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Cited by 377

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Total and Regional Brain Volumes in a Population-Based Normative Sample from 4 to 18 Years: The NIH MRI Study of Normal Brain Development

Open access
Brain Development Cooperative Group·2012·Cerebral Cortex

Abstract

Using a population-based sampling strategy, the National Institutes of Health (NIH) Magnetic Resonance Imaging Study of Normal Brain Development compiled a longitudinal normative reference database of neuroimaging and correlated clinical/behavioral data from a demographically representative sample of healthy children and adolescents aged newborn through early adulthood. The present paper reports brain volume data for 325 children, ages 4.5-18 years, from the first cross-sectional time point. Measures included volumes of whole-brain gray matter (GM) and white matter (WM), left and right lateral ventricles, frontal, temporal, parietal and occipital lobe GM and WM, subcortical GM (thalamus, caudate, putamen, and globus pallidus), cerebellum, and brainstem. Associations with cross-sectional age, sex, family income, parental education, and body mass index (BMI) were evaluated. Key observations are: 1) age-related decreases in lobar GM most prominent in parietal and occipital cortex; 2) age-related increases in lobar WM, greatest in occipital, followed by the temporal lobe; 3) age-related trajectories predominantly curvilinear in females, but linear in males; and 4) small systematic associations of brain tissue volumes with BMI but not with IQ, family income, or parental education. These findings constitute a normative reference on regional brain volumes in children and adolescents.

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Crossref · 10.1093/cercor/bhr018

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Metadata

Authors
Brain Development Cooperative Group
Venue
Cerebral Cortex
Published
2011-05-25
Volume
22
Issue
1
Pages
1-12
ISSN
  • 1047-3211 (ISSN-L)
  • 1460-2199
OpenAlex
W2990728208
Cited by
377
References
15
FWCI
19.76
Type
journal article
Language
en
Open access
bronze

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