Intramyocellular lipid and impaired myofiber contraction in normal weight and obese older adults
Open accessAbstract
BACKGROUND: Evidence implicates the amount and location of fat in aging-related loss of muscle function; however, whether intramyocellular lipids affect muscle contractile capacity is unknown. METHODS: We compared both in vivo knee extensor muscle strength, power, and quality and in vitro mechanical properties of vastus lateralis single-muscle fibers between normal weight (NW) and obese older adults and determined the relationship between muscle lipid content (both intramuscular adipose tissue and intramyocellular lipids) and in vivo and in vitro muscle function in NW and obese individuals. RESULTS: The obese group had a greater percentage of type-I fibers compared to the NW group. The cross-sectional area of type-I fibers was greater in obese compared to NW; however, maximal shortening velocity of type-I fibers in the obese was slower compared to NW. Type-I and type-IIa fibers from obese group produced lower specific force than that of type-I and type-IIa fibers from the NW group. Normalized power was also substantially lower (~50%) in type-I fibers from obese adults. The intramyocellular lipids data showed that total lipid droplet area, number of lipid droplets, and area fraction were about twofold greater in type-I fibers from the obese compared to the NW group. Interestingly, a significant inverse relationship between average number of lipid droplets and single-fiber unloaded shortening velocity, maximal velocity, and specific power was observed in obese participants. Additionally, muscle echointensity correlated with single-fiber specific force. CONCLUSIONS: These data indicate that greater intramyocellular lipids are associated with slower myofiber contraction, force, and power development in obese older adults.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Studies have reported that obese adults have about 20% higher thigh muscle mass than those with normal weight.
“Studies have reported that obese adults have about 20% higher thigh muscle mass than those with normal weight (85).”
From Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial (2019) · cites this paper as [85]
The Thigh Composition results (p. 2) report 19% greater thigh muscle volume in the obese group than in the normal-weight group, consistent with “about 20%.” The study measured volume, not thigh muscle mass, and its participants were older adults rather than adults generally (Table 2, p. 3). (LLM, conf=0.84)
Experimental — accuracy not yet measuredObesity is associated with lower muscle quality (myosteatosis and muscle fibre composition), as evidenced by decreased muscle strength.
“This could partly be explained by obesity being associated with lower muscle quality (myosteatosis and muscle fibre composition), as evidenced by decreased muscle strength”
From Changes in lean body mass with <scp>glucagon‐like peptide</scp> ‐1‐based therapies and mitigation strategies (2024) · cites this paper as [7]
The Morphological and Contractile Characteristics results (p. 3) report a different fiber-type composition in obese older adults, and the Discussion (p. 5) reports more intermuscular fat and lower knee-extensor torque relative to muscle volume. However, the obese group had higher absolute peak torque, so the claim of decreased muscle strength needs the qualification that strength was lower when normalized to muscle volume. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Visser, M., Goodpaster, B. H., Kritchevsky, S. B., Newman, A. B., Nevitt, M., Rubin, S. M., Simonsick, E. M., Harris, T. B., & Study, F. T. H. A. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.3.324 · Cited by 1,403 · see citing works
Attenuation of skeletal muscle and strength in the elderly: the Health ABC Study
Goodpaster, B. H., Carlson, C. L., Visser, M., Kelley, D. E., Scherzinger, A., Harris, T. B., Stamm, E., & Newman, A. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2157 · Cited by 1,226 · see citing works
Goodpaster, B. H. (2001) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.12.5755 · Cited by 1,194 · see citing works
Dynapenia and aging: an update
Manini, T. M., & Clark, B. C. (2012) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glr010 · Cited by 875 · see citing works
Visser, M., Kritchevsky, S. B., Goodpaster, B. H., Newman, A. B., Nevitt, M., Stamm, E., & Harris, T. B. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50217.x · Cited by 845 · see citing works
Skeletal Muscle Ultrasound: Correlation Between Fibrous Tissue and Echo Intensity
Pillen, S., Tak, R. O., Zwarts, M. J., Lammens, M. M. Y., Verrijp, K. N., Arts, I. M. P., van der Laak, J. A. W. M., Hoogerbrugge, P. M., van Engelen, B. G. M., & Verrips, A. (2008) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2008.09.016 · Cited by 615 · see citing works
McGregor, R. A., Cameron-Smith, D., & Poppitt, S. D. (2014) · Longevity & Healthspan · doi:10.1186/2046-2395-3-9 · Cited by 532 · see citing works
Skeletal muscle fat infiltration: impact of age, inactivity, and exercise
Marcus, R. L., Addison, O., Kidde, J. P., Dibble, L. E., & Lastayo, P. C. (2010) · The Journal of nutrition, health and aging · doi:10.1007/s12603-010-0081-2 · Cited by 449 · see citing works
Zoico, E., Di Francesco, V, Guralnik, J. M., Mazzali, G., Bortolani, A., Guariento, S., Sergi, G., Bosello, O., & Zamboni, M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802552 · Cited by 392 · see citing works
Skeletal muscle sonography: a correlative study of echogenicity and morphology
Reimers, K., Reimers, C. D., Wagner, S., Paetzke, I., & Pongratz, D. E. (1993) · Journal of Ultrasound in Medicine · doi:10.7863/jum.1993.12.2.73 · Cited by 385 · cited 1× · see citing works
“Increased ultrasound echointensity has been attributed to increased intermuscular adipose tissue and intramuscular fat (30) and muscle fibrosis (31) though these data were derived from humans with muscular dystrophy and canines, respectively.”
BackgroundHilton, T. N., Tuttle, L. J., Bohnert, K. L., Mueller, M. J., & Sinacore, D. R. (2008) · Physical Therapy · doi:10.2522/ptj.20080079 · Cited by 373 · see citing works
Functional consequences of sarcopenia and dynapenia in the elderly
Clark, B. C., & Manini, T. M. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e328337819e · Cited by 359 · see citing works
Fat and protein redistribution with aging: metabolic considerations
Beaufrère, B., & Morio, B. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601025 · Cited by 289 · see citing works
Koster, A., Ding, J., Stenholm, S., Caserotti, P., Houston, D. K., Nicklas, B. J., You, T., Lee, J. S., Visser, M., Newman, A. B., et al. (2011) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glr070 · Cited by 274 · see citing works
Self-citationBeavers, K. M., Beavers, D. P., Houston, D. K., Harris, T. B., Hue, T. F., Koster, A., Newman, A. B., Simonsick, E. M., Studenski, S. A., Nicklas, B. J., et al. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.047860 · Cited by 259 · see citing works
Self-citationThe effect of intramuscular fat on skeletal muscle mechanics: implications for the elderly and obese
Rahemi, H., Nigam, N., & Wakeling, J. M. (2015) · Journal of The Royal Society Interface · doi:10.1098/rsif.2015.0365 · Cited by 253 · see citing works
Effects of birth cohort and age on body composition in a sample of community-based elderly
Ding, J., Kritchevsky, S. B., Newman, A. B., Taaffe, D. R., Nicklas, B. J., Visser, M., Lee, J. S., Nevitt, M. C., Tylavsky, F. A., Rubin, S. M., et al. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.405 · Cited by 148 · see citing works
Self-citationSingle Skeletal Muscle Fiber Elastic and Contractile Characteristics in Young and Older Men
Ochala, J., Frontera, W. R., Dorer, D. J., Hoecke, J. V., & Krivickas, L. S. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.4.375 · Cited by 145 · see citing works
Nicklas, B. J., Chmelo, E., Delbono, O., Carr, J. J., Lyles, M. F., & Marsh, A. P. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.105270 · Cited by 144 · cited 1× · see citing works
“Procedures for vastus lateralis muscle biopsy and methods to measure body composition, thigh composition, and in vivo knee extensor strength, power, and quality have been described (12,13).”
MethodSelf-citationQuantitative neuromuscular ultrasound in the intensive care unit
Cartwright, M. S., Kwayisi, G., Griffin, L. P., Sarwal, A., Walker, F. O., Harris, J. M., Berry, M. J., Chahal, P. S., & Morris, P. E. (2012) · Muscle & Nerve · doi:10.1002/mus.23525 · Cited by 126 · see citing works
Marsh, A. P., Rejeski, W. J., Espeland, M. A., Miller, M. E., Church, T., Fielding, R. A., Gill, T. M., Guralnik, J. M., Newman, A. B., Pahor, M., et al. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr158 · Cited by 115 · see citing works
Self-citationShin, H., Panton, L. B., Dutton, G. R., & Ilich, J. Z. (2011) · Journal of Aging Research · doi:10.4061/2011/191896 · Cited by 78 · see citing works
Functional properties of slow and fast gastrocnemius muscle fibers after a 17-day spaceflight
Widrick, J. J., Romatowski, J. G., Norenberg, K. M., Knuth, S. T., Bain, J. L. W., Riley, D. A., Trappe, S. W., Trappe, T. A., COSTILL, D. L., & Fitts, R. H. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2203 · Cited by 78 · see citing works
Quantitative electrophoretic analysis of myosin heavy chains in single muscle fibers
Tikunov, B. A., Sweeney, H. L., & Rome, L. C. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.5.1927 · Cited by 65 · see citing works
Houmard, J. A., Pories, W. J., & Dohm, G. L. (2012) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31825d53fc · Cited by 47 · see citing works
Nam, S., Kuo, Y., Markides, K. S., & Snih, S. A. (2012) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2012.04.006 · Cited by 42 · see citing works
Determinants of lower-body muscle power in early postmenopausal women
Sipilä, S., Koskinen, S. O. A., Taaffe, D. R., Takala, T. E. S., Cheng, S., Rantanen, T., Toivanen, J., & Suominen, H. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52261.x · Cited by 40 · see citing works
Nicklas, B. J., Leng, I., Delbono, O., Kitzman, D. W., Marsh, A. P., Hundley, W. G., Lyles, M. F., O’Rourke, K. S., Annex, B. H., & Kraus, W. E. (2008) · Aging Clinical and Experimental Research · doi:10.1007/bf03324860 · Cited by 32 · see citing works
Self-citationObesity, insulin resistance, and skeletal muscle nitric oxide synthase
Kraus, R. M., Houmard, J. A., Kraus, W. E., Tanner, C. J., Pierce, J. R., Choi, M. D., & Hickner, R. C. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01018.2011 · Cited by 28 · see citing works
Choi, S.-J., Shively, C. A., Register, T. C., Feng, X., Stehle, J., High, K. P., Ip, E. H., Kritchevsky, S. B., Nicklas, B. J., & Delbono, O. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls143 · Cited by 27 · see citing works
Self-citationZhang, T., Choi, S.-J., Wang, Z.-M., Birbrair, A., Messi, M. L., Jin, J., Marsh, A. P., Nicklas, B. J., & Delbono, O. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt204 · Cited by 25 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Preserving Healthy Muscle during Weight Loss
Cava, E., Yeat, N. C., & Mittendorfer, B. (2017) · Advances in Nutrition · doi:10.3945/an.116.014506 · Cited by 452 · see citing works
Neeland, I. J., Linge, J., & Birkenfeld, A. L. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15728 · Cited by 391 · see citing works
Hand grip strength as a proposed new vital sign of health: a narrative review of evidences
Vaishya, R., Misra, A., Vaish, A., Ursino, N., & D’Ambrosi, R. (2024) · Journal of Health, Population and Nutrition · doi:10.1186/s41043-024-00500-y · Cited by 385 · see citing works
Fatty infiltration of skeletal muscle: mechanisms and comparisons with bone marrow adiposity
Hamrick, M. W., McGee-Lawrence, M. E., & Frechette, D. M. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00069 · Cited by 372 · see citing works
Athinarayanan, S. J., Adams, R. N., Hallberg, S. J., McKenzie, A. L., Bhanpuri, N. H., Campbell, W. W., Volek, J. S., Phinney, S. D., & McCarter, J. P. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00348 · Cited by 324 · see citing works
Sarcopenia in cirrhosis: from pathogenesis to interventions
Ebadi, M., Bhanji, R. A., Mazurak, V. C., & Montaño‐Loza, A. J. (2019) · Journal of Gastroenterology · doi:10.1007/s00535-019-01605-6 · Cited by 298 · see citing works
Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty
Stout, M. B., Justice, J. N., Nicklas, B. J., & Kirkland, J. L. (2017) · Physiology · doi:10.1152/physiol.00012.2016 · Cited by 272 · see citing works
Self-citationLiu, C., Wong, P. Y., Chung, Y. L., Chow, S. K., Cheung, W. H., Law, S. W., Chan, J. C. N., & Wong, R. M. Y. (2023) · Obesity Reviews · doi:10.1111/obr.13534 · Cited by 247 · see citing works
Wang, S. H., Keenan, B. T., Wiemken, A. S., Zang, Y., Staley, B. A., Sarwer, D. B., Torigian, D. A., Williams, N. N., Pack, A. I., & Schwab, R. J. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201903-0692oc · Cited by 232 · see citing works
The effects of obesity on skeletal muscle contractile function
Tallis, J. A., James, R. S., & Seebacher, F. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.163840 · Cited by 214 · see citing works
Distéfano, G., Standley, R. A., Zhang, X., Carnero, E. Á., Yi, F., Cornnell, H. H., & Coen, P. M. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12272 · Cited by 176 · see citing works
Linge, J., Birkenfeld, A. L., & Neeland, I. J. (2024) · Circulation · doi:10.1161/circulationaha.124.067676 · Cited by 180 · see citing works
St‐Jean‐Pelletier, F., Pion, C. H., Leduc‐Gaudet, J., Sgarioto, N., Zovilé, I., Barbat‐Artigas, S., Reynaud, O., Alkaterji, F., Lemieux, F. C., Grenon, A., et al. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12139 · Cited by 156 · see citing works
Englund, D. A., Kirn, D. R., Koochek, A., Zhu, H., Travison, T. G., Reid, K. F., von Berens, Å., Melin, M., Cederholm, T., Gustafsson, T., et al. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx141 · Cited by 151 · see citing works
Bianchi, L., Abete, P., Bellelli, G., Bo, M., Cherubini, A., Corica, F., Bari, M. D., Maggio, M. G., Manca, G. M., Rizzo, M. R., et al. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw343 · Cited by 136 · see citing works
Sarcopenia in Autoimmune and Rheumatic Diseases: A Comprehensive Review
An, H. J., Tizaoui, K., Terrazzino, S., Cargnin, S., Lee, K. H., Nam, S. W., Kim, J., Yang, J. W., Lee, J. Y., Smith, L., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165678 · Cited by 134 · see citing works
Yamada, Y., Buehring, B., Krueger, D. C., Anderson, R. M., Schoeller, D. A., & Binkley, N. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw225 · Cited by 133 · see citing works
Exploring the Impact of Obesity on Skeletal Muscle Function in Older Age
Morgan, P., Smeuninx, B., & Breen, L. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.569904 · Cited by 90 · see citing works
Searching for the link between inflammaging and sarcopenia
Wang, T. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101611 · Cited by 88 · see citing works
Eshima, H., Tamura, Y., Kakehi, S., Kurebayashi, N., Murayama, T., Nakamura, K., Kakigi, R., Okada, T., Sakurai, T., Kawamori, R., et al. (2017) · Physiological Reports · doi:10.14814/phy2.13250 · Cited by 88 · see citing works
Valenzuela, P. L., Maffiuletti, N. A., Tringali, G., Col, A. D., & Sartório, A. (2020) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-020-03228-y · Cited by 88 · see citing works
Bollinger, L. M. (2017) · Gait & Posture · doi:10.1016/j.gaitpost.2017.05.003 · Cited by 88 · see citing works
Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults
Moro, T., Brightwell, C. R., Volpi, E., Rasmussen, B. B., & Fry, C. S. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00723.2019 · Cited by 85 · see citing works
Waters, D. (2019) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.19.0001 · Cited by 56 · see citing works
Ferretti, R., Moura, E. G., dos Santos, V. C., Caldeira, E. J., Conte, M., Matsumura, C. Y., Pertille, A., & Mosqueira, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0199728 · Cited by 72 · see citing works
Age trajectories of musculoskeletal morbidities in adults with cerebral palsy
Whitney, D. G., Hurvitz, E. A., Devlin, M. J., Caird, M. S., French, Z. P., Ellenberg, E. C., & Peterson, M. D. (2018) · Bone · doi:10.1016/j.bone.2018.07.002 · Cited by 71 · see citing works
Poggiogalle, E., Lubrano, C., Gnessi, L., Mariani, S., Martino, M. D., Catalano, C., Lenzi, A., & Donini, L. M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.01.028 · Cited by 66 · see citing works
Guo, A., Li, K., & Xiao, Q. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.04.002 · Cited by 66 · see citing works
Lloyd, E. M., Pinniger, G. J., Murphy, R. M., & Grounds, M. D. (2023) · Acta Physiologica · doi:10.1111/apha.14012 · Cited by 65 · see citing works
The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles
Messa, G. A. M., Piasecki, M., Hurst, J., Hill, C., Tallis, J., & Degens, H. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.217117 · Cited by 63 · see citing works
Dallaway, A., Kite, C., Griffen, C., Duncan, M. J., Tallis, J. A., Renshaw, D. W., & Hattersley, J. G. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110856 · Cited by 62 · see citing works
Castillo, Í. M. P., Argilés, J. M. A., Rueda, R., Ramírez, M., & Pedrosa, J. M. L. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09954-9 · Cited by 66 · see citing works
Müller, J. N., Lanferdini, F. J., Karam, J. Y. P., & Fontana, H. D. B. (2020) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2020-0413 · Cited by 53 · see citing works
Harris‐Love, M. O., Avila, N. A., Adams, B., Zhou, J., Seamon, B. A., Ismail, C., Zaidi, S. H. E., Kassner, C. A., Liu, F., & Blackman, M. R. (2018) · Journal of Clinical Medicine · doi:10.3390/jcm7100340 · Cited by 53 · see citing works
Adiponectin receptor agonist AdipoRon improves skeletal muscle function in aged mice
Balasubramanian, P., Schaar, A. E., Gustafson, G. E., Smith, A. B., Howell, P. R., Greenman, A., Baum, S., Colman, R. J., Lamming, D. W., Diffee, G., et al. (2022) · eLife · doi:10.7554/elife.71282 · Cited by 49 · see citing works
Rhoads, T. W., Clark, J. P., Gustafson, G. E., Miller, K. N., Conklin, M. W., DeMuth, T. M., Berres, M. E., Eliceiri, K. W., Vaughan, L. K., Lary, C. W., et al. (2020) · Cell Systems · doi:10.1016/j.cels.2019.12.002 · Cited by 50 · see citing works
Liu, X., Gao, Y., Lu, J., Ma, Q., Shi, Y., Liu, J., Xin, S., & Su, H. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.791999 · Cited by 47 · see citing works
da Silva, T. L., Nogueira, V. D. S. C. S., & Mulder, A. D. R. P. (2021) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2021.07.031 · Cited by 47 · see citing works
Liu, S., Chiu, C., Wang, L.-P., & Chiang, M. (2019) · Marine Drugs · doi:10.3390/md17060380 · Cited by 47 · see citing works
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions
Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46 · see citing works
Eshima, H., Tamura, Y., Kakehi, S., Kakigi, R., Hashimoto, R., Funai, K., Kawamori, R., & Watada, H. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00530.2019 · Cited by 45 · see citing works
Tallis, J. A., Shelley, S. P., Degens, H., & Hill, C. (2021) · Biomolecules · doi:10.3390/biom11030372 · Cited by 44 · see citing works
Smith, G. I., Commean, P. K., Reeds, D. N., Klein, S., & Mittendorfer, B. (2018) · Obesity · doi:10.1002/oby.22169 · Cited by 42 · see citing works
Herda, T. J., Ryan, E. D., Kohlmeier, M., Trevino, M. A., Gerstner, G. R., & Roelofs, E. J. (2018) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.13256 · Cited by 39 · see citing works
The Pathological Links between Adiposity and the Carpal Tunnel Syndrome
Oțelea, M. R., Nartea, R., Popescu, F. G., Covaleov, A., Mitoiu, B. I., & Nica, A. S. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44060181 · Cited by 39 · see citing works
Frank-Wilson, A. W., Chalhoub, D., Figueiredo, P., Jónsson, P. V., Siggeirsdóttir, K., Sigurdsson, S., Eiriksdottir, G., Guðnason, V., Launer, L., Harris, T. B., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx262 · Cited by 37 · see citing works
Andrich, D. E., Ou, Y., Melbouci, L., Leduc‐Gaudet, J., Auclair, N., Mercier, J., Secco, B., Tomaz, L. M., Gouspillou, G., Danialou, G., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01327 · Cited by 36 · see citing works
Olsen, L. A., Levy, M. J., Medley, K., Hassan, H., Miller, B. D., Alexander, R. L., Wilcock, E. B., Yi, K., Florens, L. A., Weaver, K. J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204427120 · Cited by 36 · see citing works
Quadriceps Impairment Is Associated with Gait Mechanics in Young Adults with Obesity
Vakula, M. N., Fisher, K. L., Garcia, S. A., Holmes, S. C., Post, B. K., Costa, P. B., & Pamukoff, D. N. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001891 · Cited by 35 · see citing works
Musculoskeletal adaptations to strength training in frail elderly: a matter of quantity or quality?
Aas, S. N., Breit, M., Karsrud, S., Aase, O. J., Rognlien, S. H., Cumming, K. T., Reggiani, C., Seynnes, O., Rossi, A. P., Toniolo, L., et al. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12543 · Cited by 37 · see citing works
Campa, F., Schoenfeld, B. J., Marini, E., Stagi, S., Mauro, M., & Toselli, S. (2021) · Nutrients · doi:10.3390/nu13072267 · Cited by 37 · see citing works
Dimmick, H. L., Miller, J. D., Sterczala, A. J., Trevino, M. A., & Herda, T. J. (2018) · European Journal of Applied Physiology · doi:10.1007/s00421-018-3909-9 · Cited by 34 · see citing works
Adipose tissue in older individuals: a contributing factor to sarcopenia
Wang, T., Zhou, D., & Hong, Z. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155998 · Cited by 35 · see citing works
Pathobiology of frailty in lung disease
Koons, B., Greenland, J. R., Diamond, J. M., & Singer, J. P. (2020) · Translational research · doi:10.1016/j.trsl.2020.04.001 · Cited by 33 · see citing works
Multimodal Diagnostic Approaches to Advance Precision Medicine in Sarcopenia and Frailty
Lynch, D. H., Spangler, H., Franz, J. R., Krupenevich, R. L., Kim, H., Nissman, D., Zhang, J., Li, Y., Sumner, S., & Batsis, J. A. (2022) · Nutrients · doi:10.3390/nu14071384 · Cited by 33 · see citing works
Selvais, C. M., de Carrizosa, M. A. D., Nachit, M., Versele, R., Dubuisson, N., Noël, L., Gillard, J., Leclercq, I. A., Brichard, S. M., & Abou‐Samra, M. (2022) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13148 · Cited by 33 · see citing works
Mota, J. A., Giuliani, H. K., Gerstner, G. R., & Ryan, E. D. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-017-0829-1 · Cited by 32 · see citing works
Anderson, M. R., Kolaitis, N. A., Gao, Y., Kukreja, J., Greenland, J. R., Hays, S. R., Wolters, P. J., Golden, J. A., Diamond, J. M., Palmer, S. M., et al. (2019) · American Journal of Transplantation · doi:10.1111/ajt.15525 · Cited by 31 · see citing works
Anti-obesity efficacy of the selected high altitude Himalayan herbs: in vitro studies
Kumar, M., Guleria, S., Chawla, P., Khan, A. U., Modi, V. K., Kumar, N., & Kaushik, R. (2020) · Journal of Food Science and Technology · doi:10.1007/s13197-020-04341-5 · Cited by 31 · see citing works
Age-related reductions in muscle quality influence the relative differences in strength and power
Gerstner, G. R., Giuliani, H. K., Mota, J. A., & Ryan, E. D. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.09.009 · Cited by 31 · see citing works
Current perspectives on obesity and skeletal muscle contractile function in older adults
Straight, C. R., Toth, M. J., & Miller, M. S. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00739.2020 · Cited by 32 · see citing works
Morphological alterations of mouse skeletal muscles during early ageing are muscle specific
Messa, G. A. M., Piasecki, M., Hill, C., McPhee, J. S., Tallis, J. A., & Degens, H. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110684 · Cited by 29 · see citing works
Age‐related differences in the motor unit action potential size in relation to recruitment threshold
Sterczala, A. J., Herda, T. J., Miller, J. D., Ciccone, A. B., & Trevino, M. A. (2017) · Clinical Physiology and Functional Imaging · doi:10.1111/cpf.12453 · Cited by 28 · see citing works
Long, D. E., Peck, B. D., Tuggle, S. C., Villasante Tezanos, A. G., Windham, S. T., Bamman, M. M., Kern, P. A., Peterson, C. A., & Walton, R. G. (2021) · GeroScience · doi:10.1007/s11357-020-00315-9 · Cited by 25 · see citing works
Straight, C. R., Ades, P. A., Toth, M. J., & Miller, M. S. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.007 · Cited by 25 · see citing works
Tomlinson, D. J., Erskine, R. M., Morse, C. I., Pappachan, J. M., Sanderson-Gillard, E., & Onambélé-Pearson, G. L. (2021) · Endocrine · doi:10.1007/s12020-020-02601-0 · Cited by 25 · see citing works
Li, M., & Liu, F. (2019) · Food & Function · doi:10.1039/c9fo00182d · Cited by 24 · see citing works
Age-related degeneration of lumbar muscle morphology in healthy younger versus older men
Dallaway, A., Hattersley, J. G., Diokno, M., Tallis, J. A., Renshaw, D. W., Wilson, A. J., Wayte, S. C., Weedall, A., & Duncan, M. J. (2020) · The Aging Male · doi:10.1080/13685538.2021.1878130 · Cited by 24 · see citing works
Maeda, H., Imada, K., Ishida, K., & Akima, H. (2020) · European Neurology · doi:10.1159/000507548 · Cited by 24 · see citing works
Orange, S. T., Madden, L. A., & Vince, R. V. (2020) · Journal of physiotherapy · doi:10.1016/j.jphys.2020.09.009 · Cited by 23 · see citing works
Vakula, M. N., Garcia, S. A., Holmes, S. C., & Pamukoff, D. N. (2021) · Gait & Posture · doi:10.1016/j.gaitpost.2021.12.019 · Cited by 22 · see citing works
Yoshiko, A., Shiozawa, K., Niwa, S., Takahashi, H., Koike, T., Watanabe, K., Katayama, K., & Akima, H. (2023) · GeroScience · doi:10.1007/s11357-023-01043-6 · Cited by 20 · see citing works
Age-related differences in twitch properties and muscle activation of the first dorsal interosseous
Miller, J. D., Herda, T. J., Trevino, M. A., Sterczala, A. J., Ciccone, A. B., & Nicoll, J. X. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.03.032 · Cited by 20 · see citing works
Yoshiko, A., Watanabe, K., & Akima, H. (2023) · Physiological Reports · doi:10.14814/phy2.15563 · Cited by 19 · see citing works
Straight, C. R., Voigt, T. B., Jala, A., Chase, J. D., Ringham, O. R., Ades, P. A., Toth, M. J., & Miller, M. S. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly235 · Cited by 19 · see citing works
The Effect of Age upon the Interrelationship of BMI and Inpatient Health Outcomes
Woolley, C. S. C., Thompson, C. H., Hakendorf, P. H., & Horwood, C. (2019) · The journal of nutrition health & aging · doi:10.1007/s12603-019-1206-x · Cited by 19 · see citing works
Gómez‐Barroso, M., Moreno-Calderón, K. M., Sánchez‐Duarte, E., Cortés‐Rojo, C., Saavedra‐Molina, A., Rodríguez-Orozco, A. R., & Montoya-Pérez, R. D. C. (2020) · Antioxidants · doi:10.3390/antiox9121232 · Cited by 18 · see citing works
Vitale, J. A., Sconfienza, L. M., & Galbusera, F. (2023) · European Spine Journal · doi:10.1007/s00586-023-07982-0 · Cited by 18 · see citing works
Giuliani, H. K., Shea, N. W., Gerstner, G. R., Mota, J. A., Blackburn, J. T., & Ryan, E. D. (2020) · The Journals of Gerontology Series A · doi:10.1093/gerona/glaa206 · Cited by 18 · see citing works
Zhao, L., Zhang, X., Luo, Q., Hou, C., Xu, J., & Liu, J. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c01002 · Cited by 18 · see citing works
Qu, Q., Guo, Q.-X., Sun, J.-Y., Lu, X.-Y., Cheang, I., Zhu, X., Yao, W.-M., Li, X.-L., Zhang, H.-F., Zhou, Y.-L., et al. (2023) · BMC Geriatrics · doi:10.1186/s12877-023-04326-x · Cited by 17 · see citing works
Files, D. C., Ilaiwy, A., Parry, T. L., Gibbs, K. W., Liu, C., Bain, J. R., Delbono, O., Muehlbauer, M. J., & Willis, M. S. (2016) · Metabolomics · doi:10.1007/s11306-016-1079-5 · Cited by 15 · see citing works
Self-citationThe emerging global phenomenon of sarcopenic obesity: Role of functional foods; a conference report
Shao, A. E., Campbell, W. W., Chen, C. O., Mittendorfer, B., Rivas, D. A., & Griffiths, J. C. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.03.048 · Cited by 15 · see citing works
Body Composition and Falls Risk in Older Adults
Xu, C. L. H., Ebeling, P. R., & Scott, D. S. (2019) · Current Geriatrics Reports · doi:10.1007/s13670-019-00294-6 · Cited by 15 · see citing works
Olmos, A. A., Stratton, M. T., Ha, P. L., VanDusseldorp, T. A., Bailly, A. R., Feito, Y., Mangine, G. T., Poisal, M. J., Jones, J., Dalton, B. E., et al. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110677 · Cited by 15 · see citing works
Han, Y., & Kim, M. (2023) · Annals of Geriatric Medicine and Research · doi:10.4235/agmr.23.0101 · Cited by 13 · see citing works
Dimet‐Wiley, A., Latham, C. M., Brightwell, C. R., Neelakantan, H., Keeble, A. R., Thomas, N. T., Noehren, H., Fry, C. S., & Watowich, S. J. (2024) · Scientific Reports · doi:10.1038/s41598-024-66034-9 · Cited by 13 · see citing works
Gerstner, G. R., Giuliani, H. K., Mota, J. A., & Ryan, E. D. (2018) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000002743 · Cited by 13 · see citing works
Toselli, S., Campa, F., Matias, C. N., de Alencar Silva, B. S., dos Santos, V. R., Maietta Latessa, P., & Gobbo, L. A. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111393 · Cited by 12 · see citing works
Contribution of Intramyocellular Lipids to Decreased Computed Tomography Muscle Density With Age
Brennan, N. A., Fishbein, K. W., Reiter, D. A., Ferrucci, L., & Spencer, R. G. S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.632642 · Cited by 12 · see citing works
Knee extensor torque and BMI differently relate to sit-to-stand strategies in obesity
Bollinger, L. M., Walaszek, M. C., Seay, R. F., & Ransom, A. L. (2019) · Clinical Biomechanics · doi:10.1016/j.clinbiomech.2019.01.002 · Cited by 12 · see citing works
Sharma, A. K., Shi, X., Isales, C. M., & McGee‐Lawrence, M. E. (2019) · Current Osteoporosis Reports · doi:10.1007/s11914-019-00554-6 · Cited by 12 · see citing works
Frechette, D. M., Krishnamoorthy, D., Pamon, T., Chan, M. E., Patel, V. S., & Rubin, C. T. (2017) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13442 · Cited by 11 · see citing works
Luo, Y., Shu, L., Wang, Y., Zhao, X., Han, M., Liu, Y., Xu, Y. J., & Han, B. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01909-z · Cited by 13 · see citing works
D’Alleva, M., Gonnelli, F., Vaccari, F., Boirie, Y., Montaurier, C., Thivel, D., Isacco, L., Vermorel, M., & Lazzer, S. (2021) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2021-0273 · Cited by 10 · see citing works
Yoshiko, A., Maeda, H., Takahashi, H., Koike, T., Tanaka, N., & Akima, H. (2022) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2021-0685 · Cited by 10 · see citing works
Just‐Borràs, L., Cilleros‐Mañé, V., Polishchuk, A., Balanyà-Segura, M., Tomàs, M., García, N., Tomàs, J. M., & Lanuza, M. A. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1069940 · Cited by 10 · see citing works
Wang, Z., Leng, X., Messi, M. L., Choi, S. J., Marsh, A. P., Nicklas, B. J., & Delbono, O. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly047 · Cited by 10 · see citing works
Self-citationContreiro, C. D. E., Caldas, L. C., Nogueira, B. V., Leopoldo, A. S., Lima‐Leopoldo, A. P., & Guimarães‐Ferreira, L. (2020) · Journal of Obesity · doi:10.1155/2020/8010784 · Cited by 10 · see citing works
Body Composition and Senescence: Impact of Polyphenols on Aging-Associated Events
dos Santos, T. W., Pereira, Q. C., Fortunato, I. M., Oliveira, F. D. S., Alvarez, M. C., & Ribeiro, M. L. (2024) · Nutrients · doi:10.3390/nu16213621 · Cited by 10 · see citing works
- Authors
- Choi, S. J., Files, D. C., Zhang, T., Wang, Z.-M., Messi, M. L., Gregory, H., Stone, J., Lyles, M. F., Dhar, S., Marsh, A. P., Nicklas, B. J., & Delbono, O.
- Affiliations
- Kyungsung University (KR)
- Wake Forest University Health Sciences (US)
- Wake Forest University (US)
- ORCID
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2015-09-23
- Volume
- 71
- Issue
- 4
- Pages
- 557-564
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- PMC
- PMC5014190
- OpenAlex
- W2307246836
- Semantic Scholar
- 8fbd77bc5d0cd52c5ca154313787c9ad9b636842
- Cited by
- 171
- References
- 31
- Citations by year
- 2026: 6 · 2025: 20 · 2024: 13 · 2023: 13 · 2022: 20 · 2021: 18 · 2020: 28 · 2019: 18 · 2018: 16 · 2017: 13 · 2016: 6
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (AG 15820, R01AG020583, AG-13934, R01AG015820, P30AG-21332, P30AG021332, R01AG013934)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- intramyocellular lipid, obesity, aging, muscle strength, muscle power, lipid droplets, type I muscle fibers, vastus lateralis, muscle function, older adults
- MeSH terms
- Aged, Aged, 80 and over, Aging, Body Composition, Female, Humans, Lipids, Male, Muscle Contraction, Obesity, Muscle Fibers, Skeletal, Muscle Fibers, Fast-Twitch, Muscle Fibers, Slow-Twitch, Torque, Muscle Strength
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
