Structural and Functional Aberrations in the Cerebral Cortex of Tenascin-C Deficient Mice
Open accessAbstract
The extracellular matrix glycoprotein tenascin-C (TNC) has been implicated in neural development and plasticity but many of its functions in vivo remain obscure. Here we addressed the question as to whether the constitutive absence of TNC in mice affects cortical physiology and structure. Defined major cell populations (neurons and inhibitory neuronal subpopulations, astrocytes, oligodendrocytes and microglia) were quantified in the somatosensory and motor cortices of adult TNC deficient (TNC-/-) and wild-type (TNC+/+) mice by immunofluorescence labelling and stereology. In both areas studied we found abnormally high neuronal density, astrogliosis, low density of parvalbumin-positive interneurons and reduced ratios of oligodendrocytes to neurons and of inhibitory to excitatory neurons in the TNC deficient as opposed to the non-deficient animals. Analysis of Golgi-impregnated layer V pyramidal neurons in TNC-/- animals showed aberrant dendrite tortuosity and redistribution of stubby spines within first- to third-order dendritic arbors. Significantly enhanced responses upon whisker stimulation were recorded epicranially over the barrel and the motor cortices of TNC-/- as compared to TNC+/+ animals, and this effect might be associated with the diminished inhibitory circuitry. These results indicate that TNC is essential for normal cortical development and function.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
TnC is not a major component of perineuronal nets.
“However, TnC is not a major component of perineuronal nets52 while TnR is mainly expressed by oligodendrocytes and not by astrocytes10 (and is only present at low concentration in the co-culture of WT astrocytes with KO neurons, if at all.”
From Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses (2019) · cites this paper as [52]
Cites
Gundersen, H. J. G. (1986) · PubMed · Cited by 1,659 · see citing works
Stereology of arbitrary particles*
Gundersen, H. J. G. (1986) · Journal of Microscopy · doi:10.1111/j.1365-2818.1986.tb02764.x · Cited by 1,444 · see citing works
New insights into neuron-glia communication.
Fields, R., & Stevens-Graham, B. (2002) · Science · doi:10.1126/science.298.5593.556 · Cited by 963 · see citing works
Eng, L. F., & Ghirnikar, R. S. (1994) · Brain Pathology · doi:10.1111/j.1750-3639.1994.tb00838.x · Cited by 864 · see citing works
The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines
Peters, A., & Kaiserman‐Abramof, I. R. (1970) · American Journal of Anatomy · doi:10.1002/aja.1001270402 · Cited by 740 · see citing works
The glial identity of neural stem cells
Doetsch, F. (2003) · Nature Neuroscience · doi:10.1038/nn1144 · Cited by 724 · see citing works
Pax6 Controls Radial Glia Differentiation in the Cerebral Cortex
Götz, M., Stoykova, A., & Gruß, P. (1998) · Neuron · doi:10.1016/s0896-6273(00)80621-2 · Cited by 665 · see citing works
Interneuron Diversity series: Rhythm and mood in perisomatic inhibition
Freund, T. F. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00227-3 · Cited by 641 · see citing works
Mice develop normally without tenascin.Preprint
Saga, Y., Yagi, T., Ikawa, Y., Sakakura, T., & Aizawa, S. (1992) · Genes & Development · doi:10.1101/gad.6.10.1821 · Cited by 582 · see citing works
NeuN: a useful neuronal marker for diagnostic histopathology.
Wolf, H. K., Buslei, R., Schmidt‐Kastner, R., Schmidt-Kastner, P. K., Pietsch, T., Wiestler, O. D., & Blümcke, I. (1996) · Journal of Histochemistry & Cytochemistry · doi:10.1177/44.10.8813082 · Cited by 526 · see citing works
The small pyramidal neuron of the rat cerebral cortex: The synapses upon dendritic spines
Peters, A., & Kaiserman-Abramof, I. R. (1969) · Zeitschrift f�r Zellforschung und Mikroskopische Anatomie · doi:10.1007/bf00344370 · Cited by 441 · see citing works
Structural and quantitative analysis of astrocytes in the mouse hippocampus
Ogata, K., & Kosaka, T. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00041-6 · Cited by 397 · see citing works
Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model
Borges, K. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00086-4 · Cited by 396 · see citing works
Galarreta, M., & Hestrin, S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192159599 · Cited by 387 · see citing works
Forebrain patterning defects in Small eye mutant mice
Stoykova, A., Fritsch, R., Walther, C., & Gruß, P. (1996) · Development · doi:10.1242/dev.122.11.3453 · Cited by 378 · see citing works
Density of neurons and synapses in the cerebral cortex of the mouse
Schüz, A., & Palm, G. (1989) · Journal of Comparative Neurology · doi:10.1002/cne.902860404 · Cited by 376 · see citing works
Expression pattern of M‐cadherin in normal, denervated, and regenerating mouse muscles
Irintchev, A., Zeschnigk, M., Starzinski‐Powitz, A., & Wernig, A. (1994) · Developmental Dynamics · doi:10.1002/aja.1001990407 · Cited by 368 · see citing works
Self-citationDevelopmental and Evolutionary Adaptations of Cortical Radial Glia
RAKIC, P. T. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.541 · Cited by 346 · see citing works
Tenascin-C in development and disease: gene regulation and cell function
Jones, P. L., & Jones, F. S. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00106-2 · Cited by 320 · see citing works
Ferrer, I., Bernet, E., Soriano, E., del Rı́o, J. A., & Fonseca, M. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90281-8 · Cited by 309 · see citing works
Garcion, E., Halilagic, A., Faissner, A., & ffrench‐Constant, C. (2004) · Development · doi:10.1242/dev.01202 · Cited by 309 · see citing works
A simple and sensitive antigen retrieval method for free-floating and slide-mounted tissue sections
Jiao, Y., Sun, Z., Lee, T., Fusco, F. R., Kimble, T. D., Meade, C. A., Cuthbertson, S. L., & Reiner, A. J. (1999) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(99)00142-9 · Cited by 295 · see citing works
Regionalization and fate specification in neurospheres: the role of Olig2 and Pax6.
Hack, M., Sugimori, M., Lundberg, C., Nakafuku, M., & Götz, M. (2004) · Molecular and cellular neurosciences · doi:10.1016/j.mcn.2003.12.012 · Cited by 294 · see citing works
Demyanenko, G. P., Tsai, A. Y., & Maness, P. F. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-12-04907.1999 · Cited by 286 · see citing works
Stoykova, A., Götz, M., Gruss, P., & Price, J. (1997) · Development · doi:10.1242/dev.124.19.3765 · Cited by 284 · see citing works
Expression of tenascin in the developing and adult cerebellar cortex
Bartsch, S., Bartsch, U., Dörries, U., Faissner, A., Weller, A., Ekblom, P., & Schachner, M. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-03-00736.1992 · Cited by 271 · see citing works
Self-citationMolecular Control of Cortical Dendrite Development
Whitford, K. L., Dijkhuizen, P. A., Polleux, F., & Ghosh, A. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142932 · Cited by 266 · see citing works
Steindler, D. A., Cooper, N. G. F., Faissner, A., & Schachner, M. (1989) · Developmental Biology · doi:10.1016/s0012-1606(89)80056-9 · Cited by 264 · see citing works
Self-citationNeurone‐to‐astrocyte signalling in the brain represents a distinct multifunctional unit
Fellin, T., & Carmignoto, G. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063214 · Cited by 258 · see citing works
Srinivasan, J., Schachner, M., & Catterall, W. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15753 · Cited by 249 · see citing works
Self-citationWeber, P., Bartsch, U., Rasband, M. N., Czaniera, R., Lang, Y., Bluethmann, H., Margolis, R. U., Levinson, S. R., Shrager, P., Montag, D., et al. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04245.1999 · Cited by 247 · see citing works
Self-citationSkin wounds and severed nerves heal normally in mice lacking tenascin-C.
Forsberg, E., Hirsch, E., Fröhlich, L., Meyer, M., Ekblom, P., Aszódi, A., Werner, S., & Fässler, R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6594 · Cited by 235 · see citing works
Garcion, E., Faissner, A., & ffrench‐Constant, C. (2001) · Development · doi:10.1242/dev.128.13.2485 · Cited by 235 · see citing works
New roles for astrocytes: Regulation of CNS synaptogenesis
Ślęzak, M., & Pfrieger, F. W. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.08.005 · Cited by 224 · see citing works
Saghatelyan, A. K., Dityatev, A., Schmidt, S., Schuster, T., Bartsch, U., & Schachner, M. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0922 · Cited by 207 · see citing works
Self-citationCell death and removal in the cerebral cortex during development
Ferrer, I., Soriano, E., del Rı́o, J. A., Alcántara, S., & Auladell, C. (1992) · Progress in Neurobiology · doi:10.1016/0301-0082(92)90029-e · Cited by 205 · see citing works
The development of parvalbumin-immunoreactivity in the neocortex of the mouse
del Rio, J., de Lecea, L., Ferrer, I., & Soriano, E. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90311-5 · Cited by 205 · see citing works
Crossin, K. L., Hoffman, S., Tan, S., & Edelman, G. M. (1989) · Developmental Biology · doi:10.1016/0012-1606(89)90264-9 · Cited by 182 · see citing works
Evers, M. R., Salmen, B., Bukalo, O., Rollenhagen, A., Bösl, M. R., Morellini, F., Bartsch, U., Dityatev, A., & Schachner, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07177.2002 · Cited by 172 · see citing works
Self-citationFairén, A., Cobas, A., & Fonseca, M. (1986) · Journal of Comparative Neurology · doi:10.1002/cne.902510105 · Cited by 158 · see citing works
S100 protein expression in subpopulations of neurons of rat brain
Rickmann, M., & Wolff, J. R. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00615-c · Cited by 135 · see citing works
Steindler, D. A., O'Brien, T. F., Laywell, E. D., Harrington, K., Faissner, A., & Schachner, M. (1990) · Experimental Neurology · doi:10.1016/s0014-4886(05)80007-x · Cited by 129 · see citing works
Self-citationTenascin knockout mice: barrels, boundary molecules, and glial scars
Steindler, D. A., Settles, D. L., Erickson, H. P., Laywell, E. D., Yoshiki, A., Faissner, A., & Kusakabe, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-03-01971.1995 · Cited by 119 · see citing works
Apoptosis in the developing CNS
Naruse, I., & Keino, H. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)00024-p · Cited by 115 · see citing works
Astrogliosis in the Adult and Developing CNS: Is There a Role for Proinflammatory Cytokines?
Little, A. R., & O'Callaghan, J. D. (2001) · NeuroToxicology · doi:10.1016/s0161-813x(01)00032-8 · Cited by 110 · see citing works
Bartsch, U., Faissner, A., Trotter, J., Dörries, U., Bartsch, S., Mohajeri, H. M., & Schachner, M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04756.1994 · Cited by 110 · see citing works
Self-citationSofroniew, M. V., & Schrell, U. M. H. (1982) · Journal of Histochemistry & Cytochemistry · doi:10.1177/30.6.6178778 · Cited by 108 · see citing works
Tenascin‐C Synthesis and Influence on Axonal Growth During Rat Cortical Development
Götz, M., Bolz, J., Joester, A., & Faissner, A. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01627.x · Cited by 96 · see citing works
Abnormal Behavior and Neurotransmissions of Tenascin Gene Knockout Mouse
Fukamauchi, F., Mataga, N., Wang, Y., Sato, S., Yoshiki, A., & Kusakabe, M. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0561 · Cited by 95 · see citing works
Calcium oscillations in neocortical astrocytes under epileptiform conditions
Tashiro, A., Goldberg, J. H., & Yuste, R. (2001) · Journal of Neurobiology · doi:10.1002/neu.10019 · Cited by 91 · see citing works
Alcántara, S., de Lecea, L., del Rı́o, J. A., Ferrer, I., & Soriano, E. (1996) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1996.tb01595.x · Cited by 88 · see citing works
Cortical Interneuron Fate Determination: Diverse Sources for Distinct Subtypes?
Xu, Q. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.670 · Cited by 82 · see citing works
Dopamine Affects Parvalbumin Expression during Cortical DevelopmentIn Vitro
Porter, L. L., Rizzo, E., & Hornung, J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08990.1999 · Cited by 80 · see citing works
Artifacts in Routinely Immersion Fixed Nervous Tissue
Garman, R. H. (1990) · Toxicologic Pathology · doi:10.1177/019262339001800120 · Cited by 79 · see citing works
S-100β has a neuronal localisation in the rat hindbrain revealed by an antigen retrieval method
Yang, Q., Hamberger, A., Hydén, H., Wang, S., Stigbrand, T. I., & Haglid, K. G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00755-f · Cited by 78 · see citing works
Bartsch, U. (1996) · Progress in Neurobiology · doi:10.1016/0301-0082(96)00014-7 · Cited by 74 · see citing works
Strekalova, T. V., Sun, M., Sibbe, M., Evers, M. R., Dityatev, A. E., Gass, P., & Schachner, M. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1172 · Cited by 69 · see citing works
Self-citationMyelination and behaviour of tenascin‐C null transgenic mice
Kiernan, B. W., Garcion, E., Ferguson, J., Frost, E. E., Torres, E. M., Dunnett, S. B., Saga, Y., Aizawa, S., Faissner, A., Kaur, R., et al. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00729.x · Cited by 67 · see citing works
Activation of astrocytes during epileptogenesis in the absence of neuronal degeneration
Khurgel, M., Switzer, R. C., Teskey, G. C., Spiller, A. E., Racine, R. J., & Ivy, G. O. (1995) · Neurobiology of Disease · doi:10.1006/nbdi.1995.0003 · Cited by 64 · see citing works
Fukuda, T., & Kosaka, T. (2000) · Neuroscience Research · doi:10.1016/s0168-0102(00)00163-2 · Cited by 63 · see citing works
Ectopic skeletal muscles derived from myoblasts implanted under the skin
Irintchev, A., Rosenblatt, J. D., Cullen, M. J., Zweyer, M., & Wernig, A. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.22.3287 · Cited by 62 · see citing works
Self-citationGurevicius, K., Gureviciene, I., Valjakka, A., Schachner, M., & Tanila, H. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.12.001 · Cited by 58 · see citing works
Self-citationCharacterization of Reactive Astrocytes in the Chronic Phase of the Pilocarpine Model of Epilepsy
Garzillo, C. L., & Mello, L. E. (2002) · Epilepsia · doi:10.1046/j.1528-1157.43.s.5.40.x · Cited by 57 · see citing works
Mitrovic, N., Dörries, U., & Schachner, M. (1994) · Journal of Neurocytology · doi:10.1007/bf01666526 · Cited by 52 · see citing works
Self-citationDifferential expression of tenascin after denervation, damage or paralysis of mouse soleus muscle
Irintchev, A., Salvini, T. F., Faissner, A., & Wernig, A. (1993) · Journal of Neurocytology · doi:10.1007/bf01218353 · Cited by 47 · see citing works
Self-citationTenascin glycoproteins in developing neural tissues: only decoration?
Faissner, A., Scholze, A., & Götz, B. (1994) · PubMed · Cited by 42 · see citing works
Brenneke, F., Bukalo, O., Dityatev, A. E., & Lie, A. A. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.11.037 · Cited by 34 · see citing works
Epicranial sensory evoked potential recordings for repeated assessment of cortical functions in mice
Troncoso, E., Müller, D., Czellár, S., & Kiss, J. Z. (2000) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(00)00164-3 · Cited by 33 · see citing works
Self-citationFukamauchi, F., Mataga, N., Wang, Y., Sato, S., Yoshiki, A., & Kusakabe, M. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6101 · Cited by 30 · see citing works
Troncoso, E. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhg131 · Cited by 30 · see citing works
Self-citationModifications of S100-protein immunoreactivity in rat brain induced by tissue preparation
Rickmann, M., & Wolff, J. R. (1995) · Histochemistry and Cell Biology · doi:10.1007/bf01454011 · Cited by 29 · see citing works
Meins, M., Piosik, P., Schaeren‐Wiemers, N., Franzoni, S., Troncoso, E., Kiss, J. Z., Brösamle, C., Schwab, M. E., Molnár, Z., & Monard, D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-22-08830.2001 · Cited by 29 · see citing works
Self-citationMorphology of pulmonary rapidly adapting receptor relay neurons in the rat
Otake, K., Nakamura, Y., Tanaka, I., & Ezure, K. (2001) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010219)430:4 · Cited by 28 · see citing works
Regional difference in the neurotoxicity of ochratoxin A on the developing cerebral cortex in mice
Miki, T., Fukui, Y., Uemura, N., & Takeuchi, Y. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90168-6 · Cited by 27 · see citing works
Nishio, T., Kawaguchi, S., Iseda, T., Kawasaki, T., & Hase, T. (2003) · Brain Research · doi:10.1016/s0006-8993(03)03448-6 · Cited by 21 · see citing works
Expression of tenascin during carcinogenesis and involution of hormone-dependent tissues
Vollmer, G. (1994) · Biochemistry and Cell Biology · doi:10.1139/o94-068 · Cited by 21 · see citing works
Abreu‐Villaça, Y., Silva, W. C., Manhães, A. C., & Schmidt, S. L. (2002) · Brain Research Bulletin · doi:10.1016/s0361-9230(02)00812-2 · Cited by 21 · see citing works
Aker, R. G., & Onat, F. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.45200.x · Cited by 16 · see citing works
Fukamauchi, F., Aihara, O., & Kusakabe, M. (1998) · Neuropeptides · doi:10.1016/s0143-4179(98)90046-4 · Cited by 14 · see citing works
Seo, M. L., Seto‐Ohshima, A., & Kato, K. (1995) · Developmental Psychobiology · doi:10.1002/dev.420280604 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575 · see citing works
Tsai, P. S., Kaufhold, J. P., Blinder, P., Friedman, B., Drew, P. J., Karten, H. J., Lyden, P. D., & Kleinfeld, D. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3287-09.2009 · Cited by 575 · see citing works
Cell Densities in the Mouse Brain: A Systematic Review
Keller, D., Erö, C., & Markram, H. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00083 · Cited by 380 · see citing works
Kinney, J. W., Davis, C. N., Tabarean, I., Conti, B., Bartfai, T., & Behrens, M. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4722-05.2006 · Cited by 329 · see citing works
Oligodendrocyte development and the onset of myelination in the human fetal brain
Jakovcevski, I. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.005.2009 · Cited by 323 · see citing works
Tenascins and the Importance of Adhesion ModulationPreprint
Chiquet‐Ehrismann, R., & Tucker, R. P. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a004960 · Cited by 272 · see citing works
Crosstalk between glia, extracellular matrix and neurons
Song, I., & Dityatev, A. E. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.03.003 · Cited by 263 · see citing works
Astrocytes as a Source for Extracellular Matrix Molecules and Cytokines
Wiese, S., Karus, M., & Faissner, A. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00120 · Cited by 262 · see citing works
Selby, L., Zhang, C., & Sun, Q.-Q. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2006.11.062 · Cited by 245 · see citing works
Faissner, A., Pyka, M., Geissler, M., Sobik, T., Frischknecht, R., Gundelfinger, E. D., & Seidenbecher, C. (2010) · Brain Research Reviews · doi:10.1016/j.brainresrev.2010.01.001 · Cited by 207 · see citing works
Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
Jones, E. V., & Bouvier, D. S. (2014) · Neural Plasticity · doi:10.1155/2014/321209 · Cited by 171 · see citing works
Miyata, S., & Kitagawa, H. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.010 · Cited by 171 · see citing works
Apostolova, I., Irintchev, A., & Schachner, M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1526-06.2006 · Cited by 166 · see citing works
Self-citationGeissler, M., Gottschling, C., Aguado, A., Rauch, U., Wetzel, C. H., Hatt, H., & Faissner, A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3275-12.2013 · Cited by 140 · see citing works
Eroğlu, Ç. (2009) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-009-0078-y · Cited by 130 · see citing works
Gottschling, C., Wegrzyn, D., Denecke, B., & Faissner, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-50404-9 · Cited by 111 · see citing works
Extracellular matrix in plasticity and epileptogenesis
Dityatev, A. E., & Fellin, T. (2008) · Neuron Glia Biology · doi:10.1017/s1740925x09000118 · Cited by 116 · see citing works
Tewari, B. P., Chaunsali, L., Prim, C. E., & Sontheimer, H. W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1022754 · Cited by 107 · see citing works
Morellini, F., Sivukhina, E., Stoenica, L., Oulianova, E., Bukalo, O., Jakovcevski, I., Dityatev, A., Irintchev, A., & Schachner, M. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq017 · Cited by 104 · see citing works
Self-citationJakovčevski, I., Wu, J., Karl, N., Leshchyns’ka, I., Sytnyk, V., Chen, J., Irintchev, A., & Schachner, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0739-07.2007 · Cited by 100 · see citing works
Self-citationTenascin-C deficiency attenuates TGF-β-mediated fibrosis following murine lung injury
Carey, W. A., Taylor, G. D., Dean, W. B., & Bristow, J. D. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00385.2009 · Cited by 102 · see citing works
Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood
Levy, A. D., Omar, M. H., & Koleske, A. J. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00116 · Cited by 96 · see citing works
Blood‐brain barrier development: Systems modeling and predictive toxicology
Saili, K. S., Zurlinden, T. J., Schwab, A. J., Silvin, A., Baker, N., Hunter, E. S., Ginhoux, F., & Knudsen, T. B. (2017) · Birth Defects Research · doi:10.1002/bdr2.1180 · Cited by 96 · see citing works
Coincident Generation of Pyramidal Neurons and Protoplasmic Astrocytes in Neocortical Columns
Magavi, S. S. P., Friedmann, D., Banks, G. P., Stolfi, A., & Lois, C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.3560-11.2012 · Cited by 94 · see citing works
Schipke, C. G., Haas, B., & Kettenmann, H. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhn009 · Cited by 91 · see citing works
Darras, V. M. (2008) · The Cerebellum · doi:10.1007/s12311-008-0004-5 · Cited by 89 · see citing works
Chaker, Z., George, C., Petrovska, M., Caron, J.-B., Lacube, P., Caillé, I., & Holzenberger, M. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.008 · Cited by 82 · see citing works
Mehanna, A., Jakovčevski, I., Acar, A., Xiao, M.-F., Loers, G., Rougon, G. N., Irintchev, A., & Schachner, M. (2009) · Molecular Therapy · doi:10.1038/mt.2009.235 · Cited by 84 · see citing works
Self-citationImproved regeneration after spinal cord injury in mice lacking functional T- and B-lymphocytes
Wu, B., Matić, D. R., Djogo, N., Szpotowicz, E., Schachner, M., & Jakovčevski, I. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.07.016 · Cited by 84 · see citing works
Self-citationKarus, M., Denecke, B., ffrench‐Constant, C., Wiese, S., & Faissner, A. (2011) · Development · doi:10.1242/dev.067413 · Cited by 80 · see citing works
Extracellular Matrix in Neural Plasticity and Regeneration
Chelyshev, Y. A., Kabdesh, I. M., & Mukhamedshina, Y. O. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00986-0 · Cited by 76 · see citing works
Nikonenko, A. G., Sun, M., Lepsveridze, E., Apostolova, I. I., Petrova, I. M., Irintchev, A., Dityatev, A. E., & Schachner, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04710.x · Cited by 72 · see citing works
Self-citationMatricellular proteins of the Cyr61/CTGF/NOV (CCN) family and the nervous system
Malik, A. R., Liszewska, E., & Jaworski, J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00237 · Cited by 71 · see citing works
Releasing Addiction Memories Trapped in Perineuronal Nets
Lasek, A. W., Chen, H., & Chen, W.-Y. (2018) · Trends in Genetics · doi:10.1016/j.tig.2017.12.004 · Cited by 71 · see citing works
Casting a net on dendritic spines: The extracellular matrix and its receptors
Dansie, L. E., & Ethell, I. M. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20963 · Cited by 66 · see citing works
Lee, H. J., Jakovčevski, I., Radonjić, N. V., Hoelters, L., Schachner, M., & Irintchev, A. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.12.009 · Cited by 66 · see citing works
Self-citationYu, Y., Cristofanilli, M., Valiveti, A., Ma, L., Yoo, M., Morellini, F., & Schachner, M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.03.043 · Cited by 65 · see citing works
Self-citationGuseva, D., Angelov, D. N., Irintchev, A., & Schachner, M. (2009) · Brain · doi:10.1093/brain/awp160 · Cited by 65 · see citing works
Self-citationJakovčevski, I., Siering, J. E., Hargus, G., Karl, N., Hoelters, L., Djogo, N., Yin, S., Zečević, N., Schachner, M., & Irintchev, A. (2009) · The Journal of Comparative Neurology · doi:10.1002/cne.21981 · Cited by 63 · see citing works
Self-citationThe Adult Mouse Subependymal Zone Regenerates Efficiently in the Absence of Tenascin-C
Kazanis, I., Belhadi, A., Faissner, A., & ffrench‐Constant, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3279-07.2007 · Cited by 63 · see citing works
Maisel, M., Herr, A., Milošević, J., Hermann, A., Habisch, H., Schwarz, S., Kirsch, M., Antoniadis, G., Brenner, R., Hallmeyer-Elgner, S., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0617 · Cited by 69 · see citing works
Stamenković, V., Stamenković, S., Jaworski, T., Gawlak, M., Jovanović, M., Jakovčevski, I., Wilczynski, G. M., Kaczmarek, L., Schachner, M., Radenović, L., et al. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1224-y · Cited by 60 · see citing works
Self-citationAdhesion molecule L1 binds to amyloid beta and reduces Alzheimer's disease pathology in mice
Djogo, N., Jakovčevski, I., Müller, C., Lee, H. J., Xu, J.-C., Jakovcevski, M., Kügler, S., Loers, G., & Schachner, M. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.04.014 · Cited by 59 · see citing works
Self-citationExtracellular Matrix and Synaptic Functions
Dityatev, A. E., Frischknecht, R., & Seidenbecher, C. I. (2006) · Springer eBooks · doi:10.1007/400_025 · Cited by 59 · see citing works
Cortical maps: a role for astrocytes?
López-Hidalgo, M. A., & Schummers, J. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.11.001 · Cited by 56 · see citing works
Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population
Kornilov, S. A., Rakhlin, N., Koposov, R. A., Lee, M., Yrigollen, C. M., Çağlayan, A. O., Magnuson, J. S., Mane, S., Chang, J. T., & Grigorenko, E. L. (2016) · PEDIATRICS · doi:10.1542/peds.2015-2469 · Cited by 55 · see citing works
Morellini, F., & Schachner, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04657.x · Cited by 56 · see citing works
Self-citationThe Extracellular Matrix Glycoprotein Tenascin C and Adult Neurogenesis
Tucić, M., Stamenković, V., & Anđjus, P. R. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.674199 · Cited by 54 · see citing works
Temporal Analysis of Neural Differentiation Using Quantitative Proteomics
Chaerkady, R., Kerr, C. L., Marimuthu, A., Kelkar, D. S., Kashyap, M. K., Guček, M., Gearhart, J. D., & Pandey, A. (2009) · Journal of Proteome Research · doi:10.1021/pr8006667 · Cited by 54 · see citing works
Eagleson, K. L., Bonnin, A., & Levitt, P. R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20647 · Cited by 53 · see citing works
Dach, K., Bendt, F., Hübenthal, U., Giersiefer, S., Lein, P. J., Heuer, H., & Fritsche, E. (2017) · Scientific Reports · doi:10.1038/srep44861 · Cited by 53 · see citing works
Tenascin-C: A Key Regulator in Angiogenesis during Wound Healing
Wang, Y., Wang, G., & Liu, H. (2022) · Biomolecules · doi:10.3390/biom12111689 · Cited by 51 · see citing works
Tenascin C in Stem Cell Niches: Redundant, Permissive or Instructive?
von Holst, A. (2007) · Cells Tissues Organs · doi:10.1159/000112848 · Cited by 51 · see citing works
Perineuronal Nets: Subtle Structures with Large Implications
Carceller, H., Gramuntell, Y., Klimczak, P., & Nácher, J. (2022) · The Neuroscientist · doi:10.1177/10738584221106346 · Cited by 48 · see citing works
Delayed Applications of L1 and Chondroitinase ABC Promote Recovery after Spinal Cord Injury
Lee, H. J., Bian, S., Jakovčevski, I., Wu, B., Irintchev, A., & Schachner, M. (2012) · Journal of Neurotrauma · doi:10.1089/neu.2011.2290 · Cited by 48 · see citing works
Self-citationPeeva, G. P., Angelova, S. K., Guntinas‐Lichius, O., Streppel, M., Irintchev, A., Schütz, U., Popratiloff, A. S., Savaskan, N. E., Bräuer, A. U., Alvanou, A., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05091.x · Cited by 48 · see citing works
Self-citationMoritz, S., Lehmann, S., Faissner, A., & von Holst, A. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1095 · Cited by 48 · see citing works
Schmalbach, B., Lepsveridze, E., Djogo, N., Papashvili, G., Kuang, F., Leshchyns’ka, I., Sytnyk, V., Nikonenko, A. G., Dityatev, A. E., Jakovčevski, I., et al. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13284 · Cited by 46 · see citing works
Self-citationDermatan 4-O-sulfotransferase1 ablation accelerates peripheral nerve regeneration
Akyüz, N., Rost, S., Mehanna, A., Bian, S., Loers, G., Oezen, I., Mishra, B., Hoffmann, K., Guseva, D., Laczynska, E., et al. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.01.025 · Cited by 44 · see citing works
Self-citationHeikkinen, A., Pihlajaniemi, T., Faissner, A., & Yuzaki, M. (2014) · Progress in Brain Research · doi:10.1016/b978-0-444-63486-3.00002-5 · Cited by 42 · see citing works
Gurevicius, K., Kuang, F., Stoenica, L., Irintchev, A., Gureviciene, I., Dityatev, A. E., Schachner, M., & Tanila, H. (2009) · Hippocampus · doi:10.1002/hipo.20585 · Cited by 40 · see citing works
Self-citationExtracellular matrix and synapse formation
Yang, L., Wei, M., Xing, B., & Zhang, C. (2022) · Bioscience Reports · doi:10.1042/bsr20212411 · Cited by 39 · see citing works
The polysialic acid mimetics 5-nonyloxytryptamine and vinorelbine facilitate nervous system repair
Saini, V., Lutz, D., Kataria, H., Kaur, G., Schachner, M., & Loers, G. (2016) · Scientific Reports · doi:10.1038/srep26927 · Cited by 38 · see citing works
Self-citationFrom molecules to behavior: Implications for perineuronal net remodeling in learning and memory
Sanchez, B., Kraszewski, P., Lee, S., & Cope, E. C. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16036 · Cited by 37 · see citing works
Mueller-Buehl, C., Reinhard, J., Roll, L., Bader, V., Winklhofer, K. F., & Faissner, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.886527 · Cited by 35 · see citing works
A method to estimate the cellular composition of the mouse brain from heterogeneous datasets
Rodarie, D., Verasztó, C., Roussel, Y., Reimann, M., Keller, D. X., Ramaswamy, S., Markram, H., & Gewaltig, M.-O. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010739 · Cited by 35 · see citing works
Guseva, D., Zerwas, M., Xiao, M.-F., Jakovčevski, I., Irintchev, A., & Schachner, M. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.02.018 · Cited by 34 · see citing works
Self-citationSchreiber, J., Schachner, M., Schumacher, U., & Lorke, D. E. (2013) · Acta Histochemica · doi:10.1016/j.acthis.2013.04.009 · Cited by 34 · see citing works
Self-citationAgnati, L. F., Genedani, S., Leo, G., Forni, A., Woods, A. S., Filaferro, M., Franco, R., & Fuxé, K. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0564-9 · Cited by 33 · see citing works
Jakovčevski, I., Djogo, N., Hoelters, L., Szpotowicz, E., & Schachner, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.067 · Cited by 31 · see citing works
Self-citationGuseva, D., Jakovčevski, I., Irintchev, A., Leshchyns’ka, I., Sytnyk, V., Ponimaskin, E. G., & Schachner, M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00174 · Cited by 30 · see citing works
Self-citationTsai, H.-L., Chiu, W., Fang, C.-L., Hwang, S., Renshaw, P. F., & Lai, W. T. (2014) · Tissue Engineering Part A · doi:10.1089/ten.tea.2013.0188 · Cited by 30 · see citing works
Besser, M., Jagatheaswaran, M., Reinhard, J., Schaffelke, P., & Faissner, A. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.05.020 · Cited by 28 · see citing works
Jakovljević, A., Tucić, M., Blažíková, M., Korenić, A., Missirlis, Y. F., Stamenković, V., & Anđjus, P. R. (2021) · Cells · doi:10.3390/cells10061345 · Cited by 28 · see citing works
Tenascin-C stimulates contactin-dependent neurite outgrowth via activation of phospholipase C
Michele, M., & Faissner, A. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.04.004 · Cited by 28 · see citing works
The Barrel Cortex as a Model to Study Dynamic Neuroglial Interaction
Giaume, C., Maravall, M., Welker, E., & Bonvento, G. (2009) · The Neuroscientist · doi:10.1177/1073858409336092 · Cited by 28 · see citing works
Jansen, S., Gottschling, C., Faissner, A., & Manahan‐Vaughan, D. (2017) · Hippocampus · doi:10.1002/hipo.22742 · Cited by 26 · see citing works
Quattromani, M. J., Hakon, J., Rauch, U., Bauer, A. Q., & Wieloch, T. W. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.01.011 · Cited by 25 · see citing works
Tenascin-C and its functions in neuronal plasticity
Šekeljić, V., & Anđjus, P. R. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.02.014 · Cited by 25 · see citing works
Hundeshagen, G., Szameit, K., Thieme, H., Finkensieper, M., Angelov, D. N., Guntinas‐Lichius, O., & Irintchev, A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.019 · Cited by 24 · see citing works
Self-citationSivukhina, E. V., Helbling, J., Minni, A., Schäfer, H. H., Pallet, V., Jirikowski, G. F., & Moisan, M. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.076893 · Cited by 24 · see citing works
Raslan, A., Ernst, P., Werle, M., Thieme, H., Szameit, K., Finkensieper, M., Guntinas‐Lichius, O., & Irintchev, A. (2013) · Brain Structure and Function · doi:10.1007/s00429-013-0542-6 · Cited by 24 · see citing works
Self-citationDevelopmental control of cortico-cerebral astrogenesis
Mallamaci, A. (2013) · The International Journal of Developmental Biology · doi:10.1387/ijdb.130148am · Cited by 23 · see citing works
Sinha, A., Kawakami, J., Cole, K. S., Ladutska, A., Nguyen, M. Y., Zalmai, M. S., Holder, B. L., Broerman, V. M., Matthews, R. T., & Bouyain, S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104952 · Cited by 23 · see citing works
Retarded kindling progression in mice deficient in the extracellular matrix glycoprotein tenascin‐R
Hoffmann, K., Sivukhina, E. V., Potschka, H., Schachner, M., Löscher, W., & Dityatev, A. E. (2009) · Epilepsia · doi:10.1111/j.1528-1167.2008.01774.x · Cited by 23 · see citing works
Self-citationRadonjić, N. V., Jakovčevski, I., Bumbasirevic, V. Z., & Petronijević, N. (2013) · Psychopharmacology · doi:10.1007/s00213-013-2999-7 · Cited by 22 · see citing works
The Complementary Role of Morphology in Understanding Microglial Functional Heterogeneity
Godeanu, S., & Cătălin, B. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083811 · Cited by 21 · see citing works
Bendella, H., Pavlov, S., Grosheva, M., Irintchev, A., Angelova, S. K., Merkel, D., Sinis, N., Kaidoglou, K., Skouras, E., Dunlop, S. A., et al. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2697-9 · Cited by 21 · see citing works
Self-citationHermann, M., Reumann, R., Schostak, K., Kement, D., Gelderblom, M., Bernreuther, C., Frischknecht, R., Schipanski, A., Marik, S., Krasemann, S., et al. (2019) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2019.103420 · Cited by 21 · see citing works
Progress in mimicking brain microenvironments to understand and treat neurological disorders
Ngo, M. T., & Harley, B. A. C. (2021) · APL Bioengineering · doi:10.1063/5.0043338 · Cited by 20 · see citing works
Ontogeny of Progesterone Receptor Expression in the Subplate of Fetal and Neonatal Rat Cortex
Jahagirdar, V., & Wagner, C. K. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp165 · Cited by 19 · see citing works
Altered Hypothalamic-Pituitary-Adrenal Axis Activity in Patients with Chronic Heart Failure
Sivukhina, E. V., Поскребышева, А. С., Смурова, Ю. В., Должиков, А. А., Morozov, I. E., Jirikowski, G. F., & Grinevich, V. (2009) · Hormone and Metabolic Research · doi:10.1055/s-0029-1224182 · Cited by 17 · see citing works
Recovery after spinal cord injury by modulation of the proteoglycan receptor PTPσ
Rink, S., Arnold, D., Wöhler, A., Bendella, H., Meyer, C., Μanthou, M. E., Papamitsou, T., Sarıkçıoğlu, L., & Angelov, D. N. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.08.003 · Cited by 17 · see citing works
Vulović, M., Divac, N., & Jakovčevski, I. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00011 · Cited by 15 · see citing works
Rost, S., Akyüz, N., Martinović, T., Huckhagel, T., Jakovčevski, I., & Schachner, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.013 · Cited by 15 · see citing works
Self-citationCortical Representation of Touch in Silico
Huang, C., Zeldenrust, F., & Celikel, T. (2022) · Neuroinformatics · doi:10.1007/s12021-022-09576-5 · Cited by 14 · see citing works
Microglial morphology in the somatosensory cortex across lifespan. A quantitative study
Godeanu, S., Clarke, D., Stopper, L., Deftu, A., Popa‐Wagner, A., Bălşeanu, T. A., Scheller, A., & Cătălin, B. (2023) · Developmental Dynamics · doi:10.1002/dvdy.582 · Cited by 14 · see citing works
Tereshchenko, Y., Morellini, F., Dityatev, A. E., Schachner, M., & Irintchev, A. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22636 · Cited by 14 · see citing works
Self-citationSchmid, J. S., Bernreuther, C., Nikonenko, A. G., Zhang, L., Mies, G., Hossmann, K.-A., Jakovčevski, I., & Schachner, M. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0463-9 · Cited by 14 · see citing works
Self-citationCorrelation of tenascin-C concentrations in serum with outcome of traumatic brain injury in humans
Zhao, Y., Lou, L., Yang, K., Wang, H., Xu, Y., Lü, G., & He, H. (2017) · Clinica Chimica Acta · doi:10.1016/j.cca.2017.07.018 · Cited by 13 · see citing works
- Authors
- Irintchev, A., Rollenhagen, A., Troncoso, E., Kiss, J. Z., & Schachner, M.
- Affiliations
- Universität Hamburg (DE)
- University of Freiburg (DE)
- University of Geneva (CH)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Irintchev, Andrey
- Venue
- Cerebral Cortex
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-11-10
- Volume
- 15
- Issue
- 7
- Pages
- 950-962
- ISSN
- 1047-3211 (ISSN-L)
- 1460-2199
- OpenAlex
- W1988532274
- Cited by
- 137
- References
- 80
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 7 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 7 · 2013: 11 · 2012: 9
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by
- Locations
- Cerebral Cortex (publishedVersion)
- PubMed (publishedVersion)
- reroDoc Digital Library (submittedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- tenascin-C, cortical development, extracellular matrix, neuronal density, astrocyte activation, parvalbumin interneurons, oligodendrocytes, microglia, dendritic spine morphology, layer 5 pyramidal neurons, whisker stimulation, barrel cortex, motor cortex, cortical inhibition
- MeSH terms
- Animals, Cell Count, Evoked Potentials, Somatosensory, Female, Interneurons, Male, Mice, Inbred C57BL, Mice, Mutant Strains, Motor Cortex, Neural Inhibition, Neuroglia, Somatosensory Cortex, Vibrissae, Pyramidal Cells, Tenascin, Dendritic Spines, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review