CoChat
Sign Up
Cited by 145

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Hsa-miR-34b is a plasma-stable microRNA that is elevated in pre-manifest Huntington's disease.

Gaughwin, Philip Michael, Ciesla, Maciej, Lahiri, Nayana, Tabrizi, Sarah J., Brundin, Patrik, Björkqvist, Maria·2011·Human Molecular Genetics
DOI 10.1093/hmg/ddr111
Open this paper in CoChat — free account

Abstract

Huntington's disease (HD) is a devastating, neurodegenerative condition, which lacks effective treatment. Normal Huntingtin (HTT) and mutant Huntingtin (mHTT) are expressed in multiple tissues and can alter transcription of microRNAs (miRs). Importantly, miRs are present in a bio-stable form in human peripheral blood plasma and have recently been shown to be useful biomarkers in other diseases. We therefore sought to identify potential miR biomarkers of HD that are present in, and have functional consequences for, neuronal and non-neuronal tissues. In a cell line over-expressing mHTT-Exon-1, miR microarray analysis was used to identify candidate miRs. We then examined their presence and bio-stability in control and HD plasma. We found that miR-34b is significantly elevated in response to mHTT-Exon-1, and its blockade alters the toxicity of mHTT-Exon-1 in vitro. We also show that miR-34b is detectable in plasma from small input volumes and is insensitive to freeze-thaw-induced RNA degradation. Interestingly, miR-34b is significantly elevated in plasma from HD gene carriers prior to symptom onset. This is the first study suggesting that plasma miRs might be used as biomarkers for HD.

Overview

Integrity signals

Registry

Crossref · 10.1093/hmg/ddr111

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 4 references

Research works printed but not linked: 52

  1. Tabrizi, 2009, Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study, cross-sectional analysis of baseline data, Lancet Neurol., 8, 791, 10.1016/S1474-4422(09)70170-X · DOI · Paper page
  2. Walker, 2007, Huntington's disease, Lancet, 369, 218, 10.1016/S0140-6736(07)60111-1 · DOI
  3. van der Burg, 2009, Beyond the brain, widespread pathology in Huntington's disease, Lancet Neurol., 8, 765, 10.1016/S1474-4422(09)70178-4 · DOI
  4. Vonsattel, 1985, Neuropathological classification of Huntington's disease, J. Neuropathol. Exp. Neurol., 44, 559, 10.1097/00005072-198511000-00003 · DOI · Paper page
  5. Petersen, 2009, Huntington's disease—new perspectives based on neuroendocrine changes in rodent models, Neurodegener. Dis., 6, 154, 10.1159/000225377 · DOI
  6. Rosas, 2008, Cerebral cortex and the clinical expression of Huntington's disease, complexity and heterogeneity, Brain, 131, 1057, 10.1093/brain/awn025 · DOI · Paper page
  7. Bates, 2003, Huntingtin aggregation and toxicity in Huntington's disease, Lancet, 361, 1642, 10.1016/S0140-6736(03)13304-1 · DOI
  8. Harjes, 2003, The hunt for Huntingtin function, interaction partners tell many different stories, Trends Biochem. Sci., 28, 425, 10.1016/S0968-0004(03)00168-3 · DOI
  9. Hoffner, 2002, Protein aggregation in Huntington's disease, Biochimie, 84, 273, 10.1016/S0300-9084(02)01398-6 · DOI
  10. Sawa, 2003, Mechanisms of neuronal cell death in Huntington's disease, Cytogenet. Genome Res., 100, 287, 10.1159/000072864 · DOI
  11. Zeron, 2001, Mutant huntingtin enhances excitotoxic cell death, Mol. Cell Neurosci., 17, 41, 10.1006/mcne.2000.0909 · DOI
  12. Niclis, 2009, Human embryonic stem cell models of Huntington disease, Reprod. Biomed. Online, 19, 106, 10.1016/S1472-6483(10)60053-3 · DOI
  13. Ruvkun, 2008, The perfect storm of tiny RNAs, Nat. Med., 14, 1041, 10.1038/nm1008-1041 · DOI
  14. Chen, 2008, Characterization of microRNAs in serum, a novel class of biomarkers for diagnosis of cancer and other diseases, Cell Res., 18, 997, 10.1038/cr.2008.282 · DOI · Paper page
  15. Cortez, 2009, MicroRNA identification in plasma and serum, a new tool to diagnose and monitor diseases, Expert Opin. Biol. Ther., 9, 703, 10.1517/14712590902932889 · DOI
  16. Gilad, 2008, Serum microRNAs are promising novel biomarkers, PLoS ONE, 3, e3148, 10.1371/journal.pone.0003148 · DOI
  17. Mitchell, 2008, Circulating microRNAs as stable blood-based markers for cancer detection, Proc. Natl Acad. Sci. USA, 105, 10513, 10.1073/pnas.0804549105 · DOI · Paper page
  18. Corney, 2007, MicroRNA-34b and MicroRNA-34c are targets of P53 and cooperate in control of cell proliferation and adhesion-independent growth, Cancer Res., 67, 8433, 10.1158/0008-5472.CAN-07-1585 · DOI
  19. Benn, 2008, Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner, J. Neurosci., 28, 10720, 10.1523/JNEUROSCI.2126-08.2008 · DOI
  20. Bessert, 1995, The identification of a functional nuclear localization signal in the Huntington disease protein, Brain Res. Mol. Brain Res., 33, 165, 10.1016/0169-328X(95)00124-B · DOI
  21. Carlock, 1996, Variable sub-cellular localization of a neuron-specific protein during NTera 2 differentiation into post-mitotic human neurons, Brain Res. Mol. Brain Res., 42, 202, 10.1016/S0169-328X(96)00115-5 · DOI
  22. Andrews, 1984, Retinoic acid induces neuronal differentiation of a cloned human embryonal carcinoma cell line in vitro, Dev. Biol., 103, 285, 10.1016/0012-1606(84)90316-6 · DOI · Paper page
  23. Andrews, 1984, Pluripotent embryonal carcinoma clones derived from the human teratocarcinoma cell line Tera-2. Differentiation in vivo and in vitro, . Lab. Invest., 50, 147
  24. Subramaniam, 2009, Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity, Science, 324, 1327, 10.1126/science.1172871 · DOI
  25. He, 2009, Functional elucidation of MiR-34 in osteosarcoma cells and primary tumor samples, Biochem. Biophys. Res. Commun., 388, 35, 10.1016/j.bbrc.2009.07.101 · DOI
  26. Pigazzi, 2009, miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia, Cancer Res., 69, 2471, 10.1158/0008-5472.CAN-08-3404 · DOI
  27. Wild, 2008, Huntington's disease phenocopies are clinically and genetically heterogeneous, Mov. Disord., 23, 716, 10.1002/mds.21915 · DOI
  28. Pfister, 2009, Huntington's disease, silencing a brutal killer, Exp. Neurol., 220, 226, 10.1016/j.expneurol.2009.09.017 · DOI
  29. Roze, 2008, Pathophysiology of Huntington's disease, from huntingtin functions to potential treatments, Curr. Opin. Neurol., 21, 497, 10.1097/WCO.0b013e328304b692 · DOI
  30. Borovecki, 2005, Genome-wide expression profiling of human blood reveals biomarkers for Huntington's disease, Proc. Natl Acad. Sci. USA, 102, 11023, 10.1073/pnas.0504921102 · DOI
  31. Runne, 2007, Analysis of potential transcriptomic biomarkers for Huntington's disease in peripheral blood, Proc. Natl Acad. Sci. USA, 104, 14424, 10.1073/pnas.0703652104 · DOI
  32. Lawinger, 2000, The neuronal repressor REST/NRSF is an essential regulator in medulloblastoma cells, Nat. Med., 6, 826, 10.1038/77565 · DOI
  33. Steffan, 2000, The Huntington's disease protein interacts with P53 and CREB-binding protein and represses transcription, Proc. Natl Acad. Sci. USA, 97, 6763, 10.1073/pnas.100110097 · DOI
  34. Curtin, 2001, Retinoic acid activates P53 in human embryonal carcinoma through retinoid receptor-dependent stimulation of P53 trans-activation function, Oncogene, 20, 2559, 10.1038/sj.onc.1204370 · DOI
  35. Bae, 2005, P53 mediates cellular dysfunction and behavioural abnormalities in Huntington's disease, Neuron, 47, 29, 10.1016/j.neuron.2005.06.005 · DOI
  36. Borel, 2008, Mapping of small RNAs in the human ENCODE regions, Am. J. Hum. Genet., 82, 971, 10.1016/j.ajhg.2008.02.016 · DOI
  37. Bithell, 2009, Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease, Biochem. Soc. Trans., 37, 1270, 10.1042/BST0371270 · DOI
  38. Johnson, 2009, Gene dysregulation in Huntington's disease, REST, microRNAs and beyond, Neuromolecular Med., 11, 183, 10.1007/s12017-009-8063-4 · DOI
  39. Leucci, 2008, MYC translocation-negative classical Burkitt lymphoma cases, an alternative pathogenetic mechanism involving miRNA deregulation, J. Pathol., 216, 440, 10.1002/path.2410 · DOI
  40. Hermeking, 2007, P53 enters the microRNA world, Cancer Cell, 12, 414, 10.1016/j.ccr.2007.10.028 · DOI
  41. Sumi, 2007, Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc, Oncogene, 26, 5564, 10.1038/sj.onc.1210353 · DOI
  42. Conaco, 2006, Reciprocal actions of REST and a microRNA promote neuronal identity, Proc. Natl Acad. Sci. USA, 103, 2422, 10.1073/pnas.0511041103 · DOI · Paper page
  43. Johnson, 2008, A microRNA-based gene dysregulation pathway in Huntington's disease, Neurobiol. Dis., 29, 438, 10.1016/j.nbd.2007.11.001 · DOI · Paper page
  44. Wu, 2006, Comparative sequence analysis reveals an intricate network among REST, CREB and miRNA in mediating neuronal gene expression, Genome Biol., 7, R85, 10.1186/gb-2006-7-9-r85 · DOI · Paper page
  45. Johnson, 2008, REST regulates distinct transcriptional networks in embryonic and neural stem cells, PLoS Biol., 6, e256, 10.1371/journal.pbio.0060256 · DOI
  46. Buckley, 2009, Is REST a regulator of pluripotency?, Nature, 457, E5, 10.1038/nature07784 · DOI
  47. Jorgensen, 2009, Is REST required for ESC pluripotency?, Nature, 457, E4, 10.1038/nature07783 · DOI
  48. Singh, 2008, REST maintains self-renewal and pluripotency of embryonic stem cells, Nature, 453, 223, 10.1038/nature06863 · DOI
  49. Jorgensen, 2009, REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells, Development, 136, 715, 10.1242/dev.028548 · DOI · Paper page
  50. Dalrymple, 2007, Proteomic profiling of plasma in Huntington's disease reveals neuro-inflammatory activation and biomarker candidates, J. Proteome Res., 6, 2833, 10.1021/pr0700753 · DOI
  51. Pattyn, 2006, RTPrimerDB, the real-time PCR primer and probe database, Nucleic Acids Res., 34, D684, 10.1093/nar/gkj155 · DOI
  52. Pradervand, 2009, Impact of normalization on miRNA microarray expression profiling, RNA, 15, 493, 10.1261/rna.1295509 · DOI

Cited by

Sorted by citations

See all 145

Metadata

Authors
Gaughwin, P. M., Ciesla, M., Lahiri, N., Tabrizi, S. J., Brundin, P., & Björkqvist, M.
Venue
Human Molecular Genetics
Publisher
Oxford University Press (OUP)
Published
2011-03-19
Volume
20
Issue
11
Pages
2225-2237
ISSN
  • 1460-2083
  • 0964-6906
DOI
10.1093/hmg/ddr111
Cited by
145
References
4
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review