Renal denervation in the management of hypertension in adults. A clinical consensus statement of the ESC Council on Hypertension and the European Association of Percutaneous Cardiovascular Interventions (EAPCI)
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Since the publication of the 2018 European Society of Cardiology/European Society of Hypertension (ESC/ESH) Guidelines for the Management of Arterial Hypertension, several high-quality studies, including randomised, sham-controlled trials on catheter-based renal denervation (RDN) were published, confirming both the blood pressure (BP)-lowering efficacy and safety of radiofrequency and ultrasound RDN in a broad range of patients with hypertension, including resistant hypertension. A clinical consensus document by the ESC Council on Hypertension and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) on RDN in the management of hypertension was considered necessary to inform clinical practice. This expert group proposes that RDN is an adjunct treatment option in uncontrolled resistant hypertension, confirmed by ambulatory BP measurements, despite best efforts at lifestyle and pharmacological interventions. RDN may also be used in patients who are unable to tolerate antihypertensive medications in the long term. A shared decision-making process is a key feature and preferably includes a patient who is well informed on the benefits and limitations of the procedure. The decision-making process should take (i) the patient’s global cardiovascular (CV) risk and/or (ii) the presence of hypertension-mediated organ damage or CV complications into account. Multidisciplinary hypertension teams involving hypertension experts and interventionalists evaluate the indication and facilitate the RDN procedure. Interventionalists require expertise in renal interventions and specific training in RDN procedures. Centres performing these procedures require the skills and resources to deal with potential complications. Future research is needed to address open questions and investigate the impact of BP-lowering with RDN on clinical outcomes and potential clinical indications beyond hypertension.
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In 2023, clinical adoption of renal denervation was recommended by guidelines from the International Society of Hypertension and the European Renal Association, and from the European Society of Cardiology Council on Hypertension and the European Association of Percutaneous Cardiovascular Interventions.
“clinical adoption of RDN was recommended in 2023 guidelines from the International Society of Hypertension and the European Renal Association15, and from the European Society of Cardiology Council on Hypertension and the European Association of Percutaneous Cardiovascular Interventions16,17”
From Renal nerves in physiology, pathophysiology and interoception (2025) · cites this paper as [16]
The Introduction (p. 2) identifies this 2023 paper as a clinical consensus document of the ESC Council on Hypertension and EAPCI, and Centre selection (p. 9) recommends teams to evaluate indications for and perform renal denervation. Calling it a guideline recommending general clinical adoption overstates the source: it gives conditional consensus statements about patient selection and centre requirements. The International Society of Hypertension and European Renal Association portion is attached to a different citation and is not assessed here. (LLM, conf=0.84)
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Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026 · see citing works
2018 ESC/ESH Guidelines for the management of arterial hypertension
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy339 · Cited by 10,286 · see citing works
Self-citationMurray, C. J. L., Aravkin, A. Y., Zheng, P., Abbafati, C., Abbas, K. M., Abbasi-Kangevari, M., Abd-Allah, F., Abdelalim, A., Abdollahi, M., Abdollahpour, I., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30752-2 · Cited by 9,854 · see citing works
Self-citation2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes
Knuuti, J., Wijns, W., Saraste, A., Capodanno, D., Barbato, E., Funck-Brentano, C., Prescott, E., Storey, R. F., Deaton, C., Cuisset, T., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz425 · Cited by 7,166 · see citing works
Self-citation2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab484 · Cited by 6,485 · see citing works
Self-citationA Randomized Trial of Intensive versus Standard Blood-Pressure Control
The SPRINT Research Group (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1511939 · Cited by 6,325 · see citing works
Zhou, B., Carrillo-Larco, R. M., Danaei, G., Riley, L. M., Paciorek, C. J., Stevens, G. A., Gregg, E. W., Bennett, J. E., Solomon, B., Singleton, R. K., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)01330-1 · Cited by 3,902 · see citing works
Ettehad, D., Emdin, C. A., Kiran, A., Anderson, S. G., Callender, T., Emberson, J., Chalmers, J., Rodgers, A., & Rahimi, K. (2016) · The Lancet · doi:10.1016/s0140-6736(15)01225-8 · Cited by 3,755 · see citing works
A Controlled Trial of Renal Denervation for Resistant Hypertension
Bhatt, D. L., Kandzari, D. E., O'Neill, W. W., D'Agostino, R., Flack, J. M., Katzen, B. T., Leon, M. B., Liu, M., Mauri, L., Negoita, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402670 · Cited by 2,186 · see citing works
Self-citationRevascularization versus Medical Therapy for Renal-Artery Stenosis
The ASTRAL Investigators (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0905368 · Cited by 1,194 · see citing works
Rahimi, K., Bidel, Z., Nazarzadeh, M., Copland, E., Canoy, D., Ramakrishnan, R., Pinho-Gomes, A.-C., Woodward, M., Adler, A., Agodoa, L., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00590-0 · Cited by 1,074 · see citing works
Lifetime risks of cardiovascular disease
Berry, J. D., Dyer, A., Cai, X., Garside, D. B., Ning, H., Thomas, A., Greenland, P., Van Horn, L., Tracy, R. P., & Lloyd-Jones, D. M. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1012848 · Cited by 945 · see citing works
Adherence in Hypertension: A Review of Prevalence, Risk Factors, Impact, and Management
Burnier, M., & Egan, B. M. (2019) · Circulation Research · doi:10.1161/circresaha.118.313220 · Cited by 878 · see citing works
Adaptive designs in clinical trials: why use them, and how to run and report them
Pallmann, P., Bedding, A. W., Choodari-Oskooei, B., Dimairo, M., Flight, L., Hampson, L. V., Holmes, J., Mander, A. P., Odondi, L., Sydes, M. R., et al. (2018) · BMC Medicine · doi:10.1186/s12916-018-1017-7 · Cited by 829 · see citing works
Pocock, S., Ariti, C. A., Collier, T. J., & Wang, D. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr352 · Cited by 825 · see citing works
Kandzari, D. E., Böhm, M., Mahfoud, F., Townsend, R. R., Weber, M. A., Pocock, S., Tsioufis, K., Tousoulis, D., Choi, J. W., East, C., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30951-6 · Cited by 793 · see citing works
Self-citationTrial of Intensive Blood-Pressure Control in Older Patients with Hypertension
Zhang, W., Zhang, S., Deng, Y., Wu, S., Ren, J., Sun, G., Yang, J., Jiang, Y., Xu, X., Wang, T.-D., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2111437 · Cited by 784 · see citing works
Bundy, J. D., Li, C., Stuchlik, P., Bu, X., Kelly, T. N., Mills, K. T., He, H., Chen, J., Whelton, P. K., & He, J. (2017) · JAMA Cardiology · doi:10.1001/jamacardio.2017.1421 · Cited by 783 · cited 1× · see citing works
“Lowering BP through the use of antihypertensive drugs has been shown to reduce the risk for CV morbidity and all-cause mortality 3,4 .”
Townsend, R. R., Mahfoud, F., Kandzari, D. E., Kario, K., Pocock, S., Weber, M. A., Ewen, S., Tsioufis, K., Tousoulis, D., Sharp, A. S. P., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32281-x · Cited by 752 · see citing works
Self-citationAzizi, M., Schmieder, R. E., Mahfoud, F., Weber, M. A., Daemen, J., Davies, J., Basile, J., Kirtane, A. J., Wang, Y., Lobo, M. D., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31082-1 · Cited by 740 · see citing works
Self-citationStent Placement in Patients With Atherosclerotic Renal Artery Stenosis and Impaired Renal Function
Bax, L., Woittiez, A.-J. J., Kouwenberg, H. J., Mali, W. P. T. M., Buskens, E., Beek, F. J. A., Braam, B. G., Huysmans, F. T. M., Kool, L. J. S., Rutten, M. J. C. M., et al. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-150-12-200906160-00119 · Cited by 699 · see citing works
Böhm, M., Kario, K., Kandzari, D. E., Mahfoud, F., Weber, M. A., Schmieder, R. E., Tsioufis, K., Pocock, S., Konstantinidis, D., Choi, J. W., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30554-7 · Cited by 606 · see citing works
Self-citationPredictors of blood pressure response in the SYMPLICITY HTN-3 trial
Kandzari, D. E., Bhatt, D. L., Brar, S. K., Devireddy, C. M., Esler, M., Fahy, M. P., Flack, J. M., Katzen, B. T., Lea, J. P., Lee, D. P., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu441 · Cited by 546 · see citing works
Self-citationAzizi, M., Sapoval, M., Gosse, P., Monge, M., Bobrie, G., Delsart, P., Midulla, M., Mounier-Véhier, C., Courand, P.-Y., Lantelme, P., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61942-5 · Cited by 519 · see citing works
Self-citationThe combination of randomized and historical controls in clinical trials
Pocock, S. J. (1976) · Journal of Chronic Diseases · doi:10.1016/0021-9681(76)90044-8 · Cited by 514 · see citing works
Association of office and ambulatory blood pressure with mortality and cardiovascular outcomes
Yang, W.-Y., Melgarejo, J. D., Thijs, L., Zhang, Z.-Y., Boggia, J., Wei, F.-F., Hansen, T. W., Asayama, K., Ohkubo, T., Jeppesen, J., et al. (2019) · JAMA · doi:10.1001/jama.2019.9811 · Cited by 491 · see citing works
Renal Sympathetic Denervation for Treatment of Drug-Resistant Hypertension
Esler, M., Krum, H., Schlaich, M. P., Schmieder, R. E., Böhm, M., & Sobotka, P. A. (2012) · Circulation · doi:10.1161/circulationaha.112.130880 · Cited by 462 · see citing works
Self-citationAzizi, M., Sanghvi, K., Saxena, M., Gosse, P., Reilly, J. P., Levy, T., Rump, L. C., Persu, A., Basile, J., Bloch, M. J., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)00788-1 · Cited by 439 · see citing works
Self-citationMuntner, P., Shimbo, D., Tonelli, M. A., Reynolds, K., Arnett, D. K., & Oparil, S. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.162255 · Cited by 438 · see citing works
Pokushalov, E. A., Romanov, A. B., CORBUCCI, G., Николаевич, А. С., Викторовна, Б. В., Туров, А. Н., Shirokova, N., Karaskov, A. M., Mittal, S., & Steinberg, J. S. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.05.036 · Cited by 435 · see citing works
Anatomic Assessment of Sympathetic Peri-Arterial Renal Nerves in Man
Sakakura, K., Ladich, E., Cheng, Q., Otsuka, F., Yahagi, K., Fowler, D. R., Kolodgie, F. D., Virmani, R., & Joner, M. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.03.059 · Cited by 406 · see citing works
Aggarwal, R., Chiu, N., Wadhera, R. K., Moran, A. E., Raber, I., Shen, C., Yeh, R. W., & Kazi, D. S. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.17570 · Cited by 394 · see citing works
Rahimi, K., Bidel, Z., Nazarzadeh, M., Copland, E., Canoy, D., Wamil, M., Majert, J., McManus, R. J., Adler, A., Agodoa, L., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)01921-8 · Cited by 344 · see citing works
Blood pressure and its variability: classic and novel measurement techniques
Schutte, A. E., Kollias, A., & Stergiou, G. S. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00690-0 · Cited by 335 · see citing works
Kario, K., Hoshide, S., Mizuno, H., Kabutoya, T., Nishizawa, M., Yoshida, T., Abe, H., Katsuya, T., Fujita, Y., Okazaki, O., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.049730 · Cited by 324 · see citing works
Differential Effectiveness of Placebo Treatments
Meißner, K., Fässler, M., Rücker, G., Kleijnen, J., Hróbjartsson, A., Schneider, A., Antes, G., & Linde, K. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.10391 · Cited by 308 · see citing works
Mahfoud, F., Böhm, M., Schmieder, R. E., Narkiewicz, K., Ewen, S., Ruilope, L. M., Schlaich, M. P., Williams, B., Fahy, M. P., & Mancia, G. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz118 · Cited by 306 · see citing works
Self-citationMahfoud, F., Kandzari, D. E., Kario, K., Townsend, R. R., Weber, M. A., Schmieder, R. E., Tsioufis, K. P., Pocock, S., Dimitriadis, K. S., Choi, J. W., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)00455-x · Cited by 305 · see citing works
Self-citationWard, A. M., Takahashi, O., Stevens, R., & Heneghan, C. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834e4aed · Cited by 296 · see citing works
Non-adherence to cardiovascular medications
Kolandaivelu, K., Leiden, B. B., O’Gara, P. T., & Bhatt, D. L. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu364 · Cited by 243 · see citing works
Steinberg, J. S., Shabanov, V., Ponomarev, D., Losik, D., Ivanickiy, E., Kropotkin, E., Polyakov, K., Ptaszynski, P., Keweloh, B., Yao, C. J., et al. (2020) · JAMA · doi:10.1001/jama.2019.21187 · Cited by 243 · see citing works
Randomized Sham-Controlled Trial of Renal Sympathetic Denervation in Mild Resistant Hypertension
Desch, S., Okon, T., Heinemann, D., Kulle, K., Röhnert, K., Sonnabend, M., Petzold, M., Müller, U., Schuler, G. C., Eitel, I., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05283 · Cited by 224 · see citing works
Fengler, K., Rommel, K., Blazek, S., Besler, C., Hartung, P., von Roeder, M., Petzold, M., Winkler, S., Höllriegel, R., Desch, S., et al. (2019) · Circulation · doi:10.1161/circulationaha.118.037654 · Cited by 201 · see citing works
Wang, H., Wang, W., Cornish, K. G., Rozanski, G. J., & Zucker, I. H. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03699 · Cited by 200 · see citing works
Berra, E., Azizi, M., Capron, A., Høieggen, A., Rabbia, F., Kjeldsen, S. E., Staessen, J. A., Wallemacq, P., & Persu, A. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07464 · Cited by 195 · see citing works
Self-citationBhatt, D. L., Vaduganathan, M., Kandzari, D. E., Leon, M. B., Rocha‐Singh, K. J., Townsend, R. R., Katzen, B. T., Oparil, S., Brar, S. K., DeBruin, V., et al. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01787-1 · Cited by 186 · see citing works
Self-citationFatani, N., Dixon, D. L., Van Tassell, B. W., Fanikos, J., & Buckley, L. F. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.01.014 · Cited by 173 · see citing works
Booth, L. C., Nishi, E. E., Yao, S. T., Ramchandra, R., Lambert, G. W., Schlaich, M. P., & May, C. N. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04176 · Cited by 171 · see citing works
Self-citationBoutron, I., Estellat, C., Guittet, L., Dechartres, A., Sackett, D. L., Hróbjartsson, A., & Ravaud, P. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030425 · Cited by 168 · see citing works
Templin, C., Jaguszewski, M. J., Ghadri, J. R., Sudano, I., Gaehwiler, R., Hellermann, J. P., Schoenenberger-Berzins, R., Landmesser, U., Erné, P., Noll, G., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht141 · Cited by 168 · see citing works
Self-citationApplegate, R. J., Sacrinty, M. T., Kutcher, M. A., et al. (2008) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2008.03.013 · Cited by 161 · see citing works
Kario, K., Yokoi, Y., Okamura, K., Fujihara, M., Ogoyama, Y., Yamamoto, E., Urata, H., Cho, J. M., Kim, C. J., Choi, S., et al. (2021) · Hypertension Research · doi:10.1038/s41440-021-00754-7 · Cited by 146 · see citing works
Mahfoud, F., Bakris, G. L., Bhatt, D. L., Esler, M., Ewen, S., Fahy, M. P., Kandzari, D. E., Kario, K., Mancia, G., Weber, M. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw325 · Cited by 144 · see citing works
Self-citationKuwabara, M., Harada, K., Hishiki, Y., & Kario, K. (2019) · The Journal of Clinical Hypertension · doi:10.1111/jch.13499 · Cited by 140 · see citing works
Mathiassen, O. N., Vase, H. Ø., Bech, J. N., Christensen, K. L., Buus, N. H., Schroeder, A. P., Lederballe, O., Rickers, H., Kampmann, U., Poulsen, P. L., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000977 · Cited by 138 · see citing works
Long-Term Antihypertensive Efficacy and Safety of the Oral Direct Renin Inhibitor Aliskiren
Schmieder, R. E., Philipp, T., Guerediaga, J., Gorostidi, M., Smith, B. A., Weissbach, N., Maboudian, M., Botha, J., & van Ingen, H. (2009) · Circulation · doi:10.1161/circulationaha.107.750745 · Cited by 132 · see citing works
Self-citationTownsend, R. R., Walton, A., Hettrick, D. A., Hickey, G. L., Weil, J., Sharp, A. S. P., Blankenstijn, P. J., Böhm, M., & Mancia, G. (2020) · EuroIntervention · doi:10.4244/eij-d-19-00902 · Cited by 124 · see citing works
Self-citationDevice-based therapies for arterial hypertension
Lauder, L., Azizi, M., Kirtane, A. J., Böhm, M., & Mahfoud, F. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0364-1 · Cited by 123 · see citing works
Self-citationRenal Denervation in High-Risk Patients With Hypertension
Mahfoud, F., Mancia, G., Schmieder, R. E., Narkiewicz, K., Ruilope, L. M., Schlaich, M. P., Whitbourn, R., Zirlik, A., Zeller, T., Stawowy, P., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.04.036 · Cited by 122 · see citing works
Self-citationEwen, S., Ukena, C., Linz, D., Kindermann, I., Cremers, B., Laufs, U., Wagenpfeil, S., Schmieder, R. E., Böhm, M., & Mahfoud, F. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.04336 · Cited by 120 · see citing works
Self-citationNonadherence in Hypertension: How to Develop and Implement Chemical Adherence Testing
Lane, D., Lawson, A., Burns, A., Azizi, M., Burnier, M., Jones, D. J. L., Kably, B., Khunti, K., Kreutz, R., Patel, P., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.17596 · Cited by 112 · see citing works
Self-citationRenal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System
Sharp, T. E., Polhemus, D. J., Li, Z., Spaletra, P. M., Jenkins, J. S., Reilly, J. P., White, C. J., Kapusta, D. R., Lefer, D. J., & Goodchild, T. T. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2186 · Cited by 109 · see citing works
Egan, B. M., Li, J., Sutherland, S. E., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16418 · Cited by 100 · see citing works
Kreutz, R. H., Dobrowolski, P., Prejbisz, A., Algharably, E. A. E., Bilo, G., Creutzig, F., Grassi, G. M., Kotsis, V., Lović, D. B., Lurbe, E., et al. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002770 · Cited by 97 · see citing works
Self-citationMahfoud, F., Azizi, M., Ewen, S., Pathak, A., Ukena, C., Blankestijn, P. J., Böhm, M., Burnier, M., Châtellier, G., Durand‐Zaleski, I., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa121 · Cited by 95 · see citing works
Self-citationEpidemiology and Natural History of Atherosclerotic Renovascular Disease
Chrysochou, C., & Kalra, P. A. (2009) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2009.09.001 · Cited by 94 · see citing works
Polhemus, D. J., Trivedi, R. K., Gao, J., Li, Z., Scarborough, A. L., Goodchild, T. T., Varner, K. J., Xia, H., Smart, F. W., Kapusta, D. R., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.08.056 · Cited by 94 · see citing works
Singh, R. R., McArdle, Z. M., Iudica, M., Easton, L. K., Booth, L. C., May, C. N., Parkington, H. C., Lombardo, P., Head, G. A., Lambert, G., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12250 · Cited by 86 · see citing works
Self-citationPatient preference for therapies in hypertension: a cross-sectional survey of German patients
Schmieder, R. E., Högerl, K., Jung, S., Bramlage, P., Veelken, R. A., & Ott, C. (2019) · Clinical Research in Cardiology · doi:10.1007/s00392-019-01468-0 · Cited by 86 · see citing works
Self-citationWeber, M. A., Kirtane, A. J., Weir, M. R., Radhakrishnan, J., Das, T. S., Berk, M. R., Mendelsohn, F. O., Bouchard, A., Larrain, G., Haase, M., et al. (2020) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2019.10.061 · Cited by 85 · see citing works
Kandzari, D. E., Mahfoud, F., Weber, M. A., Townsend, R., Parati, G., Fisher, N. D. L., Lobo, M. D., Bloch, M., Böhm, M., Sharp, A. S. P., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.057687 · Cited by 80 · see citing works
Self-citationSchmieder, R. E., Ott, C., Toennes, S. W., Bramlage, P., Gertner, M. E., Dawood, O., Baumgart, P., O’Brien, B., Dasgupta, I., Nickenig, G., et al. (2017) · Journal of Hypertension · doi:10.1097/hjh.0000000000001584 · Cited by 75 · see citing works
Self-citationRenal safety of catheter-based renal denervation: systematic review and meta-analysis
Sanders, M. F., Reitsma, J. B., Morpey, M. I., Gremmels, H., Bots, M. L., Pisano, A., Bolignano, D., Zoccali, C., & Blankestijn, P. J. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfx088 · Cited by 73 · see citing works
Anker, S. D., Butler, J., Khan, M. S., Abraham, W. T., Bauersachs, J. K., Bocchi, E. A., Bozkurt, B., D, E. B. M., Chopra, V., Cleland, J. G. F., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa461 · Cited by 73 · see citing works
Kaji, A. H., & Lewis, R. (2015) · JAMA · doi:10.1001/jama.2015.6645 · Cited by 68 · see citing works
Rader, F., Kirtane, A. J., Wang, Y. L., Daemen, J., Lurz, P. C., Sayer, J., Saxena, M., Levy, T., Scicli, A. P., Thackeray, L., et al. (2022) · EuroIntervention · doi:10.4244/eij-d-22-00305 · Cited by 64 · see citing works
Self-citationOtt, C., Mahfoud, F., Mancia, G., Narkiewicz, K., Ruilope, L. M., Fahy, M., Schlaich, M. P., Böhm, M., & Schmieder, R. E. (2022) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfab154 · Cited by 62 · see citing works
Self-citationTam, T. S., Wu, M. H., Masson, S. C., Tsang, M. P., Stabler, S. N., Kinkade, A., Tung, A. C. H., & Tejani, A. M. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008996.pub2 · Cited by 52 · see citing works
Regression of organ damage following renal denervation in resistant hypertension
Kordalis, A., Tsiachris, D., Pietri, P., Tsioufis, C. P., & Stefanadis, C. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001798 · Cited by 49 · see citing works
Self-citationSchmieder, R. E., Kandzari, D. E., Wang, T., Lee, Y., Lazarus, G., & Pathak, A. (2020) · Journal of Hypertension · doi:10.1097/hjh.0000000000002592 · Cited by 48 · see citing works
Self-citationTsioufis, C. P., Papademetriou, V., Dimitriadis, K. S., Tsiachris, D., Thomopoulos, C., Park, E., Hata, C., Papalois, A. E., & Stefanadis, C. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.10.038 · Cited by 43 · see citing works
Self-citationSharp, A. S. P., Tunev, S. S., Schlaich, M. P., Lee, D. P., Finn, A. V., Trudel, J., Hettrick, D. A., Mahfoud, F., & Kandzari, D. E. (2022) · Journal of Hypertension · doi:10.1097/hjh.0000000000003236 · Cited by 40 · see citing works
Self-citationMancia, G., Facchetti, R., Seravalle, G., Cuspidi, C., Corrao, G., & Grassi, G. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16303 · Cited by 37 · see citing works
Fengler, K., Rommel, K., Lapusca, R., Blazek, S., Besler, C., Hartung, P., von Roeder, M., Kresoja, K., Desch, S., Thiele, H., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13019 · Cited by 35 · see citing works
Testing proportionality in the proportional odds model fitted with GEE
Stiger, T. R., Barnhart, H. X., & Williamson, J. M. (1999) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19990615)18:11 · Cited by 32 · see citing works
Qian, P. C., Barry, M. A., Lu, J., Pouliopoulos, J., Mina, A., Bandodkar, S., Alvarez, S., James, V., Ronquillo, J., Varikatt, W., et al. (2019) · JACC: Cardiovascular Interventions · doi:10.1016/j.jcin.2019.04.047 · Cited by 29 · see citing works
Lauder, L., da Costa, B. R., Ewen, S., Scholz, S. S., Wijns, W. C., Lüscher, T. F., Serruys, P. W. J. C., Edelman, E. R., Capodanno, D., Böhm, M., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa495 · Cited by 26 · see citing works
Self-citationCo-occurrence of risk factors for cardiovascular disease by social class: 1958 British birth cohort
Power, C., Atherton, K., & Manor, O. (2008) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2007.068817 · Cited by 23 · see citing works
Chen, W., Du, H., Lu, J., Ling, Z., Long, Y., Xu, Y., Xiao, P., Gyawali, L., Woo, K.-S., Yin, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep37218 · Cited by 20 · see citing works
Qvarnström, M., Kahan, T., Kieler, H., et al. (2019) · Blood Pressure · doi:10.1080/08037051.2019.1627858 · Cited by 19 · see citing works
Self-citationNeutel, J. M., Cushman, W. C., Lloyd, E., Barger, B., & Handley, A. (2017) · Journal of Clinical Hypertension · doi:10.1111/jch.13009 · Cited by 18 · see citing works
Renal Denervation: Is It Ready for Prime Time?
Lauder, L., Wolf, M. A., Scholz, S. S., Hohl, M., Mahfoud, F., & Böhm, M. (2019) · Current Cardiology Reports · doi:10.1007/s11886-019-1164-2 · Cited by 15 · see citing works
Self-citationRouselle, S. D., Dillon, K. N., Rousselle-Sabiac, T. H., et al. (2016) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-016-9697-x · Cited by 9 · see citing works
Lansky, A. J., Shah, T., Wijns, W. C., Stefanini, G. G., Farb, A. A., Kaplan, A. V., Xu, B., Pietras, C. G., Velazquez, E. J., Serruys, P. W. J. C., et al. (2020) · EuroIntervention · doi:10.4244/eijv16i10a147 · Cited by 9 · see citing works
Self-citationKhalid, N. M., Rogers, T., Shlofmitz, E. S., Chen, Y., Dan, K., Torguson, R., Weintraub, W. S., & Waksman, R. (2019) · Cardiovascular revascularization medicine · doi:10.1016/j.carrev.2019.07.016 · Cited by 7 · see citing works
Mahfoud, F., Galle, J. C., Schunkert, H., Schmieder, R. E., Rump, L. C., Limbourg, F. P., van der Giet, M., Elsässer, A., Kintscher, U., Böhm, M., et al. (2021) · Der Kardiologe · doi:10.1007/s12181-021-00492-7 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- [42]42. Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton AZ, Benjamin EJ, Benziger CP, Bonny A, Brauer M, Brodmann M, Cahill TJ, Carapetis J, Catapano AL, Chugh SS, Cooper LT, Coresh J, Criqui M, DeCleene N, Eagle KA, Emmons-Bell S, Feigin VL, Fernández-Solà J, Fowkes G, Gakidou E, Grundy SM, He FJ, Howard G, Hu F, Inker L, Karthikeyan G, Kassebaum N, Koroshetz W, Lavie C, Lloyd-Jones D, Lu HS, Mirijello A, Temesgen AM, Mokdad A, Moran AE, Muntner P, Narula J, Neal B, Ntsekhe M, Moraes de Oliveira G, Otto C, Owolabi M, Pratt M, Rajagopalan S, Reitsma M, Ribeiro ALP, Rigotti N, Rodgers A, Sable C, Shakil S, Sliwa-Hahnle K, Stark B, Sundström J, Timpel P, Tleyjeh IM, Valgimigli M, Vos T, Whelton PK, Yacoub M, Zuhlke L, Murray C, Fuster V; GBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group. Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study. J Am Coll Cardiol. 2020 ; 76:2982-3021.
- [45]45. Blood Pressure Lowering Treatment Trialists' Collaboration. Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet. 2014; 384 :591-8.
- [49]49. Burnier M, Egan BM. Adherence in Hypertension. Circ Res . 2019; 124 :1124-40.
- [67]67. Finkelstein DM, Schoenfeld DA. Combining mortality and longitudinal measures in clin ical trials. Stat Med . 1999; 18 :1341-54.
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Self-citation2024 ESC Guidelines for the management of elevated blood pressure and hypertension
McEvoy, J. W., McCarthy, C. P., Bruno, R. M., Brouwers, S., Canavan, M. D., Ceconi, C., Christodorescu, R. M., Daskalopoulou, S. S., Ferro, C. J., Gerdts, E., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae178 · Cited by 2,298 · see citing works
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Kandzari, D. E., Townsend, R. R., Kario, K., Mahfoud, F., Weber, M. A., Schmieder, R. E., Pocock, S., Tsioufis, K., Konstantinidis, D., Choi, J., et al. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2023.08.045 · Cited by 124 · see citing works
Self-citationRenal nerves in physiology, pathophysiology and interoception
Evans, L. C., Dayton, A., & Osborn, J. W. (2025) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00893-3 · Cited by 46 · see citing works
- Authors
- Barbato, E., Azizi, M., Schmieder, R. E., Lauder, L., Böhm, M., Brouwers, S., Bruno, R. M., Dudek, D., Kahan, T., Kandzari, D. E., Lüscher, T. F., Parati, G., Pathak, A., Ribichini, F. L., Schlaich, M. P., Sharp, A. S. P., Sudano, I., Volpe, M., Tsioufis, C., Wijns, W., & Mahfoud, F.
- Affiliations
- Sapienza University of Rome (IT)
- Inserm (FR)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum des Saarlandes (DE)
- Vrije Universiteit Brussel (BE)
- Paris Centre de Recherche Cardiovasculaire, INSERM, Université Paris Cité , Paris ,
- Jagiellonian University (PL)
- Danderyds sjukhus (SE)
- Piedmont Atlanta Hospital (US)
- King's College London (GB)
- IRCCS Istituto Auxologico Italiano (IT)
- Princess Grace Hospital Centre (MC)
- University of Verona (IT)
- The University of Western Australia (AU)
- University Hospital of Wales (GB)
- University Hospital Zurich (CH)
- Azienda Ospedaliera Sant'Andrea (IT)
- National and Kapodistrian University of Athens (GR)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Corresponding author
- Mahfoud, Felix
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2023-02-15
- Volume
- 44
- Issue
- 15
- Pages
- 1313-1330
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W4320855364
- Cited by
- 188
- References
- 97
- Citations by year
- 2026: 39 · 2025: 52 · 2024: 62 · 2023: 35
- FWCI
- 36.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Heart Journal (publishedVersion)
- UWA Profiles and Research Repository (UWA) (publishedVersion, other-oa)
- PubMed (publishedVersion)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- renal denervation, resistant hypertension, hypertension, radiofrequency ablation, ultrasound ablation, blood pressure reduction, shared decision-making, cardiovascular risk, hypertension-mediated organ damage, procedural complications
- MeSH terms
- Adult, Antihypertensive Agents, Blood Pressure, Denervation, Humans, Hypertension, Kidney, Renal Artery, Sympathectomy, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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