and the hippocampo-amygdala transition area, respectively. We then projected those markings onto the coronal plane, where the other boundaries of the amygdala are more easily seen. Using these markings as a guide and utilizing extra-amygdalar coronal landmarks for the anterior end, we outlined the whole amygdala on the coronal plane and determined its volume. We observed that 45% of the coronal slices that contained amygdala also contained some hippocampus. The amygdala measurement had high test-retest reliability, with an intra-class correlation coefficient (rICC) of 0.99 for the total volume and an rICC of 0.93 for the measurement at the level of the individual slice. The average amygdala volume was 1.05 +/- 0.17 cm3 on the right and 1.14 +/- 0.15 cm3 on the left. Our amygdala volumes are in agreement with those reported in postmortem studies, which provides the reported method with face validity.
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Head size variations across individuals were corrected by using cerebral vault volume.
“To correct for head size variations across individuals, a cerebral vault volume was obtained by measuring the volume of the compartment bounded by the dura and the tentorium cerebri (24).”
From Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly (2003) · cites this paper as [24]
The hippocampus and other brain volumes were measured by using validated methods on standardized MRIs.
“The hippocampus and other brain volumes were measured by using validated methods on standardized MRIs.”
From Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly (2003) · cites this paper as [24]
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- Authors
- Convit, A., McHugh, P., Wolf, O. T., de Leon, M. J., Bobinski, M., De Santi, S., Roche, A., & Tsui, W.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- NYU Langone Health (US)
- Corresponding author
- Convit, Antonio
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 1999-04
- Volume
- 90
- Issue
- 2
- Pages
- 113-123
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2108412665
- Cited by
- 127
- References
- 38
- Citations by year
- 2023: 2 · 2022: 2 · 2021: 1 · 2019: 3 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 8
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Psychiatry Research Neuroimaging (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- New York State Office of Mental Health
- National Institute on Aging (P30 AG 08051, R01AG13616, R01AG012101, P30AG008051, R01-AG-12101, R01AG013616)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Keywords
- amygdala volume, hippocampal formation, entorhinal cortex, volumetric MRI, test-retest reliability
- MeSH terms
- Adult, Amygdala, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Reference Values, Reproducibility of Results, Anatomy, Cross-Sectional
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