Cited by 41Neural and Behavioral Psychology StudiesCognitive Abilities and TestingMemory Processes and Influences

Differential Anterior Prefrontal Activation during the Recognition Stage of a Spatial Working Memory Task

Leung, H.-C., Gore, J.C., Goldman-Rakic, P.S.·2005·Cerebral Cortex

Abstract

Neuroimaging studies commonly show widespread activations in the prefrontal cortex during various forms of working memory and long-term memory tasks. However, the anterior prefrontal cortex (aPFC, Brodmann area 10) has been mainly associated with retrieval in episodic memory, and its role in working memory is less clear. We conducted an event-related functional magnetic resonance imaging study to examine brain activations in relation to recognition in a spatial delayed-recognition task. Similar to the results from previous findings, several frontal areas were strongly activated during the recognition phase of the task, including the aPFC, the lateral PFC and the anterior cingulate cortex. Although the aPFC was more active during the recognition phase, it was also active during the delay phase of the spatial working memory task. In addition, the aPFC showed greater activity in response to negative probes (non-targets) than to positive probes (targets). While our analyses focused on examining signal changes in the aPFC, other prefrontal regions showed similar effects and none of the areas were more active in response to the positive probes than to the negative probes. Our findings support the conclusion that the aPFC is involved in working memory and particularly in processes that distinguish target and non-target stimuli during recognition.

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  • The mature mesoprefrontal system is involved in attention, behavioral flexibility, action planning, sustainability of motivational and affective states, working memory and memory consolidation, mediated in parallel by catecholaminergic pathways.

    “Eventually, the mature mesoprefrontal system is involved in attention, behavioral flexibility, action planning, sustainability of motivational and affective states, working memory and memory consolidation which is mediated in parallel by catecholaminergic pathways [169, 174–178].”

    From Development of prefrontal cortex (2022) · cites this paper as [176]

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Authors
Leung, H.-C., Gore, J. C., & Goldman-Rakic, P. S.
Affiliations
  • State University of New York (US)
  • Vanderbilt University (US)
Corresponding author
Leung, H.-C.
Venue
Cerebral Cortex
Published
2005-02-09
Volume
15
Issue
11
Pages
1742-1749
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
OpenAlex
W2098508288
Cited by
41
References
51
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 2 · 2015: 2 · 2013: 2 · 2012: 1
FWCI
1.65
Type
journal article
Language
en
Open access
closed
Locations
  • Cerebral Cortex (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • State University of New York
  • National Institutes of Health (11794, MH30929)
  • National Institute of Mental Health (MH 44866, MH38546, MH30929-22, P50MH044866)
  • National Institute of Neurological Disorders and Stroke (NS 33332, R01NS033332)
  • National Institute of Biomedical Imaging and Bioengineering (R01EB000461, EB 00461)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
anterior prefrontal cortex, spatial working memory, recognition memory, lateral prefrontal cortex, anterior cingulate cortex, probe detection, episodic memory retrieval
MeSH terms
Adult, Discrimination Learning, Evoked Potentials, Visual, Female, Humans, Male, Memory, Short-Term, Pattern Recognition, Visual, Photic Stimulation, Space Perception, Task Performance and Analysis, Prefrontal Cortex

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