Prediction of individualized lifetime benefit from cholesterol lowering, blood pressure lowering, antithrombotic therapy, and smoking cessation in apparently healthy people
Open accessAbstract
Aims: The benefit an individual can expect from preventive therapy varies based on risk-factor burden, competing risks, and treatment duration. We developed and validated the LIFEtime-perspective CardioVascular Disease (LIFE-CVD) model for the estimation of individual-level 10 years and lifetime treatment-effects of cholesterol lowering, blood pressure lowering, antithrombotic therapy, and smoking cessation in apparently healthy people. Methods and results: Model development was conducted in the Multi-Ethnic Study of Atherosclerosis (n = 6715) using clinical predictors. The model consists of two complementary Fine and Gray competing-risk adjusted left-truncated subdistribution hazard functions: one for hard cardiovascular disease (CVD)-events, and one for non-CVD mortality. Therapy-effects were estimated by combining the functions with hazard ratios from preventive therapy trials. External validation was performed in the Atherosclerosis Risk in Communities (n = 9250), Heinz Nixdorf Recall (n = 4177), and the European Prospective Investigation into Cancer and Nutrition-Netherlands (n = 25 833), and Norfolk (n = 23 548) studies. Calibration of the LIFE-CVD model was good and c-statistics were 0.67–0.76. The output enables the comparison of short-term vs. long-term therapy-benefit. In two people aged 45 and 70 with otherwise identical risk-factors, the older patient has a greater 10-year absolute risk reduction (11.3% vs. 1.0%) but a smaller gain in life-years free of CVD (3.4 vs. 4.5 years) from the same therapy. The model was developed into an interactive online calculator available via www.U-Prevent.com. Conclusion: The model can accurately estimate individual-level prognosis and treatment-effects in terms of improved 10-year risk, lifetime risk, and life-expectancy free of CVD. The model is easily accessible and can be used to facilitate personalized-medicine and doctor–patient communication.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Earlier onset of metabolic risk factors is associated with increased risk for CVD and mortality, motivating the timely identification and treatment of risk factors.
“Earlier onset of metabolic risk factors is associated with increased risk for CVD and mortality, motivating the timely identification and treatment of risk factors.47–49”
From 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome (2026) · cites this paper as [47]
The Introduction links greater risk-factor burden with CVD prevention decisions, and the Discussion says earlier risk-reducing treatment can yield greater lifetime benefit. Neither section establishes that earlier onset of metabolic risk factors increases CVD risk or mortality; the paper models risk factors and treatment timing rather than comparing ages of risk-factor onset. (LLM, conf=0.84)
Experimental — accuracy not yet measuredSeveral studies found that GLP-1-based therapies would not be cost-effective compared with usual care, especially when used as first-line therapy.
“In general, these studies found that GLP-1–based therapies would not be cost-effective compared with usual care, especially when used as first-line therapy.”
From 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome (2026) · cites this paper as [47]
The Discussion (page unavailable) mentions cost-effectiveness only as a consideration for early cardiovascular-prevention treatment; it reports no cost-effectiveness findings. Searches for GLP-1 therapies, usual care, and first-line diabetes treatment found no passage addressing the claim. (LLM, conf=0.77)
Experimental — accuracy not yet measuredGLP-1 RAs appear to primarily reduce the risk of atherosclerotic events, such as MI and stroke.
“In contrast, GLP-1 RAs appear to primarily reduce the risk of atherosclerotic events, such as MI and stroke.45–48”
From 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome (2026) · cites this paper as [47]
The Outcomes section defines cardiovascular events to include MI and stroke, but does not assess whether GLP-1 receptor agonists reduce them. Searches for “GLP-1” and “glucagon-like peptide-1 receptor agonist” found no passage addressing that therapy; the paper’s Additional information section instead discusses other risk-reducing strategies. No page numbers were provided in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2018 ESC/ESH Guidelines for the management of arterial hypertension
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D. L., Coca, A., de Simone, G., Dominiczak, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy339 · Cited by 10,286 · see citing works
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490 · see citing works
Self-citationWhelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.11.006 · Cited by 6,616 · see citing works
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M.-T., Corrà, U., Cosyns, B., Deaton, C., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw106 · Cited by 6,457 · see citing works
Self-citationGrundy, S. M., Stone, N. J., Bailey, A. L., Beam, C., Birtcher, K. K., Blumenthal, R. S., Braun, L. T., de Ferranti, S., Faiella-Tommasino, J., Forman, D. E., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000625 · Cited by 6,185 · see citing works
2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk
Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D’Agostino, R. B., Gibbons, R., Greenland, P., Lackland, D. T., Levy, D., O’Donnell, C. J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.11.005 · Cited by 4,945 · see citing works
Multi-Ethnic Study of Atherosclerosis: Objectives and Design
Bild, D. E. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf113 · Cited by 3,942 · see citing works
Goff, D. C., Lloyd-Jones, D. M., Bennett, G., Coady, S., D’Agostino, R. B., Gibbons, R., Greenland, P., Lackland, D. T., Levy, D., O’Donnell, C. J., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437741.48606.98 · Cited by 3,697 · see citing works
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I., De Backer, G., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw272 · Cited by 3,162 · see citing works
Self-citationMortality in relation to smoking: 50 years' observations on male British doctors
Doll, R., Peto, R., Boreham, J., & Sutherland, I. (2004) · BMJ · doi:10.1136/bmj.38142.554479.ae · Cited by 2,920 · see citing works
Mortality in relation to smoking: 40 years' observations on male British doctors
Doll, R., Peto, R., Wheatley, K., Gray, R., & Sutherland, I. (1994) · BMJ · doi:10.1136/bmj.309.6959.901 · Cited by 1,321 · see citing works
Whelton, P. K., Carey, R. M., Aronow, W. S., Casey, D. E., Collins, K. J., Dennison Himmelfarb, C., DePalma, S. M., Gidding, S., Jamerson, K. A., Jones, D. W., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000596 · Cited by 1,127 · see citing works
Day, N., Oakes, S., Luben, R., Khaw, K., Bingham, S., Welch, A., & Wareham, N. (1999) · Nature · doi:10.17863/cam.89388 · Cited by 780 · see citing works
Self-citationBrook, R. D., & Rajagopalan, S. (2018) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2018.01.004 · Cited by 731 · see citing works
JBS3 Board (2014) · Heart · doi:10.1136/heartjnl-2014-305693 · Cited by 608 · see citing works
Schmermund, A., Möhlenkamp, S., Stang, A., Grönemeyer, D. H. W., Seibel, R. M. M., Hirche, H., Mann, K., Siffert, W., Lauterbach, K. W., Siegrist, J., et al. (2002) · American Heart Journal · doi:10.1067/mhj.2002.123579 · Cited by 576 · see citing works
Self-citationHippisley-Cox, J., Coupland, C., Robson, J., & Brindle, P. (2010) · British medical journal · doi:10.1136/bmj.c6624 · Cited by 366 · see citing works
Rabar, S., Harker, M., O'Flynn, N., Wierzbicki, A. S., & On behalf of the Guideline Development Group (2014) · BMJ · doi:10.1136/bmj.g4356 · Cited by 292 · see citing works
Cohort Profile: The EPIC-NL study
Beulens, J. W. J., Monninkhof, E. M., Verschuren, W. M. M., van der Schouw, Y. T., Smit, J., Ocké, M. C., Jansen, E. H. J. M., van Dieren, S., Grobbee, D. E., Peeters, P. H. M., et al. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp217 · Cited by 205 · see citing works
Self-citationDeFilippis, A. P., Young, R. L., McEvoy, J. W., Michos, E. D., Sandfort, V., Kronmal, R. A., McClelland, R. L., & Blaha, M. J. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw301 · Cited by 169 · see citing works
Self-citationLloyd‐Jones, D. M., Huffman, M. D., Karmali, K. N., Sanghavi, D. M., Wright, J. S., Pelser, C. B., Gulati, M., Masoudi, F. A., & Goff, D. C. (2016) · Circulation · doi:10.1161/cir.0000000000000467 · Cited by 163 · see citing works
Clinician-Patient Risk Discussion for Atherosclerotic Cardiovascular Disease Prevention
Martin, S. S., Sperling, L. S., Blaha, M. J., Wilson, P. W. F., Gluckman, T. J., Blumenthal, R. S., & Stone, N. J. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.01.043 · Cited by 156 · see citing works
Self-citationCalibration of the Pooled Cohort Equations for Atherosclerotic Cardiovascular Disease
Cook, N. R., & Ridker, P. M. (2016) · Annals of Internal Medicine · doi:10.7326/m16-1739 · Cited by 155 · see citing works
Risk Factors for Coronary Heart Disease in African Americans
Jones, D. W., Chambless, L. E., Folsom, A. R., HEISS, G. M., Hutchinson, R. G., Sharrett, A. R., Szklo, M., & Taylor, H. A. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.22.2565 · Cited by 148 · see citing works
Risk Factors in Early Life as Predictors of Adult Heart Disease: The Bogalusa Heart Study
Berenson, G. S., Srinivasan, S. R., Hunter, S. M., Nicklas, T. A., Freedman, D. S., Shear, C. L., & Webber, L. S. (1989) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198909000-00001 · Cited by 139 · see citing works
2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, A. L., Graham, I. M., Backer, G. D., Wiklund, O., Chapman, M. J., Drexel, H., Hoes, A. W., Jennings, C. S., Landmesser, U., Pedersen, T. R., et al. (2017) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2017.01.002 · Cited by 107 · see citing works
Self-citationLloyd‐Jones, D. M., Huffman, M. D., Karmali, K. N., Sanghavi, D. M., Wright, J. S., Pelser, C. B., Gulati, M., Masoudi, F. A., & Goff, D. C. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.10.018 · Cited by 97 · see citing works
Koller, M., Leening, M. J. G., Wolbers, M., Steyerberg, E. W., Hunink, M. G. M., Schoop, R., Albert Hofman, D., Bucher, H. C., Psaty, B. M., Lloyd‐Jones, D. M., et al. (2012) · Annals of Internal Medicine · doi:10.7326/0003-4819-157-6-201209180-00002 · Cited by 74 · see citing works
Fumo, M. T., Teeger, S., Lang, R. M., Bednarz, J., Sareli, P., & Murphy, M. B. (1992) · American Journal of Hypertension · doi:10.1093/ajh/5.3.111 · Cited by 74 · see citing works
How to translate clinical trial results into gain in healthy life expectancy for individual patients
Dorresteijn, J. A. N., Kaasenbrood, L., Cook, N. R., van Kruijsdijk, R. C. M., van der Graaf, Y., Visseren, F. L. J., & Ridker, P. M. (2016) · BMJ · doi:10.1136/bmj.i1548 · Cited by 62 · see citing works
Self-citationFerket, B. S., van Kempen, B. J. H., Heeringa, J., Spronk, S., Fleischmann, K. E., Nijhuis, R. L. G., Albert Hofman, D., Steyerberg, E. W., & Hunink, M. G. M. (2012) · PLoS Medicine · doi:10.1371/journal.pmed.1001361 · Cited by 43 · see citing works
Austin, P. C., Pencinca, M. J., & Steyerberg, E. W. (2017) · Statistical Methods in Medical Research · doi:10.1177/0962280214567141 · Cited by 39 · see citing works
Flagged first, then by citations
2 of the 34 references couldn’t be matched to a known paper.
Research works printed but not linked: 8
- [17]17. Ganesh SK, Tragante V, Guo W, et al. Loci influencing blood pressure identified using a cardiovascular gene- centric array. Hum Mol Genet 2013;22(8):1663-78.
- [27]27. Cholesterol Treatment Trialists C, Baigent C, Blackwell L, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet 2010;376(9753):1670-81.
- [28]28. Law MR, Wald NJ, Rudnicka AR. Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis. BMJ 2003;326(7404):1423.
- [29]29. Morrone D, Weintraub WS, Toth PP, et al. Lipid-altering efficacy of ezetimibe plus statin and statin monotherapy and identification of factors associated with treatment response: a pooled analysis of over 21,000 subjects from 27 clinical trials. Atherosclerosis 2012;223(2):251-61.
- [30]30. Ettehad D, Emdin CA, Kiran A, et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet 2016;387(10022):957-67.
- [31]31. Antithrombotic Trialists C, Baigent C, Blackwell L, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 2009;373(9678):1849-60.
- [32]32. Mons U, Muezzinler A, Gellert C, et al. Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: meta-analysis of individual participant data from prospective cohort studies of the CHANCES consortium. BMJ 2015;350:h1551.
- [33]33. Gellert C, Schottker B, Brenner H. Smoking and all-cause mortality in older people: systematic review and meta- analysis. Arch Intern Med 2012;172(11):837-44. p=0.04, current smoking (chi-squared 1.3, p=2.5 x10 -4 ), and type 2 diabetes (chi-squared 1.5, p=1.4x10 - 4 ).
Cited by
Sorted by citations
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab484 · Cited by 6,485 · see citing works
Self-citationMancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473 · see citing works
SCORE2 working group and ESC Cardiovascular risk collaboration, Hageman, S., Pennells, L., Ojeda, F., Kaptoge, S., Kuulasmaa, K., de Vries, T., Xu, Z., Kee, F., Chung, R., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab309 · Cited by 1,810 · see citing works
Self-citationGlobal effect of modifiable risk factors on cardiovascular disease and mortality
The Global Cardiovascular Risk Consortium (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2206916 · Cited by 909 · see citing works
de Vries, T. I., Cooney, M. T., Selmer, R. M., Hageman, S. H. J., Pennells, L. A. M., Wood, A., Kaptoge, S. K., Xu, Z., Westerink, J., Rabanal, K. S., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab312 · Cited by 625 · see citing works
Self-citation2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Bénétos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwab154 · Cited by 565 · see citing works
Self-citationMajor Global Coronary Artery Calcium Guidelines
Golub, I. S., Termeie, O. G., Kristo, S., Schroeder, L. P., Lakshmanan, S., Shafter, A. M., Hussein, L., Verghese, D., Aldana-Bitar, J., Manubolu, V. S., et al. (2023) · JACC: Cardiovascular Imaging · doi:10.1016/j.jcmg.2022.06.018 · Cited by 243 · see citing works
Age dependent associations of risk factors with heart failure: pooled population based cohort study
Tromp, J., Paniagua, S. M., Lau, E. S., Allen, N. B., Blaha, M. J., Gansevoort, R. T., Hillege, H. L., Lee, D. S., Levy, D. A., Vasan, R. S., et al. (2021) · BMJ · doi:10.1136/bmj.n461 · Cited by 243 · see citing works
Self-citationGlobal Effect of Cardiovascular Risk Factors on Lifetime Estimates
The Global Cardiovascular Risk Consortium (2025) · New England Journal of Medicine · doi:10.1056/nejmoa2415879 · Cited by 158 · see citing works
Glycoprotein Acetyls: A Novel Inflammatory Biomarker of Early Cardiovascular Risk in the Young
Chiesa, S. T., Charakida, M., Georgiopoulos, G., Roberts, J. D., Stafford, S. J., Park, C. M., Mykkänen, J., Kähönen, M. A. P., Lehtimäki, T. J., Ala‐Korpela, M., et al. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.024380 · Cited by 114 · see citing works
Chinese Guideline on the Primary Prevention of Cardiovascular Diseases
Chinese Society of Cardiology of Chinese Medical Association, C. D. P. A. R. C. O. C. A. O. R. M. (2021) · Cardiology Discovery · doi:10.1097/cd9.0000000000000025 · Cited by 109 · see citing works
Colom, C., Rull, A., Sánchez‐Quesada, J. L., & Pérez, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081798 · Cited by 102 · see citing works
Guía ESC 2021 sobre la prevención de la enfermedad cardiovascular en la práctica clínica
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Bénétos, A., Biffi, A., Boavida, J. M., Capodanno, D., et al. (2022) · Revista Española de Cardiología · doi:10.1016/j.recesp.2021.10.016 · Cited by 80 · see citing works
Self-citationVasan, R. S., Enserro, D. M., Xanthakis, V., Beiser, A., & Seshadri, S. S. (2022) · Circulation · doi:10.1161/circulationaha.121.057889 · Cited by 71 · see citing works
Lettino, M., Mascherbauer, J., Nordaby, M., Ziegler, A., Collet, J., Dérumeaux, G., Hohnloser, S. H., Leclercq, C., O’Neill, D. E., Visseren, F. L. J., et al. (2022) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwac033 · Cited by 80 · see citing works
Self-citationvan Daalen, K. R., Zhang, D., Kaptoge, S. K., Paige, E., Angelantonio, E. D., & Pennells, L. A. M. (2024) · The Lancet Global Health · doi:10.1016/s2214-109x(24)00210-9 · Cited by 69 · see citing works
Kim, K. (2023) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2023.12.2.96 · Cited by 63 · see citing works
Ndumele, C. E., Rodríguez, F., Dixon, D. L., Khan, S. S., Mukherjee, D., Bajaj, M. S., Bangalore, S., Bozkurt, B., Breathett, K. K., Clarke, S. L., et al. (2026) · Circulation · doi:10.1161/cir.0000000000001453 · Cited by 87 · see citing works
Systematic Coronary Risk Evaluation (SCORE)
Graham, I. M., Angelantonio, E. D., Visseren, F. L. J., Bacquer, D. D., Ference, B. A., Timmis, A., Halle, M., Vardas, P. E., Huculeci, R., & Cooney, M. T. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.04.052 · Cited by 60 · see citing works
Self-citationComparison of American and European Guidelines for Primary Prevention of Cardiovascular Disease
Fegers‐Wustrow, I., Gianos, E., Halle, M., & Yang, E. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.02.001 · Cited by 58 · see citing works
Cardiovascular Effects of Smoking and Smoking Cessation: A 2024 Update
Rahman, M., Alatiqi, M., Al‐Jarallah, M., Hussain, M. Y., Monayem, A., Panduranga, P., & Rajan, R. (2025) · Global Heart · doi:10.5334/gh.1399 · Cited by 57 · see citing works
Ndumele, C. E., Rodriguez, F., Dixon, D. L., Khan, S. S., Mukherjee, D., Bajaj, M., Bangalore, S., Bozkurt, B., Breathett, K., Clarke, S. L., et al. (2026) · JACC · doi:10.1016/j.jacc.2026.03.056 · Cited by 90 · see citing works
Cardiovascular risk prediction in healthy older people
Neumann, F., Thảo, L. T. P., Callander, E. J., Chowdhury, E., Williamson, J. D., Nelson, M. R., Donnan, G. A., Woods, R. L., Reid, C. M., Poppe, K., et al. (2021) · GeroScience · doi:10.1007/s11357-021-00486-z · Cited by 50 · see citing works
Vedanthan, R., Kamano, J. H., Chrysanthopoulou, S. A., Mugo, R., Andama, B., Bloomfield, G. S., Chesoli, C., DeLong, A. K., Edelman, D. E., Finkelstein, E. A., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.03.002 · Cited by 44 · see citing works
Burger, P. M., Dorresteijn, J. A. N., Koudstaal, S., Holtrop, J., Kastelein, J. J. P., Jukema, J. W., Ridker, P. M., Mosterd, A., & Visseren, F. L. J. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118540 · Cited by 43 · see citing works
Self-citationCardiovascular Disease Risk Modeling for Astronauts: Making the Leap From Earth to Space
Huff, J. L., Plante, I., Blattnig, S. R., Norman, R. B., Little, M. P., Khera, A., Simonsen, L. C., & Patel, Z. S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.873597 · Cited by 34 · see citing works
The Global Burden of Cardiovascular Disease in Adults
Victor, G., Shishani, K., Vellone, E., & Froelicher, E. S. (2025) · European Journal of Cardiovascular Nursing · doi:10.1093/eurjcn/zvaf243 · Cited by 35 · see citing works
Lindbohm, J. V., Sipilä, P. N., Mars, N., Knüppel, A., Pentti, J., Nyberg, S. T., Frank, P., Ahmadi‐Abhari, S., Brunner, E. J., Shipley, M. J., et al. (2021) · The Lancet Digital Health · doi:10.1016/s2589-7500(21)00079-0 · Cited by 32 · see citing works
Wild, R. A., Hovey, K. M. O., Andrews, C., Robinson, J. G., Kaunitz, A. M., Manson, J. E., Crandall, C. J., Paragallo, R., SHUFELT, C. L., & Merz, C. N. B. (2021) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001753 · Cited by 26 · see citing works
Atherosclerotic cardiovascular disease risk prediction: current state-of-the-art
Rout, A., Duhan, S., Umer, M., Li, M., & Kalra, D. K. (2023) · Heart · doi:10.1136/heartjnl-2023-322928 · Cited by 24 · see citing works
Constanti, M., Floyd, C. N., Glover, M., Boffa, R. J., Wierzbicki, A. S., & McManus, R. J. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14913 · Cited by 24 · see citing works
Hageman, S. H. J., Kaptoge, S. K., de Vries, T. I., Lu, W., Kist, J. M., van Os, H. J. A., Numans, M. E., Läll, K., Bobák, M., Pikhart, H., et al. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae174 · Cited by 23 · see citing works
Self-citationCardiovascular risk reduction following metabolic and bariatric surgery.
Albaugh, V. L., Kindel, T. L., Nissen, S. E., & Aminian, A. (2021) · Surgical Clinics of North America · doi:10.1016/j.suc.2020.12.012 · Cited by 21 · see citing works
Armario, P., Brotons, C., Elosúa, R., de Leciñana, M. A., Castro, A., Clarà, A. B. I., Cortés, O., Rodríguez, Á. D., Herranz, M., Justo, S., et al. (2021) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2021.02.001 · Cited by 20 · see citing works
Ferket, B. S., Hunink, M. G. M., Masharani, U. B., Max, W. B., Yeboah, J., Burke, G. L., & Fleischmann, K. E. (2022) · Diabetes Care · doi:10.2337/dc21-1607 · Cited by 21 · see citing works
The year in cardiology: cardiovascular prevention
Ray, K. K., Laufs, U., Cosentino, F., Lobo, M. D., & Landmesser, U. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz929 · Cited by 20 · see citing works
Treatment of hypercholesterolaemia in older adults calls for a patient-centred approach
Kleipool, E. E. F., Dorresteijn, J. A. N., Smulders, Y. M., Visseren, F. L. J., Peters, M. J. L., & Muller, M. (2019) · Heart · doi:10.1136/heartjnl-2019-315600 · Cited by 20 · see citing works
Self-citationRecomendaciones preventivas cardiovasculares. Actualización PAPPS 2020
Orozco-Beltrán, D., Cuixart, C. B., Sánchez, J. J. A., Banegas, J. R. B., Cebrián-Cuenca, A., Guillen, V. G., Rioboó, E. M., & Pérez, J. N. (2020) · Atención Primaria · doi:10.1016/j.aprim.2020.08.002 · Cited by 17 · see citing works
Dynamic Importance of Genomic and Clinical Risk for Coronary Artery Disease Over the Life Course
Urbut, S., Cho, S. M. J., Paruchuri, K., Truong, B. M. T., Haidermota, S., Peloso, G. M., Hornsby, W., Philippakis, A., Fahed, A. C., & Natarajan, P. (2025) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.124.004681 · Cited by 18 · see citing works
Cardiovascular risk assessment in daily clinical practice: when and how to use a risk score
Panattoni, G., Desimone, P., Toto, F., Meringolo, F., Jacomelli, I., Rebecchi, M., Cicogna, F., & Calò, L. (2025) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suae100 · Cited by 19 · see citing works
Østergaard, H. B., Hageman, S. H. J., Read, S. H., Owen, T., Pennells, L. A. M., Kaptoge, S. K., Petitjean, C., Xu, Z., Shi, F., McEvoy, J. W., et al. (2022) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwac232 · Cited by 17 · see citing works
Self-citationGramegna, A., Ruscica, M., Leonardi, G., Macchi, C., Fichtner, I., Putti, G., Schianca, M. C., Terranova, L., Alicandro, G., & Blasi, F. (2024) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2024.11.009 · Cited by 16 · see citing works
Urbut, S., Yeung, M., Khurshid, S., Cho, S. J., Schuermans, A., German, J., Taraszka, K., Paruchuri, K., Fahed, A., Ellinor, P., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49296-9 · Cited by 16 · see citing works
Chlabicz, M., Jamiołkowski, J., Łaguna, W., Sowa, P., Paniczko, M., Łapińska, M., Szpakowicz, M., Drobek, N., Raczkowski, A., & Kamiński, K. A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081584 · Cited by 15 · see citing works
Westerink, J., Matthiessen, K. S., Nuhoho, S., Fainberg, U., Wolden, M. L., Østergaard, H. B., Visseren, F. L. J., & Sattar, N. A. (2022) · Diabetes Care · doi:10.2337/dc21-1138 · Cited by 15 · see citing works
Self-citationBurger, P. M., Savarese, G., Tromp, J., Adamson, C., Jhund, P. S., Benson, L., Hage, C., Tay, W. T., Solomon, S. D., Packer, M., et al. (2023) · European Journal of Heart Failure · doi:10.1002/ejhf.3028 · Cited by 14 · see citing works
Self-citationChlabicz, M., Jamiołkowski, J., Łaguna, W., Dubatówka, M., Sowa, P., Łapińska, M., Szpakowicz, A., Zieleniewska, N. A., Zalewska, M., Raczkowski, A., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030688 · Cited by 14 · see citing works
External validation of the QLifetime cardiovascular risk prediction tool: population cohort study
Livingstone, S. J., Morales, D. R., Fleuriot, J., Donnan, P. T., & Guthrie, B. (2023) · BMC Cardiovascular Disorders · doi:10.1186/s12872-023-03209-8 · Cited by 13 · see citing works
Armario, P., Brotons, C., Elosúa, R., de Leciñana, M. A., Castro, A., Clarà, A. B. I., Cortés, O., Rodríguez, Á. D., Herranz, M., Justo, S., et al. (2020) · Hipertensión y Riesgo Vascular · doi:10.1016/j.hipert.2020.07.004 · Cited by 13 · see citing works
Yi, M., Peng, W. J., Teng, F., Kong, Q., & Chen, Z. (2022) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002462 · Cited by 12 · see citing works
Lipid Clinics Network. Rationale and design of the EAS global project
Alieva, A. S., Tokgözoğlu, L. S., Ray, K. K., & Catapano, A. L. (2020) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2021.01.002 · Cited by 12 · see citing works
Weber, J. E., Ahmadi, M., Boldt, L., Eckardt, K., Edelmann, F., Gerhardt, H., Grittner, U., Haubold, K., Hübner, N., Kollmus-Heege, J., et al. (2023) · BMJ Open · doi:10.1136/bmjopen-2023-076415 · Cited by 7 · see citing works
Crea, F. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab295 · Cited by 10 · see citing works
Validation of the 30-Year Framingham Risk Score in a German Population-Based Cohort
Rospleszcz, S., Starnecker, F., Linkohr, B., von Scheidt, M., Gieger, C., Schunkert, H., & Peters, A. (2022) · Diagnostics · doi:10.3390/diagnostics12040965 · Cited by 9 · see citing works
Panagiotakos, D. B., Chrysohoou, C. A., Damigou, E., Barkas, F., Liberopoulos, E. N., Tsioufis, C. P., Sfikakis, P. P., & Pitsavos, C. S. (2023) · Annals of Epidemiology · doi:10.1016/j.annepidem.2023.09.010 · Cited by 9 · see citing works
From evidence to practice: development of web-based Dutch lipid reference values
Nurmohamed, N. S., Collard, D., Balder, J.-W., Kuivenhoven, J. A., Stroes, E. S. G., & Reeskamp, L. F. (2021) · Netherlands Heart Journal · doi:10.1007/s12471-021-01562-x · Cited by 9 · see citing works
Cardiovascular risk prediction tools made relevant for GPs and patients
de Vries, T. I., & Visseren, F. L. J. (2020) · Heart · doi:10.1136/heartjnl-2019-316377 · Cited by 9 · see citing works
Self-citationYang, C., Na, Z., Gao, T., Zhu, Y., Chen, G., Xu, M., & Feng, C. (2025) · Preventive Medicine Reports · doi:10.1016/j.pmedr.2025.102967 · Cited by 8 · see citing works
Eskes, E. C. B., van Dussen, L., Brands, M. M. M. G., Vaz, F. M., Aerts, J. M. F. G., Kuilenburg, A. B. P., Sjouke, B., & Hollak, C. E. M. (2024) · Journal of Inherited Metabolic Disease · doi:10.1002/jimd.12789 · Cited by 8 · see citing works
Floyd, C. N., & Wierzbicki, A. S. (2020) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000759 · Cited by 8 · see citing works
Fras, Z., Sahebkar, A., & Banach, M. (2020) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-020-00424-y · Cited by 8 · see citing works
Feldman, D. I., Dudum, R., Alfaddagh, A., Marvel, F. A., Michos, E. D., Blumenthal, R. S., & Martin, S. S. (2020) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2020.100027 · Cited by 7 · see citing works
Johansson, M., Bergström, G. M. L., Jernberg, T., Hagström, E., Söderberg, S., Östgren, C. J., Engström, G., Gottsäter, A., & Nilsson, P. M. (2025) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwaf424 · Cited by 6 · see citing works
Cho, S. M. J., Rivera, R., Koyama, S., Kim, M. S., Ganesh, S., Bhattacharya, R., Paruchuri, K., Masson, P. R., Honigberg, M. C., Allen, N. B., et al. (2024) · JACC Advances · doi:10.1016/j.jacadv.2024.101257 · Cited by 6 · see citing works
Li, S., Li, H., Suo, M., Sun, Y., Su, M., Song, Y., Xiao, N., Hui, R., Qin, C., & Chen, J. (2021) · European Journal of Neurology · doi:10.1111/ene.14895 · Cited by 6 · see citing works
Xu, Z., Usher‐Smith, J. A., Pennells, L. A. M., Chung, R., Arnold, M., Kim, L. G., Kaptoge, S. K., Sperrin, M., Angelantonio, E. D., & Wood, A. (2024) · BMJ Medicine · doi:10.1136/bmjmed-2023-000633 · Cited by 6 · see citing works
Trier, T. J. V., Snaterse, M., Dorresteijn, J. A. N., van den Bogaart, M., Reimer, W. J. M. S. O., Visseren, F. L. J., Peters, R. J. G., Jorstad, H. T., & Boekholdt, S. M. (2025) · Open Heart · doi:10.1136/openhrt-2024-002981 · Cited by 5 · see citing works
Self-citationHageman, S. H. J., Dorresteijn, J. A. N., Bots, M. L., Asselbergs, F. W., Westerink, J., van der Meulen, M. P., Mosterd, A., Visseren, F. L. J., the UCC-SMART Study Group, Asselbergs, F. W., et al. (2021) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwab028 · Cited by 5 · see citing works
Self-citationCesena, F. Y. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae139 · Cited by 5 · see citing works
Armario, P., Brotons, C., Elosúa, R., de Leciñana, M. A., Castro, A., Clarà, A. B. I., Cortés, O., Rodríguez, Á. D., Herranz, M., Justo, S., et al. (2020) · PubMed Central · Cited by 4 · see citing works
The year in cardiology: cardiovascular prevention. The year in cardiology 2019.
Ray, K. K., Laufs, U., Cosentino, F., Lobo, M. D., & Landmesser, U. (2020) · SA Heart · doi:10.24170/17-1-4022 · Cited by 4 · see citing works
Towards individualized lifetime risk: combining classical and non-classical factors
Lüscher, T. F. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa155 · Cited by 4 · see citing works
Saleh, M., Salminen, H., & Taloyan, M. (2024) · BMC Family Practice · doi:10.1186/s12875-024-02446-w · Cited by 3 · see citing works
Inherited risk of coronary artery disease: redefining care with imaging and genetics
Lan, N. S. R., Dwivedi, G., Hillis, G. S., Chew, D. P., Yeap, B. B., Figtree, G. A., Khera, A. V., Watts, G. F., & Ihdayhid, A. R. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-026-01254-2 · Cited by 4 · see citing works
Update and validation of the lifetime cardiovascular risk in Spain: IBERLIFERISK2
Brotons, C., Moral-Peláez, I., Vicuña, J., Ameixeiras, C., Fernández-Lavandera, C., & Sánchez-Chaparro, M. Á. (2023) · Clínica e Investigación en Arteriosclerosis (English Edition) · doi:10.1016/j.artere.2023.05.008 · Cited by 3 · see citing works
Cardiovascular risk and the COVID-19 pandemic: a population-based and case‒control studies
Chlabicz, M., Jamiołkowski, J., Dubatówka, M., Sołomacha, S., Chlabicz, M., Zieleniewska, N. A., Sowa, P., Szpakowicz, A., Moniuszko-Malinowska, A. M., Flisiak, R., et al. (2024) · Population Health Metrics · doi:10.1186/s12963-024-00338-w · Cited by 3 · see citing works
Werba, J. P., Giroli, M., Simonelli, N., Vigo, L., Gorini, A., Bonomi, A., Veglia, F., & Tremoli, E. (2022) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.01.013 · Cited by 3 · see citing works
Italian Association of Hospital Cardiologists position paper—obesity in adults: a clinical primer
Fusco, S. A. D., Mocini, E., Gori, M., Iacoviello, M., Bilato, C., Corda, M., Luca, L. D., Marco, M. D., Geraci, G., Iacovoni, A., et al. (2024) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suae031 · Cited by 3 · see citing works
Østergaard, H. B., Humphreys, V., Hengeveld, E. M., Honoré, J. B., Mach, F., Visseren, F. L. J., Westerink, J., Yadav, G., Mosenzon, O., & the CAPTURE investigators (2022) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14887 · Cited by 3 · see citing works
Self-citationde Vries, T. I., Jaspers, N. E. M., Visseren, F. L. J., & Dorresteijn, J. A. N. (2021) · medRxiv · doi:10.1101/2021.03.15.21253400 · Cited by 3 · see citing works
Self-citationCoronary Artery Calcium: A Risk Factor for Brain Aging?
Johansen, M. C., & Blaha, M. J. (2021) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.121.013062 · Cited by 3 · see citing works
Self-citationAssessment of Lifetime Risk for Cardiovascular Disease: Time to Move Forward
Sigala, E. G., & Panagiotakos, D. B. (2024) · Current Cardiology Reviews · doi:10.2174/011573403x311031240703080650 · Cited by 2 · see citing works
Armario, P., Brotons, C., Elosúa, R., de Leciñana, M. A., Castro, A., Clarà, A. B. I., Cortés, O., Rodríguez, Á. D., Herranz, M., Justo, S., et al. (2021) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2020.11.004 · Cited by 2 · see citing works
Muiesan, M. L., Virdis, A., Tocci, G., Borghi, C., Cicero, A. F. G., Ferri, C., Pirro, M., Corsini, A., & Volpe, M. (2025) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-024-00700-x · Cited by 2 · see citing works
Chiesa, S. T., Charakida, M., Georgiopoulos, G. A., Roberts, J., Stafford, S. J., Park, C. M., Mykkänen, J., Kähönen, M. A. P., Lehtimäki, T. J., Ala‐Korpela, M., et al. (2020) · medRxiv · doi:10.1101/2020.09.30.20204479 · Cited by 2 · see citing works
Health shocks and changes in life purpose: Understanding the link between purpose and longevityPreprint
Sias, R. W., & Turtle, H. J. (2022) · medRxiv · doi:10.1101/2022.03.13.22272313 · Cited by 2 · see citing works
Urbut, S., Yeung, M. W., Khurshid, S. S., Cho, S. M. J., Schuermans, A., German, J., Taraszka, K., Fahed, A. C., Ellinor, P. T., Trinquart, L., et al. (2023) · medRxiv · doi:10.1101/2023.11.08.23298229 · Cited by 2 · see citing works
Primärprävention der koronaren Herzkrankheit
Mühleck, F., & Laufs, U. (2019) · Herz · doi:10.1007/s00059-019-04873-3 · Cited by 1 · see citing works
Baptista, E. C. M. S., Pereira, C. S. G. P., García, P. A., Ferreira, I. C. F. R., & Barreira, J. C. M. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.01.026 · Cited by 1 · see citing works
Yang, Z., van Os, H. J. A., Kist, J. M., Vos, R. C., Vos, H. M. M., Chavannes, N. H., & Petrus, A. H. J. (2025) · International Journal of Cardiology Cardiovascular Risk and Prevention · doi:10.1016/j.ijcrp.2025.200483 · Cited by 1 · see citing works
Bijkerk, S., Kist, J. M., Pennells, L. A. M., van der Schouw, Y. T., Matsushita, K., Numans, M. E., Angelantonio, E. D., de Vries, T. I., Steyerberg, E. W., Dorresteijn, J. A. N., et al. (2026) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcag092 · Cited by 1 · see citing works
Self-citationActualización y validación del riesgo cardiovascular de por vida en España: IBERLIFERISK2
Brotons, C., Moral, I., Vicuña, J., Ameixeiras, C., Fernández-Lavandera, C., & Sánchez-Chaparro, M. Á. (2022) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2022.09.003 · Cited by 1 · see citing works
Martín-Rioboó, E., Brotons-Cuixart, C., García, A. R., Sanz, F. V., Vargas, M. F., Amengual, A. M., Divisón, J. A., Vicente, M. C. S., Banegas, J. R., & Pallarés‐Carratalá, V. (2023) · PubMed Central · Cited by 1 · see citing works
Gondolatok a 2019. évi új európai dyslipidaemia és krónikus koronáriaszindróma ajánlások kapcsán
Márk, L., Bajnok, L., & Reiber, I. (2020) · Cardiologia Hungarica · doi:10.26430/chungarica.2020.50.5.378 · Cited by 1 · see citing works
Zhou, M., Guo, J., Chen, N., Ma, M., Dong, S., Li, Y., Fang, J., Zhang, Y., Zhang, Y., Bao, J., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-043450 · Cited by 1 · see citing works
Echouffo-Tcheugui, J. B., & Kengne, A. P. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz515 · Cited by 1 · see citing works
Individualized prevention in cardiovascular disease and diabetes mellitus
de Vries, T. I. (2020) · doi:10.33540/352
Karagiannidis, E., & Papazoglou, Α. S. (2021) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwab041
European Guidelines for Risk Assessment in the Primary Prevention of Cardiovascular Disease
Cawley, C., & McEvoy, J. W. (2022) · Contemporary cardiology · doi:10.1007/978-3-030-98824-1_3
Lijing Lin, A., Poppe, K., Wood, A., Martin, G. P., Peek, N. B., & Sperrin, M. (2022) · Research Square · doi:10.21203/rs.3.rs-1824359/v1
- Authors
- Jaspers, N. E. M., Blaha, M. J., Matsushita, K., van der Schouw, Y. T., Wareham, N. J., Khaw, K.-T., Geisel, M. H., Lehmann, N., Erbel, R., Jöckel, K.-H., van der Graaf, Y., Verschuren, W. M. M., Boer, J. M. A., Nambi, V., Visseren, F. L. J., & Dorresteijn, J. A. N.
- Affiliations
- University Medical Center Utrecht (NL)
- Johns Hopkins University (US)
- Julius Center for Health Sciences, University Medical Center Utrecht , Heidelberglaan 100, 3584 CX Utrecht, Netherlands
- University of Cambridge (GB)
- Essen University Hospital (DE)
- National Institute for Public Health and the Environment (NL)
- Michael E. DeBakey VA Medical Center (US)
- Corresponding author
- Visseren, Frank L J
- ORCID
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2019-05-18
- Volume
- 41
- Issue
- 11
- Pages
- 1190-1199
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- PMC
- PMC7229871
- OpenAlex
- W2946535940
- Semantic Scholar
- 368b09086d76ea5df90cd8c033f6fe36aba73100
- Cited by
- 120
- References
- 34
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 18 · 2023: 15 · 2022: 20 · 2021: 24 · 2020: 14 · 2019: 5
- FWCI
- 14.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- European Heart Journal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Rivm Repository (Netherlands National Institute for Public Health and the Environment) (submittedVersion)
- Rivm (National Institute for Public Health and the Environment) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Apollo
- Funders
- Netherlands Heart Foundation (2016T026, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169)
- National Heart, Lung, and Blood Institute (UL1-TR-000040, UL1-TR-001420)
- NCATS
- National Institutes of Health (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I)
- ‘Europe Against Cancer’ programme of the European commission
- Dutch ministry of health, Welfare and Sports
- Netherlands Organization for Research and Development
- World Cancer Research Fund
- Medical Research Council
- Heinz Nixdorf Foundation
- German Ministry of Education and Science
- BMBF
- Deutsches Zentrum für Luft- und Raumfahrt
- German Research Council Assessment (SI 236/8-1, SI 236/9-1)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Health Promotion and Cardiovascular Prevention
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- cardiovascular risk prediction, cholesterol lowering, blood pressure reduction, antithrombotic therapy, smoking cessation, prophylaxis, competing risks, absolute risk reduction, personalized medicine, physician-patient communication, online risk calculator
- MeSH terms
- Aged, Blood Pressure, Cardiovascular Diseases, Cholesterol, Fibrinolytic Agents, Humans, Middle Aged, Netherlands, Prospective Studies, Risk Factors, Smoking Cessation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
