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Clinical Features of 69 Cases With Coronavirus Disease 2019 in Wuhan, China
Open accessAbstract
Background: From December 2019 to February 2020, 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a serious outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China. Related clinical features are needed. Methods: We reviewed 69 patients who were hospitalized in Union hospital in Wuhan between 16 January and 29 January 2020. All patients were confirmed to be infected with SARS-CoV-2, and the final date of follow-up was 4 February 2020. Results: The median age of 69 enrolled patients was 42.0 years (interquartile range 35.0–62.0), and 32 patients (46%) were men. The most common symptoms were fever (60 [87%]), cough (38 [55%]), and fatigue (29 [42%]). Most patients received antiviral therapy (66 [98.5%] of 67 patients) and antibiotic therapy (66 [98.5%] of 67 patients). As of 4 February 2020, 18 (26.9%) of 67 patients had been discharged, and 5 patients had died, with a mortality rate of 7.5%. According to the lowest SpO2 during admission, cases were divided into the SpO2 ≥ 90% group (n = 55) and the SpO2 < 90% group (n = 14). All 5 deaths occurred in the SpO2 < 90% group. Compared with SpO2 ≥ 90% group, patients of the SpO2 < 90% group were older and showed more comorbidities and higher plasma levels of interleukin (IL) 6, IL10, lactate dehydrogenase, and C reactive protein. Arbidol treatment showed tendency to improve the discharging rate and decrease the mortality rate. Conclusions: COVID-19 appears to show frequent fever, dry cough, and increase of inflammatory cytokines, and induced a mortality rate of 7.5%. Older patients or those with underlying comorbidities are at higher risk of death.
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“Patients infected with SARS-CoV-2 present elevated levels of IL-6, IL-10, IL-1β, INF-γ, CCL2, TNF-α, CXCL10, CCL7, IL-1 receptor antagonist and IL-2 receptor, supposedly associated with disease severity [9, 98–105].”
From Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology (2021) · cites this paper as [105]
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“The authors provide a detailed description of major signs and symptoms of overt disease [2, 3], but fail to give an account of minor symptoms that may be present at earlier stages of the infection.”
From Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study (2020) · cites this paper as [1]
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Cancer patients and research during COVID-19 pandemic: A systematic review of current evidence
Moujaess, E., Kourié, H. R., & Ghosn, M. G. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.102972 · Cited by 222
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Neurological manifestations of COVID-19: a systematic review and meta-analysis of proportions
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SARS-CoV-2 membrane glycoprotein M antagonizes the MAVS-mediated innate antiviral response
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Minotti, C., Tirelli, F., Barbieri, E., Giaquinto, C., & Donà, D. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.04.026 · Cited by 204
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Recommendations for antibacterial therapy in adults with COVID-19 – an evidence based guideline
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Neurological and Musculoskeletal Features of COVID-19: A Systematic Review and Meta-Analysis
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Secondary Bacterial Infections in Patients With Viral Pneumonia
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Metadata
- Authors
- Wang, Z., Yang, B., Li, Q., Wen, L., & Zhang, R.
- Affiliations
- Wuhan Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Corresponding author
- Zhang, Ruiguang
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-03-16
- Volume
- 71
- Issue
- 15
- Pages
- 769-777
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC7184452
- OpenAlex
- W3012492786
- Cited by
- 1,063
- References
- 28
- Citations by year
- 2026: 3 · 2025: 10 · 2024: 32 · 2023: 92 · 2022: 120 · 2021: 288 · 2020: 516
- FWCI
- 33.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
- Keywords
- COVID-19 pandemic, SARS-CoV-2, clinical features, mortality, oxygen saturation, comorbidities, inflammatory cytokines, interleukin-6, IL-10, C-reactive protein, lactate dehydrogenase, arbidol, antiviral therapy, hospitalized patients
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Adult, Aged, C-Reactive Protein, China, Cough, Female, Fever, Hospitalization, Humans, Male, Middle Aged, Patient Discharge, Pneumonia, Viral, Interleukin-6, Interleukin-10, Coronavirus Infections, Pandemics
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