Cited by 165Atrial Fibrillation Management and OutcomesCardiac pacing and defibrillation studiesHeart rate and cardiovascular health

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Does intensity of rate-control influence outcome in atrial fibrillation? An analysis of pooled data from the RACE and AFFIRM studies

Van Gelder, Isabelle C., Wyse, D. George, Chandler, Mary L., Cooper, Howard A., Olshansky, Brian, Hagens, Vincent E., Crijns, Harry J.G.M.·2006·EP Europace

DOI 10.1093/europace/eul106

Open this paper in CoChat — free account

Abstract

AIMS: The AFFIRM and RACE studies showed that rate control is an acceptable treatment strategy for atrial fibrillation (AF). We examined whether strict rate control offers benefit over more lenient rate control. METHODS AND RESULTS: We compared the outcome of patients enrolled in the rate-control arms of AFFIRM and RACE, using data from patients who met a composite of overlapping inclusion and exclusion criteria. We evaluated 1091 patients, 874 from AFFIRM and 217 from RACE. In AFFIRM, the rate-control strategy aimed for a resting heart rate < or =80 bpm and heart rate during daily activity of < or =110 bpm. In RACE, a more lenient approach was taken: resting heart rate <100 bpm. Primary endpoint was a composite of mortality, cardiovascular hospitalization, and myocardial infarction. Mean heart rate across all follow-up visits for patients in AF was lower in AFFIRM (76.1 vs. 83.4 bpm). Event-free survival for the occurrence of the primary endpoint did not differ (64% in AFFIRM vs. 66% in RACE). Patients with mean heart rates during AF within the AFFIRM (< or =80) or RACE (<100) criteria had a better outcome than patients with heart rates > or =100 (hazard ratios 0.69 and 0.58, respectively, for < or =80 and <100 compared with > or =100 bpm). CONCLUSION: Stringency of the approach to rate control, based on the comparison of the AFFIRM and RACE studies, was not associated with an important difference in clinical events.

Integrity signals

Registry

Crossref · 10.1093/europace/eul106

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A comparison of rate control and rhythm control in patients with atrial fibrillation
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa021328 · Cited by 4,405
A Comparison of Rate Control and Rhythm Control in Patients with Recurrent Persistent Atrial Fibrillation
Gelder, I. C. V., Hagens, V. E., Bosker, H. A., Kingma, J. H., Otto Kamp, B., Kingma, T., Said, S. A., Darmanata, J. I., Timmermans, A. J. M., Tijssen, J. G. P., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021375 · Cited by 2,355
Self-citation
Relationships Between Sinus Rhythm, Treatment, and Survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study
The AFFIRM Investigators (2004) · Circulation · doi:10.1161/01.cir.0000121736.16643.11 · Cited by 1,202
Hemodynamic Effects of an Irregular Sequence of Ventricular Cycle Lengths During Atrial Fibrillation
Clark, D. M., Plumb, V. J., Epstein, A. E., & Kay, G. N. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00254-4 · Cited by 610
The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study
Olshansky, B., Rosenfeld, L. E., Warner, A. L., Solomon, A. J., O’Neill, G., Sharma, A. D., Platia, E. V., Feld, G. K., Akiyama, T., Brodsky, M. A., et al. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.11.032 · Cited by 599
Self-citation
Heart Rate and Cardiac Rhythm Relationships With Bisoprolol Benefit in Chronic Heart Failure in CIBIS II Trial
Lechat, P. P., Hulot, J., Escolano, S., Mallet, A., Leizorovicz, A., Werhlen-Grandjean, M., Pochmalicki, G., & Dargie, H. (2001) · Circulation · doi:10.1161/01.cir.103.10.1428 · Cited by 526
Tachycardia-induced cardiomyopathy: A reversible form of left ventricular dysfunction
Packer, D. L., Bardy, G. H., WORLEY, S. J., Stafford‐Smith, M., Cobb, F. R., Coleman, R. E., Gallagher, J. J., & German, L. D. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90836-2 · Cited by 524
Left ventricular dysfunction due to atrial fibrillation in patients initially believed to have idiopathic dilated cardiomyopathy
Grogan, M. A., Smith, H. C., Gersh, B. J., & Wood, D. L. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90705-4 · Cited by 519
Effect of an irregular ventricular rhythm on cardiac output
Daoud, E. G., Weiss, R., Bahu, M., Knight, B. P., Bogun, F. M., Goyal, R., Harvey, M. N., Strickberger, S. A., Man, K. C., & Morady, F. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)89297-1 · Cited by 361
Atrial Fibrillation Follow-Up Investigation of Rhythm Management—The AFFIRM Study Design
(1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00082-9 · Cited by 277

Show all 17 references

Sorted by citations

Corrigendum to: 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC.
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 20,604
2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab368 · Cited by 13,344
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429
2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castella, M., Dan, G.-A., Dilaveris, P., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa612 · Cited by 10,550
Self-citation
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418
2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866
2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)
Gelder, I. C. V., Rienstra, M., Bunting, K. V., Casado-Arroyo, R., Caso, V., Crijns, H. J. G. M., Potter, T. J. R. D., Dwight, J., Guasti, L., Hanke, T., et al. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae176 · Cited by 3,594
Self-citation
2023 ESC guidelines for the management of cardiomyopathies
Arbelo, E., Protonotarios, A., Gimeno, J. R., Arbustini, E., Barriales-Villa, R., Basso, C., Bezzina, C. R., Biagini, E., Blom, N. A., de Boer, R. A., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad194 · Cited by 2,844
2021 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Authors/Task Force Members:, McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2333 · Cited by 2,356
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403
Resting Heart Rate in Cardiovascular Disease
Fox, K., Borer, J. S., Camm, A. J., Danchin, N., Ferrari, R., Lopez Sendon, J. L., Steg, P. G., Tardif, J.-C., Tavazzi, L., & Tendera, M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.04.079 · Cited by 1,062
Lenient versus strict rate control in patients with atrial fibrillation
Van Gelder, I. C., Groenveld, H. F., Crijns, H. J. G. M., Tuininga, Y. S., Tijssen, J. G. P., Alings, A. M., Hillege, H. L., Bergsma-Kadijk, J. A., Cornel, J. H., Kamp, O., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1001337 · Cited by 1,033
Self-citation
Atrial fibrillation: Profile and burden of an evolving epidemic in the 21st century
Ball, J., Carrington, M. J., McMurray, J. J. V., & Stewart, S. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.12.093 · Cited by 652
2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P. P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González‐Juanatey, J. R., Harjola, V., Jankowska, E. A., et al. (2016) · Kardiologia Polska · doi:10.5603/kp.2016.0141 · Cited by 458
Nurse-led care vs. usual care for patients with atrial fibrillation: results of a randomized trial of integrated chronic care vs. routine clinical care in ambulatory patients with atrial fibrillation
Hendriks, J. M. L., de Wit, R., Crijns, H. J. G. M., Vrijhoef, H. J. M., Prins, M. H., Pisters, R., Pison, L. A. F. G., Blaauw, Y., & Tieleman, R. G. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs071 · Cited by 409
Self-citation
2020 Clinical practice guidelines for Chronic heart failure
Russian Society of Cardiology (2020) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2020-4083 · Cited by 553
Diretriz Brasileira de Insuficiência Cardíaca Crônica e Aguda
Rohde, L. E. P., Montera, M. W., Bocchi, E. A., Clausell, N., de Albuquerque, D. C., Rassi, S., Colafranceschi, A. S., Freitas, A. F., Ferraz, A. S., Biolo, A., et al. (2018) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20180190 · Cited by 492
Management of atrial fibrillation
Lip, G. Y., & Tse, H.-F. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61300-2 · Cited by 229
Antiarrhythmic drugs–clinical use and clinical decision making: a consensus document from the European Heart Rhythm Association (EHRA) and European Society of Cardiology (ESC) Working Group on Cardiovascular Pharmacology, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and International Society of Cardiovascular Pharmacotherapy (ISCP)
Dan, G., Martínez‐Rubio, A., Agewall, S., Boriani, G., Borggrefe, M., Gaïta, F., Gelder, I. C. V., Görenek, B., Kaski, J. C., Kjeldsen, K. P., et al. (2018) · EP Europace · doi:10.1093/europace/eux373 · Cited by 247
2024 Clinical practice guidelines for Chronic heart failure
Galyavich, A. S., Tereshchenko, S. N., Uskach, T. M., Ageev, F. T., Aronov, D. M., Arutyunov, G. P., Begrambekova, Y. L., Belenkov, Y. N., Boytsov, S. A., Bubnova, M. G., et al. (2024) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2024-6162 · Cited by 251
Rate control in atrial fibrillation
Gelder, I. C. V., Rienstra, M., Crijns, H. J. G. M., & Olshansky, B. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31258-2 · Cited by 212
Self-citation
Rate- and Rhythm-Control Therapies in Patients With Atrial Fibrillation: A Systematic Review
Al-Khatib, S. M., Allen LaPointe, N. M., Chatterjee, R., Crowley, M. J., Dupre, M. E., Kong, D. F., Lopes, R. D., Povsic, T. J., Raju, S. S., Shah, B., et al. (2014) · Annals of Internal Medicine · doi:10.7326/m13-1467 · Cited by 178
Real-Life Observations of Clinical Outcomes With Rhythm- and Rate-Control Therapies for Atrial Fibrillation
Camm, A. J., BREITHARDT, G. E., Crijns, H. J. G. M., Dorian, P., Kowey, P. R., Heuzey, J. L., Merioua, I., Pedrazzini, L., Prystowsky, E. N., Schwartz, P. J., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.03.034 · Cited by 177
Self-citation
Is Heart Rate Important for Patients With Heart Failure in Atrial Fibrillation?
Cullington, D., Goode, K. M., Zhang, J., Cleland, J. G. F., & Clark, A. L. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2014.01.005 · Cited by 138
2016 Guidelines of the Taiwan Heart Rhythm Society and the Taiwan Society of Cardiology for the management of atrial fibrillation
Chiang, C., Wu, T.-J., Ueng, K.-C., Chao, T., Chang, K., Wang, C.-C., Lin, Y., Yin, W., Kuo, J., Lin, W., et al. (2016) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2016.10.005 · Cited by 138
Symptoms, functional status and quality of life in patients with controlled and uncontrolled atrial fibrillation: data from the RealiseAF cross-sectional international registry
Steg, P. G., Alam, S., Chiang, C., Gamra, H., Goethals, M., Inoue, H., Krapf, L., Lewalter, T., Merioua, I., Murín, J., et al. (2011) · Heart · doi:10.1136/heartjnl-2011-300550 · Cited by 137
Guía ESC 2021 sobre el diagnóstico y tratamiento de la insuficiencia cardiaca aguda y crónica
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2022) · Revista Española de Cardiología · doi:10.1016/j.recesp.2021.11.027 · Cited by 147
Treatment of Atrial Fibrillation
Prystowsky, E. N., Padanilam, B. J., & Fogel, R. I. (2015) · JAMA · doi:10.1001/jama.2015.7505 · Cited by 117
JCS/JHFS 2018 Guideline on the Diagnosis and Treatment of Cardiomyopathies
Kitaoka, H., Tsutsui, H., Kubo, T., Ide, T., Chikamori, T., Fukuda, K., Fujino, N., Higo, T., Isobe, M., Kamiya, C., et al. (2021) · Circulation Journal · doi:10.1253/circj.cj-20-0910 · Cited by 119
Comparison of four single-drug regimens on ventricular rate and arrhythmia-related symptoms in patients with permanent atrial fibrillation
Ulimoen, S. R., Enger, S., Carlson, J., Platonov, P. G., Pripp, A. H., Abdelnoor, M., Arnesen, H., Gjesdal, K., & Tveit, A. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.09.020 · Cited by 113
2020 Clinical practice guidelines for Chronic heart failure
Russian Society of Cardiology (2020) · Russian Journal of Cardiology · doi:10.15829/29/1560-4071-2020-4083 · Cited by 88
Comparison of Atrial Fibrillation in the Young versus That in the Elderly: A Review
Sankaranarayanan, R., Kirkwood, G. J., Dibb, K. M., & Garratt, C. J. (2013) · Cardiology Research and Practice · doi:10.1155/2013/976976 · Cited by 82
Digoxin in patients with permanent atrial fibrillation: Data from the RACE II study
Mulder, B. A., van Veldhuisen, D. J., Crijns, H. J. G. M., Tijssen, J. G. P., Hillege, H. L., Alings, M., Rienstra, M., van den Berg, M. P., & Gelder, I. C. V. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.06.007 · Cited by 69
Self-citation
Admission heart rate and in-hospital outcomes in patients hospitalized for heart failure in sinus rhythm and in atrial fibrillation
Bui, A. L., Grau‐Sepulveda, M. V., Hernandez, A. F., Peterson, E. D., Yancy, C. W., Bhatt, D. L., & Fonarow, G. C. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.01.007 · Cited by 68
Increased Heart Rate Is Associated With Higher Mortality in Patients With Atrial Fibrillation (AF): Results From the Outcomes Registry for Better Informed Treatment of AF (ORBIT‐AF)
Steinberg, B. A., Kim, S., Thomas, L. E., Fonarow, G. C., Gersh, B. J., Holmqvist, F., Hylek, E. M., Kowey, P. R., Mahaffey, K. W., Naccarelli, G. V., et al. (2015) · Journal of the American Heart Association · doi:10.1161/jaha.115.002031 · Cited by 65
Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control
Groenveld, H. F., Tijssen, J. G. P., Crijns, H. J. G. M., van den Berg, M. P., Hillege, H. L., Alings, M., van Veldhuisen, D. J., & Gelder, I. C. V. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.11.038 · Cited by 60
Self-citation
Atrial Fibrillation
Camm, A. J., Savelieva, I., Ho, S. Y., Lindsay, B. D., Nattel, S., & Shinagawa, K. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4377-0285-9.00044-2 · Cited by 60
2026 ESC Guidelines for the management of heart failure
Køber, L., Adamo, M., Ruwald, A., Tomasoni, D., Anderson, L., Andersson, C., Brugts, J. J., Chioncel, O. D., Donal, E., Ferdinandy, P., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag100 · Cited by 109
Rate Control in Atrial Fibrillation
Heist, E. K., MANSOUR, M. C., & Ruskin, J. N. (2011) · Circulation · doi:10.1161/circulationaha.111.019919 · Cited by 53
Effect of Lenient Versus Strict Rate Control on Cardiac Remodeling in Patients With Atrial Fibrillation
Smit, M. D., Crijns, H. J. G. M., Tijssen, J. G. P., Hillege, H. L., Alings, M., Tuininga, Y. S., Groenveld, H. F., van den Berg, M. P., van Veldhuisen, D. J., & Gelder, I. C. V. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.04.030 · Cited by 50
Self-citation
A review of rate control in atrial fibrillation, and the rationale and protocol for the RATE-AF trial
Kotecha, D., Calvert, M., Deeks, J. J., GRIFFITH, M. J., Kirchhof, P. F., Lip, G. Y. H., Mehta, S. P., Slinn, G., Stanbury, M., Steeds, R. P., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015099 · Cited by 48
Treatment of atrial fibrillation
Bajpai, A., Savelieva, I., & Camm, A. J. (2008) · British Medical Bulletin · doi:10.1093/bmb/ldn046 · Cited by 42
Tachycardia-mediated cardiomyopathy: Recognition and management
Gopinathannair, R., Sullivan, R. M., & Olshansky, B. (2009) · Current Heart Failure Reports · doi:10.1007/s11897-009-0035-3 · Cited by 42
Self-citation
Retrospective Evaluation of the Effect of Heart Rate on Survival in Dogs with Atrial Fibrillation
Pedro, B., Dukes‐McEwan, J., Oyama, M. A., Kraus, M. S., & Gelzer, A. R. (2017) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14896 · Cited by 41
Effect of Bucindolol on Heart Failure Outcomes and Heart Rate Response in Patients with Reduced Ejection Fraction Heart Failure and Atrial Fibrillation
Kao, D. P., Davis, G. W., Aleong, R. G., O’Connor, C. M., Fiuzat, M., Carson, P. E., Anand, I. S., Plehn, J. F., Gottlieb, S. S., Silver, M. A., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs181 · Cited by 39
Novel Perspectives on Arrhythmia-Induced Cardiomyopathy
Rocca, D. G. D., Santini, L., Forleo, G. B., Sanniti, A., Prete, A. D., Lavalle, C., Biase, L. D., Natale, A., & Romeo, F. (2014) · Cardiology in Review · doi:10.1097/crd.0000000000000040 · Cited by 31
Does intensity of rate control influence outcome in persistent atrial fibrillation?
Groenveld, H. F., Crijns, H. J. G. M., Rienstra, M., van den Berg, M. P., van Veldhuisen, D. J., & Gelder, I. C. V. (2009) · American Heart Journal · doi:10.1016/j.ahj.2009.09.007 · Cited by 29
Self-citation
Guía ESC 2020 sobre el diagnóstico y tratamiento de la fibrilación auricular, desarrollada en colaboración de la European Association of Cardio-Thoracic Surgery (EACTS)
Hindricks, G., Potpara, T., Dagres, N., Arbelo, E., Bax, J. J., Blomström‐Lundqvist, C., Boriani, G., Castellà, M., Dan, G., Dilaveris, P., et al. (2021) · Revista Española de Cardiología · doi:10.1016/j.recesp.2020.10.022 · Cited by 34
Computational approaches to structural and functional analysis of plastocyanin and other blue copper proteins
Rienzo, F. D., Gabdoulline, R. R., Wade, R. C., Sola, M., & Menziani, M. C. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-3181-5 · Cited by 27
Atrial fibrillation: better symptom control with rate and rhythm management
Gupta, D., Rienstra, M., Gelder, I. C. V., & Fauchier, L. (2024) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2023.100801 · Cited by 31
Management of Atrial Fibrillation: Translating Clinical Trial Data into Clinical Practice
Eagle, K. A., Cannom, D. S., & Garcia, D. A. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.05.016 · Cited by 24
Medical treatment of atrial fibrillation
Camm, A. J., Camm, C. F., & Savelieva, I. (2011) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0b013e32834f23e1 · Cited by 22
Ventricular rate in atrial fibrillation and the risk of heart failure and death
Westergaard, L. M., Alhakak, A., Rørth, R., Fosbøl, E. L., Kristensen, S. L., Svendsen, J. H., Graff, C., Nielsen, J. B., Gislason, G., Køber, L., et al. (2023) · EP Europace · doi:10.1093/europace/euad088 · Cited by 22
Atrial fibrillation: the rate versus rhythm management controversy
Aj, C., & Savelieva, I. (2012) · The Journal of the Royal College of Physicians of Edinburgh · doi:10.4997/jrcpe.2012.s03 · Cited by 22
Atrial fibrillation: insights from clinical trials and novel treatment options
Blaauw, Y., & Crijns, H. J. G. M. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01885.x · Cited by 22
Self-citation
Atrial fibrillation-induced tachycardiomyopathy and heart failure: an underappreciated and elusive condition
Manolis, A. S., Manolis, T. A., Manolis, A. S., & Melita, H. (2022) · Heart Failure Reviews · doi:10.1007/s10741-022-10221-1 · Cited by 21
Pharmacotherapy for rhythm management in elderly patients with atrial fibrillation
Wyse, D. G. (2009) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-008-9329-8 · Cited by 21
Self-citation
Clinical Evaluation of the Measurement Performance of the Philips Health Watch: A Within-Person Comparative Study
Hendrikx, J., Ruijs, L. S., Cox, L. G. E., Lemmens, P. M. C., Schuijers, E. G., & Goris, A. H. C. (2017) · JMIR mhealth and uhealth · doi:10.2196/mhealth.6893 · Cited by 19
Therapeutic Considerations in Applying Rate Control Therapy for Atrial Fibrillation
Wyse, D. G. (2008) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31816d5f49 · Cited by 20
Self-citation
Heart rate and outcome in heart failure with reduced ejection fraction: Differences between atrial fibrillation and sinus rhythm—A CIBIS II analysis
Mulder, B. A., Damman, K., van Veldhuisen, D. J., Gelder, I. C. V., & Rienstra, M. (2017) · Clinical Cardiology · doi:10.1002/clc.22725 · Cited by 20
Antiarrhythmic Drugs and Strategies
Opie, L. H., Dimarco, J., & Gersh, B. J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-6158-8.50013-7 · Cited by 16
Regulatory pathways for development of antiarrhythmic drugs for management of atrial fibrillation/flutter
Savelieva, I., Kirchhof, P. F., Danchin, N., de Graeff, P. A., & Camm, A. J. (2011) · EP Europace · doi:10.1093/europace/eur181 · Cited by 15
Exercise Training in Heart Failure Patients With Persistent Atrial Fibrillation: a Practical Approach
Cornelis, J., & MYERS, J. N. (2018) · Cardiac failure review · doi:10.15420/cfr.2018.19.2 · Cited by 15
Antiarrhythmic drugs and strategies
Nattel, S., Gersh, B. J., & Opie, L. H. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-3322-4.00017-x · Cited by 15
Lenient Versus Strict Rate Control in Atrial Fibrillation
Wyse, D. G. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.04.028 · Cited by 15
Self-citation
Outcomes After Nonemergent Electrical Cardioversion for Atrial Arrhythmias
Steinberg, B. A., Schulte, P. J., Hofmann, P., Ersbøll, M. K., Alexander, J. H., Broderick-Forsgren, K., Anstrom, K. J., Granger, C. B., Piccini, J. P., Velazquez, E. J., et al. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.02.030 · Cited by 14
Impacts of ventricular rate regularization pacing at right ventricular apical vs. septal sites on left ventricular function and exercise capacity in patients with permanent atrial fibrillation
Tse, H., Wong, K.-K., Siu, C., Tang, M.-O., Tsang, V., Ho, W. Y., & Lau, C. (2009) · EP Europace · doi:10.1093/europace/eup087 · Cited by 14
Heart rate and adverse outcomes in patients with prevalent atrial fibrillation
Moschovitis, G., Johnson, L., Blum, S., Aeschbacher, S., Perna, M. L. D., Pagnamenta, A., Melchiorre, P. A. M., Benz, A. P., Kobza, R., Valentino, M. D., et al. (2021) · Open Heart · doi:10.1136/openhrt-2021-001606 · Cited by 13
Influence of Heart Rate on Quality of Life in Patients With Chronic Atrial Fibrillation
Jaber, J., Cirenza, C., Jaber, J., Amaral, A., de Sousa, J. M. A., Filho, J. A. O., & de Paola, Â. A. V. (2010) · Clinical Cardiology · doi:10.1002/clc.20528 · Cited by 13
EURASIAN ASSOCIATION OF CARDIOLOGY (EAC)/ NATIONAL SOCIETY OF HEART FAILURE AND MYOCARDIAL DISEASE (NSHFMD) GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF CHRONIC HEART FAILURE (2020)
Tereshchenko, S. N., Жиров, И. В., Uskach, T. M., Saidova, M. A., Sp, G., Михайловна, Г. Е., Николаевна, Н. С., Narusov, O. Y., Safiullina, A. A., Tereshchenko, A. S., et al. (2020) · Eurasian heart journal · doi:10.38109/2225-1685-2020-3-6-76 · Cited by 12
Incidence and economic burden of suspected adverse events and adverse event monitoring during AF therapy
Kim, M., Lin, J., Hussein, M. A., & Battleman, D. S. (2009) · Current Medical Research and Opinion · doi:10.1185/03007990903368716 · Cited by 12
Clinical Implications of Heart Rate Control in Heart Failure With Atrial Fibrillation: Multi-Center Prospective Observation Registry (CODE-AF Registry)
Song, S., Ko, J. S., Lee, H. A., Choi, E., Cha, M., Kim, T., Park, J., Lee, J.-M., Kang, K., Shim, J., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.787869 · Cited by 12
The Sertindole Cohort Prospective (SCoP) study: rationale, design and methodology
Peuskens, J., Tanghøj, P., & Mittoux, A. (2008) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1594 · Cited by 12
Incremental Changes in QRS Duration Predict Mortality in Patients with Atrial Fibrillation
Lin, Y., Liu, Y., & Chu, C.-C. (2009) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2009.02508.x · Cited by 11
Prospective observational studies of the management and outcomes in patients with atrial fibrillation: A systematic review
Hersi, A. S., Alsheikh-Ali, A. A. A., Zubaid, M., & Suwaidi, J. M. S. A. (2012) · Journal of the Saudi Heart Association · doi:10.1016/j.jsha.2012.08.001 · Cited by 10
Prognostic significance of resting heart rate in atrial fibrillation patients with heart failure with reduced ejection fraction
Suzuki, S., Motoki, H., Kanzaki, Y., Maruyama, T., Hashizume, N., Kozuka, A., Yahikozawa, K., & Kuwahara, K. (2020) · Heart and Vessels · doi:10.1007/s00380-020-01573-5 · Cited by 11
Rate Control versus Rhythm Control in Atrial Fibrillation: Lessons Learned from Clinical Trials of Atrial Fibrillation
Waldo, A. L. (2015) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2015.08.006 · Cited by 10
Ventricular Rate Control of Atrial Fibrillation in Heart Failure
Rienstra, M., & Gelder, I. C. V. (2013) · Heart Failure Clinics · doi:10.1016/j.hfc.2013.07.004 · Cited by 9
Rate control in patients with pacemaker affected by brady-tachy form of sick sinus syndrome
Boriani, G., Padeletti, L., Santini, M., Gulizia, M. M., Orazi, S., Botto, G., Capucci, A., Biffi, M., Martignani, C., Ricci, R. P., et al. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.04.001 · Cited by 9
Pharmacological Management of Atrial Fibrillation: One, None, One Hundred Thousand
Lucà, F., Meir, M. L., Rao, C. M., Parise, O., Vasquez, L., Carella, R., Lorusso, R., Daniela, B., Maessen, J. G., Gensini, G. F., et al. (2011) · Cardiology Research and Practice · doi:10.4061/2011/874802 · Cited by 9
Pharmacological Therapy for Rate and Rhythm Control for Atrial Fibrillation in 2017
Kanagaratnam, L. B., Kowey, P. R., & Whalley, D. W. (2017) · Heart Lung and Circulation · doi:10.1016/j.hlc.2017.05.134 · Cited by 10
Update on medical management of atrial fibrillation in the modern era
Gopinathannair, R., Sullivan, R. M., & Olshansky, B. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.02.013 · Cited by 8
Self-citation
Eurasian Association of Cardiology (EAC)/ National Society of Heart Failure And Myocardial Disease (NSHFMD) guidelines for the diagnosis and treatment of chronic heart failure (2024)
Tereshchenko, S. N., Жиров, И. В., Uskach, T. M., Saidova, M. A., Sp, G., Rimskaya, E. M., Николаевна, Н. С., Narusov, O. Y., Safiullina, A. A., Tereshchenko, A. S., et al. (2024) · Eurasian heart journal · doi:10.38109/2225-1685-2024-2-6-76 · Cited by 8
Brady- and tachyarrhythmias detected by continuous rhythm monitoring in paroxysmal atrial fibrillation
Frausing, M. H. J. P., van de Lande, M. E., Maass, A. H., Nguyen, B., Hemels, M. E. W., Tieleman, R. G., Koldenhof, T., Melis, M. D., Linz, D., Schotten, U., et al. (2023) · Heart · doi:10.1136/heartjnl-2022-322253 · Cited by 8
Self-citation
Predictive value of the heart rate reserve in patients with permanent atrial fibrillation treated according to a strict rate-control strategy
Schryver, N. D., Scavée, C., Marchandise, S., Pasquet, A., de Meester, C., & de Waroux, J. L. P. (2014) · EP Europace · doi:10.1093/europace/euu033 · Cited by 8
Medical, interventional, and surgical treatment strategies for atrial fibrillation
Willems, S., Gunawardene, M., Eickholt, C., Hartmann, J., Schmoeckel, M., & Schäffer, B. (2022) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.m2022.0002 · Cited by 9
Eurasian clinical guidelines for the diagnosis and treatment of atrial fibrillation in adult patients (2025)
Sp, G., Панченко, Е. П., Mironov, N. Y., Михайловна, Б. М., Gagloeva, D. A., Elfimova, E. M., Станиславовна, К. Е., Laiovich, L. I., Litvin, A. Y., Maykov, E. B., et al. (2025) · Eurasian heart journal · doi:10.38109/2225-1685-2025-3-6-77 · Cited by 8
Antiarrhythmic Treatment in Heart Failure
Könemann, H., Güler-Eren, S., Ellermann, C., Frommeyer, G., & Eckardt, L. (2024) · Current Heart Failure Reports · doi:10.1007/s11897-023-00642-w · Cited by 8
Differences in Heart Rate Response and Recovery After 6-Minute Walk Test Between Patients With Atrial Fibrillation and in Sinus Rhythm
Luo, X., Xiong, Q., Xu, J., Hong, K., Peng, Q., Li, J., Cheng, X., Lip, G. Y. H., & Su, H. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.04.048 · Cited by 7
Analysis of the ESC/EACTS 2020 Atrial Fibrillation Guidelines With Perioperative Implications
Nelson, J. A., Gue, Y. X., Christensen, J. M., Lip, G. Y. H., & Ramakrishna, H. (2021) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2021.05.011 · Cited by 8
Atrial fibrillation in patients with systolic heart failure: pathophysiology mechanisms and management.
Koniari, I. C., Artopoulou, E., Velissaris, D., Kounis, N. G., & Tsigkas, G. (2021) · PubMed Central · doi:10.11909/j.issn.1671-5411.2021.05.003 · Cited by 8
Computational Simulation of Cardiac Function and Blood Flow in the Circulatory System under Continuous Flow Left Ventricular Assist Device Support during Atrial Fibrillation
Bozkurt, S. (2020) · Applied Sciences · doi:10.3390/app10030876 · Cited by 7
Atrial fibrillation and flutter – the state of the art. Part 2
Janion−Sadowska, A., Turek, Ł., Dudek, A., Andrychowski, J., & Sadowski, M. (2021) · Medical Studies · doi:10.5114/ms.2021.109530 · Cited by 7
The Prognostic Effects of Ventricular Heart Rate Among Patients With Permanent Atrial Fibrillation With and Without Coronary Artery Disease
Wan, H., Yang, Y., Zhu, J., Shao, X., Wang, J., Huang, B., & Zhang, H. (2015) · Medicine · doi:10.1097/md.0000000000000920 · Cited by 7
Atrial fibrillation: Yesterday, today, and tomorrow
Кanorskiy, S. G., Galenko-Yaroshevsky, P. A., Алексеенко, С. Н., & Sp, G. (2025) · Кубанский научный медицинский вестник · doi:10.25207/1608-6228-2025-32-3-107-120 · Cited by 7
Rate of atrial fibrillation and flutter induced tachycardiomyopathy in a cohort of hospitalized patients with heart failure and detection of indicators for improved diagnosis
Ermert, L., Kreimer, F., Quast, D. R., Pflaumbaum, A., Mügge, A., & Gotzmann, M. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.940060 · Cited by 6
New Insights into Rate Control: Time in Target Range of Resting Heart Rate and Major Adverse Outcomes in Atrial Fibrillation
Lai, Y., Xu, X., Zhang, S., Huang, R., Huang, Y., Zhong, X., Xiong, Z., Lin, Y., Zhou, H., Guo, Y., et al. (2024) · Global Heart · doi:10.5334/gh.1251 · Cited by 6
Update on anti-coagulation in atrial fibrillation
Kreuzer, J. (2011) · QJM · doi:10.1093/qjmed/hcr107 · Cited by 6
Heart rate determines the beneficial effects of beta-blockers on cardiovascular outcomes in patients with heart failure and atrial fibrillation
Hudoyo, A. W., Fukuda, H., Imazu, M., Shindo, K., Fu, H., Iwata, Y., Ito, S., & Kitakaze, M. (2019) · Hypertension Research · doi:10.1038/s41440-019-0289-4 · Cited by 6

Authors: Van Gelder, I. C., Wyse, D. G., Chandler, M. L., Cooper, H. A., Olshansky, B., Hagens, V. E., & Crijns, H. J. G. M.
Affiliations: Libin Cardiovascular Institute of Alberta (CA)
MedStar Washington Hospital Center (US)
University of Iowa (US)
University Medical Center Groningen (NL)
Maastricht University Medical Centre (NL)
ORCID: Olshansky, Brian
Crijns, Harry J.G.M.
Venue: EP Europace
Publisher: Oxford University Press (OUP)
Published: 2006-09-14
Volume: 8
Issue: 11
Pages: 935-942
ISSN: 1099-5129 (ISSN-L)
1532-2092
DOI: 10.1093/europace/eul106
OpenAlex: W2117915052
Cited by: 165
References: 17
Citations by year: 2026: 3 · 2025: 5 · 2024: 7 · 2023: 12 · 2022: 9 · 2021: 13 · 2020: 12 · 2019: 3 · 2018: 7 · 2017: 13 · 2016: 8 · 2015: 7 · 2014: 6 · 2013: 9 · 2012: 7
FWCI: 5.71
Type: journal article
Language: en
Open access: closed
Locations: EP Europace (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Funders: National Institutes of Health (n01hc055139-000)
National Heart, Lung, and Blood Institute (N01-HC-55139)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
Keywords: atrial fibrillation, rate control, resting heart rate, target heart rate, event-free survival, mortality, cardiovascular hospitalization, myocardial infarction, AFFIRM trial, pooled analysis
MeSH terms: Aged, Atrial Fibrillation, Cardiac Pacing, Artificial, Clinical Trials as Topic, Female, Heart Rate, Humans, International Cooperation, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Factors, Survival Rate, Proportional Hazards Models, Survival Analysis, Treatment Outcome, Outcome Assessment, Health Care, Risk Assessment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Does intensity of rate-control influence outcome in atrial fibrillation? An analysis of pooled data from the RACE and AFFIRM studies

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks