Prefrontal activity associated with working memory and episodic long-term memory.
Abstract
Many recent neuroimaging studies have highlighted the role of prefrontal regions in the sustained maintenance and manipulation of information over short delays, or working memory (WM). In addition, neuroimaging findings have highlighted the role of prefrontal regions in the formation and retrieval of memories for events, or episodic long-term memory (LTM), but it remains unclear whether these regions are distinct from those that support WM. We used event-related functional magnetic resonance imaging (fMRI) to identify patterns of prefrontal activity associated with encoding and recognition during WM and LTM tasks performed by the same subjects. Results showed that the same bilateral ventrolateral prefrontal regions (at or near Brodmann's Areas [BA] 6, 44, 45, and 47) and dorsolateral prefrontal regions (BA 9/46) were engaged during encoding and recognition within the context of WM and LTM tasks. In addition, a region situated in the left anterior middle frontal gyrus (BA 10/46) was engaged during the recognition phases of the WM and LTM tasks. These results support the view that the same prefrontal regions implement reflective processes that support both WM and LTM.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Tasks that require PFC involvement, confirmable to some degree by neuroimaging, should all exhibit the curvilinear component of the Yerkes-Dodson law.
“We would suggest that, as a general rule, tasks that require the involvement of the PFC, which can be confirmed to some degree by neuroimaging techniques (Callicott et al. [411]; Ranganath et al. [412]; Taylor et al. [368]; Ranganath and D'Esposito [413]; Curtis [371]), should all exhibit the curvilinear component of the Yerkes-Dodson law.”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Ranganath et al. [412]
Cites
The fusiform face area: a module in human extrastriate cortex specialized for face perception
Kanwisher, N., McDermott, J., & Chun, M. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04302.1997 · Cited by 7,738 · see citing works
Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960 · see citing works
Neural mechanisms for visual memory and their role in attention
Desimone, R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13494 · Cited by 1,028 · cited 1× · see citing works
“One hypothesis proposed by several researchers is that lateral prefrontal regions may be critical for implementing top-down attentional modulation of posterior cortical activity that enables transient attentional selection and inhibition [13,14,16,34,49,61] , long-term memory retrieval [26,50,65] , as well as sustaine…”
BackgroundProspective coding for objects in primate prefrontal cortex
Rainer, G., Rao, S. C., & Miller, E. K. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05493.1999 · Cited by 432 · cited 3× · see citing works
“Indeed, extant evidence indicates that PFC may modulate posterior cortical activity as early as 100 ms following presentation of a visual stimulus [5,50].”
BackgroundResultThe role of the prefrontal cortex in dynamic filtering
Shimamura, A. P. (2000) · Psychobiology · doi:10.3758/bf03331979 · Cited by 394 · see citing works
Prefrontal modulation of visual processing in humans
Barceló, F., Suwazono, S., & Knight, R. T. (2000) · Nature Neuroscience · doi:10.1038/73975 · Cited by 374 · see citing works
The dependence of span and delayed-response performance on prefrontal cortex.
D’Esposito, M., & Postle, B. R. (1999) · Neuropsychologia · doi:10.1016/s0028-3932(99)00021-4 · Cited by 350 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The Mind and Brain of Short-Term Memory
Jonides, J., Lewis, R. L., Nee, D. E., Lustig, C. A., Berman, M. G., & Moore, K. S. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093615 · Cited by 957 · see citing works
Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762 · see citing works
Dissociable correlates of recollection and familiarity within the medial temporal lobes
Ranganath, C., Yonelinas, A. P., Cohen, M. X., Dy, C. J., Tom, S. M., & D’Esposito, M. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2003.07.006 · Cited by 689 · see citing works
Self-citationRecollection-like memory retrieval in rats is dependent on the hippocampus
Fortin, N. J., Wright, S. P., & Eichenbaum, H. (2004) · Nature · doi:10.1038/nature02853 · Cited by 460 · see citing works
Functional-anatomic correlates of remembering and knowing
Wheeler, M. E., & Buckner, R. L. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.001 · Cited by 434 · see citing works
Oei, N. Y. L., Everaerd, W. T. A. M., Elzinga, B. M., van Well, S., & Bermond, B. (2006) · Stress · doi:10.1080/10253890600965773 · Cited by 373 · see citing works
Functional connectivity during working memory maintenance
GAZZALEY, A., RISSMAN, J., & D'ESPOSITO, M. (2004) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.4.4.580 · Cited by 337 · see citing works
Self-citationLongcamp, M., Boucard, C., Gilhodes, J.-C., Anton, J.-L., Roth, M., Nazarian, B., & Velay, J.-L. (2008) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2008.20504 · Cited by 294 · see citing works
Gazzaley, A., Rissman, J., Cooney, J., Rutman, A., Seibert, T., Clapp, W., & D'Esposito, M. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm113 · Cited by 287 · see citing works
Self-citationEpisodic retrieval and the cortical binding of relational activity
Shimamura, A. P. (2011) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-011-0031-4 · Cited by 205 · see citing works
Schon, K., Hasselmo, M. E., LoPresti, M. L., Tricarico, M. D., & Stern, C. E. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3807-04.2004 · Cited by 191 · see citing works
Zhang, J. X., Leung, H.-C., & Johnson, M. K. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.07.016 · Cited by 167 · see citing works
Self-citationConnectivity-based parcellation of the human frontal pole with diffusion tensor imaging
Liu, H., Qin, W., Li, W., Fan, L., Wang, J., Jiang, T., & Yu, C. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4882-12.2013 · Cited by 108 · see citing works
Individual differences in long-term memory.
Unsworth, N. (2019) · Psychological Bulletin · doi:10.1037/bul0000176 · Cited by 99 · see citing works
Tsukiura, T., & Cabeza, R. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.03.013 · Cited by 90 · see citing works
Separating subjective emotion from the perception of emotion-inducing stimuli: An fMRI study
Garrett, A. S., & Maddock, R. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.024 · Cited by 82 · see citing works
Keresztes, A., Kaiser, D., Kovács, G., & Racsmány, M. (2014) · Cerebral Cortex · doi:10.1093/cercor/bht158 · Cited by 56 · see citing works
Patros, C. H. G., Alderson, R. M., Lea, S. E., Tarle, S. J., Kasper, L. J., & Hudec, K. L. (2015) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2014.12.016 · Cited by 43 · see citing works
Leung, H.-C., Gore, J. C., & Goldman-Rakic, P. S. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi051 · Cited by 41 · see citing works
Should Broca’s area include Brodmann area 47?
Ardila, A., Bernal, B., & Rosselli, M. (2017) · Psicothema · doi:10.7334/psicothema2016.11 · Cited by 39 · see citing works
Baxter, M. G., Gaffan, D., Kyriazis, D. A., & Mitchell, A. S. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06353.x · Cited by 37 · see citing works
Poissant, H., Rapin, L., Chenail, S., & Mendrek, A. (2016) · Psychiatry Journal · doi:10.1155/2016/6810215 · Cited by 15 · see citing works
Vascular cognitive impairment: prodrome to VaD?
Mayda, A., & DeCarli, C. (2009) · Vascular Cognitive Impairment in Clinical Practice · doi:10.1017/cbo9780511575976.003 · Cited by 7 · see citing works
- Authors
- Ranganath, C., Johnson, M. K., & D’Esposito, M.
- Affiliations
- Yale University (US)
- University of California, Berkeley (US)
- ORCID
- D’Esposito, Mark
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 41
- Issue
- 3
- Pages
- 378-389
- ISSN
- 0028-3932 (ISSN-L)
- OpenAlex
- W2145447384
- Cited by
- 406
- References
- 7
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 16 · 2021: 15 · 2020: 18 · 2019: 16 · 2018: 17 · 2017: 15 · 2016: 17 · 2015: 23 · 2014: 20 · 2013: 12 · 2012: 19
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Federation for Aging Research
- National Institute on Aging (AG 09253, R01AG015793, AG 15793, F32AG005863, AG05863)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- prefrontal cortex, working memory, episodic long-term memory, ventrolateral prefrontal cortex, dorsolateral prefrontal cortex, memory encoding, recognition memory, Brodmann areas, shared neural substrates
- MeSH terms
- Adult, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Pattern Recognition, Visual, Retention, Psychology, Task Performance and Analysis, Prefrontal Cortex
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
