The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men
Abstract
The impact of male age on fecundity remains controversial. Here, a large population study was used to investigate the effect of paternal age on time to conception. All couples in the Avon Health district expecting a baby between 1 April 1991 and 31 December 1992 were eligible. Questionnaires completed by both the man and the woman at 18 weeks gestation covered specific fertility factors, e.g. parity, paternity, cohabitation and oral contraception; and non-specific factors, e.g. educational achievement, housing, cigarette smoking, alcohol consumption, obesity. Logistic regression was used to identify factors independently related to conception in < or =6 or < or =12 months. Of 8515 planned pregnancies, 74% were conceived in < or =6 months, 14% in the second 6 months and 12% after more than a year. Nine variables, including the age of the woman, were independently related to time to conception. After adjustment for these, the likelihood of conception within 6 or 12 months was lower in older men. Compared to men <25 years old, the adjusted odds ratios (95% confidence interval) for conception in < or =12 months were 0.62 (0.40, 0.98), 0.50 (0.31, 0.81) and 0.51 (0.31, 0.86) in men aged 30-34, 35-39 and > or =40 years respectively.
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Cites
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Factors that affect outcome of in-vitro fertilisation treatment
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Cited by
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731
Demographic and medical consequences of the postponement of parenthood
Schmidt, L., Sobotka, T., Bentzen, J. G., Nyboe Andersen, A., & on behalf of the ESHRE Reproduction and Society Task Force (2012) · Human Reproduction Update · doi:10.1093/humupd/dmr040 · Cited by 656
Sharma, R., Agarwal, A., Rohra, V. K., Assidi, M., Abu-Elmagd, M., & Turki, R. F. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0028-x · Cited by 451
Sartorius, G. A., & Nieschlag, E. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmp027 · Cited by 355
Paul, C., & Robaire, B. (2013) · Nature Reviews Urology · doi:10.1038/nrurol.2013.18 · Cited by 109
Metadata
- Authors
- Ford, W. C. L.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-08-01
- Volume
- 15
- Issue
- 8
- Pages
- 1703-1708
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2168623790
- Cited by
- 265
- References
- 31
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. https://app.cochat.ai/papers/10.1093/humrep/15.8.1703
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- Ford, W. C. L. (2000). Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. Human Reproduction. https://doi.org/10.1093/humrep/15.8.1703
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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